Strain Name:
C57BL/6J-MtgxR7634Btlr/Mmmh
Stock Number:
045693-MU
Citation ID:
RRID:MMRRC_045693-MU
Other Names:
R7634 (G1)
Major Collection:

Strain Information

Cacna1h
Name: calcium channel, voltage-dependent, T type, alpha 1H subunit
Synonyms: T-type Cav3.2, alpha13.2, Cav3.2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 58226
HGNC: HGNC:1395
Homologene: 56913
Arhgdig
Name: Rho GDP dissociation inhibitor gamma
Synonyms: Gdi5, RIP2, Rho-GDI2, Rho-GDI-3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14570
HGNC: HGNC:680
Homologene: 7337
Mtor
Name: mechanistic target of rapamycin kinase
Synonyms: flat, RAPT1, 2610315D21Rik, RAFT1, Frap1, mechanistic target of rapamycin (serine/threonine kinase), FKBP-rapamycin-associated protein FRAP
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 56717
HGNC: HGNC:3942
Homologene: 3637
Nfya
Name: nuclear transcription factor-Y alpha
Synonyms: Sez10, Cbf-b
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 18044
HGNC: HGNC:7804
Homologene: 32114
Hvcn1
Name: hydrogen voltage-gated channel 1
Synonyms: 0610039P13Rik, BTS, mVSOP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74096
Homologene: 12535
Atg2b
Name: autophagy related 2B
Synonyms: C030004M05Rik, 2410024A21Rik, C630028L02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 76559
VEGA: 12
Homologene: 9974
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
Gtf3c3
Name: general transcription factor IIIC, polypeptide 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 98488
HGNC: HGNC:4666
Homologene: 40805
Robo1
Name: roundabout guidance receptor 1
Synonyms: DUTT1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19876
Homologene: 2206
Wnt2b
Name: wingless-type MMTV integration site family, member 2B
Synonyms: Wnt13
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22414
Homologene: 22526
Reg4
Name: regenerating islet-derived family, member 4
Synonyms: RELP, 2010002L15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 67709
Homologene: 41671
Adgrf3
Name: adhesion G protein-coupled receptor F3
Synonyms: PGR23, Gpr113, LOC381628
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381628
Homologene: 17826
Smap2
Name: small ArfGAP 2
Synonyms: Smap1l, 1810031K02Rik, Smap2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69780
Homologene: 41489
Tars3
Name: threonyl-tRNA synthetase 3
Synonyms: A530046H20Rik, Tarsl2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 272396
Homologene: 65036
Insm1
Name: insulinoma-associated 1
Synonyms: IA-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 53626
HGNC: HGNC:6090
Homologene: 31080
Nrbp2
Name: nuclear receptor binding protein 2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223649
VEGA: 15
Homologene: 135649
Nadk2
Name: NAD kinase 2, mitochondrial
Synonyms: 1110020G09Rik, Nadkd1, MNADK, 4933430B08Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 68646
Homologene: 14638
Ttn
Name: titin
Synonyms: shru, L56, mdm, connectin, D330041I19Rik, 2310057K23Rik, 2310074I15Rik, 2310036G12Rik, D830007G01Rik, 1100001C23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Tmprss7
Name: transmembrane serine protease 7
Synonyms: matriptase-3, B230219I23Rik, LOC385645
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 208171
Homologene: 18178
Plcz1
Name: phospholipase C, zeta 1
Synonyms: 1700041H07Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 114875
Homologene: 23815
Gm4847
Name: predicted gene 4847
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226604
Homologene: 101040
Aadat
Name: aminoadipate aminotransferase
Synonyms: Kyat2, Kat2, mKat-2, KATII
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23923
Homologene: 56540
Usp40
Name: ubiquitin specific peptidase 40
Synonyms: B230215L03Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227334
Homologene: 32400
Vinac1
Name: vinculin/alpha-catenin family member 1
Synonyms: Gm14025
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668894
Homologene: 86340
Nlrp1a
Name: NLR family, pyrin domain containing 1A
