Strain Name:
C57BL/6J-MtgxR7407Btlr/Mmmh
Stock Number:
045488-MU
Citation ID:
RRID:MMRRC_045488-MU
Other Names:
R7407 (G1)
Major Collection:

Strain Information

Pkd1
Name: polycystin 1, transient receptor potential channel interacting
Synonyms: polycystin-1, PC1, PC-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18763
VEGA: 17
HGNC: HGNC:9008
Homologene: 250
Dicer1
Name: dicer 1, ribonuclease type III
Synonyms: D12Ertd7e, Dicer1, 1110006F08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 192119
VEGA: 12
Homologene: 13251
Ssbp4
Name: single stranded DNA binding protein 4
Synonyms: 1210002E11Rik, Ssdp4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76900
Homologene: 41881
Trim6
Name: tripartite motif-containing 6
Synonyms: D7Ertd684e, C430046K18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 94088
Homologene: 14381
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Mhdadsk9, Dsk9, Nf-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Xpo1
Name: exportin 1
Synonyms: Crm1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103573
Homologene: 2554
Xpo6
Name: exportin 6
Synonyms: 2610005L19Rik, Ranbp20, C230091E20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74204
Homologene: 12544
Abcb8
Name: ATP-binding cassette, sub-family B member 8
Synonyms: 4833412N02Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74610
HGNC: HGNC:49
Homologene: 5203
Tenm4
Name: teneurin transmembrane protein 4
Synonyms: Doc4, l7Rn3, ELM2, Odz4, l(7)-3Rn, Ten-m4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 23966
Homologene: 8034
Ap5z1
Name: adaptor-related protein complex 5, zeta 1 subunit
Synonyms: C330006K01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231855
Homologene: 18213
Flrt2
Name: fibronectin leucine rich transmembrane protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 399558
HGNC: HGNC:3761
Homologene: 8291
Deaf1
Name: DEAF1, transcription factor
Synonyms: suppressin, NUDR, C230009B13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54006
Homologene: 9647
Palld
Name: palladin, cytoskeletal associated protein
Synonyms: 2410003B16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72333
Homologene: 75052
Galnt12
Name: polypeptide N-acetylgalactosaminyltransferase 12
Synonyms: A630062B03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230145
Homologene: 11637
Gpatch8
Name: G patch domain containing 8
Synonyms: Gpatc8, ENSMUSG00000075516, 5430405G24Rik, Fbm1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237943
Homologene: 46117
Letmd1
Name: LETM1 domain containing 1
Synonyms: HCCR1, HCCR-2, 1110019O13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68614
VEGA: 15
Homologene: 9128
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: fibrocystin L, PKHDL1, D86 mRNA
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Pcsk5
Name: proprotein convertase subtilisin/kexin type 5
Synonyms: PC5/6A, PC6, b2b1549Clo, SPC6, PC5A, b2b585Clo
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18552
VEGA: 19
HGNC: HGNC:8747
Homologene: 21244
Or2t6
Name: olfactory receptor family 2 subfamily T member 6
Synonyms: Olfr720, GA_x6K02T2PLTE-6544896-6543946, MOR274-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258387
Homologene: 74036
Vinac1
Name: vinculin/alpha-catenin family member 1
Synonyms: Gm14025
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668894
Homologene: 86340
Zfp629
Name: zinc finger protein 629
Synonyms: 9330199A09Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320683
Homologene: 65318
Lrrc7
Name: leucine rich repeat containing 7
Synonyms: densin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242274
Homologene: 10817
Ypel5
Name: yippee like 5
Synonyms: CGI-127, 2310076K21Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 383295
VEGA: 17
Homologene: 41097
Mybpc1
Name: myosin binding protein C, slow-type
Synonyms: Slow-type C-protein, 8030451F13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 109272
HGNC: HGNC:7549
Homologene: 1846
Syce1l
Name: synaptonemal complex central element protein 1 like
Synonyms: 4930481F22Rik, mmrp2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 668110
Homologene: 86343
Dnajb7
Name: DnaJ heat shock protein family (Hsp40) member B7
Synonyms: mDj5, 4933424H20Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 57755
Homologene: 77343
Agtr1b
Name: angiotensin II receptor, type 1b
Synonyms: Agtr-1b, Angtr-1b, AT1B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11608
HGNC: HGNC:336
Homologene: 84871
Crat
Name: carnitine acetyltransferase
Synonyms: CARAT
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12908
HGNC: HGNC:2342
Homologene: 598
Zfp687
Name: zinc finger protein 687
Synonyms: 4931408L03Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 78266
Homologene: 10827
Krt77
Name: keratin 77
Synonyms: 4732484G22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 406220
Homologene: 45490
Vmn2r28
Name: vomeronasal 2, receptor 28
Synonyms: EG665255
