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Strain Name:
C57BL/6J-MtgxR7440Btlr/Mmmh
Stock Number:
045516-MU
Citation ID:
RRID:MMRRC_045516-MU
Other Names:
R7440 (G1)
Major Collection:

Strain Information

Acadm
Name: acyl-Coenzyme A dehydrogenase, medium chain
Synonyms: MCAD
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11364
HGNC: HGNC:89
Homologene: 3
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Map7
Name: microtubule-associated protein 7
Synonyms: E-MAP-115, mste, ste, mshi, Mtap7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17761
VEGA: 10
HGNC: HGNC:6869
Homologene: 20851
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: BC032203, Gltscr1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Ankrd13a
Name: ankyrin repeat domain 13a
Synonyms: 1100001D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68420
Homologene: 23814
Fuz
Name: fuzzy planar cell polarity protein
Synonyms: 2600013E07Rik, b2b1273Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70300
Homologene: 11840
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Dhx9
Name: DExH-box helicase 9
Synonyms: leukophysin, nuclear DNA helicase II, RNA helicase, Ddx9, NDH II, NDHII, RHA
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13211
HGNC: HGNC:2750
Homologene: 1039
Ncapg2
Name: non-SMC condensin II complex, subunit G2
Synonyms: Mtb, 5830426I05Rik, Luzp5, mCAP-G2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76044
VEGA: 12
Homologene: 9820
Miga1
Name: mitoguardin 1
Synonyms: C030011O14Rik, Mita1, Fam73a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 215708
Homologene: 18369
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Cog4
Name: component of oligomeric golgi complex 4
Synonyms: D8Ertd515e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102339
Homologene: 7155
Cep350
Name: centrosomal protein 350
Synonyms: 6430546F08Rik, 4933409L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74081
Homologene: 8879
Ap1g1
Name: adaptor protein complex AP-1, gamma 1 subunit
Synonyms: gamma-adaptin, Adtg, D8Ertd374e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11765
HGNC: HGNC:555
Homologene: 47995
Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13078
VEGA: 17
HGNC: HGNC:2597
Homologene: 68035
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 1700012P13Rik, 2900054P12Rik, Gcap14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72972
Homologene: 10367
Adat1
Name: adenosine deaminase, tRNA-specific 1
Synonyms: mADAT1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 30947
HGNC: HGNC:228
Homologene: 8096
Tnfrsf9
Name: tumor necrosis factor receptor superfamily, member 9
Synonyms: 4-1BB, CDw137, Ly63, Cd137, ILA, A930040I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21942
Homologene: 1199
Slc39a11
Name: solute carrier family 39 (metal ion transporter), member 11
Synonyms: 1810074D23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69806
Homologene: 12331
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Rcc1
Name: regulator of chromosome condensation 1
Synonyms: 4931417M11Rik, Chc1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100088
HGNC: HGNC:1913
Homologene: 55567
Jak3
Name: Janus kinase 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16453
HGNC: HGNC:6193
Homologene: 181
Syt17
Name: synaptotagmin XVII
Synonyms: Bk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110058
Homologene: 9553
Chpf
Name: chondroitin polymerizing factor
Synonyms: 1700028N03Rik, D1Bwg1363e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74241
Homologene: 11574
Oit3
Name: oncoprotein induced transcript 3
Synonyms: EF-9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18302
Homologene: 7870
Ptprs
Name: protein tyrosine phosphatase receptor type S
Synonyms: PTP-NU3, PTPsigma, RPTPsigma, Ptpt9
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Dnajb6
Name: DnaJ heat shock protein family (Hsp40) member B6
Synonyms: Mrj, mDj4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 23950
Homologene: 38058
Mgat5b
Name: mannoside acetylglucosaminyltransferase 5, isoenzyme B
Synonyms: GnT-IX
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268510
Homologene: 27821
Steap3
Name: STEAP family member 3
Synonyms: pHyde, 1010001D01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68428
Homologene: 10084
Insc
Name: INSC spindle orientation adaptor protein
Synonyms: Inscuteable, 3830422K02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233752
