Strain Name:
C57BL/6J-MtgxR7428Btlr/Mmmh
Stock Number:
045506-MU
Citation ID:
RRID:MMRRC_045506-MU
Other Names:
R7428 (G1)
Major Collection:

Strain Information

Slc12a1
Name: solute carrier family 12, member 1
Synonyms: Nkcc2, mBSC1, D630042G03Rik, urehr3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20495
Homologene: 286
Hlcs
Name: holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
Synonyms: 410I21.SP6, D16Jhu34
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 110948
VEGA: 16
HGNC: HGNC:4976
Homologene: 37302
Pcdh9
Name: protocadherin 9
Synonyms: C630029H24Rik, 1500001L12Rik, LOC382930, A730003J17Rik, C530050I23Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211712
HGNC: HGNC:8661
Homologene: 10698
Mthfr
Name: methylenetetrahydrofolate reductase
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17769
HGNC: HGNC:7436
Homologene: 4349
Scrib
Name: scribbled planar cell polarity
Synonyms: Scrb1, Crc
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105782
Homologene: 44228
Kif13b
Name: kinesin family member 13B
Synonyms: GAKIN, N-3 kinesin, C130021D12Rik, 5330429L19Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 16554
VEGA: 14
Homologene: 9073
Nup98
Name: nucleoporin 98
Synonyms: Nup96
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 269966
HGNC: HGNC:8068
Homologene: 35472
Nup205
Name: nucleoporin 205
Synonyms: 3830404O05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70699
Homologene: 45971
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Otof
Name: otoferlin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 83762
HGNC: HGNC:8515
Homologene: 12892
Dmbt1
Name: deleted in malignant brain tumors 1
Synonyms: CRP-[b], CRP-[a], ebnerin, hensin, vomeroglandin, Crpd, MUCLIN, gp300
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12945
HGNC: HGNC:2926
Homologene: 68990
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Leng8
Name: leukocyte receptor cluster (LRC) member 8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232798
Homologene: 13612
Crtam
Name: cytotoxic and regulatory T cell molecule
Synonyms: class I-restricted T cell-associated molecule
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54698
Homologene: 10454
Cntrl
Name: centriolin
Synonyms: IB3/5, 6720467O09Rik, Ma2a8, Cep1, b2b1468Clo, Cep110
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 26920
HGNC: HGNC:1858
Homologene: 38260
Cyb5b
Name: cytochrome b5 type B
Synonyms: 1810044O22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66427
Homologene: 23546
Atl2
Name: atlastin GTPase 2
Synonyms: Aip-2, 2010110I21Rik, Arl6ip2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56298
VEGA: 17
Homologene: 56949
Inpp5f
Name: inositol polyphosphate-5-phosphatase F
Synonyms: cI-27, SAC2, 5830435P03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101490
Homologene: 8962
Tbc1d2
Name: TBC1 domain family, member 2
Synonyms: LOC381605, PARIS-1, PARIS1, A630005A06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381605
Homologene: 10190
Prom2
Name: prominin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 192212
Homologene: 44536
Wnt9b
Name: wingless-type MMTV integration site family, member 9B
Synonyms: clf, Wnt14b, Wnt15, clf1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22412
Homologene: 2551
Cep295
Name: centrosomal protein 295
Synonyms: LOC382128, 5830418K08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 319675
Homologene: 27936
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Ddit4l
Name: DNA-damage-inducible transcript 4-like
Synonyms: RTP801L, 1700108M02Rik, 1700037B15Rik, REDD2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73284
Homologene: 12698
Prkg1
Name: protein kinase, cGMP-dependent, type I
Synonyms: Prkgr1b, Prkg1b
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19091
HGNC: HGNC:9414
Homologene: 55964
Ism2
Name: isthmin 2
Synonyms: LOC217738, Thsd3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217738
Homologene: 83509
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Pclo
Name: piccolo (presynaptic cytomatrix protein)
Synonyms: Acz, Pico
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26875
Homologene: 69111
Ptprd
Name: protein tyrosine phosphatase receptor type D
Synonyms: 3000002J10Rik, B230219D21Rik, 1110002J03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19266
HGNC: HGNC:9668
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Slc35f4
Name: solute carrier family 35, member F4
Synonyms: 4930550L21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75288
Homologene: 45939
Phf7
