Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7440Btlr/Mmmh
Stock Number:
045516-MU
Citation ID:
RRID:MMRRC_045516-MU
Other Names:
R7440 (G1)
Major Collection:

Strain Information

Acadm
Name: acyl-Coenzyme A dehydrogenase, medium chain
Synonyms: MCAD
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11364
HGNC: HGNC:89
Homologene: 3
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Map7
Name: microtubule-associated protein 7
Synonyms: E-MAP-115, mste, ste, mshi, Mtap7
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 17761
VEGA: 10
HGNC: HGNC:6869
Homologene: 20851
Bicral
Name: BRD4 interacting chromatin remodeling complex associated protein like
Synonyms: BC032203, Gltscr1l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210982
VEGA: 17
Homologene: 19366
Ankrd13a
Name: ankyrin repeat domain 13a
Synonyms: 1100001D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68420
Homologene: 23814
Fuz
Name: fuzzy planar cell polarity protein
Synonyms: 2600013E07Rik, b2b1273Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 70300
Homologene: 11840
Clcn6
Name: chloride channel, voltage-sensitive 6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 26372
HGNC: HGNC:2024
Homologene: 985
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 75,475,601 bp
  • T to C, chromosome 1 at 88,166,559 bp
  • A to C, chromosome 1 at 120,241,518 bp
  • T to C, chromosome 1 at 153,481,231 bp
  • T to G, chromosome 1 at 155,940,772 bp
  • A to T, chromosome 2 at 37,105,169 bp
  • A to T, chromosome 2 at 80,293,216 bp
  • A to G, chromosome 2 at 83,920,719 bp
  • G to A, chromosome 2 at 92,413,638 bp
  • A to T, chromosome 2 at 113,441,611 bp
  • A to C, chromosome 2 at 148,846,991 bp
  • T to G, chromosome 3 at 28,041,270 bp
  • A to G, chromosome 3 at 40,697,551 bp
  • T to A, chromosome 3 at 152,338,046 bp
  • G to A, chromosome 3 at 153,922,989 bp
  • C to A, chromosome 4 at 85,063,216 bp
  • A to T, chromosome 4 at 123,455,446 bp
  • A to C, chromosome 4 at 132,337,799 bp
  • A to G, chromosome 4 at 145,128,411 bp
  • A to T, chromosome 4 at 148,014,195 bp
  • T to C, chromosome 4 at 150,929,874 bp
  • A to G, chromosome 4 at 152,384,651 bp
  • G to A, chromosome 5 at 29,757,859 bp
  • T to C, chromosome 5 at 114,803,575 bp
  • G to A, chromosome 6 at 39,802,479 bp
  • A to G, chromosome 6 at 138,150,844 bp
  • T to C, chromosome 6 at 147,019,503 bp
  • T to C, chromosome 7 at 12,321,629 bp
  • T to A, chromosome 7 at 43,187,261 bp
  • T to C, chromosome 7 at 44,896,572 bp
  • T to C, chromosome 7 at 66,290,854 bp
  • T to C, chromosome 7 at 114,845,043 bp
  • A to T, chromosome 7 at 118,381,884 bp
  • C to T, chromosome 8 at 20,356,948 bp
  • A to T, chromosome 8 at 23,153,754 bp
  • T to A, chromosome 8 at 71,680,718 bp
  • T to A, chromosome 8 at 109,802,724 bp
  • T to C, chromosome 8 at 110,879,706 bp
  • A to T, chromosome 8 at 111,989,898 bp
  • T to C, chromosome 8 at 124,895,781 bp
  • A to G, chromosome 9 at 50,764,913 bp
  • G to T, chromosome 9 at 66,530,255 bp
  • G to T, chromosome 9 at 105,881,431 bp
  • T to G, chromosome 10 at 11,390,875 bp
  • C to T, chromosome 10 at 20,261,859 bp
  • A to G, chromosome 10 at 41,489,016 bp
  • T to C, chromosome 10 at 59,429,570 bp
  • T to C, chromosome 11 at 30,950,818 bp
  • T to C, chromosome 11 at 71,092,324 bp
  • C to A, chromosome 11 at 73,277,974 bp
  • T to A, chromosome 11 at 102,674,237 bp
  • C to T, chromosome 11 at 113,562,092 bp
  • T to A, chromosome 11 at 116,968,445 bp
  • T to C, chromosome 12 at 24,655,491 bp
  • G to T, chromosome 12 at 116,450,413 bp
  • G to A, chromosome 13 at 23,878,483 bp
  • C to T, chromosome 13 at 68,796,667 bp
  • T to C, chromosome 14 at 36,898,217 bp
  • T to A, chromosome 14 at 50,361,344 bp
  • T to C, chromosome 14 at 61,191,605 bp
  • T to C, chromosome 14 at 75,121,013 bp
  • G to T, chromosome 16 at 17,213,201 bp
  • A to G, chromosome 16 at 90,787,408 bp
  • T to A, chromosome 17 at 23,475,565 bp
  • T to A, chromosome 17 at 36,957,844 bp
  • C to T, chromosome 17 at 46,825,784 bp
  • A to G, chromosome 17 at 56,424,256 bp
  • C to T, chromosome 17 at 78,942,117 bp
  • T to C, chromosome 17 at 79,713,557 bp
  • A to G, chromosome 19 at 60,842,204 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7440 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045516-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.