Strain Name:
C57BL/6J-MtgxR7497Btlr/Mmmh
Stock Number:
045570-MU
Citation ID:
RRID:MMRRC_045570-MU
Other Names:
R7497 (G1)
Major Collection:

Strain Information

Myo5a
Name: myosin VA
Synonyms: flail, MVa, 9630007J19Rik, MyoVA, Myo5, Dbv
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17918
HGNC: HGNC:7602
Homologene: 20100
Elp2
Name: elongator acetyltransferase complex subunit 2
Synonyms: StIP1, Stat3-interacting protein, Statip1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 58523
VEGA: 18
Homologene: 6019
Sbf2
Name: SET binding factor 2
Synonyms: SBF2, 4833411B01Rik, mMTMH1, B430219L04Rik, Mtmr13
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319934
HGNC: HGNC:2135
Homologene: 41810
Cdh11
Name: cadherin 11
Synonyms: osteoblast-cadherin, OB-cadherin, Cad11
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12552
HGNC: HGNC:1750
Homologene: 1361
Dock1
Name: dedicator of cytokinesis 1
Synonyms: Dock180, 9130006G06Rik, D630004B07Rik, b2b3190Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Ppp1r9a
Name: protein phosphatase 1, regulatory subunit 9A
Synonyms: neurabin-I, NRB, Neurabin I, A230094E16Rik, 4930518N04Rik, 2810430P21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243725
Homologene: 14247
Atm
Name: ataxia telangiectasia mutated
Synonyms: C030026E19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11920
HGNC: HGNC:795
Homologene: 30952
Hira
Name: histone cell cycle regulator
Synonyms: D16Ertd95e, Gm15797, Tuple1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15260
HGNC: HGNC:4916
Homologene: 48172
Vps13c
Name: vacuolar protein sorting 13C
Synonyms: C230055H22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320528
VEGA: 9
Homologene: 41188
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: D16Ium21, TPRD, D16Ium21e, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Ints1
Name: integrator complex subunit 1
Synonyms: 1110015K06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68510
Homologene: 53111
Rfc1
Name: replication factor C (activator 1) 1
Synonyms: Recc1, 140kDa, RFC140, Alp145
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19687
HGNC: HGNC:9969
Homologene: 2187
Diaph1
Name: diaphanous related formin 1
Synonyms: Drf1, Dia1, Diap1, p140mDia, D18Wsu154e, mDia1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13367
HGNC: HGNC:2876
Homologene: 129567
Snx5
Name: sorting nexin 5
Synonyms: 1810032P22Rik, D2Ertd52e, 0910001N05Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69178
Homologene: 40944
Pptc7
Name: PTC7 protein phosphatase homolog
Synonyms: 9130017A15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 320717
Homologene: 6100
Setdb1
Name: SET domain, bifurcated 1
Synonyms: ESET, KMT1E
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 84505
Homologene: 32157
Krit1
Name: KRIT1, ankyrin repeat containing
Synonyms: Krit1A, Ccm1, Krit1B, A630036P20Rik, Krit1, 2010007K12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 79264
HGNC: HGNC:1573
Homologene: 12746
Zfp160
Name: zinc finger protein 160
Synonyms: 6720480D16Rik, 6720480D16Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224585
VEGA: 17
Homologene: 137372
Vps13b
Name: vacuolar protein sorting 13B
Synonyms: 1810042B05Rik, Coh1, 2310042E16Rik, C330002D13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 666173
VEGA: 15
HGNC: HGNC:2183
Homologene: 49516
Fgfr3
Name: fibroblast growth factor receptor 3
Synonyms: Fgfr-3, HBGFR, sam3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 14184
HGNC: HGNC:3690
Homologene: 55437
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Mtnap1
Name: mitochondrial nucleoid associated protein 1
Synonyms: D11Wsu47e, Gm57859
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276852
Homologene: 9928
Eif2a
Name: eukaryotic translation initiation factor 2A
Synonyms: D3Ertd194e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229317
HGNC: HGNC:3254
Homologene: 5969
Nolc1
Name: nucleolar and coiled-body phosphoprotein 1
Synonyms: 3230402K17Rik, P130, NOPP140
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70769
VEGA: 19
Kdm2a
Name: lysine (K)-specific demethylase 2A
Synonyms: Fbl7, Gm4560, Jhdm1a, Cxxc8, 5530401A10Rik, Fbxl11, lalina
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 225876
Homologene: 56564
Gp2
Name: glycoprotein 2 zymogen granule membrane
Synonyms: 2310037I18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67133
HGNC: HGNC:4441
Homologene: 133790
Gm7361
Name: predicted gene 7361
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 664837
Homologene: 69402
Adgrv1
Name: adhesion G protein-coupled receptor V1
Synonyms: Mgr1, Gpr98, Mass1, VLGR1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 110789
