Strain Name:
C57BL/6J-MtgxR7460Btlr/Mmmh
Stock Number:
045534-MU
Citation ID:
RRID:MMRRC_045534-MU
Other Names:
R7460 (G1)
Major Collection:

Strain Information

Myo10
Name: myosin X
Synonyms: myosin-X, D15Ertd600e
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17909
HGNC: HGNC:7593
Homologene: 36328
Mrtfb
Name: myocardin related transcription factor B
Synonyms: MRTF-B, Mkl2, Mrtfb, Gt4-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239719
Homologene: 40917
Jmjd1c
Name: jumonji domain containing 1C
Synonyms: D630035I23Rik, TRIP8, 5430433L24Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108829
Homologene: 3129
Birc2
Name: baculoviral IAP repeat-containing 2
Synonyms: HIAP1, MIHB, IAP1, mcIAP1, Api1, cIAP-1, MIAP1, cIAP1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11797
HGNC: HGNC:590
Homologene: 900
U2surp
Name: U2 snRNP-associated SURP domain containing
Synonyms: 2610101N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67958
Homologene: 13964
Agrn
Name: agrin
Synonyms: NMF380, nmf380, Agrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Ddx1
Name: DEAD box helicase 1
Synonyms: DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104721
VEGA: 12
HGNC: HGNC:2734
Homologene: 3627
Senp7
Name: SUMO1/sentrin specific peptidase 7
Synonyms: 2410152H17Rik, 2900036C23Rik, 2810413I22Rik, 6030449K19Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 66315
Homologene: 10778
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Dmxl1
Name: Dmx-like 1
Synonyms: C630007L23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240283
HGNC: HGNC:2937
Homologene: 21136
Atxn3
Name: ataxin 3
Synonyms: Mjd, ataxin-3, Atx3, 2210008M02Rik, MJD1, Sca3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 110616
HGNC: HGNC:7106
Homologene: 3658
Abi2
Name: abl interactor 2
Synonyms: 8430425M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329165
Homologene: 4209
Ddb1
Name: damage specific DNA binding protein 1
Synonyms: damage-specific DNA-binding protein, DNA repair, DNA repair protein, p127-Ddb1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13194
VEGA: 19
HGNC: HGNC:2717
Homologene: 1448
Cenpf
Name: centromere protein F
Synonyms: Lek1, mitosin, 6530404A22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108000
HGNC: HGNC:1857
Homologene: 22969
Rspry1
Name: ring finger and SPRY domain containing 1
Synonyms: 4930470D19Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67610
Homologene: 12164
Mrps5
Name: mitochondrial ribosomal protein S5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 77721
Homologene: 32726
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Tle3
Name: transducin-like enhancer of split 3
Synonyms: ESG, 2610103N05Rik, Grg3a, Grg3b
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 21887
Homologene: 21059
Fan1
Name: FANCD2/FANCI-associated nuclease 1
Synonyms: Mtmr15, 6030441H18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330554
Homologene: 45598
Hepacam2
Name: HEPACAM family member 2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101202
Homologene: 18724
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Dync1i2
Name: dynein cytoplasmic 1 intermediate chain 2
Synonyms: 3110079H08Rik, Dncic2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13427
HGNC: HGNC:2964
Homologene: 37921
Mnt
Name: max binding protein
Synonyms: bHLHd3, Rox
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17428
HGNC: HGNC:7188
Homologene: 7842
Mfsd14b
Name: major facilitator superfamily domain containing 14B
Synonyms: Hiatl1, 5730414C17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66631
Homologene: 64464
Atad2b
Name: ATPase family, AAA domain containing 2B
Synonyms: 1110014E10Rik, D530031C13Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320817
VEGA: 12
Homologene: 86351
Trhde
Name: TRH-degrading enzyme
Synonyms: 9330155P21Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237553
Homologene: 75007
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, Fath2, mKIAA0811, LOC245827
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Trappc14
Name: trafficking protein particle complex 14
Synonyms: Map11, BC037034
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231807
