Strain Name:
C57BL/6J-MtgxR7610Btlr/Mmmh
Stock Number:
045679-MU
Citation ID:
RRID:MMRRC_045679-MU
Other Names:
R7610 (G1)
Major Collection:

Strain Information

Epha7
Name: Eph receptor A7
Synonyms: Ebk, Mdk1, Hek11, Ehk3, Cek11, MDK1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13841
HGNC: HGNC:3390
Homologene: 20935
Mtarc2
Name: mitochondrial amidoxime reducing component 2
Synonyms: 2810484M10Rik, Marc2, Mosc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67247
Homologene: 9904
Ggta1
Name: glycoprotein galactosyltransferase alpha 1, 3
Synonyms: alpha Gal, alpha3GalT, Ggta, glycoprotein alpha galactosyl transferase 1, Gal, GALT, Ggta-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14594
HGNC: HGNC:4253
Homologene: 7730
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: 4933425K22Rik, Gtar, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Ttc3
Name: tetratricopeptide repeat domain 3
Synonyms: TPRD, D16Ium21e, D16Ium21, 2610202A04Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22129
Homologene: 2487
Asf1b
Name: anti-silencing function 1B histone chaperone
Synonyms: 1700003K02Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66929
Homologene: 56797
Akap9
Name: A kinase anchor protein 9
Synonyms: repro12, 5730481H23Rik, G1-448-15, AKAP450, mei2-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Grb10
Name: growth factor receptor bound protein 10
Synonyms: 5730571D09Rik, Meg1, maternally expressed gene 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14783
HGNC: HGNC:4564
Homologene: 3882
Cdc37l1
Name: cell division cycle 37-like 1
Synonyms: Harc, Hsp90-associating relative of Cdc37, 2700033A15Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 67072
VEGA: 19
Homologene: 9912
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Mgrn1
Name: mahogunin, ring finger 1
Synonyms: 2610042J20Rik, nc
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17237
VEGA: 16
Homologene: 41020
Ank3
Name: ankyrin 3, epithelial
Synonyms: 2900054D09Rik, Ank-3, Ankyrin-G, AnkG, Ankyrin-3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11735
HGNC: HGNC:494
Homologene: 56908
Mcm3ap
Name: minichromosome maintenance complex component 3 associated protein
Synonyms: GANP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 54387
VEGA: 10
HGNC: HGNC:6946
Homologene: 2902
Syt17
Name: synaptotagmin XVII
Synonyms: Bk
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 110058
Homologene: 9553
Fcrl2
Name: Fc receptor like 2
Synonyms: 2810439C17Rik, IFGP2, Msr2, Fcrls, Fcrh2, moFcRH2sc
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80891
Homologene: 57117
Ntng1
Name: netrin G1
Synonyms: Lmnt1, A930010C08Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80883
Homologene: 8949
Notch1
Name: notch 1
Synonyms: Mis6, 9930111A19Rik, lin-12, N1, Motch A, Tan1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18128
HGNC: HGNC:7881
Homologene: 32049
Snrnp48
Name: small nuclear ribonucleoprotein 48 (U11/U12)
Synonyms: 1110050F08Rik, 6530403A03Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 67797
VEGA: 13
Homologene: 12191
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Cpped1
Name: calcineurin-like phosphoesterase domain containing 1
Synonyms: C530044N13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 223978
Homologene: 10142
Rtn3
Name: reticulon 3
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 20168
VEGA: 19
Homologene: 24934
Acta2
Name: actin alpha 2, smooth muscle, aorta
Synonyms: Actvs, alphaSMA, a-SMA, SMalphaA, 0610041G09Rik, SMAalpha
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 11475
VEGA: 19
HGNC: HGNC:130
Homologene: 133938
Fig4
Name: FIG4 phosphoinositide 5-phosphatase
Synonyms: A530089I17Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103199
VEGA: 10
Homologene: 6713
Pgm5
Name: phosphoglucomutase 5
Synonyms: 9530034F03Rik, aciculin
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226041
HGNC: HGNC:8908
Homologene: 74881
Adtrp
Name: androgen dependent TFPI regulating protein
Synonyms: 9530008L14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109254
Homologene: 13107
Zscan18
Name: zinc finger and SCAN domain containing 18
Synonyms: EG232875
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232875
Homologene: 122136
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: mXin beta, myomaxin, 2310003D02Rik, Cmya3, 2310008C07Rik, A530024P18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
D130043K22Rik
Name: RIKEN cDNA D130043K22 gene
Synonyms: Kiaa0319
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 210108
Homologene: 8878
Plcb2
Name: phospholipase C, beta 2
Synonyms: B230205M18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18796
HGNC: HGNC:9055
Homologene: 20957
Rab11fip1
Name: RAB11 family interacting protein 1 (class I)
Synonyms: 2010200K21Rik, 4833414G05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 75767
Homologene: 11853
Rhpn1
Name: rhophilin, Rho GTPase binding protein 1
Synonyms: Grbp, Rhophilin
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14787
Homologene: 7346
Smc1b
Name: structural maintenance of chromosomes 1B
Synonyms: SMC1beta, Smc1l2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140557