Homologene: 19815
Gm11639
Name: predicted gene 11639
Synonyms: Gm11639, Efcab15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 105242472
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Nlrc5
Name: NLR family, CARD domain containing 5
Synonyms: AI451557
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 434341
Homologene: 88935
Muc5b
Name: mucin 5, subtype B, tracheobronchial
Synonyms: MUC5, 2300002I04Rik, MUC9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 74180
HGNC: HGNC:7516
Homologene: 136756
Klkb1
Name: kallikrein B, plasma 1
Synonyms: Kal-3, Klk3, Kal3, PSA
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16621
HGNC: HGNC:6371
Homologene: 68097
Taok2
Name: TAO kinase 2
Synonyms: 1110033K02Rik, PSK1, TAO2, TAO1, MAP3K17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 381921
Homologene: 74531
Usp12
Name: ubiquitin specific peptidase 12
Synonyms: Ubh1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22217
Homologene: 56137
Scara3
Name: scavenger receptor class A, member 3
Synonyms: C130058N24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219151
VEGA: 14
Homologene: 9437
Pnma8b
Name: PNMA family member 8B
Synonyms: Pnmal2, EG434128
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434128
Homologene: 35491
Agap2
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Synonyms: Centg1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216439
VEGA: 10
Homologene: 86815
Sema5b
Name: sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
Synonyms: Semag, SemG, SemG
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20357
Homologene: 8427
Postn
Name: periostin, osteoblast specific factor
Synonyms: Periostin, Osf2, peri, A630052E07Rik, OSF-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 50706
Homologene: 4730
Cyp26b1
Name: cytochrome P450, family 26, subfamily b, polypeptide 1
Synonyms: CP26, retinoic acid B1, P450RAI-2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232174
Homologene: 23179
Dok4
Name: docking protein 4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 114255
Homologene: 10009
Gadl1
Name: glutamate decarboxylase-like 1
Synonyms: 1110027M19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73748
Homologene: 45812
Or52s19
Name: olfactory receptor family 52 subfamily S member 19
Synonyms: Olfr601, GA_x6K02T2PBJ9-6068534-6067590, MOR24-3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258311
Homologene: 64851
Zfp788
Name: zinc finger protein 788
Synonyms: 2810426N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67607
Homologene: 137363
Map3k21
Name: mitogen-activated protein kinase kinase kinase 21
Synonyms: BC021891
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234878
Homologene: 32778
Pnpt1
Name: polyribonucleotide nucleotidyltransferase 1
Synonyms: 1200003F12Rik, PNPase, polynucleotide phosphorylase
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71701
Homologene: 12404
Gcnt4
Name: glucosaminyl (N-acetyl) transferase 4, core 2 (beta-1,6-N-acetylglucosaminyltransferase)
Synonyms: LOC218476, C2GNT3, Gm73, LOC238786
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218476
VEGA: 13
Homologene: 41144
Or4b1b
Name: olfactory receptor family 4 subfamily B member 1B
Synonyms: GA_x6K02T2Q125-51636504-51635578, Olfr1272, MOR227-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258982
HGNC: HGNC:8290
Homologene: 133649
Usp16
Name: ubiquitin specific peptidase 16
Synonyms: 6330514E22Rik, 1200004E02Rik, UBP-M, 2810483I07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74112
Homologene: 38183
Dqx1
Name: DEAQ RNA-dependent ATPase
Synonyms: 2310066E11Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 93838
Homologene: 14143
Vmn2r106
Name: vomeronasal 2, receptor 106
Synonyms: EG224576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224576
Homologene: 135824
Or8u8
Name: olfactory receptor family 8 subfamily U member 8
Synonyms: MOR185-6, IE6, Olfr52, GA_x6K02T2Q125-47650922-47649963
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18352
Homologene: 105200
Slc19a3
Name: solute carrier family 19, member 3
Synonyms: ThTr2, A230084E24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 80721
Homologene: 23530
Acvr2b
Name: activin receptor IIB
Synonyms: ActRIIB
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 11481
VEGA: 9
HGNC: HGNC:174
Homologene: 863
Abcd2
Name: ATP-binding cassette, sub-family D member 2
Synonyms: ALDR, ALDL1, adrenoleukodystrophy related, ABC39
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 26874
VEGA: 15
HGNC: HGNC:66
Homologene: 55873
Aph1b
Name: aph1 homolog B, gamma secretase subunit
Synonyms: 2310057K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208117
Homologene: 12844
Or4k15
