Strain Name:
C57BL/6J-MtgxR7666Btlr/Mmmh
Stock Number:
045705-MU
Citation ID:
RRID:MMRRC_045705-MU
Other Names:
R7666 (G1)
Major Collection:

Strain Information

Ltbp3
Name: latent transforming growth factor beta binding protein 3
Synonyms: Ltbp2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 16998
VEGA: 19
HGNC: HGNC:6716
Homologene: 7405
Atl3
Name: atlastin GTPase 3
Synonyms: 5730596K20Rik, 4633402C03Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109168
VEGA: 19
Homologene: 9149
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: Mrf2alpha, Desrt, 5430435G07Rik, Mrf2, Mrf2beta
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Ppp1r9a
Name: protein phosphatase 1, regulatory subunit 9A
Synonyms: neurabin-I, NRB, Neurabin I, A230094E16Rik, 4930518N04Rik, 2810430P21Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243725
Homologene: 14247
Cilk1
Name: ciliogenesis associated kinase 1
Synonyms: Ick, 2210420N10Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56542
Homologene: 69218
Gk5
Name: glycerol kinase 5
Synonyms: C330018K18Rik, G630067D24Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235533
Homologene: 15141
Cdk13
Name: cyclin dependent kinase 13
Synonyms: Cdc2l5, 2310015O17Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 69562
VEGA: 13
HGNC: HGNC:1733
Homologene: 135707
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268936
Homologene: 16092
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Snx30
Name: sorting nexin family member 30
Synonyms: 4732481H14Rik, C030041J06Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 209131
Homologene: 2811
Aldh4a1
Name: aldehyde dehydrogenase 4 family, member A1
Synonyms: P5CDH, Ahd-1, A930035F14Rik, ALDH4, Ahd1, Ssdh1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212647
HGNC: HGNC:406
Homologene: 6081
Smc5
Name: structural maintenance of chromosomes 5
Synonyms: Smc5l1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226026
VEGA: 19
Homologene: 41009
Dnah7a
Name: dynein, axonemal, heavy chain 7A
Synonyms: Dnahc7a, LOC381341, Dnahc7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 627872
Homologene: 41287
Gucy2c
Name: guanylate cyclase 2c
Synonyms: GC-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14917
HGNC: HGNC:4688
Homologene: 3641
C6
Name: complement component 6
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12274
HGNC: HGNC:1339
Homologene: 47
Ubr4
Name: ubiquitin protein ligase E3 component n-recognin 4
Synonyms: p600, LOC381562, 1810009A16Rik, D930005K06Rik, A930005E13Rik, Zubr1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 69116
Homologene: 10804
Clec14a
Name: C-type lectin domain family 14, member a
Synonyms: 1200003C23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 66864
VEGA: 12
Homologene: 12047
Muc16
Name: mucin 16
Synonyms: 1110008I14Rik, LOC385009, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Hnrnpa2b1
Name: heterogeneous nuclear ribonucleoprotein A2/B1
Synonyms: Hnrpa2, 9130414A06Rik, Hnrpa2b1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 53379
HGNC: HGNC:5033
Homologene: 22992
Mrpl48
Name: mitochondrial ribosomal protein L48
Synonyms: D4Ertd786e, 1810030E20Rik, CGI-118
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 52443
Homologene: 32294
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Swiss-cheese, MSws, Nte
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50767
Homologene: 21333
Wnt5a
Name: wingless-type MMTV integration site family, member 5A
Synonyms: Wnt-5a, 8030457G12Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 22418
Homologene: 20720
Car3
Name: carbonic anhydrase 3
Synonyms: Car-3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12350
HGNC: HGNC:1374
Homologene: 31298
Zfp808
Name: zinc finger protein 808
Synonyms: Gm7036
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 630579
