Strain Name:
C57BL/6J-MtgxR7636Btlr/Mmmh
Stock Number:
045722-MU
Citation ID:
RRID:MMRRC_045722-MU
Other Names:
R7636 (G1)
Major Collection:

Strain Information

Lyst
Name: lysosomal trafficking regulator
Synonyms: D13Sfk13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17101
VEGA: 13
HGNC: HGNC:1968
Homologene: 61
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Rad54l2
Name: RAD54 like 2 (S. cerevisiae)
Synonyms: Arip4, G630026H09Rik, Srisnf2l
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 81000
Homologene: 56698
Ctnna1
Name: catenin alpha 1
Synonyms: alpha(E)-catenin, alpha E catenin, Catna1, 2010010M04Rik, catenin (cadherin associated protein), alpha 1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12385
VEGA: 18
HGNC: HGNC:2509
Homologene: 1433
Ankrd17
Name: ankyrin repeat domain 17
Synonyms: 4933425K22Rik, Gtar, A130069E23Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81702
Homologene: 82403
Sin3b
Name: transcriptional regulator, SIN3B (yeast)
Synonyms: 2810430C10Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20467
Homologene: 81810
Depdc5
Name: DEP domain containing 5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 277854
Homologene: 34718
Zfhx3
Name: zinc finger homeobox 3
Synonyms: WBP9, A230102L03Rik, Atbf1, Sci
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11906
HGNC: HGNC:777
Homologene: 21366
Akap13
Name: A kinase anchor protein 13
Synonyms: AKAP-Lbc, PROTO-LBC, PROTO-LB, Ht31, 5730522G15Rik, 1700026G02Rik, 5830460E08Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Heatr5a
Name: HEAT repeat containing 5A
Synonyms: D930036F22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320487
VEGA: 12
Homologene: 19635
Amhr2
Name: anti-Mullerian hormone type 2 receptor
Synonyms: MIS TypeII receptor, MISIIR
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 110542
HGNC: HGNC:465
Homologene: 10746
Tmem161b
Name: transmembrane protein 161B
Synonyms: 2810446P07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 72745
Homologene: 14519
2610318N02Rik
Name: RIKEN cDNA 2610318N02 gene
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 70458
Homologene: 79715
Aldh16a1
Name: aldehyde dehydrogenase 16 family, member A1
Synonyms: 2410004H02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69748
Homologene: 34938
Robo1
Name: roundabout guidance receptor 1
Synonyms: DUTT1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19876
Homologene: 2206
Casp12
Name: caspase 12
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12364
Homologene: 7654
Dcdc2a
Name: doublecortin domain containing 2a
Synonyms: RU2, Dcdc2
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 195208
Homologene: 9483
Apob
Name: apolipoprotein B
Synonyms: apob-100, apob-48
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238055
HGNC: HGNC:603
Homologene: 328
Zzz3
Name: zinc finger, ZZ domain containing 3
Synonyms: 3110065C23Rik, 6430567E01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 108946
Homologene: 9182
Sorl1
Name: sortilin-related receptor, LDLR class A repeats-containing
Synonyms: LR11, mSorLA, 2900010L19Rik, Sorla
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20660
Homologene: 2336
Sh2d3c
Name: SH2 domain containing 3C
Synonyms: Shep1, SH2-containing Eph receptor-binding protein 1, Cas/HEF1-associated signal transducer, Chat, Nsp3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27387
Homologene: 69145
C1ql3
Name: C1q-like 3
Synonyms: K100, 1110065A22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227580
Homologene: 17701
Clcn1
Name: chloride channel, voltage-sensitive 1
Synonyms: SMCC1, Clc-1, Clc1, NMF355, nmf355