Synonyms: Nalp1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 195046
Homologene: 133820
Slc22a26
Name: solute carrier family 22 (organic cation transporter), member 26
Synonyms: BC014805
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 236149
Odad4
Name: outer dynein arm complex subunit 4
Synonyms: Ttc25, 4933404O19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74407
Homologene: 12860
Lrriq1
Name: leucine-rich repeats and IQ motif containing 1
Synonyms: Gm1557, 4930503E15Rik, LOC380658
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 74978
Homologene: 46007
Guf1
Name: GUF1 homolog, GTPase
Synonyms: mtEF4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231279
Homologene: 6505
Rint1
Name: RAD50 interactor 1
Synonyms: 2810450M21Rik, 1500019C06Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 72772
Homologene: 11070
Adam25
Name: ADAM metallopeptidase domain 25
Synonyms: testase 2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23793
HGNC: HGNC:199
Homologene: 128364
Wnk4
Name: WNK lysine deficient protein kinase 4
Synonyms: 2010002J11Rik, Prkwnk4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69847
Homologene: 13020
Cfap65
Name: cilia and flagella associated protein 65
Synonyms: B230363K08Rik, Ccdc108
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 241116
Homologene: 28093
Vmn2r104
Name: vomeronasal 2, receptor 104
Synonyms: V2r7
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 22313
Homologene: 129751
Cyp26c1
Name: cytochrome P450, family 26, subfamily c, polypeptide 1
Synonyms: EG546726
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 546726
VEGA: 19
Homologene: 28089
Oas2
Name: 2'-5' oligoadenylate synthetase 2
Synonyms: Oasl11, 2'-5' oligoadenylate synthetase-like 11
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 246728
HGNC: HGNC:8087
Homologene: 49478
Pcdhb2
Name: protocadherin beta 2
Synonyms: PcdhbB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93873
HGNC: HGNC:8687
Homologene: 69266
Asb10
Name: ankyrin repeat and SOCS box-containing 10
Synonyms: Asb-10
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 117590
Homologene: 135975
Adam26b
Name: a disintegrin and metallopeptidase domain 26B
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 382007
Homologene: 128363
Cenpj
Name: centromere protein J
Synonyms: Sas4, 4932437H03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219103
Homologene: 10204
Vmn2r54
Name: vomeronasal 2, receptor 54
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666085
Homologene: 104040
Slc52a3
Name: solute carrier protein family 52, member 3
Synonyms: 2310046K01Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69698
Homologene: 12324
Arg1
Name: arginase, liver
Synonyms: AI, PGIF, Arg-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11846
VEGA: 10
HGNC: HGNC:663
Homologene: 29
Spag6l
Name: sperm associated antigen 6-like
Synonyms: Spag6, PF16
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 50525
Homologene: 8252
Antxr1
Name: anthrax toxin receptor 1
Synonyms: 2810405N18Rik, Tem8, 2310008J16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 69538
Homologene: 12976
Dnajb13
Name: DnaJ heat shock protein family (Hsp40) member B13
Synonyms: 1700014P03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69387
Homologene: 70141
Lrrc71
Name: leucine rich repeat containing 71
Synonyms: 4933430H15Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74485
Homologene: 83646
Zbtb8b
Name: zinc finger and BTB domain containing 8b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 215627
Homologene: 65127
Tpi1
Name: triosephosphate isomerase 1
Synonyms: Tpi-1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 21991
Homologene: 128432
Slc7a11
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Synonyms: System xc, 9930009M05Rik, sut, xc, xCT
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26570
Homologene: 22684
Mtmr6
Name: myotubularin related protein 6
