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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7426Btlr/Mmmh
Stock Number:
045504-MU
Citation ID:
RRID:MMRRC_045504-MU
Other Names:
R7426 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Fn1
Name: fibronectin 1
Synonyms: Fn-1, Fn
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533

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Sema6d
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
Synonyms: 1110067B02Rik, Sema6D-6, Sema6D-5, Sema6D-4, Sema6D-2, Sema6D-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214968
Homologene: 16195

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Ppp1r1b
Name: protein phosphatase 1, regulatory inhibitor subunit 1B
Synonyms: DARPP-32, Darpp32
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 19049
HGNC: HGNC:9287
Homologene: 12972

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
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Mouse Phenome DB
Mouse Mine
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Monarch
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ClinGen
Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Zfp423
Name: zinc finger protein 423
Synonyms: Roaz, ataxia1, Zfp104, Ebfaz
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94187
Homologene: 9010

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Zmym1
Name: zinc finger, MYM domain containing 1
Synonyms: 5830412B09Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68310
Homologene: 32904

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Gon4l
Name: gon-4 like
Synonyms: 1500041I23Rik, 2610100B20Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76022
Homologene: 13002

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 58,289,983 bp
  • A to T, chromosome 1 at 71,649,225 bp
  • A to G, chromosome 1 at 74,920,426 bp
  • A to T, chromosome 1 at 93,621,228 bp
  • A to G, chromosome 1 at 116,442,380 bp
  • A to T, chromosome 1 at 134,595,833 bp
  • T to A, chromosome 1 at 157,105,086 bp
  • A to C, chromosome 1 at 174,117,187 bp
  • A to T, chromosome 2 at 58,017,139 bp
  • A to T, chromosome 2 at 74,675,225 bp
  • T to C, chromosome 2 at 76,917,283 bp
  • A to T, chromosome 2 at 82,980,097 bp
  • T to C, chromosome 2 at 124,654,158 bp
  • T to A, chromosome 2 at 136,000,219 bp
  • T to A, chromosome 2 at 167,048,555 bp
  • A to T, chromosome 3 at 88,907,522 bp
  • G to T, chromosome 3 at 89,381,059 bp
  • A to G, chromosome 3 at 90,528,204 bp
  • A to T, chromosome 3 at 104,800,052 bp
  • A to G, chromosome 3 at 105,943,802 bp
  • G to T, chromosome 3 at 106,155,706 bp
  • A to G, chromosome 3 at 116,758,755 bp
  • A to G, chromosome 4 at 55,370,469 bp
  • A to G, chromosome 4 at 56,804,230 bp
  • A to T, chromosome 4 at 88,755,326 bp
  • A to G, chromosome 4 at 101,745,656 bp
  • A to G, chromosome 4 at 127,049,398 bp
  • A to C, chromosome 4 at 132,114,067 bp
  • T to A, chromosome 4 at 154,156,127 bp
  • C to T, chromosome 4 at 155,385,513 bp
  • T to A, chromosome 4 at 155,651,584 bp
  • C to A, chromosome 4 at 156,249,400 bp
  • G to A, chromosome 5 at 21,971,953 bp
  • T to C, chromosome 5 at 24,595,812 bp
  • T to G, chromosome 5 at 32,321,247 bp
  • A to G, chromosome 5 at 33,026,641 bp
  • A to T, chromosome 5 at 72,524,174 bp
  • A to T, chromosome 5 at 76,915,979 bp
  • A to G, chromosome 5 at 108,100,970 bp
  • A to T, chromosome 5 at 121,205,592 bp
  • A to G, chromosome 6 at 124,779,125 bp