Name: PHD finger protein 7
Synonyms: 1700010P14Rik, 1700006H01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71838
VEGA: 14
Homologene: 69217
Bpifb5
Name: BPI fold containing family B, member 5
Synonyms: BC018465
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228802
Homologene: 64814
Zfp867
Name: zinc finger protein 867
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237775
Homologene: 64827
Nxpe5
Name: neurexophilin and PC-esterase domain family, member 5
Synonyms: Fam55 related, BC055004
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381680
Homologene: 134143
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192187
Homologene: 9035
Vmn1r195
Name: vomeronasal 1 receptor 195
Synonyms: V1ri6
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 171257
Homologene: 110880
Vmn2r93
Name: vomeronasal 2, receptor 93
Synonyms: EG627132
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627132
Homologene: 129750
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68915
Homologene: 57502
Tmem145
Name: transmembrane protein 145
Synonyms: B930076A02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330485
Homologene: 18333
Rfx4
Name: regulatory factor X, 4 (influences HLA class II expression)
Synonyms: 4933412G19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71137
HGNC: HGNC:9985
Homologene: 31119
Zfp541
Name: zinc finger protein 541
Synonyms: EG666528
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666528
Homologene: 12991
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Pde6c
Name: phosphodiesterase 6C, cGMP specific, cone, alpha prime
Synonyms: cpfl1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 110855
VEGA: 19
HGNC: HGNC:8787
Homologene: 4521
Sap30
Name: sin3 associated polypeptide
Synonyms: 30kDa
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 60406
Homologene: 2869
Or5m3
Name: olfactory receptor family 5 subfamily M member 3
Synonyms: GA_x6K02T2Q125-47485813-47486745, MOR199-1, Olfr1032
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258572
Homologene: 17299
Or5m12
Name: olfactory receptor family 5 subfamily M member 12
Synonyms: GA_x6K02T2Q125-47384320-47383337, MOR197-1, Olfr1024
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 257900
Homologene: 128271
Or9s18
Name: olfactory receptor family 9 subfamily S member 18
Synonyms: GA_x6K02T2PB7A-3051266-3052192, MOR209-1, Olfr466
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 258816
Homologene: 72032
Slco4c1
Name: solute carrier organic anion transporter family, member 4C1
Synonyms: SLC21A20, PRO2176, OATP4C1, OATP-M1, OATP-H, C330017E21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227394
Homologene: 62654
Cxcr6
Name: C-X-C motif chemokine receptor 6
Synonyms: STRL33, BONZO
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80901
VEGA: 9
Homologene: 38197
Hpdl
Name: 4-hydroxyphenylpyruvate dioxygenase-like
Synonyms: A830048M07Rik, Gloxd1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242642
Homologene: 13109
Creb5
Name: cAMP responsive element binding protein 5
Synonyms: D430026C09Rik, Crebpa, 9430076C15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 231991
Homologene: 18215
Or12e9
Name: olfactory receptor family 12 subfamily E member 9
Synonyms: GA_x6K02T2Q125-48863863-48864807, MOR264-18, Olfr1121
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258345
Homologene: 74084
Vmn2r69
Name: vomeronasal 2, receptor 69
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330581
Homologene: 115466
Or52m1
Name: olfactory receptor family 52 subfamily M member 1
Synonyms: GA_x6K02T2PBJ9-5356887-5357840, MOR25-1, Olfr554
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258322
Homologene: 105158
Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Synonyms: RIP14, FXR, HRR1, Rxrip14, Fxr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20186
HGNC: HGNC:7967
Homologene: 3760
Taar8c
Name: trace amine-associated receptor 8C
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 494546
Homologene: 77586
Cry2
Name: cryptochrome circadian regulator 2
Synonyms: D130054K12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12953
HGNC: HGNC:2385
Homologene: 56466
Anxa10
Name: annexin A10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26359
HGNC: HGNC:534
Homologene: 21409
Zfp128
Name: zinc finger protein 128
Synonyms: mZnf8, 9630016P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243833
Homologene: 10889
Slc35f1
Name: solute carrier family 35, member F1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215085
Homologene: 33552
Zfp971
Name: zinc finger protein 971
