Strain Name:
C57BL/6J-MtgxR7406Btlr/Mmmh
Stock Number:
045487-MU
Citation ID:
RRID:MMRRC_045487-MU
Other Names:
R7406 (G1)
Major Collection:

Strain Information

Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: Cav3.2, alpha13.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Chst5
Name: carbohydrate sulfotransferase 5
Synonyms: GST-4, I-GlcNAc6ST
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56773
Homologene: 56927
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Agrn
Name: agrin
Synonyms: Agrin, NMF380, nmf380
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Srek1
Name: splicing regulatory glutamine/lysine-rich protein 1
Synonyms: AL118220, Sfrs12, SRrp86, SRrp508
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218543
Homologene: 10581
Slx4ip
Name: SLX4 interacting protein
Synonyms: 2410004I22Rik, 2210009G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74243
Homologene: 49913
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: 2210403E04Rik, d1401, alpha-ketoglutarate dehydrogenase, 2210412K19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Dcp2
Name: decapping mRNA 2
Synonyms: 2410015D23Rik, 5730537H01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70640
Homologene: 13968
Nedd1
Name: neural precursor cell expressed, developmentally down-regulated gene 1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17997
VEGA: 10
HGNC: HGNC:7723
Homologene: 7439
Wdr26
Name: WD repeat domain 26
Synonyms: Gid7, 1600024A01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226757
Homologene: 11857
Zbtb40
Name: zinc finger and BTB domain containing 40
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230848
Homologene: 8912
Cops7b
Name: COP9 signalosome subunit 7B
Synonyms: COP9 complex S7b, D1Wsu66e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 26895
Homologene: 8068
Clock
Name: clock circadian regulator
Synonyms: bHLHe8, KAT13D, 5330400M04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12753
HGNC: HGNC:2082
Homologene: 3603
Ctr9
Name: CTR9 homolog, Paf1/RNA polymerase II complex component
Synonyms: Sh2bp1, Tsbp, Tsp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22083
Homologene: 40668
Sfxn5
Name: sideroflexin 5
Synonyms: C230001H08Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 94282
Homologene: 16936
Rasal1
Name: RAS protein activator like 1 (GAP1 like)
Synonyms: MRASAL
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19415
HGNC: HGNC:9873
Homologene: 3423
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, 2300002E22Rik, DP, rul
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Snx29
Name: sorting nexin 29
Synonyms: Gm11170, LOC381035, LOC385605, Rundc2a, 4933437K13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74478
Homologene: 32706
Ccdc71
Name: coiled-coil domain containing 71
Synonyms: 2600016J21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72454
Homologene: 11288
Atp2a3
Name: ATPase, Ca++ transporting, ubiquitous
Synonyms: Serca3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 53313
HGNC: HGNC:813
Homologene: 69131
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Abhd8
Name: abhydrolase domain containing 8
Synonyms: 0910001L24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64296
Homologene: 11188
Fhip1a
Name: FHF complex subunit HOOK interacting protein 1A
Synonyms: 9930021J17Rik, Fam160a1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229488
Homologene: 85149
2900092C05Rik
Name: RIKEN cDNA 2900092C05 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73090
Homologene: 49900
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Prss43
Name: serine protease 43
Synonyms: LOC272643, Tessp3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 272643
Homologene: 138484
Hdhd2
Name: haloacid dehalogenase-like hydrolase domain containing 2
Synonyms: 3110052N05Rik, 0610039H12Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 76987
