Strain Name:
C57BL/6J-MtgxR7495Btlr/Mmmh
Stock Number:
045568-MU
Citation ID:
RRID:MMRRC_045568-MU
Other Names:
R7495 (G1)
Major Collection:

Strain Information

Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, ne, b2b1562Clo, 6030440P17Rik, my
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Slk
Name: STE20-like kinase
Synonyms: SLK, 9A2, mSLK, Etk4, Stk2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20874
Homologene: 22515
Dgkh
Name: diacylglycerol kinase, eta
Synonyms: 5930402B05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 380921
VEGA: 14
HGNC: HGNC:2854
Homologene: 99373
Ptma
Name: prothymosin alpha
Synonyms: Thym
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19231
HGNC: HGNC:9623
Homologene: 137217
Dpp3
Name: dipeptidylpeptidase 3
Synonyms: 4930533O14Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 75221
VEGA: 19
HGNC: HGNC:3008
Homologene: 40210
Arap2
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms: Centd1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 212285
Homologene: 9064
Hk2
Name: hexokinase 2
Synonyms: HKII
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15277
HGNC: HGNC:4923
Homologene: 37273
Ice2
Name: interactor of little elongation complex ELL subunit 2
Synonyms: Narg2, B230343B06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93697
Homologene: 11618
Rxfp3
Name: relaxin family peptide receptor 3
Synonyms: Rln3r1, Salpr
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 239336
Homologene: 9568
Oit3
Name: oncoprotein induced transcript 3
Synonyms: EF-9
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 18302
Homologene: 7870
Htt
Name: huntingtin
Synonyms: HD, IT15, C430023I11Rik, htt, Hdh, huntingtin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 15194
HGNC: HGNC:4851
Homologene: 1593
Cpq
Name: carboxypeptidase Q
Synonyms: Lal-1, Pgcp, 1190003P12Rik, HLS2, 2610034C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 54381
VEGA: 15
Homologene: 9401
Paxbp1
Name: PAX3 and PAX7 binding protein 1
Synonyms: Pax3/7bp, 1810007M14Rik, Gcfc1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67367
Homologene: 9604
Zfp473
Name: zinc finger protein 473
Synonyms: D030014N22Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243963
Homologene: 18698
Pde12
Name: phosphodiesterase 12
Synonyms: E430028B21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 211948
Homologene: 14272
Dpp9
Name: dipeptidylpeptidase 9
Synonyms: DPRP2, 6430584G11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224897
VEGA: 17
Homologene: 16385
Zfp984
Name: zinc finger protein 984
Synonyms: Gm13157
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100041677
Homologene: 133076
Nr4a2
Name: nuclear receptor subfamily 4, group A, member 2
Synonyms: RNR-1, Nurr1, HZF-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18227
HGNC: HGNC:7981
Homologene: 4509
Cfap46
Name: cilia and flagella associated protein 46
Synonyms: Ttc40, 9330101J02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 212124
Med12l
Name: mediator complex subunit 12-like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 329650
Homologene: 43143
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Fstl5
Name: follistatin-like 5
Synonyms: 9130207J01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 213262
Homologene: 10584
Trpm3
Name: transient receptor potential cation channel, subfamily M, member 3
Synonyms: MLSN2, melastatin 2, 6330504P12Rik, LTRPC3, B930001P07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226025
VEGA: 19
Homologene: 62287
Scn5a
Name: sodium channel, voltage-gated, type V, alpha
Synonyms: Nav1.5, mH1, SkM2, Nav1.5c
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20271
Homologene: 22738
Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Synonyms: mdr, Mdr1b, Mdr1, Pgy-1, Abcb1, Pgy1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18669
HGNC: HGNC:40