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 665255
Homologene: 129605
Vmn1r25
Name: vomeronasal 1 receptor 25
Synonyms: V1rc8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113865
Homologene: 137652
Ccdc186
Name: coiled-coil domain containing 186
Synonyms: A630007B06Rik, 1810028B20Rik, Otg1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 213993
Homologene: 9963
Amer2
Name: APC membrane recruitment 2
Synonyms: 2600011E07Rik, Amer2, Fam123a
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72125
VEGA: 14
Homologene: 45141
Or8b44
Name: olfactory receptor family 8 subfamily B member 44
Synonyms: Olfr907, MOR165-5, GA_x6K02T2PVTD-32204729-32205661
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258801
VEGA: 9
Homologene: 27268
Adamts17
Name: ADAM metallopeptidase with thrombospondin type 1 motif 17
Synonyms: AU023434
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233332
Homologene: 16373
Rhag
Name: Rhesus blood group-associated A glycoprotein
Synonyms: CD241, Rh50A, Rh50
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19743
Homologene: 68045
Zbtb24
Name: zinc finger and BTB domain containing 24
Synonyms: ZNF450
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 268294
VEGA: 10
Homologene: 8870
Ankub1
Name: ankyrin repeat and ubiquitin domain containing 1
Synonyms: LOC242037, Gm410
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242037
Homologene: 54680
Rcor3
Name: REST corepressor 3
Synonyms: E130101E15Rik, 4921514E24Rik, C730034D20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 214742
Homologene: 135671
Meltf
Name: melanotransferrin
Synonyms: melanotransferrin, Mfi2, CD228, MTf
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 30060
VEGA: 16
HGNC: HGNC:7037
Homologene: 4335
Cldn19
Name: claudin 19
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242653
HGNC: HGNC:2040
Homologene: 17528
Actbl2
Name: actin, beta-like 2
Synonyms: 4732495G21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238880
Homologene: 134276
Kdelr3
Name: KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105785
VEGA: 15
HGNC: HGNC:6306
Homologene: 68533
Pcmtd2
Name: protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2
Synonyms: 5330414D10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 245867
Homologene: 10099
Timd6
Name: T cell immunoglobulin and mucin domain containing 6
Synonyms: BC053393
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 407814
Homologene: 86792
4933405O20Rik
Name: RIKEN cDNA 4933405O20 gene
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243996
Gm32742
Name: predicted gene, 32742
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 102635385
Homologene: 132734
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 192,101,672 bp
  • C to T, chromosome 2 at 30,404,565 bp
  • A to G, chromosome 2 at 129,038,809 bp
  • T to C, chromosome 2 at 181,846,605 bp
  • T to C, chromosome 3 at 20,315,731 bp
  • T to C, chromosome 3 at 57,665,203 bp
  • C to T, chromosome 3 at 95,007,530 bp
  • G to A, chromosome 3 at 158,135,241 bp
  • T to C, chromosome 4 at 47,120,362 bp
  • A to G, chromosome 4 at 119,255,685 bp
  • T to C, chromosome 5 at 24,400,676 bp
  • A to G, chromosome 5 at 142,466,575 bp
  • T to A, chromosome 6 at 57,979,059 bp
  • A to G, chromosome 7 at 5,481,309 bp
  • A to G, chromosome 7 at 50,599,878 bp
  • C to A, chromosome 7 at 67,047,556 bp
  • T to C, chromosome 7 at 96,773,987 bp
  • T to C, chromosome 7 at 104,225,901 bp
  • A to T, chromosome 7 at 126,171,052 bp
  • T to C, chromosome 7 at 127,610,243 bp
  • G to A, chromosome 7 at 141,297,579 bp
  • G to T, chromosome 8 at 61,515,941 bp
  • A to G, chromosome 8 at 70,599,022 bp
  • C to T, chromosome 8 at 113,655,138 bp
  • T to A, chromosome 9 at 38,499,504 bp
  • A to G, chromosome 9 at 51,156,674 bp
  • A to G, chromosome 9 at 58,859,370 bp
  • C to A, chromosome 10 at 41,464,779 bp
  • T to A, chromosome 10 at 88,549,347 bp
  • T to A, chromosome 11 at 23,285,823 bp
  • A to G, chromosome 11 at 46,577,390 bp
  • A to G, chromosome 11 at 79,448,143 bp
  • G to A, chromosome 11 at 102,479,830 bp
  • A to T, chromosome 12 at 95,779,300 bp
  • G to T, chromosome 12 at 104,722,351 bp
  • A to T, chromosome 13 at 111,256,218 bp
  • T to A, chromosome 14 at 14,175,402 bp
  • A to G, chromosome 14 at 60,378,842 bp
  • A to G, chromosome 15 at 44,595,011 bp
  • A to G, chromosome 15 at 79,524,838 bp
  • G to T, chromosome 15 at 81,407,626 bp
  • G to T, chromosome 15 at 100,469,238 bp
  • T to C, chromosome 15 at 101,860,095 bp
  • T to C, chromosome 16 at 31,894,735 bp
  • T to C, chromosome 17 at 24,594,594 bp
  • A to G, chromosome 17 at 40,831,334 bp
  • A to G, chromosome 17 at 72,846,379 bp
  • T to A, chromosome 19 at 17,675,516 bp
  • T to C, chromosome 19 at 56,813,385 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7407 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045488-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.