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12723
HGNC: HGNC:2019
Homologene: 63
Itga4
Name: integrin alpha 4
Synonyms: VLA-4 receptor, alpha 4 subunit
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16401
HGNC: HGNC:6140
Homologene: 37364
Scn7a
Name: sodium channel, voltage-gated, type VII, alpha
Synonyms: Nav2.3, NaG, Nav2, 1110034K09Rik, Scn6a, Nax
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20272
Homologene: 55706
Olfm2
Name: olfactomedin 2
Synonyms: A030009A06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244723
VEGA: 9
Homologene: 14380
Megf10
Name: multiple EGF-like-domains 10
Synonyms: LOC240312, 3000002B06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 70417
Homologene: 23771
Hfm1
Name: HFM1, ATP-dependent DNA helicase homolog
Synonyms: LOC381663, A330009G12Rik, Sec63d1, Mer3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 330149
Homologene: 87103
Gbgt1
Name: globoside alpha-1,3-N-acetylgalactosaminyltransferase 1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227671
Homologene: 110677
Gsdmc2
Name: gasdermin C2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 331063
HGNC: HGNC:7151
Homologene: 69487
Insr
Name: insulin receptor
Synonyms: IR, CD220, 4932439J01Rik, D630014A15Rik, IR-B, IR-A
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16337
HGNC: HGNC:6091
Homologene: 20090
Lipe
Name: lipase, hormone sensitive
Synonyms: HSL, 4933403G17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16890
HGNC: HGNC:6621
Homologene: 3912
Tmem147
Name: transmembrane protein 147
Synonyms: 2010004E11Rik, 5033425B17Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69804
Homologene: 12330
Rab11fip2
Name: RAB11 family interacting protein 2 (class I)
Synonyms: Rab11-FIP2, nRip11, 4930470G04Rik, A830046J09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74998
Homologene: 8937
Spata31h1
Name: SPATA31 subfamily H member 1
Synonyms: 4932415D10Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 102635990
VEGA: 10
Homologene: 82476
Fam83e
Name: family with sequence similarity 83, member E
Synonyms: 4930403C10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 73813
Homologene: 9791
Or52s6
Name: olfactory receptor family 52 subfamily S member 6
Synonyms: GA_x6K02T2PBJ9-6164792-6163848, MOR202-22P, MOR24-5, Olfr605
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258156
Homologene: 79414
Ano3
Name: anoctamin 3
Synonyms: B230324K02Rik, Tmem16c
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228432
Homologene: 57147
Mrgpra4
Name: MAS-related GPR, member A4
Synonyms: MrgA4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 235854
Homologene: 131159
Cimip2a
Name: ciliary microtubule inner protein 2A
Synonyms: Fam166a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68222
Homologene: 12247
Repin1
Name: replication initiator 1
Synonyms: AP4, E430037F08Rik, Zfp464
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 58887
Homologene: 22810
Fbxl15
Name: F-box and leucine-rich repeat protein 15
Synonyms: 0710008C12Rik, Fbxo37
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 68431
VEGA: 19
Homologene: 44220
Lrriq3
Name: leucine-rich repeats and IQ motif containing 3
Synonyms: 4930438B07Rik, 4930511J15Rik, 4933403H06Rik, Lrrc44
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74435
Homologene: 23668
Or2w3b
Name: olfactory receptor family 2 subfamily W member 3B
Synonyms: GA_x6K02T2NKPP-680866-681849, MOR256-47, Olfr317
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 257931
Homologene: 128382
Rab1b
Name: RAB1B, member RAS oncogene family
Synonyms: 1110011F09Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76308
