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Strain Name:
C57BL/6J-MtgxR7406Btlr/Mmmh
Stock Number:
045487-MU
Citation ID:
RRID:MMRRC_045487-MU
Other Names:
R7406 (G1)
Major Collection:

Strain Information

Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: alpha13.2, Cav3.2, T-type Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Mapt
Name: microtubule-associated protein tau
Synonyms: Mtapt, Tau
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17762
HGNC: HGNC:6893
Homologene: 74962
Chst5
Name: carbohydrate sulfotransferase 5
Synonyms: I-GlcNAc6ST, GST-4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 56773
Homologene: 56927
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Agrn
Name: agrin
Synonyms: NMF380, Agrin, nmf380
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Srek1
Name: splicing regulatory glutamine/lysine-rich protein 1
Synonyms: SRrp508, SRrp86, Sfrs12, AL118220
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218543
Homologene: 10581
Slx4ip
Name: SLX4 interacting protein
Synonyms: 2410004I22Rik, 2210009G21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74243
Homologene: 49913
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 86,046,509 bp
  • T to A, chromosome 1 at 86,601,130 bp
  • A to T, chromosome 1 at 181,187,675 bp
  • G to A, chromosome 2 at 4,985,359 bp
  • T to C, chromosome 2 at 41,376,018 bp
  • A to T, chromosome 2 at 137,000,242 bp
  • T to G, chromosome 2 at 154,009,819 bp
  • T to C, chromosome 3 at 85,730,477 bp
  • T to A, chromosome 4 at 111,780,820 bp
  • T to C, chromosome 4 at 112,389,231 bp
  • A to T, chromosome 4 at 124,860,368 bp
  • A to T, chromosome 4 at 137,000,894 bp
  • A to C, chromosome 4 at 156,172,301 bp
  • A to T, chromosome 5 at 76,266,845 bp
  • A to G, chromosome 5 at 108,800,576 bp
  • A to T, chromosome 5 at 120,662,937 bp
  • A to G, chromosome 6 at 40,663,525 bp
  • A to G, chromosome 6 at 85,267,907 bp
  • A to G, chromosome 7 at 12,515,464 bp
  • A to T, chromosome 7 at 12,616,223 bp
  • T to C, chromosome 7 at 44,812,956 bp
  • T to A, chromosome 7 at 48,021,985 bp
  • A to G, chromosome 7 at 111,053,408 bp
  • A to G, chromosome 7 at 116,354,007 bp
  • T to A, chromosome 7 at 120,778,915 bp
  • T to C, chromosome 7 at 143,640,827 bp
  • T to C, chromosome 8 at 16,288,693 bp
  • T to G, chromosome 8 at 70,110,099 bp
  • A to G, chromosome 8 at 71,461,762 bp
  • A to G, chromosome 8 at 111,890,613 bp
  • T to A, chromosome 8 at 121,590,616 bp
  • C to G, chromosome 9 at 3,006,912 bp
  • T to A, chromosome 9 at 38,464,143 bp
  • T to A, chromosome 9 at 108,463,324 bp
  • T to G, chromosome 9 at 110,828,696 bp
  • A to T, chromosome 10 at 92,711,323 bp
  • A to T, chromosome 10 at 129,945,566 bp
  • A to G, chromosome 11 at 6,348,351 bp
  • A to G, chromosome 11 at 46,577,458 bp
  • A to T, chromosome 11 at 52,033,542 bp
  • A to G, chromosome 11 at 72,978,750 bp
  • G to T, chromosome 11 at 97,351,594 bp
  • G to A, chromosome 11 at 104,322,524 bp
  • A to T, chromosome 11 at 115,055,302 bp
  • T to C, chromosome 13 at 21,639,146 bp
  • A to G, chromosome 13 at 23,684,359 bp
  • G to T, chromosome 13 at 33,334,560 bp
  • A to G, chromosome 13 at 38,197,196 bp
  • A to T, chromosome 13 at 103,769,382 bp
  • T to A, chromosome 14 at 50,186,558 bp
  • A to T, chromosome 14 at 70,245,938 bp
  • A to C, chromosome 14 at 78,982,234 bp
  • T to C, chromosome 15 at 73,787,734 bp
  • T to C, chromosome 15 at 100,335,408 bp
  • T to G, chromosome 15 at 101,679,078 bp
  • G to T, chromosome 16 at 11,755,316 bp
  • T to C, chromosome 17 at 18,062,044 bp
  • C to T, chromosome 17 at 25,385,626 bp
  • A to C, chromosome 18 at 37,726,185 bp
  • A to G, chromosome 18 at 44,410,187 bp
  • C to T, chromosome 18 at 76,944,115 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7406 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045487-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.