Strain Name:
C57BL/6J-MtgxR7503Btlr/Mmmh
Stock Number:
045576-MU
Citation ID:
RRID:MMRRC_045576-MU
Other Names:
R7503 (G1)
Major Collection:

Strain Information

Slc16a3
Name: solute carrier family 16 (monocarboxylic acid transporters), member 3
Synonyms: MCT3, monocarboxylate transporter 4, MCT4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 80879
Homologene: 37900
Mef2c
Name: myocyte enhancer factor 2C
Synonyms: 9930028G15Rik, 5430401D19Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17260
HGNC: HGNC:6996
Homologene: 31087
Smad2
Name: SMAD family member 2
Synonyms: Madr2, Madh2, Smad 2, 7120426M23Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17126
HGNC: HGNC:6768
Homologene: 21197
Scaper
Name: S phase cyclin A-associated protein in the ER
Synonyms: D530014O03Rik, Zfp291
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244891
VEGA: 9
Homologene: 32488
Myo1b
Name: myosin IB
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17912
HGNC: HGNC:7596
Homologene: 7856
Bard1
Name: BRCA1 associated RING domain 1
Synonyms: ENSMUSG00000060893, ENSMUSG00000073653
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12021
HGNC: HGNC:952
Homologene: 400
Xdh
Name: xanthine dehydrogenase
Synonyms: Xox1, Xox-1, xanthine oxidase, Xor, XO
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22436
VEGA: 17
Homologene: 324
Zzef1
Name: zinc finger, ZZ-type with EF hand domain 1
Synonyms: 8430405D05Rik, C130099L13Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195018
Homologene: 9027
Zfp281
Name: zinc finger protein 281
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226442
Homologene: 8270
Fam120a
Name: family with sequence similarity 120, member A
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218236
VEGA: 13
Homologene: 8752
Prpf39
Name: pre-mRNA processing factor 39
Synonyms: Srcs1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 328110
Homologene: 32377
Recql5
Name: RecQ protein-like 5
Synonyms: Recq5b, Recql5b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 170472
HGNC: HGNC:9950
Homologene: 31232
Utf1
Name: undifferentiated embryonic cell transcription factor 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22286
Homologene: 48226
Ints2
Name: integrator complex subunit 2
Synonyms: 2810417D08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 70422
Homologene: 10801
Inava
Name: innate immunity activator
Synonyms: 5730559C18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67313
Homologene: 10103
Tsc1
Name: TSC complex subunit 1
Synonyms: hamartin, tuberous sclerosis 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 64930
Homologene: 314
Pnpla7
Name: patatin-like phospholipase domain containing 7
Synonyms: E430013P11Rik, NRE
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241274
Homologene: 62431
Akap11
Name: A kinase anchor protein 11
Synonyms: 6330501D17Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219181
HGNC: HGNC:369
Homologene: 8279
Pomgnt1
Name: protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase
Synonyms: 4930467B06Rik, 0610016I07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68273
Homologene: 9806
Stra6
Name: stimulated by retinoic acid gene 6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20897
Homologene: 7554
Anpep
Name: alanyl aminopeptidase, membrane
Synonyms: Cd13, aminopeptidase N, Apn
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16790
HGNC: HGNC:500
Homologene: 68163
Invs
Name: inversin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16348
Homologene: 7786
Ttn
Name: titin
Synonyms: connectin, shru, D330041I19Rik, 2310057K23Rik, mdm, D830007G01Rik, 2310074I15Rik, 1100001C23Rik, 2310036G12Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Msh4
Name: mutS homolog 4
Synonyms: mMsh4, 4930485C04Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 55993
HGNC: HGNC:7327
Homologene: 1830
Sorcs1
Name: sortilin-related VPS10 domain containing receptor 1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 58178
Homologene: 10967
F5
Name: coagulation factor V
Synonyms: Cf5, Cf-5
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14067
HGNC: HGNC:3542
Homologene: 104
Wdr11
Name: WD repeat domain 11
Synonyms: Wdr11, 2900055P10Rik, Brwd2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207425