Homologene: 10106
Mrc1
Name: mannose receptor, C type 1
Synonyms: CD206, MR
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17533
HGNC: HGNC:7228
Homologene: 37622
Cdh16
Name: cadherin 16
Synonyms: KSP-cadherin
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12556
HGNC: HGNC:1755
Homologene: 2997
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Zc3h12c
Name: zinc finger CCCH type containing 12C
Synonyms: C230027N18Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244871
VEGA: 9
Homologene: 35462
Sdr16c6
Name: short chain dehydrogenase/reductase family 16C, member 6
Synonyms: 4833413O15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242286
Homologene: 135698
Arhgef15
Name: Rho guanine nucleotide exchange factor 15
Synonyms: D530030K12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 442801
Homologene: 18345
Ros1
Name: Ros1 proto-oncogene
Synonyms: Ros-1, c-ros
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19886
Homologene: 2207
Ptprn2
Name: protein tyrosine phosphatase receptor type N polypeptide 2
Synonyms: IA-2 beta, 4930425H11Rik, PTP-NP, IA-2beta, phogrin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19276
HGNC: HGNC:9677
Homologene: 2134
Tmem94
Name: transmembrane protein 94
Synonyms: 2310067B10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71947
Homologene: 8831
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Slc6a7
Name: solute carrier family 6 (neurotransmitter transporter, L-proline), member 7
Synonyms: Prot
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 240332
VEGA: 18
Homologene: 8592
Disp2
Name: dispatched RND transporter family member 2
Synonyms: DispB, B230210L08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 214240
Homologene: 24916
Pdhx
Name: pyruvate dehydrogenase complex, component X
Synonyms: Pdx1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27402
Homologene: 55757
Inhca
Name: inhibitor of carbonic anhydrase
Synonyms: mICA, 1300017J02Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71775
Homologene: 826
Zfp948
Name: zinc finger protein 948
Synonyms: BC049807
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 381066
VEGA: 17
Urgcp
Name: upregulator of cell proliferation
Synonyms: 2010005J08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 72046
Homologene: 69243
Fdxr
Name: ferredoxin reductase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14149
HGNC: HGNC:3642
Homologene: 3033
Lrrc27
Name: leucine rich repeat containing 27
Synonyms: 1700071K18Rik, 2310044E02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76612
Homologene: 19268
Fbh1
Name: F-box DNA helicase 1
Synonyms: Fbx18, Fbxo18
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 50755
Homologene: 9272
Fgf14
Name: fibroblast growth factor 14
Synonyms: Fhf4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14169
HGNC: HGNC:3671
Homologene: 3037
Psg22
Name: pregnancy-specific beta-1-glycoprotein 22
Synonyms: cea9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243862
HGNC: HGNC:1816
Homologene: 110989
BC051665
Name: cDNA sequence BC051665
Synonyms: cathepsin L-like
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218275
VEGA: 13
Homologene: 74298
Or51a25
Name: olfactory receptor family 51 subfamily A member 25
Synonyms: MOR11-1, Olfr559, GA_x6K02T2PBJ9-5441154-5440198
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259116
Homologene: 74124
Arhgap24
Name: Rho GTPase activating protein 24
Synonyms: 0610025G21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231532
Homologene: 32754
Gnat3
Name: G protein subunit alpha transducin 3
Synonyms: alpha-gustducin, Gtn, Ggust
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242851
Homologene: 24284
Slc6a20b
Name: solute carrier family 6 (neurotransmitter transporter), member 20B
Synonyms: Xtrp3, XT3, Slc6a20, Sit1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22599
Homologene: 130652
Mapk10
Name: mitogen-activated protein kinase 10
Synonyms: Serk2, p493F12, JNK3, C230008H04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 26414
HGNC: HGNC:6872
Homologene: 56439
Vps45
Name: vacuolar protein sorting 45
Synonyms: mVps45
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22365