Homologene: 78662
Pld1
Name: phospholipase D1
Synonyms: Pld1b, Pld1a
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 18805
HGNC: HGNC:9067
Homologene: 116234
Intu
Name: inturned planar cell polarity protein
Synonyms: 9430087H23Rik, 9230116I04Rik, Pdzk6, Pdzd6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 380614
Homologene: 41059
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195046
Homologene: 133820
Adcy2
Name: adenylate cyclase 2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210044
VEGA: 13
HGNC: HGNC:233
Homologene: 75133
Chd5
Name: chromodomain helicase DNA binding protein 5
Synonyms: B230399N07Rik, 4930532L22Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269610
Homologene: 56712
Col6a5
Name: collagen, type VI, alpha 5
Synonyms: Col6a5, Gm7455
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 665033
Homologene: 122792
Tlr11
Name: toll-like receptor 11
Synonyms: LOC239081
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239081
Homologene: 77905
Trpv3
Name: transient receptor potential cation channel, subfamily V, member 3
Synonyms: 1110036I10Rik, VRL3, Nh
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246788
Homologene: 17040
Lrrk1
Name: leucine-rich repeat kinase 1
Synonyms: D130026O16Rik, C230002E15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233328
Homologene: 23464
Cntln
Name: centlein, centrosomal protein
Synonyms: B430108F07Rik, D530005L17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 338349
Homologene: 9805
Ppfibp1
Name: PTPRF interacting protein, binding protein 1 (liprin beta 1)
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 67533
HGNC: HGNC:9249
Homologene: 2685
Nkx6-3
Name: NK6 homeobox 3
Synonyms: Nkx6.3, 9130417I07Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74561
Homologene: 46375
Usp3
Name: ubiquitin specific peptidase 3
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235441
Homologene: 4766
Klf11
Name: Kruppel-like transcription factor 11
Synonyms: Tieg2b, D12Ertd427e, Tieg2, Tieg3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 194655
Homologene: 2668
Rimbp3
Name: RIMS binding protein 3
Synonyms: LOC239731, LOC385766, RIM-BP3
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239731
Homologene: 77940
Meioc
Name: meiosis specific with coiled-coil domain
Synonyms: LOC380729, LOC268491, Gm1564
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268491
Homologene: 19559
Vmn2r117
Name: vomeronasal 2, receptor 117
Synonyms: EG619788, V2Rp6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 619788
Homologene: 86604
Mgst1
Name: microsomal glutathione S-transferase 1
Synonyms: 1500002K10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 56615
HGNC: HGNC:7061
Homologene: 10544
Lrrc63
Name: leucine rich repeat containing 63
Synonyms: 4921509B22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70859
Homologene: 52823
Prdx6b
Name: peroxiredoxin 6B
Synonyms: Aop2-rs1, 1-cysPrx-P1, 4930414C22Rik, Prdx6-ps1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320769
Homologene: 71226
Zfp936
Name: zinc finger protein 936
Synonyms: EG435970, Gm9272, I1C0022H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668620
Ndufaf7
Name: NADH:ubiquinone oxidoreductase complex assembly factor 7
Synonyms: 2410091C18Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 73694
VEGA: 17
Homologene: 12508
Mrps33
Name: mitochondrial ribosomal protein S33
Synonyms: MRP-S33, CGI-139, PTD003, Gdap3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14548
Homologene: 7729
Zswim2
Name: zinc finger SWIM-type containing 2
Synonyms: 1700025P14Rik, 4933437F18Rik, MEX
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71861
Homologene: 32689
Vmn1r83
Name: vomeronasal 1 receptor 83
Synonyms: V1rg8
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 171243
Homologene: 74330
Erlec1
Name: endoplasmic reticulum lectin 1
Synonyms: 4933407N01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66753
Homologene: 9247
Cry2
Name: cryptochrome circadian regulator 2
Synonyms: D130054K12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12953
HGNC: HGNC:2385
Homologene: 56466
Exoc8
Name: exocyst complex component 8
Synonyms: Exo84p, SEC84, EXO84
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102058
Homologene: 44545
Or1b1
Name: olfactory receptor family 1 subfamily B member 1
Synonyms: GA_x6K02T2NLDC-33797415-33796462, MOR158-1, Olfr362
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259053
HGNC: HGNC:8181
Homologene: 17479
