Strain Name:
C57BL/6J-MtgxR7619Btlr/Mmmh
Stock Number:
045686-MU
Citation ID:
RRID:MMRRC_045686-MU
Other Names:
R7619 (G1)
Major Collection:

Strain Information

Dnm2
Name: dynamin 2
Synonyms: Dyn2, b2b2159Clo
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13430
HGNC: HGNC:2974
Homologene: 90883
Marchf4
Name: membrane associated ring-CH-type finger 4
Synonyms: March4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381270
Homologene: 66199
Dst
Name: dystonin
Synonyms: Macf2, A830042E19Rik, Bpag1, Bpag, bullous pemphigoid antigen 1, nmf203, athetoid, nmf339, BPAG1, BPAG1-n, 2310001O04Rik, bullous pemphigoid antigen 1, ah
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Zfp930
Name: zinc finger protein 930
Synonyms: zinc finger protein, D10627
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234358
Sdf2
Name: stromal cell derived factor 2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20316
Homologene: 5045
Thoc7
Name: THO complex 7
Synonyms: 1500006O09Rik, 9230101K24Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66231
VEGA: 14
Homologene: 11821
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: flat, RAPT1, 2610315D21Rik, RAFT1, Frap1, mechanistic target of rapamycin (serine/threonine kinase), FKBP-rapamycin-associated protein FRAP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Fbxo42
Name: F-box protein 42
Synonyms: 6720460I06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 213499
Homologene: 16234
Mki67
Name: antigen identified by monoclonal antibody Ki 67
Synonyms: Ki67, Ki-67, D630048A14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17345
HGNC: HGNC:7107
Homologene: 1814
Cttnbp2nl
Name: CTTNBP2 N-terminal like
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80281
Homologene: 36371
Ep300
Name: E1A binding protein p300
Synonyms: KAT3B, p300
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Ubfd1
Name: ubiquitin family domain containing 1
Synonyms: D7Wsu105e, D7Wsu128e
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 28018
Homologene: 10430
Zfp691
Name: zinc finger protein 691
Synonyms: 6430544H17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 195522
Homologene: 9300
Ric1
Name: RAB6A GEF complex partner 1
Synonyms: C030046E11Rik, C130057E09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226089
Homologene: 13806
Syn3
Name: synapsin III
Synonyms: Synapsin IIIa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27204
Homologene: 68320
Wdr25
Name: WD repeat domain 25
Synonyms: B930090D16Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 212198
VEGA: 12
Homologene: 56993
Nbeal2
Name: neurobeachin-like 2
Synonyms: 1110014F23Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235627
Homologene: 86422
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: M6P/IGF2R, mannose-6-phosphate receptor, cation independent, CD222, CI-MPR, Mpr300, IGF-II/CI-MPR
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Arpc1a
Name: actin related protein 2/3 complex, subunit 1A
Synonyms: Sid32, 0610010H08Rik, 1110030K07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56443
HGNC: HGNC:703
Homologene: 4675
Dnhd1
Name: dynein heavy chain domain 1
Synonyms: 8030491N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 77505
Homologene: 131117
Zfp560
Name: zinc finger protein 560
Synonyms: 2310030G09Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 434377
Homologene: 103820
Myef2
Name: myelin basic protein expression factor 2, repressor
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17876
Homologene: 69079
Neb
Name: nebulin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17996
HGNC: HGNC:7720
Homologene: 136285
Fbn2
Name: fibrillin 2
Synonyms: Fib-2, sy, Sne
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 14119
VEGA: 18
HGNC: HGNC:3604
Homologene: 1515
Scn2a
Name: sodium channel, voltage-gated, type II, alpha
Synonyms: Scn2a1, A230052E19Rik, Nav1.2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 110876
Homologene: 75001
Abcc12
Name: ATP-binding cassette, sub-family C member 12
Synonyms: 4930467B22Rik, MRP9
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244562
Homologene: 57211
Gm10800
Name: predicted gene 10800
Type: Gene
Species: Mouse
Chromosome: 2
Skint5
Name: selection and upkeep of intraepithelial T cells 5
Synonyms: OTTMUSG00000008560
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242627
Homologene: 135888
Anxa3
Name: annexin A3
Synonyms: Anx3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11745
HGNC: HGNC:541
Homologene: 68445
Tcp11l2
Name: t-complex 11 (mouse) like 2
Synonyms: E430026E19Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216198
Homologene: 17129
Vmn2r15
Name: vomeronasal 2, receptor 15
Synonyms: EG211223
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 211223
Homologene: 129606
Stab1
Name: stabilin 1
Synonyms: MS-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 192187
Homologene: 9035
Otol1
Name: otolin 1
Synonyms: LOC229389, Gm414
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229389
Homologene: 19018
Fam227a
Name: family with sequence similarity 227, member A
Synonyms: 4933432B09Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75729
Homologene: 123434
Vmn2r108
Name: vomeronasal 2, receptor 108
Synonyms: EG627805
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627805
Homologene: 129678
Dmc1
Name: DNA meiotic recombinase 1
Synonyms: Mei11, sgdp, Dmc1h, Dmc1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 13404
