Strain Name:
C57BL/6J-MtgxR7457Btlr/Mmmh
Stock Number:
045531-MU
Citation ID:
RRID:MMRRC_045531-MU
Other Names:
R7457 (G1)
Major Collection:

Strain Information

Gstt2
Name: glutathione S-transferase, theta 2
Synonyms: mGSTT2, Yrs
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14872
VEGA: 10
Homologene: 37358
Sox10
Name: SRY (sex determining region Y)-box 10
Synonyms: gt, Sox21
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20665
VEGA: 15
Homologene: 5055
Wwp2
Name: WW domain containing E3 ubiquitin protein ligase 2
Synonyms: 1300010O06Rik, AIP2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66894
Homologene: 48490
Cdyl2
Name: chromodomain protein, Y chromosome-like 2
Synonyms: 1700029M19Rik, 4930453I21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75796
Homologene: 41779
Kdm4b
Name: lysine (K)-specific demethylase 4B
Synonyms: Jmjd2b, 4732474L06Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 193796
Homologene: 27773
Hdlbp
Name: high density lipoprotein (HDL) binding protein
Synonyms: 1110005P14Rik, D1Ertd101e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110611
HGNC: HGNC:4857
Homologene: 38035
Alkbh8
Name: alkB homolog 8, tRNA methyltransferase
Synonyms: Abh8, 8030431D03Rik, 9430088N01Rik, 4930562C03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67667
Homologene: 44488
Fmn2
Name: formin 2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 54418
Homologene: 137334
Ubr1
Name: ubiquitin protein ligase E3 component n-recognin 1
Synonyms: E3 alpha
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22222
Homologene: 7582
Slc30a6
Name: solute carrier family 30 (zinc transporter), member 6
Synonyms: ZnT-6, ZnT6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210148
VEGA: 17
Homologene: 32380
Atp9b
Name: ATPase, class II, type 9B
Synonyms: IIb
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 50771
VEGA: 18
Homologene: 21915
Dhx16
Name: DEAH-box helicase 16
Synonyms: 2410006N22Rik, DEAH (Asp-Glu-Ala-His) box polypeptide 16, DBP2, Ddx16
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 69192
HGNC: HGNC:2739
Homologene: 2658
Efs
Name: embryonal Fyn-associated substrate
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13644
VEGA: 14
Homologene: 4284
Map3k1
Name: mitogen-activated protein kinase kinase kinase 1
Synonyms: MEKK1, Mekk
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26401
HGNC: HGNC:6848
Homologene: 8056
Isl2
Name: insulin related protein 2 (islet 2)
Synonyms: islet-2, 3110001N10Rik, islet 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 104360
Homologene: 10730
Adam32
Name: a disintegrin and metallopeptidase domain 32
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 353188
Homologene: 17021
Ptprs
Name: protein tyrosine phosphatase receptor type S
Synonyms: PTP-NU3, RPTPsigma, Ptpt9, PTPsigma
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19280
HGNC: HGNC:9681
Homologene: 20626
Sass6
Name: SAS-6 centriolar assembly protein
Synonyms: 2810453L12Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 72776
Homologene: 45668
Gzf1
Name: GDNF-inducible zinc finger protein 1
Synonyms: 8430437G08Rik, Zfp336
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74533
Homologene: 11200
Clstn1
Name: calsyntenin 1
Synonyms: 1810034E21Rik, calsyntenin-1, alcadein alpha, Cst-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 65945
Homologene: 8814
Zbtb10
Name: zinc finger and BTB domain containing 10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229055
Homologene: 11395
Pot1a
Name: protection of telomeres 1A
Synonyms: 1500031H18Rik, Pot1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101185
Homologene: 32263
Tspan12
Name: tetraspanin 12
Synonyms: Tm4sf12
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269831
Homologene: 8212
Wnt5a
Name: wingless-type MMTV integration site family, member 5A
Synonyms: Wnt-5a, 8030457G12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22418
Homologene: 20720
Atp4a
Name: ATPase, H+/K+ exchanging, gastric, alpha polypeptide
Synonyms: H+/K+-ATPase alpha, H+K+-transporting alpha 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11944
HGNC: HGNC:819
Homologene: 68081