Slc17a1
Name: solute carrier family 17 (sodium phosphate), member 1
Synonyms: Npt1, NAPI-1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20504
Homologene: 48324
Smpd2
Name: sphingomyelin phosphodiesterase 2, neutral
Synonyms: nSMase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20598
Homologene: 31129
Epm2a
Name: epilepsy, progressive myoclonic epilepsy, type 2 gene alpha
Synonyms: laforin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 13853
HGNC: HGNC:3413
Homologene: 38087
Cfap68
Name: cilia and flagella associated protein 68
Synonyms: 1110032A03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68721
HGNC: HGNC:1163
Homologene: 11242
Cstdc2
Name: cystatin domain containing 2
Synonyms: mCST E2, 9230104L09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77705
Homologene: 87070
Ugt1a5
Name: UDP glucuronosyltransferase 1 family, polypeptide A5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 394433
Homologene: 88621
Polr1h
Name: RNA polymerase I subunit H
Synonyms: 1110014N07Rik, Znrd1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 66136
Homologene: 40960
Potefam3a
Name: POTE ankyrin domain family member 3A
Synonyms: Pote3a, Gm15319, Poteb
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100040599
Homologene: 128726
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 75,475,601 bp
  • T to C, chromosome 1 at 88,166,559 bp
  • A to C, chromosome 1 at 120,241,518 bp
  • T to C, chromosome 1 at 153,481,231 bp
  • T to G, chromosome 1 at 155,940,772 bp
  • A to T, chromosome 2 at 37,105,169 bp
  • A to T, chromosome 2 at 80,293,216 bp
  • A to G, chromosome 2 at 83,920,719 bp
  • G to A, chromosome 2 at 92,413,638 bp
  • A to T, chromosome 2 at 113,441,611 bp
  • A to C, chromosome 2 at 148,846,991 bp
  • T to G, chromosome 3 at 28,041,270 bp
  • A to G, chromosome 3 at 40,697,551 bp
  • T to A, chromosome 3 at 152,338,046 bp
  • G to A, chromosome 3 at 153,922,989 bp
  • C to A, chromosome 4 at 85,063,216 bp
  • A to T, chromosome 4 at 123,455,446 bp
  • A to C, chromosome 4 at 132,337,799 bp
  • A to G, chromosome 4 at 145,128,411 bp
  • A to T, chromosome 4 at 148,014,195 bp
  • T to C, chromosome 4 at 150,929,874 bp
  • A to G, chromosome 4 at 152,384,651 bp
  • G to A, chromosome 5 at 29,757,859 bp
  • T to C, chromosome 5 at 114,803,575 bp
  • G to A, chromosome 6 at 39,802,479 bp
  • A to G, chromosome 6 at 138,150,844 bp
  • T to C, chromosome 6 at 147,019,503 bp
  • T to C, chromosome 7 at 12,321,629 bp
  • T to A, chromosome 7 at 43,187,261 bp
  • T to C, chromosome 7 at 44,896,572 bp
  • T to C, chromosome 7 at 66,290,854 bp
  • T to C, chromosome 7 at 114,845,043 bp
  • A to T, chromosome 7 at 118,381,884 bp
  • C to T, chromosome 8 at 20,356,948 bp
  • A to T, chromosome 8 at 23,153,754 bp
  • T to A, chromosome 8 at 71,680,718 bp
  • T to A, chromosome 8 at 109,802,724 bp
  • T to C, chromosome 8 at 110,879,706 bp
  • A to T, chromosome 8 at 111,989,898 bp
  • T to C, chromosome 8 at 124,895,781 bp
  • A to G, chromosome 9 at 50,764,913 bp
  • G to T, chromosome 9 at 66,530,255 bp
  • G to T, chromosome 9 at 105,881,431 bp
  • T to G, chromosome 10 at 11,390,875 bp
  • C to T, chromosome 10 at 20,261,859 bp
  • A to G, chromosome 10 at 41,489,016 bp
  • T to C, chromosome 10 at 59,429,570 bp
  • T to C, chromosome 11 at 30,950,818 bp
  • T to C, chromosome 11 at 71,092,324 bp
  • C to A, chromosome 11 at 73,277,974 bp
  • T to A, chromosome 11 at 102,674,237 bp
  • C to T, chromosome 11 at 113,562,092 bp
  • T to A, chromosome 11 at 116,968,445 bp
  • T to C, chromosome 12 at 24,655,491 bp
  • G to T, chromosome 12 at 116,450,413 bp
  • G to A, chromosome 13 at 23,878,483 bp
  • C to T, chromosome 13 at 68,796,667 bp
  • T to C, chromosome 14 at 36,898,217 bp
  • T to A, chromosome 14 at 50,361,344 bp
  • T to C, chromosome 14 at 61,191,605 bp
  • T to C, chromosome 14 at 75,121,013 bp
  • G to T, chromosome 16 at 17,213,201 bp
  • A to G, chromosome 16 at 90,787,408 bp
  • T to A, chromosome 17 at 23,475,565 bp
  • T to A, chromosome 17 at 36,957,844 bp
  • C to T, chromosome 17 at 46,825,784 bp
  • A to G, chromosome 17 at 56,424,256 bp
  • C to T, chromosome 17 at 78,942,117 bp
  • T to C, chromosome 17 at 79,713,557 bp
  • A to G, chromosome 19 at 60,842,204 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7440 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045516-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.