Strain Name:
C57BL/6J-MtgxR7528Btlr/Mmmh
Stock Number:
045600-MU
Citation ID:
RRID:MMRRC_045600-MU
Other Names:
R7528 (G1)
Major Collection:

Strain Information

Sptbn4
Name: spectrin beta, non-erythrocytic 4
Synonyms: SpbIV, ROSA62, neuroaxonal dystrophy, dyn, 1700022P15Rik, 5830426A08Rik, nmf261, Spnb4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80297
Homologene: 11879
Btrc
Name: beta-transducin repeat containing protein
Synonyms: beta-TrCP, Beta-Trcp1, Fbw1a, SCF b-TRCP, Slimb
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 12234
VEGA: 19
HGNC: HGNC:1144
Homologene: 39330
Ptch1
Name: patched 1
Synonyms: Ptc, wig, Ptc1, Patched 1, A230106A15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19206
HGNC: HGNC:9585
Homologene: 223
App
Name: amyloid beta precursor protein
Synonyms: betaAPP, Adap, appican, protease nexin II, E030013M08Rik, Cvap, Abeta
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11820
VEGA: 16
HGNC: HGNC:620
Homologene: 56379
Dst
Name: dystonin
Synonyms: Bpag1, bullous pemphigoid antigen 1, Bpag, ah, 2310001O04Rik, BPAG1, BPAG1-n, bullous pemphigoid antigen 1, nmf203, A830042E19Rik, Macf2, athetoid, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Macf1
Name: microtubule-actin crosslinking factor 1
Synonyms: Aclp7, Acf7, trabeculin alpha
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11426
Homologene: 136191
Phf20
Name: PHD finger protein 20
Synonyms: 6820402O20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228829
Homologene: 9507
Fos
Name: FBJ osteosarcoma oncogene
Synonyms: cFos, c-fos, D12Rfj1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 14281
HGNC: HGNC:3796
Homologene: 3844
Pik3c2a
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Synonyms: PI3KC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 18704
HGNC: HGNC:8971
Homologene: 20581
Ppp4r1
Name: protein phosphatase 4, regulatory subunit 1
Synonyms: Pp4r1, 3110001J10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70351
HGNC: HGNC:9320
Homologene: 81737
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Pard3
Name: par-3 family cell polarity regulator
Synonyms: PAR-3, ASIP, D8Ertd580e, Pard3a, Par3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 93742
Homologene: 10489
Tdh
Name: L-threonine dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 58865
Homologene: 10987
Slain2
Name: SLAIN motif family, member 2
Synonyms: 5033405K12Rik, 8030444K12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 75991
Homologene: 18952
Abcc4
Name: ATP-binding cassette, sub-family C member 4
Synonyms: MOAT-B, D630049P08Rik, MRP4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239273
VEGA: 14
HGNC: HGNC:55
Homologene: 74563
Akap9
Name: A kinase anchor protein 9
Synonyms: repro12, 5730481H23Rik, G1-448-15, AKAP450, mei2-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Prc1
Name: protein regulator of cytokinesis 1
Synonyms: D7Ertd348e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233406
HGNC: HGNC:9341
Homologene: 37868
Kars1
Name: lysyl-tRNA synthetase 1
Synonyms: D8Wsu108e, D8Ertd698e, Kars, LysRS
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 85305
HGNC: HGNC:6215
Homologene: 4053
Gprin3
Name: GPRIN family member 3
Synonyms: C030038J10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243385
Homologene: 52334
Ppp1r7
Name: protein phosphatase 1, regulatory subunit 7
Synonyms: SDS22, 2310014J01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 66385
HGNC: HGNC:9295
Homologene: 2032
Golga3
Name: golgin A3
Synonyms: Mea2, 5430416E01Rik, repro27, Mea-2, G1-499-14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269682
HGNC: HGNC:4426
Homologene: 4308
Gmeb1
Name: glucocorticoid modulatory element binding protein 1
Synonyms: 1110050A04Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56809
HGNC: HGNC:4370
Homologene: 10647
Vps13d
Name: vacuolar protein sorting 13D
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230895
Homologene: 15583
Zfp960
Name: zinc finger protein 960
Synonyms: BC018101
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 449000
Homologene: 133884
Amtn
Name: amelotin