Name: olfactory receptor family 4 subfamily K member 15
Synonyms: MOR246-2, Olfr727, GA_x6K02T2PMLR-5817082-5818056
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258316
Homologene: 84571
Erich2
Name: glutamate rich 2
Synonyms: 4933404M02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66748
Homologene: 75226
Gm10972
Name: predicted gene 10972
Type: Gene
Species: Mouse
Chromosome: 3
Flacc1
Name: flagellum associated containing coiled-coil domains 1
Synonyms: 4933425F06Rik, Als2cr12, 4933405P16Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108812
Homologene: 51399
Ces2f
Name: carboxylesterase 2F
Synonyms: 2310038E17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71903
HGNC: HGNC:1864
Homologene: 135673
Cfap210
Name: cilia and flagella associated protein 210
Synonyms: 4930525K21Rik, 4930578N16Rik, Ccdc173
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75051
Homologene: 18989
Prdm11
Name: PR domain containing 11
Synonyms: 8030443D09Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 100042784
Homologene: 82511
Taar8c
Name: trace amine-associated receptor 8C
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 494546
Homologene: 77586
Hcar2
Name: hydroxycarboxylic acid receptor 2
Synonyms: Gpr109a, PUMA-G, HM74, Gpr109b, Pumag, Niacr1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 80885
Homologene: 4391
Ighv1-5
Name: immunoglobulin heavy variable V1-5
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 668469
Duxf3
Name: double homeobox family member 3
Synonyms: 4933403O03Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74399
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 58,678,308 bp
  • T to C, chromosome 1 at 83,013,928 bp
  • A to C, chromosome 2 at 69,758,448 bp
  • T to C, chromosome 2 at 70,534,322 bp
  • T to C, chromosome 2 at 86,182,073 bp
  • T to A, chromosome 2 at 90,281,754 bp
  • T to A, chromosome 2 at 93,012,707 bp
  • T to C, chromosome 2 at 112,730,473 bp
  • T to C, chromosome 2 at 144,257,974 bp
  • A to G, chromosome 3 at 54,362,670 bp
  • C to A, chromosome 3 at 58,548,681 bp
  • A to G, chromosome 3 at 94,643,580 bp
  • T to C, chromosome 3 at 95,341,828 bp
  • A to G, chromosome 5 at 3,812,349 bp
  • C to A, chromosome 5 at 26,261,190 bp
  • GGACCTCTCCGTG to GG, chromosome 5 at 33,735,422 bp
  • A to G, chromosome 5 at 65,279,498 bp
  • G to A, chromosome 5 at 122,284,879 bp
  • C to T, chromosome 5 at 123,865,186 bp
  • C to T, chromosome 5 at 139,768,976 bp
  • A to T, chromosome 5 at 146,752,454 bp
  • A to C, chromosome 6 at 4,905,775 bp
  • T to A, chromosome 6 at 83,059,047 bp
  • C to A, chromosome 6 at 84,576,982 bp
  • A to G, chromosome 7 at 16,944,949 bp
  • A to T, chromosome 7 at 41,648,851 bp
  • T to C, chromosome 7 at 103,359,012 bp
  • C to A, chromosome 7 at 110,614,716 bp
  • C to T, chromosome 7 at 119,454,606 bp
  • G to A, chromosome 7 at 126,874,878 bp
  • A to G, chromosome 7 at 134,765,274 bp
  • T to G, chromosome 7 at 141,861,513 bp
  • T to A, chromosome 8 at 45,294,790 bp
  • T to C, chromosome 8 at 94,521,970 bp
  • A to T, chromosome 8 at 94,867,425 bp
  • T to C, chromosome 8 at 102,673,824 bp
  • T to A, chromosome 8 at 104,954,698 bp
  • A to T, chromosome 8 at 125,927,601 bp
  • C to T, chromosome 9 at 18,645,089 bp
  • G to A, chromosome 9 at 53,511,891 bp
  • A to C, chromosome 9 at 66,794,119 bp
  • A to G, chromosome 9 at 67,840,479 bp
  • T to C, chromosome 9 at 75,197,701 bp
  • A to T, chromosome 9 at 116,074,087 bp
  • T to A, chromosome 9 at 119,433,286 bp
  • G to A, chromosome 10 at 24,101,218 bp
  • A to T, chromosome 10 at 58,230,736 bp
  • T to C, chromosome 10 at 127,090,965 bp
  • A to T, chromosome 11 at 29,130,860 bp
  • T to C, chromosome 11 at 104,762,690 bp
  • T to A, chromosome 11 at 113,692,397 bp
  • T to A, chromosome 12 at 114,513,536 bp
  • A to T, chromosome 13 at 81,440,225 bp
  • A to G, chromosome 13 at 96,946,960 bp
  • T to A, chromosome 14 at 50,127,495 bp
  • T to C, chromosome 14 at 65,931,202 bp
  • T to A, chromosome 15 at 35,876,697 bp
  • T to A, chromosome 15 at 91,191,176 bp
  • T to C, chromosome 16 at 18,952,079 bp
  • T to A, chromosome 16 at 35,661,330 bp
  • T to A, chromosome 16 at 87,466,286 bp
  • C to A, chromosome 16 at 94,418,682 bp
  • C to T, chromosome 17 at 20,267,939 bp
  • T to A, chromosome 17 at 21,026,193 bp
  • C to T, chromosome 18 at 24,611,928 bp
  • T to C, chromosome 18 at 37,895,300 bp
  • A to C, chromosome 19 at 4,324,376 bp
  • A to G, chromosome 19 at 46,082,818 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7497 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045570-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.