Synonyms: Etohi1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 626848
Homologene: 134324
Cbarp
Name: calcium channel, voltage-dependent, beta subunit associated regulatory protein
Synonyms: R29144/1, Dos
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100503659
Homologene: 82309
Tex36
Name: testis expressed 36
Synonyms: 4930404H21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73808
Homologene: 67014
Mocs2
Name: molybdenum cofactor synthesis 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17434
HGNC: HGNC:7193
Homologene: 32193
Rhobtb1
Name: Rho-related BTB domain containing 1
Synonyms: 1700008H16Rik, 3110048G13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69288
Homologene: 8892
B3gnt4
Name: UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
Synonyms: 1010001G17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231727
Homologene: 81939
Pdia6
Name: protein disulfide isomerase associated 6
Synonyms: CaBP5, P5, 1700015E05Rik, Txndc7
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71853
Homologene: 4198
Sprr2f
Name: small proline-rich protein 2F
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20760
D630036H23Rik
Name: RIKEN cDNA D630036H23 gene
Type: Gene
Species: Mouse
Chromosome: 12
Gm21886
Name: predicted gene, 21886
Type: Gene
Species: Mouse
Chromosome: 18
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 96,837,520 bp
  • T to C, chromosome 1 at 155,894,619 bp
  • T to A, chromosome 2 at 35,170,534 bp
  • T to G, chromosome 2 at 76,720,354 bp
  • T to A, chromosome 2 at 85,904,131 bp
  • A to T, chromosome 2 at 86,008,219 bp
  • G to T, chromosome 2 at 87,371,690 bp
  • T to C, chromosome 2 at 92,413,047 bp
  • C to A, chromosome 2 at 125,214,132 bp
  • A to G, chromosome 2 at 127,539,811 bp
  • G to A, chromosome 2 at 154,225,122 bp
  • T to A, chromosome 2 at 178,033,174 bp
  • G to A, chromosome 3 at 92,365,944 bp
  • A to G, chromosome 3 at 137,626,170 bp
  • G to A, chromosome 4 at 46,649,965 bp
  • G to A, chromosome 4 at 76,086,468 bp
  • A to T, chromosome 4 at 116,820,865 bp
  • A to G, chromosome 4 at 148,051,603 bp
  • A to T, chromosome 5 at 14,750,517 bp
  • G to T, chromosome 5 at 30,389,825 bp
  • A to G, chromosome 5 at 123,510,731 bp
  • A to C, chromosome 5 at 138,239,760 bp
  • T to A, chromosome 6 at 35,227,559 bp
  • C to A, chromosome 6 at 53,681,158 bp
  • C to T, chromosome 7 at 4,143,573 bp
  • A to G, chromosome 7 at 12,890,362 bp
  • A to T, chromosome 7 at 16,092,868 bp
  • T to C, chromosome 7 at 25,307,165 bp
  • T to C, chromosome 7 at 85,411,259 bp
  • A to T, chromosome 7 at 102,135,001 bp
  • A to G, chromosome 7 at 102,640,326 bp
  • A to G, chromosome 7 at 128,679,805 bp
  • A to T, chromosome 7 at 131,108,463 bp
  • T to C, chromosome 7 at 133,595,137 bp
  • A to G, chromosome 8 at 16,023,850 bp
  • C to T, chromosome 8 at 57,487,512 bp
  • T to A, chromosome 8 at 62,092,509 bp
  • A to G, chromosome 8 at 107,170,416 bp
  • A to G, chromosome 9 at 15,333,498 bp
  • G to C, chromosome 9 at 40,981,182 bp
  • T to C, chromosome 9 at 109,108,168 bp
  • A to T, chromosome 9 at 123,810,240 bp
  • A to C, chromosome 10 at 24,101,548 bp
  • T to A, chromosome 10 at 53,089,414 bp
  • T to A, chromosome 10 at 69,248,824 bp
  • T to C, chromosome 10 at 80,131,304 bp
  • C to A, chromosome 10 at 84,896,012 bp
  • T to C, chromosome 10 at 89,498,405 bp
  • C to T, chromosome 11 at 59,463,934 bp
  • A to G, chromosome 11 at 67,332,564 bp
  • T to C, chromosome 11 at 103,730,817 bp
  • T to C, chromosome 12 at 17,278,545 bp
  • T to C, chromosome 12 at 36,381,538 bp
  • G to T, chromosome 12 at 87,286,995 bp
  • T to C, chromosome 13 at 22,278,852 bp
  • A to G, chromosome 13 at 65,153,052 bp
  • A to G, chromosome 13 at 114,820,864 bp
  • A to G, chromosome 14 at 29,064,275 bp
  • T to C, chromosome 14 at 31,159,259 bp
  • C to T, chromosome 14 at 31,240,413 bp
  • T to A, chromosome 14 at 49,298,898 bp
  • T to C, chromosome 14 at 64,788,460 bp
  • G to T, chromosome 14 at 93,887,111 bp
  • G to A, chromosome 15 at 76,061,198 bp
  • A to G, chromosome 16 at 94,267,899 bp
  • A to T, chromosome 17 at 18,326,410 bp
  • A to T, chromosome 17 at 35,666,686 bp
  • T to C, chromosome 17 at 79,875,798 bp
  • A to T, chromosome 18 at 80,089,652 bp
  • T to C, chromosome 19 at 30,578,835 bp
  • T to C, chromosome 19 at 38,157,536 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7428 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045506-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.