Strain Name:
C57BL/6J-MtgxR7652Btlr/Mmmh
Stock Number:
045729-MU
Citation ID:
RRID:MMRRC_045729-MU
Other Names:
R7652 (G1)
Major Collection:

Strain Information

Wnt3
Name: wingless-type MMTV integration site family, member 3
Synonyms: Int-4, Wnt-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 22415
Homologene: 22527
Hnrnpab
Name: heterogeneous nuclear ribonucleoprotein A/B
Synonyms: CBF-A, Hnrpab, Cgbfa
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15384
HGNC: HGNC:5034
Homologene: 74950
Setd5
Name: SET domain containing 5
Synonyms: 2900045N06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 72895
Homologene: 12485
Kmt2c
Name: lysine (K)-specific methyltransferase 2C
Synonyms: E330008K23Rik, HALR, Mll3
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231051
Homologene: 46480
Ebf2
Name: early B cell factor 2
Synonyms: O/E-3, Mmot1, D14Ggc1e
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13592
Homologene: 56471
Rgs7
Name: regulator of G protein signaling 7
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 24012
Homologene: 2193
Dnajc11
Name: DnaJ heat shock protein family (Hsp40) member C11
Synonyms: E030019A03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230935
Homologene: 14558
Setd3
Name: SET domain containing 3
Synonyms: D12Ertd771e, 2610102I01Rik, 2610305M23Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 52690
Homologene: 41748
Wdr70
Name: WD repeat domain 70
Synonyms: 4833422F06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 545085
VEGA: 15
Homologene: 9972
Drosha
Name: drosha, ribonuclease type III
Synonyms: 1110013A17Rik, Etohi2, Rnasen
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 14000
Homologene: 8293
Agrn
Name: agrin
Synonyms: NMF380, nmf380, Agrin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 11603
HGNC: HGNC:329
Homologene: 27907
Ube3a
Name: ubiquitin protein ligase E3A
Synonyms: 5830462N02Rik, A130086L21Rik, Hpve6a, E6-AP ubiquitin protein ligase
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22215
Homologene: 7988
Fasn
Name: fatty acid synthase
Synonyms: FAS, A630082H08Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14104
HGNC: HGNC:3594
Homologene: 55800
Lrp6
Name: low density lipoprotein receptor-related protein 6
Synonyms: skam26Jus, skax26, Cd, ska26
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16974
HGNC: HGNC:6698
Homologene: 1747
Usp53
Name: ubiquitin specific peptidase 53
Synonyms: mbo, Sp6, Phxr3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99526
Homologene: 34521
Atp13a1
Name: ATPase type 13A1
Synonyms: catp, Cgi152, Atp13a
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 170759
VEGA: 8
Homologene: 5791
Gas8
Name: growth arrest specific 8
Synonyms: Gas11
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104346
HGNC: HGNC:4166
Homologene: 1135
Kri1
Name: KRI1 homolog
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 215194
Homologene: 133742
Grid2ip
Name: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1
Synonyms: delphilin
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 170935
Homologene: 15781
Apoe
Name: apolipoprotein E
Synonyms: Apoe
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11816
HGNC: HGNC:613
Homologene: 30951
Lef1
Name: lymphoid enhancer binding factor 1
Synonyms: Lef-1, lymphoid enhancer factor 1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 16842
HGNC: HGNC:6551
Homologene: 7813
Alb
Name: albumin
Synonyms: Alb1, Alb-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11657
HGNC: HGNC:399
Homologene: 405
Fat1
Name: FAT atypical cadherin 1
Synonyms: mFat1, Fath, 2310038E12Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 14107
HGNC: HGNC:3595
Homologene: 66302
Rnf13
Name: ring finger protein 13
Synonyms: Rzf, 2010001H16Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 24017
Homologene: 13493
Hbs1l
Name: Hbs1-like (S. cerevisiae)
Synonyms: eRFS, 2810035F15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 56422
VEGA: 10
HGNC: HGNC:4834
Homologene: 68525
Prss35
Name: serine protease 35
Synonyms: 6030424L22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244954
Homologene: 17734
Dnajc6
Name: DnaJ heat shock protein family (Hsp40) member C6
Synonyms: auxilin, 2810027M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72685
Homologene: 8865
Maml2
Name: mastermind like transcriptional coactivator 2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270118
Homologene: 134147
Cacna2d2
Name: calcium channel, voltage-dependent, alpha 2/delta subunit 2
