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Strain Name:
C57BL/6J-MtgxR7472Btlr/Mmmh
Stock Number:
045546-MU
Citation ID:
RRID:MMRRC_045546-MU
Other Names:
R7472 (G1)
Major Collection:

Strain Information

Suz12
Name: SUZ12 polycomb repressive complex 2 subunit
Synonyms: 2610028O16Rik, D11Ertd530e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 52615
Homologene: 32256
Irx3
Name: Iroquois related homeobox 3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16373
Homologene: 7385
Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Synonyms: Int-5, Int5, aromatase, Ar, Cyp19, ArKO, p450arom
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13075
VEGA: 9
HGNC: HGNC:2594
Homologene: 30955
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Acf7, Aclp7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Tet1
Name: tet methylcytosine dioxygenase 1
Synonyms: 2510010B09Rik, D10Ertd17e, Cxxc6, BB001228
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52463
Homologene: 12735
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,218,497 bp
  • A to G, chromosome 1 at 84,896,580 bp
  • A to G, chromosome 1 at 136,281,393 bp
  • G to T, chromosome 1 at 155,587,467 bp
  • G to A, chromosome 1 at 160,110,347 bp
  • A to C, chromosome 1 at 170,815,491 bp
  • A to T, chromosome 1 at 174,099,733 bp
  • T to C, chromosome 1 at 174,246,499 bp
  • A to G, chromosome 2 at 19,540,408 bp
  • A to T, chromosome 2 at 29,783,373 bp
  • A to G, chromosome 2 at 90,138,324 bp
  • A to T, chromosome 2 at 91,131,656 bp
  • A to G, chromosome 2 at 101,697,192 bp
  • G to T, chromosome 2 at 104,410,139 bp
  • C to T, chromosome 2 at 149,405,576 bp
  • A to T, chromosome 2 at 153,989,329 bp
  • T to C, chromosome 3 at 27,461,744 bp
  • T to C, chromosome 3 at 64,275,532 bp
  • T to C, chromosome 3 at 79,069,273 bp
  • A to C, chromosome 3 at 95,735,320 bp
  • T to C, chromosome 3 at 95,862,798 bp
  • T to C, chromosome 3 at 129,686,263 bp
  • T to C, chromosome 4 at 43,568,967 bp
  • A to G, chromosome 4 at 59,217,156 bp
  • G to A, chromosome 4 at 73,624,499 bp
  • A to T, chromosome 4 at 106,458,897 bp
  • A to G, chromosome 4 at 123,433,067 bp
  • A to G, chromosome 4 at 126,345,517 bp
  • A to G, chromosome 4 at 134,758,996 bp
  • G to A, chromosome 4 at 141,964,626 bp
  • A to G, chromosome 5 at 48,256,838 bp
  • A to T, chromosome 5 at 134,915,121 bp
  • A to G, chromosome 5 at 145,154,730 bp
  • T to A, chromosome 6 at 108,403,396 bp
  • TG to TGG, chromosome 6 at 108,664,857 bp
  • C to A, chromosome 6 at 124,850,631 bp
  • A to T, chromosome 6 at 129,775,382 bp
  • T to C, chromosome 7 at 3,611,150 bp
  • T to C, chromosome 7 at 26,267,399 bp
  • G to A, chromosome 7 at 75,730,465 bp
  • A to C, chromosome 7 at 98,064,793 bp
  • A to G, chromosome 7 at 103,320,449 bp
  • T to G, chromosome 7 at 107,190,044 bp
  • A to G, chromosome 7 at 124,397,026 bp
  • A to G, chromosome 8 at 72,753,225 bp
  • G to A, chromosome 8 at 85,432,809 bp
  • T to G, chromosome 8 at 91,799,997 bp
  • G to A, chromosome 8 at 114,236,799 bp
  • C to A, chromosome 9 at 37,537,567 bp
  • A to T, chromosome 9 at 38,594,904 bp
  • G to C, chromosome 9 at 53,448,125 bp
  • A to G, chromosome 9 at 54,166,993 bp
  • T to A, chromosome 9 at 54,884,054 bp
  • A to G, chromosome 9 at 75,448,341 bp
  • T to A, chromosome 9 at 105,782,423 bp
  • C to A, chromosome 9 at 108,486,148 bp
  • C to A, chromosome 9 at 110,898,106 bp
  • T to C, chromosome 9 at 111,272,399 bp
  • A to G, chromosome 10 at 28,761,419 bp
  • A to T, chromosome 10 at 39,087,373 bp
  • A to C, chromosome 10 at 62,813,350 bp
  • G to T, chromosome 10 at 75,658,647 bp
  • T to A, chromosome 10 at 75,897,539 bp
  • A to T, chromosome 10 at 81,089,467 bp
  • G to A, chromosome 10 at 81,179,550 bp
  • T to C, chromosome 10 at 82,283,587 bp
  • C to T, chromosome 10 at 88,476,368 bp
  • A to T, chromosome 11 at 58,625,434 bp
  • C to T, chromosome 11 at 80,024,975 bp
  • T to C, chromosome 11 at 101,571,939 bp
  • A to T, chromosome 11 at 106,836,095 bp
  • A to G, chromosome 11 at 119,263,148 bp
  • A to T, chromosome 12 at 4,866,481 bp
  • A to T, chromosome 12 at 83,272,385 bp
  • T to C, chromosome 12 at 87,069,158 bp
  • A to T, chromosome 12 at 101,885,380 bp
  • C to T, chromosome 12 at 110,665,675 bp
  • A to C, chromosome 13 at 67,593,883 bp
  • A to G, chromosome 13 at 74,363,107 bp
  • A to G, chromosome 14 at 26,856,635 bp
  • T to A, chromosome 14 at 31,261,590 bp
  • T to A, chromosome 14 at 31,300,791 bp
  • T to A, chromosome 14 at 43,783,637 bp
  • T to C, chromosome 14 at 63,138,101 bp
  • T to C, chromosome 14 at 79,771,251 bp
  • C to T, chromosome 15 at 75,891,758 bp
  • T to C, chromosome 15 at 78,605,894 bp
  • T to C, chromosome 15 at 79,122,560 bp
  • T to A, chromosome 15 at 85,135,245 bp
  • A to T, chromosome 16 at 38,505,418 bp
  • T to C, chromosome 16 at 91,055,856 bp
  • T to C, chromosome 17 at 21,880,200 bp
  • C to T, chromosome 17 at 25,750,734 bp
  • G to T, chromosome 17 at 29,204,740 bp
  • C to A, chromosome 17 at 35,528,351 bp
  • A to T, chromosome 17 at 45,559,307 bp
  • T to C, chromosome 17 at 48,249,845 bp
  • G to A, chromosome 18 at 60,629,823 bp
  • T to C, chromosome 19 at 13,028,075 bp
  • A to G, chromosome 19 at 57,368,585 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7472 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045546-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.