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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7439Btlr/Mmmh
Stock Number:
045515-MU
Citation ID:
RRID:MMRRC_045515-MU
Other Names:
R7439 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Lamb3
Name: laminin, beta 3
Synonyms: nicein, 125kDa
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16780
HGNC: HGNC:6490
Homologene: 191

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ClinGen
Lhx5
Name: LIM homeobox protein 5
Synonyms: Lim2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 16873
Homologene: 40621

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Xrn1
Name: 5'-3' exoribonuclease 1
Synonyms: mXrn1, Dhm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 24127
Homologene: 5894

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ClinGen
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: 2410098H20Rik, D5Bwg1524e, Rutbc2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485

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IMPC
Google
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Dscaml1
Name: DS cell adhesion molecule like 1
Synonyms: 4930435C18Rik, 4921507G06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 114873
VEGA: 9
Homologene: 79549

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IMPC
Google
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PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Coa4
Name: cytochrome c oxidase assembly factor 4
Synonyms: 5330414O08Rik, Chchd8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68185
Homologene: 9567

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
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Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
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ClinGen
Swt1
Name: SWT1 RNA endoribonuclease homolog (S. cerevisiae)
Synonyms: 1200016B10Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66875
Homologene: 32355

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 37,911,137 bp
  • A to C, chromosome 1 at 38,051,637 bp
  • A to C, chromosome 1 at 120,241,518 bp
  • A to G, chromosome 1 at 131,762,818 bp
  • A to T, chromosome 1 at 151,411,064 bp
  • T to C, chromosome 1 at 152,771,436 bp
  • C to A, chromosome 1 at 193,332,166 bp
  • A to T, chromosome 2 at 6,018,932 bp
  • T to A, chromosome 2 at 86,171,010 bp
  • A to G, chromosome 2 at 89,993,839 bp
  • T to C, chromosome 2 at 90,449,819 bp
  • A to T, chromosome 2 at 113,441,611 bp
  • A to G, chromosome 2 at 154,228,933 bp
  • A to G, chromosome 3 at 60,086,696 bp
  • G to A, chromosome 3 at 72,909,041 bp
  • T to C, chromosome 4 at 144,777,762 bp
  • A to G, chromosome 4 at 145,105,856 bp
  • T to A, chromosome 4 at 152,113,935 bp
  • T to A, chromosome 5 at 31,244,956 bp
  • T to C, chromosome 5 at 73,491,536 bp
  • T to A, chromosome 5 at 76,545,348 bp
  • T to C, chromosome 5 at 113,274,321 bp
  • T to C, chromosome 5 at 114,195,642 bp
  • C to A, chromosome 5 at 117,250,909 bp
  • T to A, chromosome 5 at 120,440,284 bp
  • T to A, chromosome 5 at 124,463,788 bp
  • T to G, chromosome 5 at 139,166,113 bp
  • C to CTCA, chromosome 6 at 4,756,453 bp
  • A to G, chromosome 6 at 5,177,399 bp
  • T to G, chromosome 6 at 131,490,391 bp
  • T to A, chromosome 7 at 7,817,014 bp
  • T to C, chromosome 7 at 19,822,611 bp
  • T to A, chromosome 7 at 79,117,269 bp
  • T to A, chromosome 7 at 100,539,271 bp
  • C to T, chromosome 8 at 13,223,069 bp
  • A to G, chromosome 9 at 45,710,326 bp
  • T to A, chromosome 9 at 57,027,433 bp
  • T to C, chromosome 9 at 96,051,629 bp
  • A to G, chromosome 9 at 106,214,398 bp
  • A to G, chromosome 9 at 107,023,732 bp
  • A to G, chromosome 10 at 24,049,987 bp
  • A to G, chromosome 10 at 58,256,901 bp
  • G to A, chromosome 10 at 62,430,615 bp
  • T to C, chromosome 10 at 103,214,519 bp
  • G to A, chromosome 10 at 117,238,697 bp
  • T to C, chromosome 10 at 130,392,113 bp
  • T to C, chromosome 11 at 50,922,397 bp
  • C to T, chromosome 11 at 61,451,028 bp
  • A to T, chromosome 11 at 61,546,848 bp
  • A to T, chromosome 11 at 84,126,986 bp
  • G to A, chromosome 11 at 94,484,041 bp
  • G to T, chromosome 11 at 102,400,046 bp
  • A to T, chromosome 11 at 120,611,383 bp
  • A to G, chromosome 12 at 76,576,485 bp
  • G to A, chromosome 12 at 79,089,550 bp
  • T to G, chromosome 12 at 110,636,453 bp
  • T to C, chromosome 12 at 112,124,821 bp
  • G to A, chromosome 13 at 13,994,485 bp
  • T to C, chromosome 13 at 38,176,502 bp
  • A to G, chromosome 13 at 38,195,449 bp
  • T to A, chromosome 14 at 27,471,645 bp
  • T to A, chromosome 14 at 44,722,940 bp
  • A to G, chromosome 14 at 75,126,257 bp
  • A to G, chromosome 15 at 64,130,256 bp
  • A to T, chromosome 15 at 71,463,680 bp
  • A to G, chromosome 15 at 84,804,903 bp
  • T to G, chromosome 16 at 19,530,900 bp
  • A to T, chromosome 17 at 21,560,870 bp
  • T to A, chromosome 17 at 34,610,909 bp
  • A to G, chromosome 17 at 56,297,931 bp
  • T to A, chromosome 18 at 34,312,073 bp
  • A to G, chromosome 19 at 23,242,700 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7439 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045515-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.