Homologene: 134631
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Spata31d1c
Name: spermatogenesis associated 31 subfamily D, member 1C
Synonyms: 4932441B19Rik, Fam75d1c
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238683
VEGA: 13
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Or2t6
Name: olfactory receptor family 2 subfamily T member 6
Synonyms: MOR274-2, GA_x6K02T2PLTE-6544896-6543946, Olfr720
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258387
Homologene: 74036
Celsr2
Name: cadherin, EGF LAG seven-pass G-type receptor 2
Synonyms: mfmi1, Adgrc2, flamingo, EGFL2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 53883
HGNC: HGNC:3231
Homologene: 1078
Phf7
Name: PHD finger protein 7
Synonyms: 1700006H01Rik, 1700010P14Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71838
VEGA: 14
Homologene: 69217
Zfp804a
Name: zinc finger protein 804A
Synonyms: C630007C17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241514
Homologene: 18461
Fbxl4
Name: F-box and leucine-rich repeat protein 4
Synonyms: FBL5, FBL4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 269514
Homologene: 8128
Ptprn2
Name: protein tyrosine phosphatase receptor type N polypeptide 2
Synonyms: PTP-NP, phogrin, 4930425H11Rik, IA-2beta, IA-2 beta
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 19276
HGNC: HGNC:9677
Homologene: 2134
Ccdc148
Name: coiled-coil domain containing 148
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227933
Homologene: 16353
Myh4
Name: myosin, heavy polypeptide 4, skeletal muscle
Synonyms: MM, Minimsc, Myhsf, Minmus, MYH-2B, MyHC-IIb, MHC2B
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17884
HGNC: HGNC:7574
Homologene: 123880
Thsd7a
Name: thrombospondin, type I, domain containing 7A
Synonyms: LOC330267
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330267
Homologene: 46582
Mug1
Name: murinoglobulin 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17836
HGNC: HGNC:9750
Homologene: 136663
Dlg5
Name: discs large MAGUK scaffold protein 5
Synonyms: 4933429D20Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 71228
HGNC: HGNC:2904
Homologene: 3486
Vwa5a
Name: von Willebrand factor A domain containing 5A
Synonyms: BCSC-1, 5830475I06Rik, Loh11cr2a
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 67776
HGNC: HGNC:6658
Homologene: 18222
Or5b12
Name: olfactory receptor family 5 subfamily B member 12
Synonyms: Olfr1448, MOR202-5, GA_x6K02T2RE5P-3249780-3248836
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258696
Homologene: 64904
Or10ak7
Name: olfactory receptor family 10 subfamily AK member 7
Synonyms: MOR259-1, GA_x6K02T2QD9B-18602750-18603691, Olfr1519, Olfr1328, MOR259-13, MOR259-1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258394
Homologene: 121524
Zfp618
Name: zinc finger protein 618
Synonyms: 2810040O04Rik, Nedd10, D430033D05Rik, 2810031P15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72701
Homologene: 18975
Usp31
Name: ubiquitin specific peptidase 31
Synonyms: 6330567E21Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76179
Homologene: 44504
Armh1
Name: armadillo-like helical domain containing 1
Synonyms: LOC381544, LOC381543, Gm1661, Ncrna00082
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381544
Homologene: 28727
Cr2
Name: complement receptor 2
Synonyms: Cr-1, Cr1, CD35, CD21, Cr-2, C3DR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12902
HGNC: HGNC:2336
Homologene: 55611
Cyp2c38
Name: cytochrome P450, family 2, subfamily c, polypeptide 38
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 13097
Homologene: 117948
Nek5
Name: NIMA (never in mitosis gene a)-related expressed kinase 5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330721
HGNC: HGNC:7748
Homologene: 87952
Cchcr1
Name: coiled-coil alpha-helical rod protein 1
Synonyms: Hcr
