Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7457Btlr/Mmmh
Stock Number:
045531-MU
Citation ID:
RRID:MMRRC_045531-MU
Other Names:
R7457 (G1)
Major Collection:

Strain Information

Gstt2
Name: glutathione S-transferase, theta 2
Synonyms: mGSTT2, Yrs
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14872
VEGA: 10
Homologene: 37358
Sox10
Name: SRY (sex determining region Y)-box 10
Synonyms: Sox21, gt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20665
VEGA: 15
Homologene: 5055
Wwp2
Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: 1300010O06Rik, AIP2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66894
Homologene: 48490
Cdyl2
Name: chromodomain protein, Y chromosome-like 2
Synonyms: 1700029M19Rik, 4930453I21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75796
Homologene: 41779
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: 4732474L06Rik, Jmjd2b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193796
Homologene: 27773
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: D1Ertd101e, 1110005P14Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Alkbh8
Name: alkB homolog 8, tRNA methyltransferase
Synonyms: 8030431D03Rik, 9430088N01Rik, 4930562C03Rik, Abh8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67667
Homologene: 44488
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 93,428,222 bp
  • T to C, chromosome 1 at 118,199,252 bp
  • T to C, chromosome 1 at 162,794,103 bp
  • C to A, chromosome 1 at 163,996,761 bp
  • T to A, chromosome 1 at 174,503,737 bp
  • T to A, chromosome 2 at 69,401,267 bp
  • T to A, chromosome 2 at 120,917,828 bp
  • T to C, chromosome 2 at 125,351,747 bp
  • G to T, chromosome 2 at 148,690,082 bp
  • A to T, chromosome 2 at 170,870,815 bp
  • A to G, chromosome 3 at 9,251,478 bp
  • A to G, chromosome 3 at 90,269,315 bp
  • A to T, chromosome 3 at 116,620,164 bp
  • T to A, chromosome 4 at 62,499,790 bp
  • A to T, chromosome 4 at 65,189,266 bp
  • A to T, chromosome 4 at 118,589,001 bp
  • A to T, chromosome 4 at 149,634,916 bp
  • T to C, chromosome 5 at 105,119,553 bp
  • C to A, chromosome 5 at 146,104,750 bp
  • T to A, chromosome 6 at 21,772,683 bp
  • T to C, chromosome 6 at 25,771,622 bp
  • C to T, chromosome 6 at 28,244,229 bp
  • C to T, chromosome 6 at 89,870,190 bp
  • A to G, chromosome 6 at 90,072,552 bp
  • A to G, chromosome 7 at 30,720,767 bp
  • T to C, chromosome 7 at 44,305,955 bp
  • A to T, chromosome 8 at 24,884,619 bp
  • G to T, chromosome 8 at 83,236,680 bp
  • C to T, chromosome 8 at 104,737,389 bp
  • T to A, chromosome 8 at 107,517,960 bp
  • A to T, chromosome 8 at 116,579,196 bp
  • T to A, chromosome 9 at 3,343,056 bp
  • A to G, chromosome 9 at 44,256,510 bp
  • A to G, chromosome 9 at 55,544,956 bp
  • T to A, chromosome 10 at 7,710,891 bp
  • G to A, chromosome 10 at 75,832,520 bp
  • A to T, chromosome 10 at 109,696,328 bp
  • T to C, chromosome 10 at 129,501,706 bp
  • A to G, chromosome 11 at 49,630,328 bp
  • G to C, chromosome 11 at 73,776,826 bp
  • A to T, chromosome 13 at 59,716,909 bp
  • A to T, chromosome 13 at 111,756,255 bp
  • A to T, chromosome 14 at 24,309,514 bp
  • A to G, chromosome 14 at 28,518,279 bp
  • A to T, chromosome 14 at 50,238,368 bp
  • A to G, chromosome 14 at 54,919,994 bp
  • T to C, chromosome 14 at 62,392,952 bp
  • GTCTCTC to GTC, chromosome 14 at 79,427,924 bp
  • A to T, chromosome 15 at 64,920,680 bp
  • A to T, chromosome 15 at 76,900,624 bp
  • A to T, chromosome 15 at 79,156,139 bp
  • T to C, chromosome 15 at 103,453,806 bp
  • G to T, chromosome 17 at 33,244,051 bp
  • G to A, chromosome 17 at 34,334,347 bp
  • T to C, chromosome 17 at 35,891,060 bp
  • T to C, chromosome 17 at 37,610,565 bp
  • T to A, chromosome 17 at 56,396,319 bp
  • G to T, chromosome 17 at 56,419,502 bp
  • T to C, chromosome 17 at 74,407,238 bp
  • A to G, chromosome 17 at 87,427,578 bp
  • A to T, chromosome 18 at 80,917,618 bp
  • A to G, chromosome 19 at 43,612,547 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7457 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045531-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.