VEGA: 19
Homologene: 128838
Fbxw2
Name: F-box and WD-40 domain protein 2
Synonyms: MD6, Fwd2, FBW2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 30050
Homologene: 8131
Pkd2l1
Name: polycystic kidney disease 2-like 1
Synonyms: polycystin-L, Pkdl, PCL, TRPP3, PKD2L
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 329064
HGNC: HGNC:9011
Homologene: 22946
Mkx
Name: mohawk homeobox
Synonyms: 9430023B20Rik, Irxl1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 210719
Homologene: 72239
Zfp128
Name: zinc finger protein 128
Synonyms: mZnf8, 9630016P15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 243833
Homologene: 10889
Or4a15
Name: olfactory receptor family 4 subfamily A member 15
Synonyms: GA_x6K02T2Q125-50805620-50804676, MOR231-2, Olfr1234
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258975
Homologene: 128156
Tubg2
Name: tubulin, gamma 2
Synonyms: Tubgl
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103768
Homologene: 69216
Tmem179
Name: transmembrane protein 179
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104885
VEGA: 12
Homologene: 16809
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to T, chromosome 2 at 13,010,810 bp
  • A to T, chromosome 2 at 25,218,820 bp
  • T to A, chromosome 2 at 28,505,314 bp
  • T to C, chromosome 2 at 32,725,011 bp
  • T to C, chromosome 2 at 34,812,944 bp
  • A to G, chromosome 2 at 65,497,689 bp
  • A to T, chromosome 2 at 66,743,828 bp
  • A to G, chromosome 2 at 79,313,832 bp
  • A to T, chromosome 2 at 89,363,239 bp
  • A to T, chromosome 2 at 110,682,703 bp
  • T to A, chromosome 3 at 53,653,247 bp
  • G to A, chromosome 3 at 152,427,652 bp
  • A to G, chromosome 3 at 155,188,150 bp
  • T to A, chromosome 5 at 32,917,983 bp
  • A to T, chromosome 5 at 90,232,380 bp
  • C to A, chromosome 5 at 106,917,466 bp
  • A to T, chromosome 6 at 42,291,334 bp
  • T to C, chromosome 6 at 48,596,365 bp
  • A to T, chromosome 7 at 12,890,112 bp
  • A to G, chromosome 7 at 25,388,617 bp
  • A to T, chromosome 7 at 30,728,301 bp
  • G to T, chromosome 7 at 45,147,531 bp
  • G to A, chromosome 7 at 45,727,026 bp
  • C to A, chromosome 7 at 47,980,973 bp
  • C to A, chromosome 7 at 75,609,873 bp
  • C to A, chromosome 7 at 103,442,833 bp
  • A to G, chromosome 8 at 3,258,709 bp
  • A to T, chromosome 8 at 72,747,734 bp
  • T to C, chromosome 8 at 108,946,809 bp
  • A to G, chromosome 9 at 5,358,344 bp
  • A to G, chromosome 9 at 20,668,297 bp
  • A to G, chromosome 9 at 42,092,334 bp
  • A to T, chromosome 9 at 106,720,387 bp
  • T to A, chromosome 10 at 82,295,139 bp
  • A to T, chromosome 11 at 58,732,447 bp
  • A to T, chromosome 11 at 101,160,087 bp
  • T to C, chromosome 12 at 8,009,516 bp
  • C to A, chromosome 12 at 51,888,196 bp
  • G to A, chromosome 12 at 51,952,558 bp
  • C to T, chromosome 12 at 112,510,743 bp
  • T to C, chromosome 13 at 13,616,747 bp
  • A to T, chromosome 13 at 25,102,622 bp
  • C to A, chromosome 13 at 84,222,418 bp
  • T to A, chromosome 15 at 63,828,192 bp
  • T to A, chromosome 15 at 102,452,458 bp
  • C to T, chromosome 16 at 17,117,837 bp
  • A to G, chromosome 16 at 72,563,727 bp
  • A to G, chromosome 18 at 7,000,630 bp
  • T to A, chromosome 18 at 35,223,473 bp
  • T to A, chromosome 18 at 57,276,989 bp
  • A to T, chromosome 19 at 5,100,782 bp
  • G to T, chromosome 19 at 44,191,431 bp
  • G to A, chromosome 19 at 46,329,175 bp
  • A to T, chromosome 19 at 59,942,885 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7636 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045722-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.