Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7468Btlr/Mmmh
Stock Number:
045542-MU
Citation ID:
RRID:MMRRC_045542-MU
Other Names:
R7468 (G1)
Major Collection:

Strain Information

Zdbf2
Name: zinc finger, DBF-type containing 2
Synonyms: 9330107J05Rik, 4930431J08Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 73884
Homologene: 52868
Abl2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
Synonyms: Arg, Abll
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11352
HGNC: HGNC:77
Homologene: 5278
Cilk1
Name: ciliogenesis associated kinase 1
Synonyms: 2210420N10Rik, Ick
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56542
Homologene: 69218
Spop
Name: speckle-type BTB/POZ protein
Synonyms: TEF2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20747
Homologene: 68354
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Cdc42bpb
Name: CDC42 binding protein kinase beta
Synonyms: DMPK-like
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217866
VEGA: 12
HGNC: HGNC:1738
Homologene: 55945
Zmym4
Name: zinc finger, MYM-type 4
Synonyms: 6330503C17Rik, Zfp262
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67785
Homologene: 35470
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 20,935,218 bp
  • A to T, chromosome 1 at 51,797,480 bp
  • A to C, chromosome 1 at 59,068,685 bp
  • T to A, chromosome 1 at 63,307,510 bp
  • T to G, chromosome 1 at 156,622,534 bp
  • G to A, chromosome 1 at 162,321,629 bp
  • C to A, chromosome 1 at 172,535,310 bp
  • A to T, chromosome 2 at 26,408,149 bp
  • G to A, chromosome 2 at 26,919,342 bp
  • T to C, chromosome 2 at 35,028,051 bp
  • T to C, chromosome 2 at 88,652,278 bp
  • A to T, chromosome 2 at 110,731,517 bp
  • G to T, chromosome 2 at 128,933,295 bp
  • C to T, chromosome 2 at 149,405,576 bp
  • A to G, chromosome 2 at 152,414,695 bp
  • A to G, chromosome 2 at 181,383,342 bp
  • T to A, chromosome 3 at 30,603,676 bp
  • A to T, chromosome 3 at 36,624,416 bp
  • A to T, chromosome 3 at 86,988,276 bp
  • A to G, chromosome 4 at 126,882,236 bp
  • A to G, chromosome 4 at 141,199,606 bp
  • T to A, chromosome 5 at 77,010,429 bp
  • T to C, chromosome 5 at 90,243,043 bp
  • T to A, chromosome 5 at 114,733,897 bp
  • A to T, chromosome 5 at 150,067,336 bp
  • A to T, chromosome 6 at 43,280,671 bp
  • A to G, chromosome 6 at 82,092,021 bp
  • C to T, chromosome 6 at 124,522,444 bp
  • C to A, chromosome 6 at 145,173,701 bp
  • A to G, chromosome 7 at 4,148,801 bp
  • T to A, chromosome 7 at 22,163,359 bp
  • T to A, chromosome 7 at 43,773,356 bp
  • A to T, chromosome 7 at 45,060,263 bp
  • T to C, chromosome 7 at 46,264,119 bp
  • T to G, chromosome 7 at 67,733,223 bp
  • T to A, chromosome 7 at 72,211,690 bp
  • G to A, chromosome 7 at 75,730,465 bp
  • C to A, chromosome 7 at 81,100,998 bp
  • T to C, chromosome 7 at 100,010,125 bp
  • T to C, chromosome 7 at 100,341,862 bp
  • C to A, chromosome 7 at 143,069,262 bp
  • T to G, chromosome 8 at 121,949,849 bp
  • C to A, chromosome 9 at 21,403,411 bp
  • T to C, chromosome 9 at 45,328,423 bp
  • G to T, chromosome 9 at 61,937,175 bp
  • A to G, chromosome 9 at 78,157,939 bp
  • T to A, chromosome 9 at 83,423,456 bp
  • T to C, chromosome 9 at 106,437,722 bp
  • A to G, chromosome 9 at 107,331,089 bp
  • A to T, chromosome 9 at 108,069,009 bp
  • T to A, chromosome 10 at 17,799,334 bp
  • A to G, chromosome 10 at 45,315,021 bp
  • T to C, chromosome 10 at 117,074,102 bp
  • T to A, chromosome 10 at 127,693,054 bp
  • G to T, chromosome 11 at 4,412,245 bp
  • G to A, chromosome 11 at 67,192,542 bp
  • A to G, chromosome 11 at 67,785,284 bp
  • T to C, chromosome 11 at 78,075,393 bp
  • A to T, chromosome 11 at 79,689,652 bp
  • C to T, chromosome 11 at 95,485,901 bp
  • T to G, chromosome 11 at 97,033,166 bp
  • A to G, chromosome 11 at 99,949,306 bp
  • G to T, chromosome 11 at 104,749,700 bp
  • T to C, chromosome 11 at 116,178,175 bp
  • T to C, chromosome 11 at 116,842,449 bp
  • T to C, chromosome 12 at 51,744,805 bp
  • C to A, chromosome 12 at 104,411,397 bp
  • T to C, chromosome 12 at 111,339,873 bp
  • T to C, chromosome 13 at 23,482,763 bp
  • T to C, chromosome 13 at 32,816,377 bp
  • C to T, chromosome 13 at 34,177,983 bp
  • T to C, chromosome 13 at 67,425,604 bp
  • T to C, chromosome 14 at 26,900,848 bp
  • T to A, chromosome 14 at 52,792,513 bp
  • T to C, chromosome 14 at 55,565,509 bp
  • A to G, chromosome 14 at 70,558,212 bp
  • T to A, chromosome 14 at 120,478,926 bp
  • A to G, chromosome 16 at 18,259,623 bp
  • A to C, chromosome 16 at 97,835,642 bp
  • T to C, chromosome 17 at 20,846,884 bp
  • T to A, chromosome 17 at 26,124,615 bp
  • T to A, chromosome 17 at 34,417,565 bp
  • T to C, chromosome 17 at 37,225,385 bp
  • C to T, chromosome 17 at 37,772,019 bp
  • G to T, chromosome 17 at 74,445,512 bp
  • G to T, chromosome 17 at 80,216,150 bp
  • C to A, chromosome 19 at 3,802,799 bp
  • T to A, chromosome 19 at 4,306,035 bp
  • C to A, chromosome 19 at 34,149,292 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7468 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045542-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.