Synonyms: 5430427O21Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71421
Homologene: 52640
Fbxw4
Name: F-box and WD-40 domain protein 4
Synonyms: Fbw4, dactylyn, dactylin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 30838
Homologene: 32197
Zfp142
Name: zinc finger protein 142
Synonyms: 9330177B18Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77264
Homologene: 3723
Plxna2
Name: plexin A2
Synonyms: 2810428A13Rik, PlexA2, OCT, Plxn2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18845
HGNC: HGNC:9100
Homologene: 56427
Dnajc13
Name: DnaJ heat shock protein family (Hsp40) member C13
Synonyms: LOC382100, D030002L11Rik, Rme8
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235567
Homologene: 13574
Ccdc181
Name: coiled-coil domain containing 181
Synonyms: 4930455F23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74895
Homologene: 10912
Hydin
Name: HYDIN, axonemal central pair apparatus protein
Synonyms: 4930545D19Rik, 1700034M11Rik, hy3, hyrh, hy-3
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244653
Homologene: 52118
Agpat3
Name: 1-acylglycerol-3-phosphate O-acyltransferase 3
Synonyms: LPAAT3, D10Jhu12e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 28169
HGNC: HGNC:326
Homologene: 10591
Dnah2
Name: dynein, axonemal, heavy chain 2
Synonyms: 2900022L05Rik, Dnhd3, Dnahc2, D330014H01Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327954
HGNC: HGNC:2948
Homologene: 72110
Myo3a
Name: myosin IIIA
Synonyms: 9030416P08Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 667663
HGNC: HGNC:7601
Homologene: 49486
Serpinb6e
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6e
Synonyms: Gm11396, ovalbumin, SPI3B
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 435350
HGNC: HGNC:8950
Homologene: 50933
Impg2
Name: interphotoreceptor matrix proteoglycan 2
Synonyms: IPM200, PG10.2, Spacrcan
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224224
Homologene: 9439
Ctrb1
Name: chymotrypsinogen B1
Synonyms: 2200008D09Rik, Prt-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66473
Homologene: 88564
Nsun4
Name: NOL1/NOP2/Sun domain family, member 4
Synonyms: 2810405F18Rik, 2310010O12Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72181
Homologene: 12455
Top2b
Name: topoisomerase (DNA) II beta
Synonyms: D230016L12Rik, Top-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21974
Homologene: 134711
Foxh1
Name: forkhead box H1
Synonyms: Fast2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14106
VEGA: 15
HGNC: HGNC:3814
Homologene: 2914
Bphl
Name: biphenyl hydrolase like
Synonyms: 2010012D11Rik, 5730533B08Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 68021
VEGA: 13
HGNC: HGNC:1094
Homologene: 55812
Hpse2
Name: heparanase 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 545291
VEGA: 19
Homologene: 19680
Xkr6
Name: X-linked Kx blood group related 6
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219149
Homologene: 18287
Klhdc7a
Name: kelch domain containing 7A
Synonyms: B230308G19Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242721
Homologene: 17567
Rnf43
Name: ring finger protein 43
Synonyms: 4732452J19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 207742
Homologene: 37742
Vmn2r60
Name: vomeronasal 2, receptor 60
Synonyms: Gprc2a-rs3, Casr-rs3, EG637898
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637898
Homologene: 129683
Vmn1r172
Name: vomeronasal 1 receptor 172
Synonyms: V1rd9, V3R9
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 81010
Homologene: 79577
Slfn3
Name: schlafen 3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20557
Homologene: 133236
Adam3
Name: ADAM metallopeptidase domain 3
Synonyms: Cyrn1, tMDC, Taz83, ADAM3, Taz83
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11497
HGNC: HGNC:209
Homologene: 69052
Rab24
Name: RAB24, member RAS oncogene family
Synonyms: 6530406O07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 19336
VEGA: 13
HGNC: HGNC:9765
Homologene: 40641
Or56a3b
Name: olfactory receptor family 56 subfamily A member 3B
Synonyms: Olfr681, MOR40-14, GA_x6K02T2PBJ9-7750163-7751110
