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Strain Name:
C57BL/6J-MtgxR7567Btlr/Mmmh
Stock Number:
045629-MU
Citation ID:
RRID:MMRRC_045629-MU
Other Names:
R7567 (G1)
Major Collection:

Strain Information

Kif5a
Name: kinesin family member 5A
Synonyms: Kns, Kif5, D10Bwg0738e, Khc
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Ankrd13a
Name: ankyrin repeat domain 13a
Synonyms: 1100001D10Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68420
Homologene: 23814
Atp2a2
Name: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms: sarco/endoplasmic reticulum Ca2+-ATPase 2, SERCA2, 9530097L16Rik, D5Wsu150e, SERCA2B, Serca2a
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11938
HGNC: HGNC:812
Homologene: 80167
Epc1
Name: enhancer of polycomb homolog 1
Synonyms: A930032N02Rik, 5730566F07Rik, 2400007E14Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13831
Homologene: 32627
Nf1
Name: neurofibromin 1
Synonyms: neurofibromin, Nf-1, Dsk9, Mhdadsk9
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18015
HGNC: HGNC:7765
Homologene: 226
Wdr48
Name: WD repeat domain 48
Synonyms: 8430408H12Rik, Uaf1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67561
VEGA: 9
Homologene: 10830
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 22,468,210 bp
  • A to T, chromosome 1 at 33,734,731 bp
  • T to A, chromosome 1 at 98,497,527 bp
  • T to C, chromosome 1 at 150,102,697 bp
  • T to C, chromosome 1 at 155,146,728 bp
  • A to C, chromosome 1 at 173,901,835 bp
  • A to T, chromosome 2 at 14,325,293 bp
  • A to T, chromosome 2 at 67,515,982 bp
  • A to G, chromosome 2 at 101,643,661 bp
  • A to G, chromosome 2 at 118,450,314 bp
  • A to T, chromosome 2 at 120,456,101 bp
  • C to T, chromosome 2 at 165,004,251 bp
  • T to A, chromosome 3 at 38,889,336 bp
  • G to T, chromosome 3 at 87,095,681 bp
  • G to T, chromosome 3 at 90,242,422 bp
  • T to A, chromosome 4 at 46,397,034 bp
  • T to A, chromosome 4 at 46,546,674 bp
  • T to C, chromosome 4 at 48,468,787 bp
  • T to C, chromosome 4 at 101,837,134 bp
  • A to G, chromosome 5 at 24,126,846 bp
  • T to C, chromosome 5 at 33,846,226 bp
  • T to A, chromosome 5 at 76,537,715 bp
  • G to A, chromosome 5 at 93,270,872 bp
  • C to T, chromosome 5 at 113,065,893 bp
  • T to A, chromosome 5 at 114,789,484 bp
  • A to T, chromosome 5 at 122,491,784 bp
  • A to T, chromosome 5 at 140,686,075 bp
  • A to G, chromosome 5 at 143,949,426 bp
  • A to T, chromosome 6 at 22,959,780 bp
  • A to C, chromosome 6 at 30,573,890 bp
  • A to T, chromosome 6 at 39,522,809 bp
  • C to A, chromosome 6 at 41,033,193 bp
  • C to T, chromosome 6 at 111,358,761 bp
  • A to T, chromosome 6 at 112,472,467 bp
  • T to C, chromosome 6 at 136,854,430 bp
  • A to T, chromosome 7 at 16,994,762 bp
  • A to G, chromosome 7 at 25,527,908 bp
  • A to G, chromosome 7 at 25,914,779 bp
  • A to G, chromosome 7 at 27,489,902 bp
  • G to T, chromosome 7 at 85,565,035 bp
  • T to C, chromosome 7 at 100,430,815 bp
  • G to T, chromosome 7 at 127,299,788 bp
  • G to A, chromosome 7 at 131,061,363 bp
  • T to C, chromosome 8 at 4,255,314 bp
  • T to C, chromosome 8 at 14,895,057 bp
  • T to A, chromosome 8 at 36,102,606 bp
  • T to A, chromosome 8 at 65,001,525 bp
  • T to C, chromosome 8 at 95,068,056 bp
  • A to G, chromosome 8 at 104,741,298 bp
  • T to C, chromosome 8 at 105,347,837 bp
  • G to A, chromosome 9 at 38,499,073 bp
  • T to C, chromosome 9 at 39,461,877 bp
  • A to T, chromosome 9 at 119,916,828 bp
  • T to C, chromosome 10 at 61,626,309 bp
  • T to A, chromosome 10 at 79,017,545 bp
  • T to A, chromosome 10 at 79,787,400 bp
  • T to C, chromosome 10 at 80,576,788 bp
  • T to C, chromosome 10 at 81,346,659 bp
  • T to C, chromosome 10 at 107,123,313 bp
  • C to T, chromosome 10 at 127,237,379 bp
  • T to A, chromosome 10 at 128,255,053 bp
  • A to G, chromosome 11 at 58,455,166 bp
  • A to T, chromosome 11 at 79,547,226 bp
  • T to C, chromosome 11 at 95,574,321 bp
  • C to T, chromosome 11 at 97,534,725 bp
  • A to G, chromosome 11 at 117,864,141 bp
  • A to G, chromosome 12 at 35,086,914 bp
  • A to T, chromosome 12 at 35,995,947 bp
  • G to A, chromosome 12 at 80,581,310 bp
  • A to G, chromosome 12 at 100,878,364 bp
  • A to T, chromosome 12 at 116,254,510 bp
  • T to G, chromosome 13 at 49,193,880 bp
  • A to G, chromosome 13 at 81,433,529 bp
  • T to C, chromosome 13 at 81,579,477 bp
  • A to G, chromosome 14 at 20,719,933 bp
  • T to C, chromosome 14 at 104,479,378 bp
  • G to A, chromosome 15 at 84,406,713 bp
  • G to T, chromosome 15 at 85,143,247 bp
  • T to A, chromosome 16 at 17,836,788 bp
  • A to T, chromosome 16 at 20,405,510 bp
  • G to A, chromosome 16 at 43,822,684 bp
  • A to T, chromosome 17 at 9,008,006 bp
  • A to G, chromosome 17 at 13,888,808 bp
  • T to A, chromosome 17 at 37,337,171 bp
  • T to A, chromosome 17 at 42,667,442 bp
  • T to A, chromosome 17 at 46,654,595 bp
  • A to C, chromosome 18 at 6,450,084 bp
  • A to C, chromosome 18 at 10,090,820 bp
  • A to G, chromosome 18 at 12,689,879 bp
  • T to C, chromosome 19 at 3,272,981 bp
  • A to G, chromosome 19 at 3,392,218 bp
  • T to C, chromosome 19 at 5,551,586 bp
  • A to T, chromosome 19 at 55,081,630 bp
  • T to C, chromosome 19 at 57,699,523 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7567 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045629-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.