Loading Mouse GIF
Loading...

Strain Name:
C57BL/6J-MtgxR7594Btlr/Mmmh
Stock Number:
045670-MU
Citation ID:
RRID:MMRRC_045670-MU
Other Names:
R7594 (G1)
Major Collection:

Strain Information

Nfatc2
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2
Synonyms: NFAT1, NFATp, NFAT1-D
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18019
HGNC: HGNC:7776
Homologene: 7861
Tnrc6b
Name: trinucleotide repeat containing 6b
Synonyms: A730065C02Rik, D230019K20Rik, 2700090M07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 213988
VEGA: 15
Homologene: 66194
App
Name: amyloid beta precursor protein
Synonyms: betaAPP, Abeta, protease nexin II, Adap, Cvap, appican, E030013M08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 11820
VEGA: 16
HGNC: HGNC:620
Homologene: 56379
Ppp1r14c
Name: protein phosphatase 1, regulatory inhibitor subunit 14C
Synonyms: 6330514J04Rik, KEPI
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76142
VEGA: 10
Homologene: 12805
Acvr2a
Name: activin receptor IIA
Synonyms: ActRIIa, tActRII, Acvr2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11480
HGNC: HGNC:173
Homologene: 20391
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21899
Homologene: 21223
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 34,213,013 bp
  • G to A, chromosome 1 at 85,579,092 bp
  • T to C, chromosome 2 at 28,506,360 bp
  • G to T, chromosome 2 at 34,860,729 bp
  • T to A, chromosome 2 at 48,894,737 bp
  • T to C, chromosome 2 at 76,726,842 bp
  • G to A, chromosome 2 at 76,751,354 bp
  • A to G, chromosome 2 at 87,388,269 bp
  • T to A, chromosome 2 at 89,752,562 bp
  • A to G, chromosome 2 at 168,523,348 bp
  • C to T, chromosome 2 at 172,429,648 bp
  • A to G, chromosome 2 at 178,034,000 bp
  • A to G, chromosome 2 at 180,675,112 bp
  • C to G, chromosome 4 at 20,049,833 bp
  • G to T, chromosome 4 at 32,696,359 bp
  • T to C, chromosome 4 at 128,617,680 bp
  • T to C, chromosome 4 at 132,694,825 bp
  • T to C, chromosome 4 at 138,277,925 bp
  • A to T, chromosome 4 at 143,812,716 bp
  • C to T, chromosome 4 at 155,007,027 bp
  • A to G, chromosome 5 at 38,351,291 bp
  • T to C, chromosome 5 at 64,953,251 bp
  • T to C, chromosome 5 at 67,651,592 bp
  • C to A, chromosome 5 at 117,555,066 bp
  • A to G, chromosome 5 at 120,556,530 bp
  • T to C, chromosome 5 at 144,173,746 bp
  • G to T, chromosome 5 at 148,077,406 bp
  • A to G, chromosome 6 at 83,306,683 bp
  • T to A, chromosome 7 at 10,447,415 bp
  • A to G, chromosome 7 at 16,076,386 bp
  • T to C, chromosome 7 at 28,131,460 bp
  • A to T, chromosome 7 at 56,982,695 bp
  • T to C, chromosome 7 at 104,059,263 bp
  • A to G, chromosome 7 at 105,157,673 bp
  • A to G, chromosome 7 at 119,784,990 bp
  • A to T, chromosome 7 at 143,693,797 bp
  • G to A, chromosome 8 at 83,609,844 bp
  • T to C, chromosome 8 at 84,675,002 bp
  • T to A, chromosome 8 at 121,552,368 bp
  • T to C, chromosome 9 at 18,645,062 bp
  • T to C, chromosome 10 at 3,366,670 bp
  • A to G, chromosome 10 at 5,215,190 bp
  • C to A, chromosome 10 at 7,862,618 bp
  • A to G, chromosome 11 at 4,111,213 bp
  • A to G, chromosome 11 at 6,602,457 bp
  • G to A, chromosome 11 at 57,810,121 bp
  • T to C, chromosome 11 at 98,715,097 bp
  • G to A, chromosome 11 at 98,821,485 bp
  • G to T, chromosome 11 at 121,161,365 bp
  • C to T, chromosome 12 at 79,076,503 bp
  • A to T, chromosome 12 at 81,474,578 bp
  • A to G, chromosome 13 at 14,637,246 bp
  • C to A, chromosome 13 at 99,320,282 bp
  • A to G, chromosome 14 at 16,428,587 bp
  • T to A, chromosome 14 at 19,768,723 bp
  • A to T, chromosome 14 at 70,141,794 bp
  • T to A, chromosome 15 at 66,729,583 bp
  • T to A, chromosome 15 at 80,880,307 bp
  • T to C, chromosome 15 at 96,390,994 bp
  • T to C, chromosome 16 at 85,080,002 bp
  • T to C, chromosome 17 at 20,360,373 bp
  • A to G, chromosome 17 at 30,954,805 bp
  • A to G, chromosome 17 at 80,370,305 bp
  • A to T, chromosome 19 at 37,174,151 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7594 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045670-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.