Homologene: 12667
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Vwa3a
Name: von Willebrand factor A domain containing 3A
Synonyms: E030013G06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233813
Homologene: 18607
Cdkl3
Name: cyclin dependent kinase like 3
Synonyms: B230379H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 213084
Homologene: 49467
Gpr179
Name: G protein-coupled receptor 179
Synonyms: 5330439C02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217143
Homologene: 34917
Spata6
Name: spermatogenesis associated 6
Synonyms: Hash, 1700062C23Rik, KRP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67946
Homologene: 10410
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Or8b1b
Name: olfactory receptor family 8 subfamily B member 1B
Synonyms: MOR167-3, GA_x6K02T2PVTD-32156773-32157705, Olfr904
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258797
VEGA: 9
Homologene: 133629
Cd300e
Name: CD300E molecule
Synonyms: Clm2, Trem5, Cd300le
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217306
Homologene: 18145
Mroh5
Name: maestro heat-like repeat family member 5
Synonyms: Gm628, LOC268816
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 268816
Ppp3cc
Name: protein phosphatase 3, catalytic subunit, gamma isoform
Synonyms: Calnc, PP2BA gamma
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 19057
VEGA: 14
HGNC: HGNC:9316
Homologene: 68475
Serpinb9f
Name: serine (or cysteine) peptidase inhibitor, clade B, member 9f
Synonyms: NK21, ovalbumin, Spi13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20709
HGNC: HGNC:8955
Homologene: 69093
Gm11168
Name: predicted gene 11168
Type: Gene
Species: Mouse
Chromosome: 9
Map1lc3b
Name: microtubule-associated protein 1 light chain 3 beta
Synonyms: Atg8, Map1lc3, 1010001C15Rik, LC3b
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67443
Homologene: 69359
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666085
Homologene: 104040
Mrgprx1
Name: MAS-related GPR, member X1
Synonyms: Mrgprc11, MrgC11
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404242
Homologene: 86184
Ncan
Name: neurocan
Synonyms: Cspg3, Cspg3-rs, Tgfbit
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13004
HGNC: HGNC:2465
Homologene: 3229
Or4k2
Name: olfactory receptor family 4 subfamily K member 2
Synonyms: GA_x6K02T2PMLR-5881670-5880717, MOR247-1, Olfr730
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258486
Homologene: 17269
Vmn2r8
Name: vomeronasal 2, receptor 8
Synonyms: EG627479
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 627479
Homologene: 129606
Vmn2r124
Name: vomeronasal 2, receptor 124
Synonyms: Vmn2r-ps113, Gm7196
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 637021
Homologene: 115024
Skint9
Name: selection and upkeep of intraepithelial T cells 9
Synonyms: A030013N09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329918
Homologene: 136292
Atf5
Name: activating transcription factor 5
Synonyms: ODA-10, Atf7, AFTA, Atfx
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 107503
HGNC: HGNC:790
Homologene: 32142
Krt6b
Name: keratin 6B
Synonyms: Krt2-6b, mK6[b]
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16688
VEGA: 15
Homologene: 136794
Or2b6
Name: olfactory receptor family 2 subfamily B member 6
Synonyms: GA_x6K02T2QHY8-11597382-11598323, MOR256-11, Olfr11
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218066
HGNC: HGNC:8241
Homologene: 40838
Tmt1a3
Name: thiol methyltransferase 1A3
Synonyms: Gm10035, Mettl7a3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 668178
VEGA: 15
Homologene: 117485
Or6c219
Name: olfactory receptor family 6 subfamily C member 219
Synonyms: GA_x6K02T2PULF-11624146-11623190, MOR110-2, Olfr818
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258773
Homologene: 74100
Tnfrsf22
Name: tumor necrosis factor receptor superfamily, member 22
Synonyms: Tnfrh2, SOBa, mDcTrailr2, C130035G06Rik, 2810028K06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 79202
