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Strain Name:
C57BL/6J-MtgxR7636Btlr/Mmmh
Stock Number:
045722-MU
Citation ID:
RRID:MMRRC_045722-MU
Other Names:
R7636 (G1)
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Ctnna1
Name: catenin alpha 1
Synonyms: alpha(E)-catenin, alpha E catenin, Catna1, 2010010M04Rik, catenin (cadherin associated protein), alpha 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12385
VEGA: 18
HGNC: HGNC:2509
Homologene: 1433
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: Gtar, 4933425K22Rik, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 2 at 13,010,810 bp
  • A to T, chromosome 2 at 25,218,820 bp
  • T to A, chromosome 2 at 28,505,314 bp
  • T to C, chromosome 2 at 32,725,011 bp
  • T to C, chromosome 2 at 34,812,944 bp
  • A to G, chromosome 2 at 65,497,689 bp
  • A to T, chromosome 2 at 66,743,828 bp
  • A to G, chromosome 2 at 79,313,832 bp
  • A to T, chromosome 2 at 89,363,239 bp
  • A to T, chromosome 2 at 110,682,703 bp
  • T to A, chromosome 3 at 53,653,247 bp
  • G to A, chromosome 3 at 152,427,652 bp
  • A to G, chromosome 3 at 155,188,150 bp
  • T to A, chromosome 5 at 32,917,983 bp
  • A to T, chromosome 5 at 90,232,380 bp
  • C to A, chromosome 5 at 106,917,466 bp
  • A to T, chromosome 6 at 42,291,334 bp
  • T to C, chromosome 6 at 48,596,365 bp
  • A to T, chromosome 7 at 12,890,112 bp
  • A to G, chromosome 7 at 25,388,617 bp
  • A to T, chromosome 7 at 30,728,301 bp
  • G to T, chromosome 7 at 45,147,531 bp
  • G to A, chromosome 7 at 45,727,026 bp
  • C to A, chromosome 7 at 47,980,973 bp
  • C to A, chromosome 7 at 75,609,873 bp
  • C to A, chromosome 7 at 103,442,833 bp
  • A to G, chromosome 8 at 3,258,709 bp
  • A to T, chromosome 8 at 72,747,734 bp
  • T to C, chromosome 8 at 108,946,809 bp
  • A to G, chromosome 9 at 5,358,344 bp
  • A to G, chromosome 9 at 20,668,297 bp
  • A to G, chromosome 9 at 42,092,334 bp
  • A to T, chromosome 9 at 106,720,387 bp
  • T to A, chromosome 10 at 82,295,139 bp
  • A to T, chromosome 11 at 58,732,447 bp
  • A to T, chromosome 11 at 101,160,087 bp
  • T to C, chromosome 12 at 8,009,516 bp
  • C to A, chromosome 12 at 51,888,196 bp
  • G to A, chromosome 12 at 51,952,558 bp
  • C to T, chromosome 12 at 112,510,743 bp
  • T to C, chromosome 13 at 13,616,747 bp
  • A to T, chromosome 13 at 25,102,622 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • T to A, chromosome 15 at 63,828,192 bp
  • T to A, chromosome 15 at 102,452,458 bp
  • C to T, chromosome 16 at 17,117,837 bp
  • A to G, chromosome 16 at 72,563,727 bp
  • A to G, chromosome 18 at 7,000,630 bp
  • T to A, chromosome 18 at 35,223,473 bp
  • T to A, chromosome 18 at 57,276,989 bp
  • A to T, chromosome 19 at 5,100,782 bp
  • G to T, chromosome 19 at 44,191,431 bp
  • G to A, chromosome 19 at 46,329,175 bp
  • A to T, chromosome 19 at 59,942,885 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7636 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045722-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.