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240084
Homologene: 10396
Chrng
Name: cholinergic receptor, nicotinic, gamma polypeptide
Synonyms: Achr-3, Acrg
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11449
HGNC: HGNC:1967
Homologene: 3810
Gimap8
Name: GTPase, IMAP family member 8
Synonyms: IAN9, LOC243374
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243374
Homologene: 69703
Tubb2b
Name: tubulin, beta 2B class IIB
Synonyms: brdp, 2410129E14Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73710
VEGA: 13
Homologene: 49734
Unc50
Name: unc-50 homolog
Synonyms: 1110002A21Rik, GMH1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 67387
Homologene: 6391
Myl7
Name: myosin, light polypeptide 7, regulatory
Synonyms: MLC2a, MLC-2alpha, Mylc2a, RLC-A
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17898
Homologene: 23290
Ppp2r3d
Name: protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta
Synonyms: Ppp2r3a, Ppp2r3, PR59
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19054
Fthl17b
Name: ferritin, heavy polypeptide-like 17, member B
Synonyms: Gm5634
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 434726
Homologene: 23725
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 37,431,415 bp
  • A to T, chromosome 1 at 53,547,297 bp
  • A to T, chromosome 1 at 87,209,453 bp
  • A to G, chromosome 1 at 195,154,225 bp
  • C to T, chromosome 2 at 31,380,233 bp
  • A to G, chromosome 2 at 58,934,500 bp
  • C to T, chromosome 2 at 82,259,060 bp
  • C to T, chromosome 2 at 125,306,471 bp
  • A to G, chromosome 3 at 14,870,064 bp
  • A to G, chromosome 3 at 108,398,588 bp
  • A to G, chromosome 4 at 22,376,869 bp
  • T to C, chromosome 4 at 59,885,047 bp
  • T to A, chromosome 4 at 63,132,717 bp
  • C to A, chromosome 4 at 117,213,741 bp
  • T to A, chromosome 4 at 118,934,264 bp
  • A to G, chromosome 4 at 139,413,480 bp
  • G to A, chromosome 4 at 139,633,957 bp
  • A to T, chromosome 4 at 143,728,515 bp
  • A to T, chromosome 6 at 5,143,238 bp
  • C to T, chromosome 6 at 12,379,438 bp
  • A to C, chromosome 6 at 48,659,155 bp
  • A to T, chromosome 6 at 51,466,937 bp
  • C to A, chromosome 6 at 121,861,220 bp
  • G to A, chromosome 6 at 136,697,968 bp
  • A to G, chromosome 7 at 100,565,201 bp
  • T to C, chromosome 7 at 121,649,181 bp
  • C to T, chromosome 7 at 130,716,814 bp
  • A to G, chromosome 8 at 3,541,591 bp
  • T to C, chromosome 8 at 22,090,517 bp
  • T to C, chromosome 9 at 18,558,427 bp
  • A to G, chromosome 9 at 38,733,963 bp
  • G to C, chromosome 9 at 78,167,620 bp
  • T to A, chromosome 9 at 96,153,107 bp
  • A to T, chromosome 9 at 124,440,873 bp
  • C to T, chromosome 10 at 68,098,587 bp
  • A to G, chromosome 11 at 5,897,140 bp
  • A to T, chromosome 11 at 67,256,281 bp
  • T to A, chromosome 12 at 58,267,757 bp
  • C to A, chromosome 12 at 116,841,320 bp
  • G to A, chromosome 13 at 17,772,576 bp
  • A to G, chromosome 13 at 34,128,135 bp
  • C to T, chromosome 13 at 62,171,411 bp
  • A to C, chromosome 13 at 65,036,000 bp
  • A to T, chromosome 14 at 14,176,075 bp
  • G to A, chromosome 14 at 24,157,799 bp
  • T to C, chromosome 14 at 28,518,372 bp
  • C to T, chromosome 14 at 31,240,354 bp
  • T to A, chromosome 15 at 4,789,505 bp
  • A to T, chromosome 16 at 59,559,337 bp
  • T to C, chromosome 17 at 28,810,572 bp
  • C to T, chromosome 17 at 35,526,486 bp
  • C to T, chromosome 19 at 5,747,006 bp
  • T to C, chromosome 19 at 7,510,040 bp
  • A to G, chromosome 19 at 12,920,162 bp
  • A to T, chromosome 19 at 23,229,017 bp
  • A to T, chromosome 19 at 39,438,242 bp
  • C to T, chromosome X at 8,962,804 bp
  • C to T, chromosome X at 8,962,808 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7666 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045705-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.