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Strain Name:
C57BL/6J-MtgxR7392Btlr/Mmmh
Stock Number:
045474-MU
Citation ID:
RRID:MMRRC_045474-MU
Other Names:
R7392 (G1)
Major Collection:

Strain Information

Col2a1
Name: collagen, type II, alpha 1
Synonyms: Del1, Col2a-1, Col2a, Col2, M100856, Rgsc856, Lpk, M100413, Rgsc413
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12824
HGNC: HGNC:2200
Homologene: 55607
Bdnf
Name: brain derived neurotrophic factor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12064
HGNC: HGNC:1033
Homologene: 7245
Bmp7
Name: bone morphogenetic protein 7
Synonyms: osteogenic protein 1, OP1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12162
HGNC: HGNC:1074
Homologene: 20410
Gpr37
Name: G protein-coupled receptor 37
Synonyms: Pael-R, parkin-associated endothelin B-like receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Hsp90ab1
Name: heat shock protein 90 alpha (cytosolic), class B member 1
Synonyms: Hsp84, Hsp90, Hsp84-1, C81438, Hspcb
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 15516
Homologene: 74306
Plcd3
Name: phospholipase C, delta 3
Synonyms: 2610205J15Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72469
HGNC: HGNC:9061
Homologene: 14858
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 24,534,034 bp
  • T to C, chromosome 1 at 53,501,661 bp
  • A to G, chromosome 1 at 151,696,224 bp
  • A to G, chromosome 1 at 183,409,276 bp
  • C to T, chromosome 2 at 26,989,324 bp
  • G to T, chromosome 2 at 34,435,154 bp
  • T to C, chromosome 2 at 44,063,774 bp
  • A to C, chromosome 2 at 85,608,488 bp
  • A to G, chromosome 2 at 86,413,152 bp
  • A to C, chromosome 2 at 109,723,930 bp
  • T to C, chromosome 2 at 125,343,924 bp
  • C to T, chromosome 2 at 172,870,205 bp
  • G to A, chromosome 3 at 87,717,175 bp
  • A to G, chromosome 4 at 11,338,809 bp
  • A to T, chromosome 4 at 33,209,265 bp
  • G to T, chromosome 4 at 83,013,827 bp
  • A to G, chromosome 4 at 109,794,843 bp
  • T to A, chromosome 4 at 129,432,890 bp
  • G to A, chromosome 5 at 30,890,771 bp
  • T to C, chromosome 5 at 45,439,376 bp
  • A to G, chromosome 5 at 45,463,909 bp
  • A to T, chromosome 5 at 62,698,385 bp
  • A to G, chromosome 5 at 88,501,664 bp
  • T to C, chromosome 5 at 138,291,366 bp
  • C to T, chromosome 6 at 25,688,787 bp
  • T to C, chromosome 6 at 81,943,012 bp
  • T to A, chromosome 6 at 87,890,275 bp
  • T to A, chromosome 6 at 118,741,920 bp
  • A to G, chromosome 6 at 128,404,950 bp
  • A to G, chromosome 6 at 142,157,277 bp
  • T to C, chromosome 6 at 146,359,340 bp
  • A to G, chromosome 7 at 25,615,676 bp
  • C to T, chromosome 7 at 28,164,372 bp
  • A to G, chromosome 7 at 28,509,669 bp
  • T to C, chromosome 7 at 29,828,625 bp
  • T to A, chromosome 7 at 41,626,566 bp
  • C to T, chromosome 7 at 44,462,015 bp
  • T to C, chromosome 7 at 45,742,438 bp
  • A to G, chromosome 7 at 104,336,397 bp
  • T to C, chromosome 7 at 106,753,382 bp
  • C to A, chromosome 7 at 108,508,084 bp
  • T to A, chromosome 7 at 140,101,160 bp
  • A to G, chromosome 10 at 53,919,187 bp
  • A to G, chromosome 10 at 90,680,786 bp
  • A to G, chromosome 10 at 97,509,998 bp
  • T to C, chromosome 11 at 60,505,976 bp
  • C to T, chromosome 11 at 76,801,779 bp
  • T to A, chromosome 11 at 87,604,557 bp
  • A to T, chromosome 11 at 100,135,560 bp
  • C to A, chromosome 11 at 103,101,557 bp
  • T to A, chromosome 12 at 3,969,588 bp
  • C to A, chromosome 12 at 54,898,765 bp
  • A to T, chromosome 12 at 61,840,304 bp
  • G to T, chromosome 12 at 76,624,229 bp
  • A to C, chromosome 12 at 81,314,803 bp
  • T to A, chromosome 13 at 55,721,586 bp
  • A to T, chromosome 13 at 81,560,689 bp
  • T to C, chromosome 13 at 91,893,737 bp
  • G to A, chromosome 13 at 106,891,691 bp
  • A to G, chromosome 14 at 19,768,656 bp
  • A to G, chromosome 14 at 52,232,855 bp
  • T to A, chromosome 14 at 69,705,880 bp
  • T to C, chromosome 14 at 103,152,191 bp
  • A to T, chromosome 14 at 103,243,128 bp
  • C to A, chromosome 15 at 83,988,951 bp
  • G to A, chromosome 15 at 97,980,151 bp
  • A to G, chromosome 15 at 98,340,311 bp
  • A to T, chromosome 16 at 3,866,505 bp
  • G to A, chromosome 16 at 22,806,502 bp
  • T to A, chromosome 16 at 32,986,755 bp
  • A to T, chromosome 16 at 56,712,609 bp
  • G to A, chromosome 17 at 24,638,624 bp
  • T to C, chromosome 17 at 27,717,288 bp
  • A to T, chromosome 17 at 28,908,377 bp
  • A to C, chromosome 17 at 30,982,332 bp
  • G to C, chromosome 17 at 45,569,048 bp
  • C to A, chromosome 17 at 80,424,200 bp
  • G to A, chromosome 18 at 34,906,050 bp
  • A to C, chromosome 18 at 37,265,118 bp
  • A to G, chromosome 19 at 3,610,199 bp
  • G to T, chromosome 19 at 12,394,465 bp
  • A to G, chromosome 19 at 12,862,587 bp
  • T to C, chromosome 19 at 43,808,687 bp
  • T to A, chromosome 19 at 47,127,997 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7392 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045474-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.