Homologene: 5250
Tmem102
Name: transmembrane protein 102
Synonyms: Tmem102-ps, Cbap
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 380705
Homologene: 86820
Or8b3
Name: olfactory receptor family 8 subfamily B member 3
Synonyms: Olfr147, MOR164-1, M3, GA_x6K02T2PVTD-32098059-32099003
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258869
VEGA: 9
Homologene: 128279
Fam114a1
Name: family with sequence similarity 114, member A1
Synonyms: 1190001N04Rik, 9130005N14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68303
Homologene: 12259
Or3a1c
Name: olfactory receptor family 3 subfamily A member 1C
Synonyms: Olfr402, GA_x6K02T2P1NL-4307199-4308146, MOR255-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258703
HGNC: HGNC:8282
Homologene: 1915
Or7a40
Name: olfactory receptor family 7 subfamily A member 40
Synonyms: Olfr19, MTPCR15, MOR140-1, M12, GA_x54KRFPKG5P-13123979-13123050
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 18316
Homologene: 137402
Prr7
Name: proline rich 7 (synaptic)
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 432763
VEGA: 13
Homologene: 57114
Pigb
Name: phosphatidylinositol glycan anchor biosynthesis, class B
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 55981
HGNC: HGNC:8959
Homologene: 3570
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 60,434,307 bp
  • T to C, chromosome 1 at 189,654,050 bp
  • C to T, chromosome 2 at 11,756,685 bp
  • T to C, chromosome 2 at 14,248,869 bp
  • T to C, chromosome 2 at 40,598,466 bp
  • T to C, chromosome 2 at 71,250,886 bp
  • A to G, chromosome 2 at 76,751,273 bp
  • G to A, chromosome 2 at 103,046,779 bp
  • A to G, chromosome 2 at 118,789,780 bp
  • G to A, chromosome 2 at 127,591,891 bp
  • T to A, chromosome 3 at 96,048,387 bp
  • A to G, chromosome 4 at 4,076,575 bp
  • C to A, chromosome 4 at 156,174,424 bp
  • A to T, chromosome 5 at 17,999,658 bp
  • T to G, chromosome 5 at 65,038,707 bp
  • T to C, chromosome 5 at 102,892,346 bp
  • C to T, chromosome 5 at 103,038,577 bp
  • G to A, chromosome 5 at 138,262,729 bp
  • G to A, chromosome 6 at 3,487,199 bp
  • A to G, chromosome 6 at 12,554,934 bp
  • A to G, chromosome 7 at 18,724,404 bp
  • T to A, chromosome 7 at 64,372,486 bp
  • A to T, chromosome 7 at 102,723,821 bp
  • A to G, chromosome 7 at 130,624,633 bp
  • T to A, chromosome 7 at 139,223,658 bp
  • T to C, chromosome 8 at 94,650,335 bp
  • A to T, chromosome 8 at 104,622,291 bp
  • A to T, chromosome 9 at 7,818,761 bp
  • T to C, chromosome 9 at 38,403,353 bp
  • T to C, chromosome 9 at 52,144,102 bp
  • A to G, chromosome 9 at 61,413,084 bp
  • C to T, chromosome 9 at 73,038,675 bp
  • C to A, chromosome 9 at 95,462,824 bp
  • T to C, chromosome 9 at 103,254,648 bp
  • T to C, chromosome 9 at 123,604,949 bp
  • T to C, chromosome 10 at 52,118,203 bp
  • A to G, chromosome 10 at 67,217,036 bp
  • T to A, chromosome 10 at 114,413,263 bp
  • T to C, chromosome 11 at 5,716,622 bp
  • T to A, chromosome 11 at 55,278,963 bp
  • A to G, chromosome 11 at 68,947,035 bp
  • A to G, chromosome 11 at 69,804,123 bp
  • A to T, chromosome 11 at 74,155,846 bp
  • T to A, chromosome 11 at 74,843,283 bp
  • A to C, chromosome 11 at 115,276,854 bp
  • G to T, chromosome 11 at 115,786,256 bp
  • C to A, chromosome 12 at 4,952,660 bp
  • A to G, chromosome 12 at 13,231,439 bp
  • T to A, chromosome 12 at 101,926,517 bp
  • T to C, chromosome 12 at 117,248,681 bp
  • T to A, chromosome 13 at 11,705,710 bp
  • C to A, chromosome 13 at 55,472,353 bp
  • T to C, chromosome 13 at 60,784,643 bp
  • C to T, chromosome 13 at 65,072,023 bp
  • T to A, chromosome 14 at 124,676,693 bp
  • A to G, chromosome 15 at 25,807,827 bp
  • G to T, chromosome 16 at 13,400,976 bp
  • C to A, chromosome 16 at 16,673,166 bp
  • A to G, chromosome 16 at 56,173,182 bp
  • A to T, chromosome 17 at 21,588,415 bp
  • T to C, chromosome 17 at 67,767,018 bp
  • A to G, chromosome 18 at 49,878,612 bp
  • A to G, chromosome 18 at 61,001,602 bp
  • T to C, chromosome 19 at 10,607,911 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7460 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045534-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.