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Strain Name:
C57BL/6J-MtgxR7479Btlr/Mmmh
Stock Number:
045553-MU
Citation ID:
RRID:MMRRC_045553-MU
Other Names:
R7479 (G1)
Major Collection:

Strain Information

Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
Itga6
Name: integrin alpha 6
Synonyms: Cd49f, 5033401O05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16403
HGNC: HGNC:6142
Homologene: 20091
Emb
Name: embigin
Synonyms: Gp70
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13723
Homologene: 7743
B4galt1
Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Synonyms: Ggtb, Ggtb2, B-1,4-GalT1, beta-1,4-GalT1, GalT, beta 1,4-Galactosyltransferase I, b1,4-Galactosyltransferase I
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14595
HGNC: HGNC:924
Homologene: 20378
Lrrc41
Name: leucine rich repeat containing 41
Synonyms: D730026A16Rik, MUF1, D630045E04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230654
Homologene: 4645
Fryl
Name: FRY like transcription coactivator
Synonyms: 2310004H21Rik, 2510002A14Rik, 9030227G01Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72313
Homologene: 103956
Scn8a
Name: sodium channel, voltage-gated, type VIII, alpha
Synonyms: med, seal, motor end-plate disease, nmf2, ataxia 3, mnd2, mnd-2, C630029C19Rik, nmf58, NaCh6, Nav1.6, nmf335, NMF335, nur14
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20273
Homologene: 7927
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 89,930,651 bp
  • C to A, chromosome 1 at 184,037,420 bp
  • A to C, chromosome 1 at 195,158,410 bp
  • T to C, chromosome 2 at 40,801,505 bp
  • T to C, chromosome 2 at 51,627,529 bp
  • C to T, chromosome 2 at 71,838,336 bp
  • C to A, chromosome 2 at 76,738,608 bp
  • T to C, chromosome 2 at 147,084,168 bp
  • C to T, chromosome 3 at 114,102,569 bp
  • T to A, chromosome 3 at 124,578,493 bp
  • A to G, chromosome 4 at 16,155,154 bp
  • T to C, chromosome 4 at 40,823,587 bp
  • T to A, chromosome 4 at 46,681,166 bp
  • T to C, chromosome 4 at 64,017,628 bp
  • T to A, chromosome 4 at 86,799,353 bp
  • A to T, chromosome 4 at 97,183,035 bp
  • C to T, chromosome 4 at 116,089,041 bp
  • C to T, chromosome 4 at 120,715,825 bp
  • C to A, chromosome 4 at 127,194,625 bp
  • C to T, chromosome 4 at 137,539,403 bp
  • A to G, chromosome 5 at 24,325,492 bp
  • G to T, chromosome 5 at 53,117,120 bp
  • A to G, chromosome 5 at 73,097,561 bp
  • A to T, chromosome 5 at 93,156,945 bp
  • C to G, chromosome 5 at 134,707,575 bp
  • G to A, chromosome 6 at 35,024,148 bp
  • T to A, chromosome 6 at 71,936,297 bp
  • C to T, chromosome 6 at 112,735,833 bp
  • T to A, chromosome 6 at 121,878,508 bp
  • T to C, chromosome 6 at 122,526,862 bp
  • G to A, chromosome 6 at 124,517,725 bp
  • G to A, chromosome 7 at 17,042,635 bp
  • T to A, chromosome 7 at 42,613,179 bp
  • T to A, chromosome 7 at 57,824,423 bp
  • T to C, chromosome 7 at 64,739,859 bp
  • T to C, chromosome 7 at 65,301,180 bp
  • T to A, chromosome 7 at 79,835,370 bp
  • C to T, chromosome 7 at 126,963,659 bp
  • C to T, chromosome 7 at 127,393,324 bp
  • T to C, chromosome 7 at 141,102,435 bp
  • T to A, chromosome 8 at 61,130,145 bp
  • G to T, chromosome 8 at 85,270,805 bp
  • A to G, chromosome 8 at 111,197,735 bp
  • G to A, chromosome 8 at 124,334,338 bp
  • A to T, chromosome 9 at 106,653,851 bp
  • G to A, chromosome 9 at 110,068,824 bp
  • T to C, chromosome 9 at 119,759,875 bp
  • T to A, chromosome 10 at 50,649,799 bp
  • C to T, chromosome 10 at 53,655,014 bp
  • G to A, chromosome 11 at 3,917,703 bp
  • A to G, chromosome 11 at 67,785,206 bp
  • A to G, chromosome 11 at 94,992,032 bp
  • A to G, chromosome 11 at 98,704,961 bp
  • T to C, chromosome 11 at 121,492,605 bp
  • T to C, chromosome 12 at 99,891,395 bp
  • C to T, chromosome 13 at 14,340,840 bp
  • A to T, chromosome 13 at 61,537,755 bp
  • T to A, chromosome 13 at 117,249,426 bp
  • C to T, chromosome 15 at 9,513,031 bp
  • A to G, chromosome 15 at 80,889,126 bp
  • C to A, chromosome 15 at 99,423,246 bp
  • A to G, chromosome 15 at 99,720,103 bp
  • T to A, chromosome 15 at 100,955,477 bp
  • A to T, chromosome 17 at 22,851,366 bp
  • A to T, chromosome 17 at 23,177,318 bp
  • A to G, chromosome 17 at 25,840,749 bp
  • A to G, chromosome 17 at 34,863,465 bp
  • A to G, chromosome 17 at 66,379,490 bp
  • T to A, chromosome 19 at 26,640,487 bp
  • T to C, chromosome 19 at 39,881,557 bp
  • T to A, chromosome 19 at 60,858,674 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7479 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045553-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.