VEGA: 15
Homologene: 13786
Frmpd1
Name: FERM and PDZ domain containing 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666060
Homologene: 8939
Tpsg1
Name: tryptase gamma 1
Synonyms: TMT, Prss31
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26945
Homologene: 74994
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Or8i2
Name: olfactory receptor family 8 subfamily I member 2
Synonyms: Olfr1104, MOR207-1, GA_x6K02T2Q125-48508763-48507833
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258763
Homologene: 64916
Rgl1
Name: ral guanine nucleotide dissociation stimulator,-like 1
Synonyms: Rgl
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19731
Homologene: 9039
Alg11
Name: ALG11 alpha-1,2-mannosyltransferase
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 207958
Homologene: 68893
Ctsk
Name: cathepsin K
Synonyms: catK, Cat K
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 13038
HGNC: HGNC:2536
Homologene: 68053
Pramel26
Name: PRAME like 26
Synonyms: Gm13084
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381569
Homologene: 77858
Rgs6
Name: regulator of G-protein signaling 6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 50779
Homologene: 68385
Hivep3
Name: human immunodeficiency virus type I enhancer binding protein 3
Synonyms: Schnurri-3, E030045D18Rik, 2900056N03Rik, Shn3, Krc
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16656
Homologene: 7803
Fam228a
Name: family with sequence similarity 228, member A
Synonyms: 4930417G10Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74855
VEGA: 12
Homologene: 54902
Or13a21
Name: olfactory receptor family 13 subfamily A member 21
Synonyms: MOR251-1, GA_x6K02T2PBJ9-42570051-42569122, Olfr532
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259028
Homologene: 133605
Slfn5
Name: schlafen 5
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 327978
Homologene: 18839
Nt5el
Name: 5' nucleotidase, ecto-like
Synonyms: 4933425L06Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 66763
Homologene: 12028
Ddx25
Name: DEAD box helicase 25
Synonyms: GRTH, DEAD (Asp-Glu-Ala-Asp) box polypeptide 25
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 30959
Homologene: 8310
Rwdd1
Name: RWD domain containing 1
Synonyms: 2610002D06Rik, 2700069A07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66521
Homologene: 41082
Dhrs9
Name: dehydrogenase/reductase 9
Synonyms: C730025I08Rik, Rdh15, dehydrogenase/reductase (SDR family) member 9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241452
Homologene: 26079
Wdr54
Name: WD repeat domain 54
Synonyms: 1700030E05Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 75659
Homologene: 11382
Klf14
Name: Kruppel-like transcription factor 14
Synonyms: BTEB5, 5330411L03Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 619665
Homologene: 76469
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 152,552,620 bp
  • A to G, chromosome 1 at 184,819,286 bp
  • A to T, chromosome 2 at 26,478,179 bp
  • C to T, chromosome 2 at 35,414,218 bp
  • C to T, chromosome 2 at 67,525,962 bp
  • C to A, chromosome 2 at 69,392,947 bp
  • A to G, chromosome 2 at 87,021,797 bp
  • T to A, chromosome 2 at 118,719,759 bp
  • C to A, chromosome 3 at 87,252,697 bp
  • T to C, chromosome 3 at 95,500,844 bp
  • A to G, chromosome 3 at 109,934,825 bp
  • C to T, chromosome 4 at 28,871,937 bp
  • T to C, chromosome 4 at 45,279,098 bp
  • CGG to CG, chromosome 4 at 120,097,911 bp
  • A to T, chromosome 4 at 143,812,866 bp
  • T to G, chromosome 5 at 3,957,677 bp
  • A to G, chromosome 5 at 90,232,363 bp
  • A to G, chromosome 6 at 3,376,754 bp
  • A to G, chromosome 6 at 30,958,070 bp
  • C to T, chromosome 6 at 83,152,858 bp
  • T to C, chromosome 7 at 12,769,310 bp
  • A to T, chromosome 7 at 118,434,459 bp
  • A to T, chromosome 7 at 140,419,553 bp
  • G to A, chromosome 8 at 22,065,131 bp
  • G to A, chromosome 8 at 27,152,036 bp
  • T to G, chromosome 8 at 83,965,049 bp
  • T to A, chromosome 9 at 35,554,597 bp
  • A to C, chromosome 10 at 34,001,138 bp
  • C to A, chromosome 10 at 41,253,713 bp
  • A to T, chromosome 10 at 69,986,422 bp
  • A to G, chromosome 10 at 76,496,720 bp
  • T to C, chromosome 11 at 11,943,955 bp
  • T to C, chromosome 11 at 82,961,484 bp
  • A to G, chromosome 12 at 4,731,423 bp
  • T to C, chromosome 12 at 65,105,680 bp
  • T to C, chromosome 12 at 83,091,779 bp
  • A to T, chromosome 13 at 24,876,002 bp
  • A to G, chromosome 13 at 38,209,961 bp
  • A to G, chromosome 13 at 41,816,194 bp
  • T to A, chromosome 13 at 105,111,187 bp
  • A to G, chromosome 15 at 75,712,396 bp
  • T to C, chromosome 15 at 85,070,820 bp
  • T to C, chromosome 16 at 4,934,233 bp
  • C to A, chromosome 16 at 11,894,878 bp
  • CACTTAC to CAC, chromosome 16 at 90,772,573 bp
  • T to C, chromosome 16 at 94,427,838 bp
  • G to T, chromosome 17 at 25,373,210 bp
  • A to G, chromosome 19 at 7,457,929 bp
  • A to C, chromosome 19 at 24,834,756 bp
  • G to T, chromosome 19 at 29,007,732 bp
  • G to A, chromosome 19 at 34,252,531 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7610 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045679-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.