Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7431Btlr/Mmmh
Stock Number:
045509-MU
Citation ID:
RRID:MMRRC_045509-MU
Other Names:
R7431 (G1)
Major Collection:

Strain Information

Prkar2b
Name: protein kinase, cAMP dependent regulatory, type II beta
Synonyms: Pkarb2, RII(beta), PKARIIbeta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19088
HGNC: HGNC:9392
Homologene: 37666
Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Dpagt1
Name: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
Synonyms: GPT, Dpagt2, Gnpta
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13478
VEGA: 9
HGNC: HGNC:2995
Homologene: 1058
Cyp39a1
Name: cytochrome P450, family 39, subfamily a, polypeptide 1
Synonyms: oxysterol 7-alpha-hydroxylase
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 56050
VEGA: 17
Homologene: 9580
Golga4
Name: golgin A4
Synonyms: golgin-245, Olp-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 54214
HGNC: HGNC:4427
Homologene: 68224
Znfx1
Name: zinc finger, NFX1-type containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98999
Homologene: 10877
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 69,923,872 bp
  • T to A, chromosome 1 at 87,821,337 bp
  • A to T, chromosome 1 at 93,750,501 bp
  • A to G, chromosome 1 at 164,051,620 bp
  • A to G, chromosome 1 at 172,250,907 bp
  • A to T, chromosome 1 at 174,028,377 bp
  • C to T, chromosome 1 at 178,256,441 bp
  • G to T, chromosome 2 at 62,352,238 bp
  • A to G, chromosome 2 at 87,489,938 bp
  • T to C, chromosome 2 at 130,394,046 bp
  • T to C, chromosome 2 at 161,026,328 bp
  • T to C, chromosome 2 at 167,055,792 bp
  • T to A, chromosome 3 at 39,009,157 bp
  • C to A, chromosome 3 at 87,258,926 bp
  • T to A, chromosome 3 at 101,897,940 bp
  • T to A, chromosome 3 at 102,749,791 bp
  • A to T, chromosome 3 at 115,892,732 bp
  • A to T, chromosome 3 at 144,911,133 bp
  • T to C, chromosome 4 at 43,770,882 bp
  • T to A, chromosome 4 at 72,851,441 bp
  • A to T, chromosome 4 at 99,221,395 bp
  • T to C, chromosome 4 at 110,226,633 bp
  • A to G, chromosome 4 at 119,477,811 bp
  • A to T, chromosome 5 at 8,092,818 bp
  • T to C, chromosome 5 at 35,511,142 bp
  • A to C, chromosome 5 at 41,813,120 bp
  • A to G, chromosome 5 at 52,162,611 bp
  • T to C, chromosome 5 at 122,354,478 bp
  • T to A, chromosome 6 at 42,215,974 bp
  • C to T, chromosome 6 at 70,011,004 bp
  • G to A, chromosome 6 at 71,926,659 bp
  • G to T, chromosome 6 at 72,336,268 bp
  • A to T, chromosome 6 at 119,244,276 bp
  • T to A, chromosome 7 at 26,061,551 bp
  • T to C, chromosome 7 at 33,739,249 bp
  • T to C, chromosome 7 at 34,284,794 bp
  • T to G, chromosome 7 at 45,929,246 bp
  • T to A, chromosome 7 at 63,891,756 bp
  • G to T, chromosome 7 at 110,351,750 bp
  • T to A, chromosome 7 at 120,051,744 bp
  • T to A, chromosome 7 at 120,730,650 bp
  • T to C, chromosome 7 at 123,983,290 bp
  • G to T, chromosome 8 at 111,160,754 bp
  • A to G, chromosome 8 at 119,870,382 bp
  • A to G, chromosome 9 at 18,607,993 bp
  • T to C, chromosome 9 at 20,770,835 bp
  • T to A, chromosome 9 at 44,274,700 bp
  • T to A, chromosome 9 at 44,326,087 bp
  • A to T, chromosome 9 at 105,928,269 bp
  • T to C, chromosome 9 at 111,362,402 bp
  • G to A, chromosome 9 at 118,559,731 bp
  • A to T, chromosome 10 at 10,391,955 bp
  • T to A, chromosome 10 at 79,491,472 bp
  • T to A, chromosome 10 at 80,302,183 bp
  • T to A, chromosome 10 at 127,458,147 bp
  • A to G, chromosome 11 at 22,973,580 bp
  • G to A, chromosome 11 at 40,753,918 bp
  • G to A, chromosome 11 at 55,309,101 bp
  • A to G, chromosome 11 at 69,578,487 bp
  • G to A, chromosome 11 at 83,504,953 bp
  • G to T, chromosome 11 at 83,519,268 bp
  • CA to C, chromosome 11 at 110,127,426 bp
  • A to T, chromosome 12 at 31,963,151 bp
  • G to A, chromosome 12 at 40,133,922 bp
  • T to G, chromosome 12 at 70,078,223 bp
  • A to G, chromosome 12 at 101,884,019 bp
  • T to C, chromosome 14 at 55,772,672 bp
  • A to G, chromosome 14 at 95,881,837 bp
  • A to G, chromosome 14 at 105,117,092 bp
  • G to T, chromosome 16 at 20,558,789 bp
  • G to T, chromosome 16 at 22,825,813 bp
  • G to T, chromosome 16 at 45,593,484 bp
  • A to G, chromosome 16 at 89,041,213 bp
  • A to G, chromosome 17 at 43,683,015 bp
  • G to A, chromosome 17 at 66,342,906 bp
  • T to A, chromosome 17 at 81,441,663 bp
  • T to G, chromosome 18 at 22,516,953 bp
  • A to T, chromosome 18 at 61,147,445 bp
  • C to A, chromosome 18 at 69,347,178 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7431 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045509-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.