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Ces2a
Name: carboxylesterase 2A
Synonyms: Ces6, 9130231C15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102022
HGNC: HGNC:1864
Homologene: 136396
Nav3
Name: neuron navigator 3
Synonyms: Pomfil1p, steerin 3, unc53H3, 9630020C08Rik, 4732483H20Rik, POMFIL1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 260315
Homologene: 56688
Nckap1l
Name: NCK associated protein 1 like
Synonyms: Hem1, 4930568P13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105855
VEGA: 15
HGNC: HGNC:4862
Homologene: 3901
Adcy8
Name: adenylate cyclase 8
Synonyms: AC8
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 11514
VEGA: 15
HGNC: HGNC:239
Homologene: 37443
Clec11a
Name: C-type lectin domain family 11, member a
Synonyms: Clecsf3, Scgf
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 20256
Homologene: 2236
Tbc1d9
Name: TBC1 domain family, member 9
Synonyms: C76116, 4933431N12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71310
Homologene: 57079
Pappa
Name: pregnancy-associated plasma protein A
Synonyms: 8430414N03Rik, IGFBP-4ase, PAPP-A, PAG1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18491
HGNC: HGNC:8602
Homologene: 31097
Or1e29
Name: olfactory receptor family 1 subfamily E member 29
Synonyms: Olfr389, GA_x6K02T2P1NL-3932085-3931147, MOR135-6
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259011
Homologene: 85925
Dennd4b
Name: DENN domain containing 4B
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229541
Homologene: 28281
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, Wdr65, LOC384050, 1110020C03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Zfp955a
Name: zinc finger protein 955A
Synonyms: AI842447
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 77652
VEGA: 17
Homologene: 104925
Gbp4
Name: guanylate binding protein 4
Synonyms: Mpa-2, Mag-2, Mpa2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 17472
Homologene: 128731
Lats1
Name: large tumor suppressor
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16798
VEGA: 10
HGNC: HGNC:6514
Homologene: 55843
Gucy1b2
Name: guanylate cyclase 1, soluble, beta 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239134
HGNC: HGNC:4686
Homologene: 136630
Mettl18
Name: methyltransferase like 18
Synonyms: 2810422O20Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 69962
Homologene: 32680
Zfp800
Name: zinc finger protein 800
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 627049
Homologene: 18529
Cyp3a59
Name: cytochrome P450, family 3, subfamily a, polypeptide 59
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100041449
Homologene: 135775
Flt4
Name: FMS-like tyrosine kinase 4
Synonyms: VEGFR3, VEGFR-3, Flt-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14257
HGNC: HGNC:3767
Homologene: 7321
Stpg4
Name: sperm tail PG rich repeat containing 4
Synonyms: 1700011E24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 75467
Homologene: 18339
Dok5
Name: docking protein 5
Synonyms: 2700055C10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76829
Homologene: 10195
Vmn1r43
Name: vomeronasal 1 receptor 43
Synonyms: V1ra5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 113847
Homologene: 130651
Nlrx1
Name: NLR family member X1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270151
VEGA: 9
Homologene: 11623
H2-Eb2
Name: histocompatibility 2, class II antigen E beta2
Synonyms: H-2Eb2, Ia5, A130038H09Rik, Ia-5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381091
Homologene: 128636
Vmn1r49
Name: vomeronasal 1, receptor 49
Synonyms: V1rb2, V1r5, VRi2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 24112
Homologene: 113975
E330034G19Rik
Name: RIKEN cDNA E330034G19 gene
Synonyms: ZPAC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105418
Fmo4
Name: flavin containing monooxygenase 4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226564
HGNC: HGNC:3772
Homologene: 68219
Or4k6
Name: olfactory receptor family 4 subfamily K member 6
Synonyms: GA_x6K02T2PMLR-5936117-5935137, MOR246-5, Olfr731
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258360
Homologene: 84579
Commd5
Name: COMM domain containing 5
Synonyms: Hcarg, 2310065H03Rik, D15Ertd81e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66398