Homologene: 84848
Maneal
Name: mannosidase, endo-alpha-like
Synonyms: LOC215090
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 215090
Homologene: 17597
Bpifa2
Name: BPI fold containing family A, member 2
Synonyms: Bpifa2e, Psp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19194
Homologene: 69034
2810459M11Rik
Name: RIKEN cDNA 2810459M11 gene
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 72792
Homologene: 54780
H2bc4
Name: H2B clustered histone 4
Synonyms: Hist1h2bc, H2bfs, 2610022J01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68024
Homologene: 135944
Timd6
Name: T cell immunoglobulin and mucin domain containing 6
Synonyms: BC053393
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 407814
Homologene: 86792
Ucma
Name: upper zone of growth plate and cartilage matrix associated
Synonyms: 1110017I16Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68527
Homologene: 12272
Pcdhga8
Name: protocadherin gamma subfamily A, 8
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93716
HGNC: HGNC:8706
Homologene: 57162
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 86,046,509 bp
  • T to A, chromosome 1 at 86,601,130 bp
  • A to T, chromosome 1 at 181,187,675 bp
  • G to A, chromosome 2 at 4,985,359 bp
  • T to C, chromosome 2 at 41,376,018 bp
  • A to T, chromosome 2 at 137,000,242 bp
  • T to G, chromosome 2 at 154,009,819 bp
  • T to C, chromosome 3 at 85,730,477 bp
  • T to A, chromosome 4 at 111,780,820 bp
  • T to C, chromosome 4 at 112,389,231 bp
  • A to T, chromosome 4 at 124,860,368 bp
  • A to T, chromosome 4 at 137,000,894 bp
  • A to C, chromosome 4 at 156,172,301 bp
  • A to T, chromosome 5 at 76,266,845 bp
  • A to G, chromosome 5 at 108,800,576 bp
  • A to T, chromosome 5 at 120,662,937 bp
  • A to G, chromosome 6 at 40,663,525 bp
  • A to G, chromosome 6 at 85,267,907 bp
  • A to G, chromosome 7 at 12,515,464 bp
  • A to T, chromosome 7 at 12,616,223 bp
  • T to C, chromosome 7 at 44,812,956 bp
  • T to A, chromosome 7 at 48,021,985 bp
  • A to G, chromosome 7 at 111,053,408 bp
  • A to G, chromosome 7 at 116,354,007 bp
  • T to A, chromosome 7 at 120,778,915 bp
  • T to C, chromosome 7 at 143,640,827 bp
  • T to C, chromosome 8 at 16,288,693 bp
  • T to G, chromosome 8 at 70,110,099 bp
  • A to G, chromosome 8 at 71,461,762 bp
  • A to G, chromosome 8 at 111,890,613 bp
  • T to A, chromosome 8 at 121,590,616 bp
  • C to G, chromosome 9 at 3,006,912 bp
  • T to A, chromosome 9 at 38,464,143 bp
  • T to A, chromosome 9 at 108,463,324 bp
  • T to G, chromosome 9 at 110,828,696 bp
  • A to T, chromosome 10 at 92,711,323 bp
  • A to T, chromosome 10 at 129,945,566 bp
  • A to G, chromosome 11 at 6,348,351 bp
  • A to G, chromosome 11 at 46,577,458 bp
  • A to T, chromosome 11 at 52,033,542 bp
  • A to G, chromosome 11 at 72,978,750 bp
  • G to T, chromosome 11 at 97,351,594 bp
  • G to A, chromosome 11 at 104,322,524 bp
  • A to T, chromosome 11 at 115,055,302 bp
  • T to C, chromosome 13 at 21,639,146 bp
  • A to G, chromosome 13 at 23,684,359 bp
  • G to T, chromosome 13 at 33,334,560 bp
  • A to G, chromosome 13 at 38,197,196 bp
  • A to T, chromosome 13 at 103,769,382 bp
  • T to A, chromosome 14 at 50,186,558 bp
  • A to T, chromosome 14 at 70,245,938 bp
  • A to C, chromosome 14 at 78,982,234 bp
  • T to C, chromosome 15 at 73,787,734 bp
  • T to C, chromosome 15 at 100,335,408 bp
  • T to G, chromosome 15 at 101,679,078 bp
  • G to T, chromosome 16 at 11,755,316 bp
  • T to C, chromosome 17 at 18,062,044 bp
  • C to T, chromosome 17 at 25,385,626 bp
  • A to C, chromosome 18 at 37,726,185 bp
  • A to G, chromosome 18 at 44,410,187 bp
  • C to T, chromosome 18 at 76,944,115 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7406 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045487-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.