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 404318
Homologene: 81538
Mlc1
Name: megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)
Synonyms: Kiaa0027-hp, WKL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170790
Homologene: 15775
Cd55b
Name: CD55 molecule, decay accelerating factor for complement B
Synonyms: Daf-TM, TM-DAF, complement-transmembrane, Daf2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13137
HGNC: HGNC:2665
Homologene: 479
Ifi204
Name: interferon activated gene 204
Synonyms: p204
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15951
Homologene: 115929
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: Acas2, AceCS1, ACAS, Acas1, Acs1, acetyl-CoA synthetase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60525
Homologene: 6469
Or4k1
Name: olfactory receptor family 4 subfamily K member 1
Synonyms: Olfr728, MOR246-1P, GA_x6K02T2PMLR-5831021-5830086
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258039
Homologene: 74224
Krtap5-3
Name: keratin associated protein 5-3
Synonyms: A030007E19Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77215
Trav15-2-dv6-2
Name: T cell receptor alpha variable 15-2-DV6-2
Synonyms: Trav15-2/dv6-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 436545
Eppk1
Name: epiplakin 1
Synonyms: EPPK, EPIPL1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223650
VEGA: 15
Homologene: 20006
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to G, chromosome 1 at 11,204,092 bp
  • T to A, chromosome 1 at 34,294,522 bp
  • T to C, chromosome 1 at 74,570,902 bp
  • C to T, chromosome 1 at 93,354,401 bp
  • T to C, chromosome 1 at 130,419,736 bp
  • A to C, chromosome 1 at 164,279,958 bp
  • T to C, chromosome 1 at 173,751,840 bp
  • A to G, chromosome 1 at 194,812,156 bp
  • A to T, chromosome 2 at 22,266,114 bp
  • A to C, chromosome 2 at 155,557,146 bp
  • T to A, chromosome 2 at 156,303,008 bp
  • G to T, chromosome 4 at 116,034,194 bp
  • G to A, chromosome 4 at 123,432,059 bp
  • G to A, chromosome 4 at 132,232,050 bp
  • A to T, chromosome 4 at 139,967,517 bp
  • T to C, chromosome 4 at 145,091,922 bp
  • C to G, chromosome 5 at 3,968,745 bp
  • C to A, chromosome 5 at 72,914,800 bp
  • C to A, chromosome 5 at 88,378,852 bp
  • T to A, chromosome 5 at 110,212,232 bp
  • T to C, chromosome 6 at 59,354,032 bp
  • G to T, chromosome 7 at 23,659,764 bp
  • A to G, chromosome 7 at 27,442,535 bp
  • AG to A, chromosome 7 at 42,195,734 bp
  • T to C, chromosome 7 at 80,300,435 bp
  • T to C, chromosome 7 at 105,121,864 bp
  • A to G, chromosome 7 at 116,394,239 bp
  • T to C, chromosome 7 at 142,201,482 bp
  • C to A, chromosome 8 at 24,677,263 bp
  • G to A, chromosome 8 at 110,380,572 bp
  • T to A, chromosome 8 at 111,687,151 bp
  • T to C, chromosome 8 at 112,011,234 bp
  • G to A, chromosome 8 at 127,603,165 bp
  • A to G, chromosome 9 at 104,178,965 bp
  • A to G, chromosome 10 at 78,287,912 bp
  • T to C, chromosome 11 at 69,500,796 bp
  • A to G, chromosome 11 at 83,214,905 bp
  • A to T, chromosome 11 at 87,732,128 bp
  • T to A, chromosome 12 at 85,475,658 bp
  • T to C, chromosome 13 at 33,832,491 bp
  • T to A, chromosome 13 at 34,060,490 bp
  • A to T, chromosome 13 at 55,321,108 bp
  • C to T, chromosome 13 at 63,511,714 bp
  • T to A, chromosome 14 at 16,395,427 bp
  • A to G, chromosome 14 at 50,139,820 bp
  • A to C, chromosome 14 at 53,649,851 bp
  • T to C, chromosome 14 at 63,494,011 bp
  • G to T, chromosome 14 at 63,819,161 bp
  • T to C, chromosome 14 at 118,529,905 bp
  • G to A, chromosome 15 at 76,120,108 bp
  • A to G, chromosome 15 at 76,669,311 bp
  • A to T, chromosome 15 at 88,974,507 bp
  • T to C, chromosome 16 at 56,260,380 bp
  • T to G, chromosome 16 at 84,978,258 bp
  • C to T, chromosome 17 at 17,087,563 bp
  • C to A, chromosome 17 at 65,813,498 bp
  • T to C, chromosome 19 at 42,813,024 bp
  • T to A, chromosome 19 at 45,503,086 bp
  • T to C, chromosome 19 at 45,660,010 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7528 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045600-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.