Synonyms: Gm38641, 4022440C11Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219135
VEGA: 14
HGNC: HGNC:7453
Homologene: 55842
Mylk4
Name: myosin light chain kinase family, member 4
Synonyms: EG238564
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238564
Homologene: 66243
Pdpr
Name: pyruvate dehydrogenase phosphatase regulatory subunit
Synonyms: 4930402E16Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 319518
Homologene: 9948
Slc22a7
Name: solute carrier family 22 (organic anion transporter), member 7
Synonyms: OAT2, NLT
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 108114
VEGA: 17
Homologene: 21328
Psg17
Name: pregnancy specific beta-1-glycoprotein 17
Synonyms: mmCGM5, Cea-2, Cea2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26437
HGNC: HGNC:1819
Homologene: 110989
Fam107b
Name: family with sequence similarity 107, member B
Synonyms: 3110001A13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66540
Homologene: 75316
Gm13762
Name: predicted gene 13762
Type: Gene
Species: Mouse
Chromosome: 2
Ppp1r3d
Name: protein phosphatase 1, regulatory subunit 3D
Synonyms: LOC228966, 2610024M03Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228966
HGNC: HGNC:9294
Homologene: 4547
Gm3127
Name: predicted gene 3127
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100041076
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 1 at 54,419,641 bp
  • G to T, chromosome 1 at 74,902,434 bp
  • A to T, chromosome 1 at 87,962,430 bp
  • A to C, chromosome 1 at 166,632,680 bp
  • T to C, chromosome 2 at 3,770,740 bp
  • T to C, chromosome 2 at 76,798,512 bp
  • G to T, chromosome 2 at 88,973,657 bp
  • T to A, chromosome 2 at 129,038,272 bp
  • A to G, chromosome 2 at 146,223,107 bp
  • C to A, chromosome 2 at 152,004,614 bp
  • A to G, chromosome 2 at 178,413,372 bp
  • C to T, chromosome 3 at 50,424,037 bp
  • A to G, chromosome 3 at 87,742,974 bp
  • T to C, chromosome 3 at 98,233,112 bp
  • T to C, chromosome 3 at 104,947,116 bp
  • T to C, chromosome 4 at 121,016,799 bp
  • A to G, chromosome 4 at 129,432,962 bp
  • G to C, chromosome 4 at 148,452,350 bp
  • A to G, chromosome 5 at 23,805,479 bp
  • C to A, chromosome 5 at 24,540,877 bp
  • T to C, chromosome 5 at 30,202,247 bp
  • T to C, chromosome 5 at 69,564,544 bp
  • A to G, chromosome 5 at 120,733,228 bp
  • A to G, chromosome 5 at 122,233,523 bp
  • G to A, chromosome 6 at 87,137,291 bp
  • T to A, chromosome 6 at 124,812,854 bp
  • A to G, chromosome 6 at 140,016,127 bp
  • G to A, chromosome 7 at 12,615,703 bp
  • A to G, chromosome 7 at 18,814,491 bp
  • T to A, chromosome 7 at 65,676,012 bp
  • G to T, chromosome 7 at 100,503,186 bp
  • A to G, chromosome 8 at 40,754,846 bp
  • T to A, chromosome 8 at 43,520,997 bp
  • A to T, chromosome 8 at 60,516,068 bp
  • T to A, chromosome 8 at 111,125,685 bp
  • T to A, chromosome 10 at 24,915,729 bp
  • T to C, chromosome 10 at 103,200,601 bp
  • A to G, chromosome 11 at 71,099,528 bp
  • G to A, chromosome 11 at 100,561,905 bp
  • C to A, chromosome 11 at 101,262,895 bp
  • T to C, chromosome 12 at 105,652,120 bp
  • T to A, chromosome 13 at 32,708,908 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • A to G, chromosome 14 at 4,166,014 bp
  • T to C, chromosome 14 at 56,542,800 bp
  • T to A, chromosome 14 at 60,296,147 bp
  • T to G, chromosome 15 at 9,092,846 bp
  • C to T, chromosome 15 at 76,087,408 bp
  • T to C, chromosome 16 at 16,777,414 bp
  • C to T, chromosome 16 at 45,663,274 bp
  • T to G, chromosome 16 at 73,042,978 bp
  • T to A, chromosome 17 at 20,041,709 bp
  • A to T, chromosome 17 at 25,392,109 bp
  • T to C, chromosome 17 at 26,199,391 bp
  • C to T, chromosome 17 at 46,438,230 bp
  • T to C, chromosome 17 at 48,392,417 bp
  • G to T, chromosome 18 at 37,294,947 bp
  • A to C, chromosome 19 at 7,802,587 bp
  • T to C, chromosome 19 at 37,692,999 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7634 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045693-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.