VEGA: 15
HGNC: HGNC:2927
Homologene: 5135
Grid2
Name: glutamate receptor, ionotropic, delta 2
Synonyms: B230104L07Rik, GluRdelta2, tpr
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14804
HGNC: HGNC:4576
Homologene: 74399
C5ar1
Name: complement component 5a receptor 1
Synonyms: C5r1, C5aR, Cd88, D7Msu1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12273
HGNC: HGNC:1338
Homologene: 20413
Clip1
Name: CAP-GLY domain containing linker protein 1
Synonyms: Clip 170, Clip50, CLIP-170, 4631429H07Rik, cytoplasmic linker protein 50, Rsn, restin, 1110007I12Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56430
Homologene: 74455
Abcc1
Name: ATP-binding cassette, sub-family C member 1
Synonyms: Mrp1, Abcc1a, Mdrap, MRP, Abcc1b
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 17250
HGNC: HGNC:51
Homologene: 133779
Zfp354c
Name: zinc finger protein 354C
Synonyms: 5330421P20Rik, Kid3, AJ18
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 30944
Homologene: 56606
Or52l1
Name: olfactory receptor family 52 subfamily L member 1
Synonyms: MOR37-1, GA_x6K02T2PBJ9-7810071-7809121, Olfr685
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258160
Homologene: 66455
Mettl15
Name: methyltransferase like 15
Synonyms: Mett5d1, 0610027B03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 76894
Homologene: 12661
Tvp23a
Name: trans-golgi network vesicle protein 23A
Synonyms: Fam18a
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 383103
Homologene: 19919
Napepld
Name: N-acyl phosphatidylethanolamine phospholipase D
Synonyms: NAPE-PLD
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 242864
Homologene: 7094
Zkscan14
Name: zinc finger with KRAB and SCAN domains 14
Synonyms: 2310046C23Rik, 2810437E14Rik, Zfp99
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 67235
Homologene: 11342
Rhbdl1
Name: rhomboid like 1
Synonyms: Rhbdl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 214951
Homologene: 2946
Sap30l
Name: SAP30-like
Synonyms: L55, 2310079P12Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 50724
Homologene: 11632
Vmn1r160
Name: vomeronasal 1 receptor 160
Synonyms: Gm6178
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 620758
Homologene: 104166
Ggnbp1
Name: gametogenetin binding protein 1
Synonyms: 0610031G08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 70772
Homologene: 79568
C330018D20Rik
Name: RIKEN cDNA C330018D20 gene
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 77422
Homologene: 35412
Ccl27a
Name: C-C motif chemokine ligand 27A
Synonyms: Ccl27, skinskine, ALP, CTACK, ILC, CTAK, ESkine, Scya27a, Scya27, PESKY, mILC, ESkine
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 20301
Homologene: 134761
Pcdhga9
Name: protocadherin gamma subfamily A, 9
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93717
HGNC: HGNC:8707
Homologene: 56827
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 34,199,428 bp
  • A to G, chromosome 1 at 72,534,989 bp
  • C to T, chromosome 2 at 52,296,426 bp
  • T to C, chromosome 2 at 65,715,903 bp
  • AAAGAAAACTGAA to ACAAGAAAACTGAA, chromosome 2 at 98,667,033 bp
  • T to A, chromosome 2 at 109,092,875 bp
  • C to T, chromosome 2 at 125,123,476 bp
  • A to T, chromosome 3 at 70,027,869 bp
  • A to G, chromosome 3 at 105,004,760 bp
  • G to A, chromosome 4 at 41,774,166 bp
  • T to G, chromosome 4 at 101,941,300 bp
  • T to C, chromosome 4 at 113,524,108 bp
  • C to T, chromosome 4 at 119,170,984 bp
  • T to G, chromosome 4 at 141,200,362 bp
  • T to C, chromosome 4 at 148,462,795 bp
  • A to T, chromosome 5 at 21,675,848 bp
  • T to C, chromosome 5 at 96,830,404 bp
  • A to T, chromosome 5 at 109,288,324 bp
  • T to C, chromosome 5 at 123,614,279 bp
  • C to A, chromosome 5 at 145,104,858 bp
  • A to G, chromosome 5 at 145,195,359 bp
  • T to C, chromosome 6 at 63,931,101 bp
  • A to G, chromosome 7 at 16,248,579 bp
  • A to T, chromosome 7 at 22,871,542 bp
  • A to G, chromosome 7 at 105,180,749 bp
  • A to G, chromosome 7 at 105,674,268 bp
  • G to A, chromosome 7 at 122,067,383 bp
  • A to T, chromosome 7 at 135,699,377 bp
  • T to A, chromosome 8 at 69,209,158 bp
  • A to G, chromosome 8 at 86,566,553 bp
  • G to T, chromosome 9 at 20,348,910 bp
  • A to G, chromosome 9 at 21,505,634 bp
  • T to C, chromosome 9 at 110,625,818 bp
  • T to C, chromosome 10 at 84,594,758 bp
  • A to G, chromosome 10 at 86,057,564 bp
  • C to T, chromosome 11 at 50,817,808 bp
  • G to A, chromosome 11 at 57,808,061 bp
  • G to A, chromosome 11 at 78,251,163 bp
  • G to A, chromosome 12 at 108,992,893 bp
  • T to A, chromosome 14 at 13,961,819 bp
  • A to G, chromosome 14 at 31,145,237 bp
  • A to T, chromosome 15 at 79,596,242 bp
  • T to C, chromosome 15 at 79,617,766 bp
  • T to A, chromosome 15 at 81,608,198 bp
  • C to A, chromosome 16 at 10,428,738 bp
  • C to G, chromosome 16 at 14,445,419 bp
  • A to G, chromosome 17 at 12,698,273 bp
  • T to A, chromosome 17 at 20,472,195 bp
  • T to C, chromosome 17 at 25,837,017 bp
  • T to A, chromosome 17 at 27,018,131 bp
  • A to G, chromosome 18 at 37,738,752 bp
  • A to G, chromosome 18 at 56,962,411 bp
  • G to T, chromosome 18 at 58,080,227 bp
  • A to G, chromosome 19 at 29,579,775 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7619 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045686-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.