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Strain Name:
C57BL/6J-MtgxR7506Btlr/Mmmh
Stock Number:
045579-MU
Citation ID:
RRID:MMRRC_045579-MU
Other Names:
R7506 (G1)
Major Collection:

Strain Information

Nrtn
Name: neurturin
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18188
VEGA: 17
HGNC: HGNC:8007
Homologene: 7450
Zfp97
Name: zinc finger protein 97
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22759
Homologene: 133884
Cwf19l2
Name: CWF19 like cell cycle control factor 2
Synonyms: 3230401L03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244672
Homologene: 12366
P4htm
Name: prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Synonyms: 4933406E20Rik, P4h-tm
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74443
Homologene: 41765
Nptn
Name: neuroplastin
Synonyms: Sdfr1, NP65
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20320
Homologene: 105617
Rapgef6
Name: Rap guanine nucleotide exchange factor (GEF) 6
Synonyms: PDZ-GEF2, RA-GEF-2, Pdzgef2, C030018K18Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192786
Homologene: 22968
Ppard
Name: peroxisome proliferator activator receptor delta
Synonyms: Nr1c2, PPARdelta/beta, Pparb, Peroxisome proliferator-activated receptor beta, NUC1, PPAR-delta, Pparb/d
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19015
HGNC: HGNC:9235
Homologene: 4544
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 58,049,403 bp
  • A to C, chromosome 1 at 127,366,455 bp
  • T to C, chromosome 1 at 178,529,499 bp
  • T to A, chromosome 2 at 71,420,347 bp
  • A to G, chromosome 2 at 73,368,339 bp
  • T to A, chromosome 2 at 76,889,468 bp
  • A to T, chromosome 2 at 152,518,301 bp
  • T to A, chromosome 3 at 59,319,354 bp
  • G to T, chromosome 3 at 90,259,212 bp
  • T to C, chromosome 3 at 135,884,306 bp
  • T to G, chromosome 3 at 157,069,233 bp
  • T to C, chromosome 4 at 62,532,261 bp
  • A to C, chromosome 4 at 65,231,182 bp
  • G to A, chromosome 5 at 108,163,739 bp
  • A to G, chromosome 5 at 151,585,020 bp
  • G to A, chromosome 6 at 38,332,940 bp
  • G to A, chromosome 6 at 72,356,770 bp
  • A to T, chromosome 6 at 89,747,177 bp
  • G to T, chromosome 6 at 90,662,806 bp
  • A to G, chromosome 6 at 90,667,909 bp
  • G to A, chromosome 6 at 124,039,741 bp
  • T to C, chromosome 7 at 5,544,862 bp
  • C to T, chromosome 7 at 15,988,213 bp
  • A to T, chromosome 7 at 42,926,967 bp
  • A to T, chromosome 7 at 82,514,978 bp
  • C to T, chromosome 9 at 3,456,775 bp
  • C to T, chromosome 9 at 15,297,906 bp
  • T to C, chromosome 9 at 58,618,873 bp
  • T to A, chromosome 9 at 74,863,240 bp
  • T to C, chromosome 9 at 77,164,803 bp
  • A to G, chromosome 9 at 108,583,679 bp
  • T to C, chromosome 10 at 20,353,385 bp
  • A to G, chromosome 10 at 23,992,994 bp
  • T to C, chromosome 10 at 75,511,185 bp
  • C to A, chromosome 10 at 79,550,342 bp
  • T to C, chromosome 10 at 117,690,691 bp
  • T to C, chromosome 11 at 4,177,561 bp
  • T to A, chromosome 11 at 54,636,171 bp
  • G to T, chromosome 11 at 72,437,898 bp
  • A to T, chromosome 11 at 74,289,123 bp
  • G to A, chromosome 11 at 94,108,464 bp
  • A to T, chromosome 11 at 121,670,914 bp
  • G to A, chromosome 13 at 23,571,484 bp
  • G to T, chromosome 13 at 72,629,209 bp
  • T to A, chromosome 14 at 4,893,441 bp
  • A to G, chromosome 14 at 20,730,085 bp
  • A to G, chromosome 14 at 51,920,601 bp
  • A to G, chromosome 14 at 101,919,609 bp
  • A to G, chromosome 15 at 13,034,310 bp
  • C to T, chromosome 15 at 65,936,382 bp
  • C to A, chromosome 15 at 76,343,685 bp
  • A to T, chromosome 16 at 64,791,848 bp
  • G to A, chromosome 16 at 76,294,459 bp
  • A to G, chromosome 17 at 17,145,280 bp
  • A to T, chromosome 17 at 28,298,761 bp
  • G to A, chromosome 17 at 34,715,691 bp
  • C to T, chromosome 17 at 56,751,633 bp
  • T to A, chromosome 18 at 20,533,464 bp
  • A to C, chromosome 18 at 37,732,472 bp
  • T to A, chromosome 19 at 7,429,753 bp
  • C to T, chromosome 19 at 50,182,674 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7506 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045579-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.