Homologene: 41229
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114875
Homologene: 23815
Mylk3
Name: myosin light chain kinase 3
Synonyms: D830007F02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 213435
Homologene: 35278
Vmn2r6
Name: vomeronasal 2, receptor 6
Synonyms: EG667069, EG620718
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 667069
Homologene: 129754
Eno1b
Name: enolase 1B, retrotransposed
Synonyms: Gm5506
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433182
VEGA: 18
HGNC: HGNC:3350
Homologene: 134343
Farp2
Name: FERM, RhoGEF and pleckstrin domain protein 2
Synonyms: Fir, D030026M03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227377
Homologene: 8877
Arhgef5
Name: Rho guanine nucleotide exchange factor 5
Synonyms: 2210412D05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54324
Homologene: 66300
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 435975
Homologene: 104832
Pcdhb22
Name: protocadherin beta 22
Synonyms: Pcdhb15, PcdhbV
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93893
HGNC: HGNC:8686
Homologene: 113752
Cfap251
Name: cilia and flagella associated protein 251
Synonyms: 4930415N18Rik, 4933428F06Rik, Wdr66
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269701
Homologene: 16964
Vmn2r90
Name: vomeronasal 2, receptor 90
Synonyms: EG626942
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 626942
A230072I06Rik
Name: RIKEN cDNA A230072I06 gene
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 619290
VEGA: 8
Or52a24
Name: olfactory receptor family 52 subfamily A member 24
Synonyms: MOR22-4P, Olfr628, MOR22-4P, Olfr1526-ps1, MOR22-1, GA_x6K02T2PBJ9-6457667-6458617
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259159
Homologene: 8420
Wdhd1
Name: WD repeat and HMG-box DNA binding protein 1
Synonyms: D630024B06Rik, AND-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 218973
Homologene: 56019
Spopfm1
Name: speckle-type BTB/POZ protein family member 1
Synonyms: Gm4778
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 212727
Evc
Name: EvC ciliary complex subunit 1
Synonyms: Ellis van Creveld gene syndrome
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59056
HGNC: HGNC:3497
Homologene: 10949
Tmem14a
Name: transmembrane protein 14A
Synonyms: PTD011, 5730496E24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75712
Homologene: 36341
Aif1
Name: allograft inflammatory factor 1
Synonyms: Iba1, D17H6S50E, G1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 11629
HGNC: HGNC:352
Homologene: 1226
Dsc1
Name: desmocollin 1
Synonyms: Dsc1a, Dsc1b
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13505
VEGA: 18
HGNC: HGNC:3035
Homologene: 22761
Pcdhb21
Name: protocadherin beta 21
Synonyms: Pcdhb18, PcdhbU
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93892
Homologene: 134302
Nsmce1
Name: NSE1 homolog, SMC5-SMC6 complex component
Synonyms: 2510027N19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 67711
Homologene: 41672
Cfhr2
Name: complement factor H-related 2
Synonyms: FHR-B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545366
Homologene: 134349
Or5d43
Name: olfactory receptor family 5 subfamily D member 43
Synonyms: Olfr1173, GA_x6K02T2Q125-49759783-49758845, MOR174-20_p
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404329
Homologene: 128091
Vmn2r97
Name: vomeronasal 2, receptor 97
Synonyms: EG627367
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627367
Homologene: 115024
Arsj
Name: arylsulfatase J
Synonyms: 9330196J05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 271970
Homologene: 35257
Hmgcs2
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2
Synonyms: mHS
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 15360
HGNC: HGNC:5008
Homologene: 38066
Prl3d3
Name: prolactin family 3, subfamily d, member 3
Synonyms: PL-Ig, Plig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 215029
Homologene: 137215
Eif3i
Name: eukaryotic translation initiation factor 3, subunit I
Synonyms: 36kDa, D4Ertd632e, TRIP-1, Eif3s2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54709
HGNC: HGNC:3272
Homologene: 2786
Eva1a
Name: eva-1 homolog A, regulator of programmed cell death