  • T to C, chromosome 7 at 19,970,234 bp
  • A to G, chromosome 7 at 28,086,524 bp
  • T to C, chromosome 7 at 75,124,064 bp
  • T to C, chromosome 7 at 79,693,986 bp
  • T to A, chromosome 7 at 79,777,307 bp
  • T to A, chromosome 7 at 85,751,140 bp
  • A to T, chromosome 7 at 102,477,676 bp
  • C to T, chromosome 7 at 104,617,852 bp
  • T to A, chromosome 7 at 104,703,589 bp
  • T to A, chromosome 7 at 106,689,210 bp
  • T to A, chromosome 7 at 116,372,854 bp
  • C to A, chromosome 7 at 120,345,998 bp
  • T to A, chromosome 7 at 126,438,719 bp
  • A to G, chromosome 7 at 126,581,740 bp
  • T to C, chromosome 7 at 127,475,286 bp
  • T to C, chromosome 7 at 127,538,517 bp
  • T to C, chromosome 7 at 131,554,503 bp
  • C to A, chromosome 7 at 142,383,541 bp
  • G to A, chromosome 8 at 3,516,540 bp
  • A to T, chromosome 8 at 70,748,972 bp
  • C to A, chromosome 8 at 87,780,713 bp
  • T to C, chromosome 8 at 105,950,836 bp
  • C to A, chromosome 8 at 109,575,200 bp
  • G to T, chromosome 9 at 5,321,345 bp
  • T to A, chromosome 9 at 54,601,208 bp
  • G to A, chromosome 9 at 55,762,277 bp
  • G to T, chromosome 9 at 70,802,168 bp
  • G to A, chromosome 9 at 75,251,527 bp
  • C to T, chromosome 9 at 87,192,766 bp
  • C to A, chromosome 9 at 106,895,583 bp
  • C to T, chromosome 9 at 118,559,495 bp
  • C to T, chromosome 10 at 14,131,317 bp
  • T to A, chromosome 10 at 14,716,479 bp
  • G to T, chromosome 10 at 39,045,755 bp
  • T to C, chromosome 10 at 45,605,540 bp
  • G to A, chromosome 10 at 80,344,859 bp
  • A to G, chromosome 10 at 80,529,629 bp
  • G to T, chromosome 10 at 81,502,997 bp
  • A to G, chromosome 10 at 115,347,699 bp
  • G to T, chromosome 10 at 128,116,078 bp
  • A to G, chromosome 10 at 129,160,751 bp
  • T to C, chromosome 10 at 129,647,158 bp
  • C to A, chromosome 11 at 3,530,249 bp
  • T to C, chromosome 11 at 53,372,875 bp
  • A to T, chromosome 11 at 67,893,016 bp
  • G to A, chromosome 11 at 70,462,188 bp
  • A to G, chromosome 11 at 87,731,852 bp
  • A to G, chromosome 11 at 97,213,156 bp
  • G to A, chromosome 11 at 98,355,479 bp
  • G to T, chromosome 11 at 100,464,352 bp
  • A to T, chromosome 11 at 102,456,294 bp
  • A to G, chromosome 11 at 114,928,302 bp
  • T to A, chromosome 11 at 118,090,717 bp
  • T to C, chromosome 11 at 120,642,923 bp
  • A to T, chromosome 12 at 72,084,931 bp
  • A to C, chromosome 13 at 12,997,480 bp
  • T to A, chromosome 13 at 13,637,524 bp
  • T to C, chromosome 13 at 14,181,306 bp
  • T to C, chromosome 13 at 24,694,205 bp
  • C to A, chromosome 13 at 36,726,851 bp
  • C to T, chromosome 13 at 65,035,361 bp
  • T to A, chromosome 14 at 26,724,626 bp
  • T to C, chromosome 14 at 121,954,744 bp
  • A to G, chromosome 15 at 27,856,107 bp
  • G to T, chromosome 16 at 5,180,875 bp
  • T to C, chromosome 16 at 95,459,156 bp
  • G to A, chromosome 17 at 6,069,314 bp
  • G to A, chromosome 17 at 35,669,358 bp
  • A to G, chromosome 17 at 46,400,069 bp
  • A to G, chromosome 18 at 4,675,529 bp
  • G to T, chromosome 18 at 37,092,497 bp
  • G to A, chromosome 18 at 37,423,260 bp
  • A to G, chromosome 18 at 61,504,385 bp
  • C to T, chromosome 19 at 6,318,398 bp
  • C to T, chromosome 19 at 34,116,198 bp
  • T to C, chromosome 19 at 41,948,278 bp
  • T to C, chromosome 19 at 45,033,647 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7426 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045504-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.