Homologene: 69084
Apba1
Name: amyloid beta precursor protein binding family A member 1
Synonyms: Lin-10, X11alpha, 6430513E09Rik, X11, Mint, Mint1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 319924
VEGA: 19
HGNC: HGNC:578
Homologene: 897
Catip
Name: ciliogenesis associated TTC17 interacting protein
Synonyms: LOC241112, Gm216
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241112
Nfe2l1
Name: nuclear factor, erythroid derived 2,-like 1
Synonyms: TCF-11, NRF1, TCF11, Lcrf1, LCR-F1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18023
HGNC: HGNC:7781
Homologene: 20685
Vmn2r107
Name: vomeronasal 2, receptor 107
Synonyms: V2r6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22312
Homologene: 129750
Ptprb
Name: protein tyrosine phosphatase receptor type B
Synonyms: VE-PTP, 3230402H02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Stt3a
Name: STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)
Synonyms: Itm1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 16430
HGNC: HGNC:6172
Homologene: 40617
Hrh1
Name: histamine receptor H1
Synonyms: Hir, Bphs
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15465
HGNC: HGNC:5182
Homologene: 668
Vmn2r49
Name: vomeronasal 2, receptor 49
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 625605
Homologene: 113703
Sema4c
Name: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
Synonyms: Semacl1, M-Sema F, Semacl1, Semai, Semaf
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20353
Homologene: 23047
Klk1b27
Name: kallikrein 1-related peptidase b27
Synonyms: mGK-27, Klk21l, Klk27
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16619
Homologene: 68141
Capn10
Name: calpain 10
Synonyms: Capn8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23830
HGNC: HGNC:1477
Homologene: 36323
Pfkfb3
Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
Synonyms: uPFK-2, E330010H22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 170768
HGNC: HGNC:8874
Homologene: 88708
Gm28168
Name: predicted gene 28168
Type: Gene
Species: Mouse
Chromosome: 1
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to A, chromosome 1 at 36,550,693 bp
  • T to C, chromosome 1 at 74,362,692 bp
  • GGAAGAAG to GGAAGAAGAAG, chromosome 1 at 86,529,539 bp
  • T to C, chromosome 1 at 92,943,370 bp
  • T to C, chromosome 1 at 117,947,907 bp
  • A to C, chromosome 2 at 11,482,501 bp
  • T to C, chromosome 2 at 57,112,159 bp
  • T to C, chromosome 2 at 76,709,955 bp
  • T to C, chromosome 3 at 53,516,837 bp
  • A to G, chromosome 3 at 59,244,773 bp
  • A to G, chromosome 3 at 76,707,792 bp
  • A to C, chromosome 4 at 147,754,830 bp
  • A to G, chromosome 5 at 8,865,871 bp
  • C to T, chromosome 5 at 34,811,477 bp
  • C to T, chromosome 5 at 62,676,550 bp
  • C to T, chromosome 6 at 82,727,365 bp
  • A to C, chromosome 6 at 114,480,673 bp
  • A to T, chromosome 7 at 9,976,899 bp
  • G to A, chromosome 7 at 44,056,076 bp
  • A to T, chromosome 7 at 44,737,944 bp
  • A to G, chromosome 7 at 139,603,196 bp
  • A to G, chromosome 9 at 36,747,939 bp
  • G to T, chromosome 9 at 69,416,229 bp
  • A to G, chromosome 9 at 119,543,134 bp
  • T to C, chromosome 10 at 59,423,943 bp
  • C to A, chromosome 10 at 116,341,448 bp
  • A to G, chromosome 11 at 96,819,796 bp
  • A to T, chromosome 14 at 26,668,839 bp
  • A to G, chromosome 14 at 78,578,799 bp
  • C to A, chromosome 15 at 11,035,925 bp
  • C to T, chromosome 15 at 33,302,440 bp
  • T to C, chromosome 16 at 91,016,949 bp
  • A to G, chromosome 17 at 20,375,009 bp
  • T to C, chromosome 17 at 56,195,044 bp
  • T to C, chromosome 19 at 4,917,913 bp
  • T to C, chromosome 19 at 22,897,796 bp
  • T to C, chromosome 19 at 23,936,599 bp
  • C to A, chromosome 19 at 47,638,978 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7495 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045568-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.