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Strain Name:
C57BL/6J-MtgxR7513Btlr/Mmmh
Stock Number:
045586-MU
Citation ID:
RRID:MMRRC_045586-MU
Other Names:
R7513 (G1)
Major Collection:

Strain Information

Mycn
Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
Synonyms: Nmyc, N-myc, Nmyc-1, Nmyc1, bHLHe37
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 18109
HGNC: HGNC:7559
Homologene: 3922
Mmp10
Name: matrix metallopeptidase 10
Synonyms: stromelysin 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17384
VEGA: 9
HGNC: HGNC:7156
Homologene: 20546
Trpc2
Name: transient receptor potential cation channel, subfamily C, member 2
Synonyms: TRPC2b, TRPC2a, mTrp2, trp2, Trrp2, 3010009O07Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22064
Homologene: 135989
Rbms1
Name: RNA binding motif, single stranded interacting protein 1
Synonyms: YC1, MSSP-3, MSSP-2, MSSP-1, 2600014B10Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56878
HGNC: HGNC:9907
Homologene: 9640
Timeless
Name: timeless circadian clock 1
Synonyms: tim
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 21853
Homologene: 31206
Lrsam1
Name: leucine rich repeat and sterile alpha motif containing 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227738
Homologene: 44526
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 46,124,346 bp
  • G to A, chromosome 1 at 97,853,185 bp
  • T to A, chromosome 1 at 117,801,419 bp
  • T to G, chromosome 1 at 135,959,967 bp
  • T to A, chromosome 1 at 171,884,618 bp
  • A to T, chromosome 1 at 173,695,654 bp
  • A to T, chromosome 2 at 13,578,632 bp
  • T to C, chromosome 2 at 32,953,485 bp
  • T to C, chromosome 2 at 52,209,540 bp
  • A to G, chromosome 2 at 52,412,145 bp
  • A to G, chromosome 2 at 60,758,821 bp
  • T to A, chromosome 2 at 67,510,764 bp
  • C to T, chromosome 2 at 76,851,596 bp
  • G to T, chromosome 2 at 76,944,963 bp
  • T to A, chromosome 2 at 80,502,291 bp
  • T to C, chromosome 2 at 93,840,092 bp
  • A to G, chromosome 2 at 130,024,404 bp
  • A to T, chromosome 2 at 150,408,756 bp
  • T to A, chromosome 2 at 167,225,283 bp
  • G to A, chromosome 3 at 15,411,443 bp
  • C to A, chromosome 3 at 15,542,140 bp
  • T to A, chromosome 3 at 36,164,643 bp
  • A to T, chromosome 3 at 87,922,427 bp
  • T to A, chromosome 4 at 6,741,507 bp
  • C to T, chromosome 4 at 101,191,651 bp
  • A to G, chromosome 4 at 126,792,264 bp
  • G to A, chromosome 5 at 8,715,771 bp
  • A to T, chromosome 5 at 122,308,129 bp
  • A to T, chromosome 6 at 35,283,337 bp
  • A to G, chromosome 6 at 40,492,150 bp
  • T to C, chromosome 7 at 12,362,067 bp
  • G to T, chromosome 7 at 18,475,300 bp
  • T to C, chromosome 7 at 44,306,356 bp
  • T to A, chromosome 7 at 79,711,028 bp
  • A to T, chromosome 7 at 102,090,068 bp
  • A to G, chromosome 7 at 106,927,276 bp
  • T to C, chromosome 7 at 131,090,512 bp
  • G to A, chromosome 7 at 131,272,071 bp
  • T to C, chromosome 7 at 135,693,223 bp
  • C to T, chromosome 7 at 143,081,835 bp
  • G to A, chromosome 8 at 109,560,589 bp
  • C to A, chromosome 8 at 117,579,853 bp
  • G to T, chromosome 8 at 122,408,254 bp
  • A to T, chromosome 9 at 7,508,127 bp
  • T to C, chromosome 9 at 57,139,399 bp
  • T to C, chromosome 10 at 18,523,952 bp
  • A to G, chromosome 10 at 62,971,968 bp
  • A to T, chromosome 10 at 76,313,235 bp
  • T to C, chromosome 10 at 128,249,530 bp
  • G to A, chromosome 11 at 36,051,900 bp
  • T to A, chromosome 11 at 69,105,571 bp
  • T to C, chromosome 11 at 69,187,844 bp
  • A to G, chromosome 11 at 73,240,541 bp
  • A to T, chromosome 11 at 85,027,112 bp
  • T to C, chromosome 11 at 94,112,083 bp
  • T to A, chromosome 11 at 94,503,556 bp
  • A to G, chromosome 11 at 97,856,229 bp
  • T to C, chromosome 11 at 107,656,115 bp
  • C to A, chromosome 12 at 12,939,742 bp
  • C to T, chromosome 12 at 37,244,353 bp
  • C to A, chromosome 12 at 100,115,514 bp
  • C to A, chromosome 12 at 103,419,106 bp
  • A to T, chromosome 12 at 111,540,252 bp
  • A to T, chromosome 12 at 113,288,851 bp
  • T to A, chromosome 13 at 50,702,873 bp
  • G to C, chromosome 14 at 47,664,084 bp
  • T to C, chromosome 15 at 28,370,415 bp
  • T to A, chromosome 15 at 77,525,711 bp
  • C to A, chromosome 15 at 82,558,420 bp
  • T to A, chromosome 15 at 89,158,322 bp
  • T to A, chromosome 15 at 100,207,748 bp
  • C to A, chromosome 15 at 100,482,416 bp
  • T to A, chromosome 16 at 58,915,932 bp
  • A to G, chromosome 17 at 28,858,807 bp
  • G to T, chromosome 17 at 33,575,814 bp
  • G to A, chromosome 17 at 33,932,555 bp
  • C to T, chromosome 18 at 36,953,339 bp
  • A to G, chromosome 19 at 10,860,128 bp
  • T to A, chromosome 19 at 36,978,403 bp
  • A to T, chromosome Y at 759,852 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7513 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045586-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.