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Strain Name:
C57BL/6J-MtgxR7552Btlr/Mmmh
Stock Number:
045621-MU
Citation ID:
RRID:MMRRC_045621-MU
Other Names:
R7552 (G1)
Major Collection:

Strain Information

Ncor1
Name: nuclear receptor co-repressor 1
Synonyms: N-CoR, Rxrip13, A230020K14Rik, 5730405M06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20185
HGNC: HGNC:7672
Homologene: 38166
Slc12a6
Name: solute carrier family 12, member 6
Synonyms: KCC3, gaxp
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 107723
Homologene: 21069
D630045J12Rik
Name: RIKEN cDNA D630045J12 gene
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330286
Homologene: 19782
Pias3
Name: protein inhibitor of activated STAT 3
Synonyms: Pias3L
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229615
Homologene: 4447
Atp1a1
Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide
Synonyms: Atpa-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 11928
HGNC: HGNC:799
Homologene: 564
Orc1
Name: origin recognition complex, subunit 1
Synonyms: MmORC1, Orc1l
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18392
HGNC: HGNC:8487
Homologene: 31221
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 74,192,614 bp
  • T to C, chromosome 1 at 87,099,073 bp
  • G to A, chromosome 1 at 91,105,283 bp
  • A to T, chromosome 1 at 131,272,150 bp
  • A to G, chromosome 1 at 175,785,581 bp
  • A to C, chromosome 1 at 183,365,695 bp
  • T to C, chromosome 1 at 188,267,044 bp
  • A to T, chromosome 2 at 40,677,570 bp
  • A to G, chromosome 2 at 52,247,190 bp
  • A to G, chromosome 2 at 85,904,103 bp
  • A to G, chromosome 2 at 88,643,408 bp
  • G to T, chromosome 2 at 89,930,720 bp
  • A to C, chromosome 2 at 101,901,065 bp
  • A to T, chromosome 2 at 103,046,754 bp
  • A to G, chromosome 2 at 104,727,240 bp
  • A to G, chromosome 2 at 112,341,974 bp
  • A to G, chromosome 2 at 118,113,362 bp
  • A to G, chromosome 2 at 120,284,139 bp
  • G to A, chromosome 3 at 89,946,764 bp
  • ACC to AC, chromosome 3 at 96,701,385 bp
  • A to T, chromosome 3 at 101,582,121 bp
  • A to G, chromosome 4 at 108,588,754 bp
  • T to G, chromosome 4 at 132,113,781 bp
  • G to A, chromosome 5 at 94,448,535 bp
  • G to A, chromosome 5 at 96,768,438 bp
  • A to T, chromosome 5 at 109,292,908 bp
  • G to A, chromosome 5 at 129,770,736 bp
  • A to T, chromosome 5 at 150,661,821 bp
  • A to G, chromosome 6 at 38,148,448 bp
  • T to C, chromosome 6 at 41,462,573 bp
  • A to G, chromosome 6 at 83,368,307 bp
  • A to G, chromosome 6 at 124,307,228 bp
  • T to C, chromosome 6 at 132,700,542 bp
  • A to G, chromosome 7 at 15,950,506 bp
  • T to C, chromosome 7 at 20,045,766 bp
  • C to A, chromosome 7 at 44,353,028 bp
  • C to T, chromosome 7 at 51,546,780 bp
  • T to A, chromosome 7 at 79,380,113 bp
  • A to G, chromosome 7 at 81,023,642 bp
  • T to C, chromosome 7 at 107,001,327 bp
  • A to T, chromosome 7 at 144,506,245 bp
  • G to A, chromosome 8 at 24,955,972 bp
  • A to T, chromosome 8 at 39,623,962 bp
  • C to A, chromosome 8 at 43,569,970 bp
  • A to G, chromosome 8 at 47,203,119 bp
  • A to G, chromosome 8 at 57,322,237 bp
  • T to C, chromosome 8 at 75,121,592 bp
  • A to T, chromosome 8 at 83,239,931 bp
  • A to G, chromosome 9 at 73,034,488 bp
  • T to A, chromosome 9 at 89,601,835 bp
  • A to G, chromosome 9 at 110,653,917 bp
  • G to A, chromosome 10 at 4,856,903 bp
  • A to T, chromosome 10 at 75,773,214 bp
  • A to G, chromosome 10 at 80,583,903 bp
  • T to A, chromosome 10 at 129,526,560 bp
  • T to C, chromosome 11 at 21,298,831 bp
  • T to C, chromosome 11 at 62,373,424 bp
  • T to A, chromosome 11 at 82,788,891 bp
  • G to A, chromosome 11 at 106,071,948 bp
  • T to C, chromosome 11 at 106,187,004 bp
  • T to A, chromosome 11 at 106,349,169 bp
  • A to T, chromosome 11 at 113,873,213 bp
  • T to C, chromosome 11 at 116,456,254 bp
  • A to T, chromosome 11 at 119,346,552 bp
  • G to A, chromosome 12 at 79,290,957 bp
  • A to T, chromosome 13 at 14,316,250 bp
  • A to T, chromosome 13 at 24,456,955 bp
  • T to C, chromosome 13 at 62,492,891 bp
  • A to G, chromosome 13 at 65,036,123 bp
  • C to T, chromosome 13 at 73,494,895 bp
  • C to T, chromosome 13 at 93,069,312 bp
  • A to T, chromosome 13 at 119,440,820 bp
  • G to A, chromosome 14 at 20,142,281 bp
  • T to C, chromosome 14 at 27,498,863 bp
  • A to T, chromosome 14 at 51,410,858 bp
  • G to A, chromosome 14 at 55,773,465 bp
  • G to A, chromosome 14 at 66,356,278 bp
  • A to G, chromosome 15 at 57,940,740 bp
  • T to C, chromosome 15 at 81,903,941 bp
  • T to A, chromosome 16 at 11,420,785 bp
  • T to C, chromosome 16 at 17,291,216 bp
  • C to A, chromosome 17 at 21,261,451 bp
  • T to C, chromosome 17 at 25,033,115 bp
  • A to T, chromosome 17 at 27,193,836 bp
  • A to G, chromosome 17 at 33,018,651 bp
  • T to C, chromosome 17 at 67,737,667 bp
  • A to T, chromosome 17 at 86,829,043 bp
  • T to A, chromosome 19 at 9,006,824 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7552 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045621-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.