Homologene: 8548
Or6c75
Name: olfactory receptor family 6 subfamily C member 75
Synonyms: MOR112-1, GA_x6K02T2PULF-11179777-11180721, Olfr790
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258935
Homologene: 74101
Hdhd3
Name: haloacid dehalogenase-like hydrolase domain containing 3
Synonyms: 2810435D12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72748
Homologene: 11497
Kbtbd7
Name: kelch repeat and BTB (POZ) domain containing 7
Synonyms: LOC211255, 1110008P08Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211255
VEGA: 14
Homologene: 41849
Or14j4
Name: olfactory receptor family 14 subfamily J member 4
Synonyms: Olfr115, GA_x6K02T2PSCP-2070203-2069271, MOR218-11P
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 257908
Homologene: 115497
Nkx2-3
Name: NK2 homeobox 3
Synonyms: Nkx2.3, Nkx-2.3, tinman
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 18089
HGNC: HGNC:7836
Homologene: 17061
Dhrs9
Name: dehydrogenase/reductase 9
Synonyms: C730025I08Rik, dehydrogenase/reductase (SDR family) member 9, Rdh15
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241452
Homologene: 26079
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Gm4934, Fam75d1b
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238662
VEGA: 13
Gm29106
Name: predicted gene 29106
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 93,428,222 bp
  • T to C, chromosome 1 at 118,199,252 bp
  • T to C, chromosome 1 at 162,794,103 bp
  • C to A, chromosome 1 at 163,996,761 bp
  • T to A, chromosome 1 at 174,503,737 bp
  • T to A, chromosome 2 at 69,401,267 bp
  • T to A, chromosome 2 at 120,917,828 bp
  • T to C, chromosome 2 at 125,351,747 bp
  • G to T, chromosome 2 at 148,690,082 bp
  • A to T, chromosome 2 at 170,870,815 bp
  • A to G, chromosome 3 at 9,251,478 bp
  • A to G, chromosome 3 at 90,269,315 bp
  • A to T, chromosome 3 at 116,620,164 bp
  • T to A, chromosome 4 at 62,499,790 bp
  • A to T, chromosome 4 at 65,189,266 bp
  • A to T, chromosome 4 at 118,589,001 bp
  • A to T, chromosome 4 at 149,634,916 bp
  • T to C, chromosome 5 at 105,119,553 bp
  • C to A, chromosome 5 at 146,104,750 bp
  • T to A, chromosome 6 at 21,772,683 bp
  • T to C, chromosome 6 at 25,771,622 bp
  • C to T, chromosome 6 at 28,244,229 bp
  • C to T, chromosome 6 at 89,870,190 bp
  • A to G, chromosome 6 at 90,072,552 bp
  • A to G, chromosome 7 at 30,720,767 bp
  • T to C, chromosome 7 at 44,305,955 bp
  • A to T, chromosome 8 at 24,884,619 bp
  • G to T, chromosome 8 at 83,236,680 bp
  • C to T, chromosome 8 at 104,737,389 bp
  • T to A, chromosome 8 at 107,517,960 bp
  • A to T, chromosome 8 at 116,579,196 bp
  • T to A, chromosome 9 at 3,343,056 bp
  • A to G, chromosome 9 at 44,256,510 bp
  • A to G, chromosome 9 at 55,544,956 bp
  • T to A, chromosome 10 at 7,710,891 bp
  • G to A, chromosome 10 at 75,832,520 bp
  • A to T, chromosome 10 at 109,696,328 bp
  • T to C, chromosome 10 at 129,501,706 bp
  • A to G, chromosome 11 at 49,630,328 bp
  • G to C, chromosome 11 at 73,776,826 bp
  • A to T, chromosome 13 at 59,716,909 bp
  • A to T, chromosome 13 at 111,756,255 bp
  • A to T, chromosome 14 at 24,309,514 bp
  • A to G, chromosome 14 at 28,518,279 bp
  • A to T, chromosome 14 at 50,238,368 bp
  • A to G, chromosome 14 at 54,919,994 bp
  • T to C, chromosome 14 at 62,392,952 bp
  • GTCTCTC to GTC, chromosome 14 at 79,427,924 bp
  • A to T, chromosome 15 at 64,920,680 bp
  • A to T, chromosome 15 at 76,900,624 bp
  • A to T, chromosome 15 at 79,156,139 bp
  • T to C, chromosome 15 at 103,453,806 bp
  • G to T, chromosome 17 at 33,244,051 bp
  • G to A, chromosome 17 at 34,334,347 bp
  • T to C, chromosome 17 at 35,891,060 bp
  • T to C, chromosome 17 at 37,610,565 bp
  • T to A, chromosome 17 at 56,396,319 bp
  • G to T, chromosome 17 at 56,419,502 bp
  • T to C, chromosome 17 at 74,407,238 bp
  • A to G, chromosome 17 at 87,427,578 bp
  • A to T, chromosome 18 at 80,917,618 bp
  • A to G, chromosome 19 at 43,612,547 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7457 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045531-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.