Synonyms: Tmem166, Fam176a
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232146
Homologene: 12969
Speer3
Name: spermatogenesis associated glutamate (E)-rich protein 3
Synonyms: 4933405P08Rik, SPEER-3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71026
Homologene: 69402
Pigu
Name: phosphatidylinositol glycan anchor biosynthesis, class U
Synonyms: Cdc91l1, 5430426F17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228812
Homologene: 6553
Spata21
Name: spermatogenesis associated 21
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329972
Homologene: 18639
Runx3
Name: runt related transcription factor 3
Synonyms: Rx3, Cbfa3, AML2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12399
Homologene: 37914
Cfap54
Name: cilia and flagella associated protein 54
Synonyms: LOC380653, Gm872, 4930485B16Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 380654
Homologene: 133438
Slc25a1
Name: solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
Synonyms: Dgsj, Slc20a3, 2610100G11Rik, 1300019P08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13358
Homologene: 4362
Cc2d2b
Name: coiled-coil and C2 domain containing 2B
Synonyms: EG668310
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 668310
Homologene: 141114
Gm20379
Name: predicted gene, 20379
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 115488195
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 21,229,399 bp
  • A to T, chromosome 1 at 51,776,602 bp
  • T to C, chromosome 1 at 71,030,836 bp
  • T to G, chromosome 1 at 93,567,497 bp
  • T to C, chromosome 1 at 136,215,937 bp
  • T to A, chromosome 1 at 136,626,940 bp
  • T to A, chromosome 1 at 139,831,214 bp
  • T to A, chromosome 1 at 164,192,210 bp
  • C to A, chromosome 2 at 24,983,532 bp
  • T to A, chromosome 2 at 28,687,076 bp
  • T to C, chromosome 2 at 76,781,057 bp
  • T to C, chromosome 2 at 88,274,695 bp
  • C to T, chromosome 2 at 155,331,144 bp
  • G to A, chromosome 3 at 64,539,951 bp
  • A to T, chromosome 3 at 94,266,473 bp
  • T to C, chromosome 3 at 98,302,624 bp
  • T to C, chromosome 3 at 126,364,844 bp
  • A to C, chromosome 3 at 153,867,750 bp
  • C to T, chromosome 4 at 48,396,347 bp
  • T to C, chromosome 4 at 116,152,752 bp
  • C to T, chromosome 4 at 129,600,414 bp
  • C to A, chromosome 4 at 135,155,368 bp
  • T to A, chromosome 4 at 141,095,303 bp
  • A to T, chromosome 5 at 13,793,334 bp
  • T to C, chromosome 5 at 37,300,767 bp
  • G to T, chromosome 5 at 123,297,458 bp
  • A to T, chromosome 6 at 43,273,999 bp
  • G to A, chromosome 6 at 82,071,229 bp
  • T to A, chromosome 6 at 139,990,748 bp
  • A to T, chromosome 7 at 42,933,590 bp
  • A to G, chromosome 7 at 79,826,637 bp
  • T to A, chromosome 7 at 103,732,267 bp
  • A to G, chromosome 7 at 125,471,934 bp
  • A to G, chromosome 7 at 129,603,110 bp
  • A to G, chromosome 7 at 139,944,133 bp
  • G to A, chromosome 8 at 12,279,554 bp
  • T to C, chromosome 8 at 85,353,589 bp
  • T to C, chromosome 9 at 55,807,754 bp
  • A to G, chromosome 9 at 58,151,245 bp
  • T to A, chromosome 10 at 92,887,436 bp
  • T to A, chromosome 11 at 72,826,067 bp
  • T to C, chromosome 11 at 86,232,055 bp
  • C to A, chromosome 11 at 115,895,055 bp
  • T to C, chromosome 11 at 120,957,027 bp
  • A to G, chromosome 12 at 65,053,393 bp
  • A to G, chromosome 13 at 27,161,113 bp
  • A to T, chromosome 13 at 48,949,247 bp
  • A to C, chromosome 13 at 83,662,504 bp
  • C to T, chromosome 13 at 92,306,057 bp
  • T to C, chromosome 14 at 47,250,791 bp
  • T to C, chromosome 14 at 78,512,001 bp
  • G to T, chromosome 16 at 17,926,439 bp
  • T to C, chromosome 17 at 17,713,248 bp
  • A to G, chromosome 17 at 18,928,208 bp
  • A to T, chromosome 17 at 35,171,573 bp
  • A to C, chromosome 17 at 73,926,210 bp
  • G to A, chromosome 18 at 20,085,865 bp
  • G to A, chromosome 18 at 37,514,975 bp
  • T to G, chromosome 18 at 37,519,102 bp
  • A to T, chromosome 18 at 48,046,811 bp
  • A to G, chromosome 18 at 76,286,885 bp
  • A to G, chromosome 19 at 40,794,612 bp
  • A to G, chromosome 19 at 50,153,052 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7503 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045576-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.