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Strain Name:
C57BL/6J-MtgxR7612Btlr/Mmmh
Stock Number:
045680-MU
Citation ID:
RRID:MMRRC_045680-MU
Other Names:
R7612 (G1)
Major Collection:

Strain Information

Spry4
Name: sprouty RTK signaling antagonist 4
Synonyms: sprouty4, A030006O18Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 24066
VEGA: 18
Homologene: 8042
Kdm5b
Name: lysine demethylase 5B
Synonyms: PLU-1, 2010009J12Rik, Plu1, Rb-Bp2, 2210016I17Rik, D1Ertd202e, Jarid1b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75605
Homologene: 48448
Depdc7
Name: DEP domain containing 7
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 211896
Homologene: 16386
Hcrtr1
Name: hypocretin (orexin) receptor 1
Synonyms: OX1R
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230777
HGNC: HGNC:4848
Homologene: 37492
Rexo1
Name: REX1, RNA exonuclease 1
Synonyms: 1700021P10Rik, 2610511M11Rik, Tceb3bp1, Rex1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 66932
Homologene: 41391
Urb1
Name: URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
Synonyms: 5730405K23Rik, 4921511H13Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207932
Homologene: 45941
Csad
Name: cysteine sulfinic acid decarboxylase
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 246277
VEGA: 15
Homologene: 41086
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 36,163,235 bp
  • T to C, chromosome 1 at 134,542,007 bp
  • C to T, chromosome 1 at 134,624,918 bp
  • T to A, chromosome 1 at 166,307,792 bp
  • T to G, chromosome 2 at 88,958,505 bp
  • T to A, chromosome 2 at 104,730,508 bp
  • T to A, chromosome 2 at 151,039,238 bp
  • T to C, chromosome 2 at 165,687,737 bp
  • A to T, chromosome 3 at 36,025,357 bp
  • A to G, chromosome 3 at 152,218,015 bp
  • T to C, chromosome 4 at 76,086,459 bp
  • T to A, chromosome 4 at 101,597,926 bp
  • T to A, chromosome 4 at 102,869,808 bp
  • A to G, chromosome 4 at 128,896,884 bp
  • A to T, chromosome 4 at 129,293,582 bp
  • A to G, chromosome 4 at 130,135,685 bp
  • T to A, chromosome 5 at 112,865,302 bp
  • T to C, chromosome 5 at 145,237,189 bp
  • T to A, chromosome 5 at 150,540,611 bp
  • C to T, chromosome 7 at 13,007,399 bp
  • T to A, chromosome 7 at 17,759,416 bp
  • T to A, chromosome 7 at 102,559,535 bp
  • A to T, chromosome 7 at 120,752,615 bp
  • G to T, chromosome 7 at 126,414,324 bp
  • T to A, chromosome 7 at 140,001,051 bp
  • A to T, chromosome 8 at 94,557,420 bp
  • A to G, chromosome 8 at 122,584,954 bp
  • A to G, chromosome 9 at 13,706,485 bp
  • T to A, chromosome 9 at 106,474,194 bp
  • G to C, chromosome 10 at 80,549,663 bp
  • A to G, chromosome 10 at 117,740,880 bp
  • A to T, chromosome 11 at 16,859,025 bp
  • A to G, chromosome 11 at 83,070,263 bp
  • T to A, chromosome 11 at 105,108,821 bp
  • T to C, chromosome 11 at 119,333,579 bp
  • G to T, chromosome 13 at 21,116,047 bp
  • A to G, chromosome 14 at 44,858,637 bp
  • T to G, chromosome 15 at 75,864,954 bp
  • C to T, chromosome 15 at 76,597,009 bp
  • G to A, chromosome 15 at 102,188,922 bp
  • G to A, chromosome 16 at 34,314,212 bp
  • A to T, chromosome 16 at 59,303,627 bp
  • A to G, chromosome 16 at 65,529,925 bp
  • A to T, chromosome 16 at 88,773,608 bp
  • A to G, chromosome 16 at 90,797,910 bp
  • T to G, chromosome 17 at 42,714,380 bp
  • C to A, chromosome 18 at 20,470,990 bp
  • C to A, chromosome 18 at 38,589,929 bp
  • T to C, chromosome 18 at 63,042,539 bp
  • T to C, chromosome 18 at 77,429,975 bp
  • A to G, chromosome 19 at 6,070,608 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7612 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045680-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.