Synonyms: a2d2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56808
HGNC: HGNC:1400
Homologene: 4400
Nos3
Name: nitric oxide synthase 3, endothelial cell
Synonyms: 2310065A03Rik, ecNOS, Nos-3, eNOS
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18127
HGNC: HGNC:7876
Homologene: 504
Arap3
Name: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
Synonyms: DRAG1, E030006K04Rik, Centd3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 106952
VEGA: 18
Homologene: 11199
Ptpn13
Name: protein tyrosine phosphatase, non-receptor type 13
Synonyms: PTP-BL, PTPL1, Ptpri
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19249
HGNC: HGNC:9646
Homologene: 7909
Ints10
Name: integrator complex subunit 10
Synonyms: 4921521J11Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 70885
Homologene: 10029
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
C7
Name: complement component 7
Synonyms: LOC383055
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 109828
VEGA: 15
HGNC: HGNC:1346
Homologene: 489
Slc26a6
Name: solute carrier family 26, member 6
Synonyms: Pat1, CFEX, B930010B04Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 171429
Homologene: 99903
Trpc3
Name: transient receptor potential cation channel, subfamily C, member 3
Synonyms: Trcp3, Trp3, Trrp3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 22065
Homologene: 20708
Eqtn
Name: equatorin, sperm acrosome associated
Synonyms: Afaf, 4930579C15Rik, 1700028B15Rik, equatorin
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 67753
HGNC: HGNC:1359
Homologene: 75250
Or4c111
Name: olfactory receptor family 4 subfamily C member 111
Synonyms: GA_x6K02T2Q125-50494588-50493653, Olfr1216, MOR233-9
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258895
Homologene: 74241
Mmrn1
Name: multimerin 1
Synonyms: 4921530G03Rik, Emilin4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70945
HGNC: HGNC:7178
Homologene: 49134
Homer2
Name: homer scaffolding protein 2
Synonyms: Vesl-2, Cupidin, CPD, 9330120H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 26557
Homologene: 3560
Or5w13
Name: olfactory receptor family 5 subfamily W member 13
Synonyms: Olfr1136, GA_x6K02T2Q125-49193051-49192119, MOR177-3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258653
Homologene: 74193
Or2y14
Name: olfactory receptor family 2 subfamily Y member 14
Synonyms: MOR256-23, Olfr1384, GA_x6K02T2QP88-5922712-5921756
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258464
Homologene: 74259
Hdac3
Name: histone deacetylase 3
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15183
HGNC: HGNC:4854
Homologene: 48250
Rft1
Name: RFT1 homolog
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 328370
Homologene: 5343
Or6c70
Name: olfactory receptor family 6 subfamily C member 70
Synonyms: GA_x6K02T2PULF-11553313-11552381, MOR113-5, Olfr814, MOR113-8
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 259165
Homologene: 133585
Tlr1
Name: toll-like receptor 1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21897
Homologene: 20694
Vmn2r96
Name: vomeronasal 2, receptor 96
Synonyms: EG433070
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 433070
Or5an1b
Name: olfactory receptor family 5 subfamily AN member 1B
Synonyms: MOR214-6, Olfr1437, GA_x6K02T2RE5P-2658227-2657289
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258117
Homologene: 83129
Stom
Name: stomatin
Synonyms: protein 7.2b, Epb7.2, stomatin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 13830
HGNC: HGNC:3383
Homologene: 81681
Ugt2b35
Name: UDP glucuronosyltransferase 2 family, polypeptide B35
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243085
Homologene: 128251
Ikbke
Name: inhibitor of kappaB kinase epsilon
Synonyms: IKKepsilon, IKK-i
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 56489
Homologene: 23168
Epx
Name: eosinophil peroxidase
Synonyms: EPO
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13861
HGNC: HGNC:3423
Homologene: 20144
Klk9
Name: kallikrein related-peptidase 9
Synonyms: 1200016C12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101533
HGNC: HGNC:6370
Homologene: 40832
Stambp
Name: STAM binding protein
Synonyms: 5730422L11Rik, Amsh, 5330424L14Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 70527
Homologene: 4719
Aph1b
Name: aph1 homolog B, gamma secretase subunit
Synonyms: 2310057K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 208117
Homologene: 12844
Dnajc25
Name: DnaJ heat shock protein family (Hsp40) member C25
Synonyms: 2010109C08Rik, 2010203O07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72429
Homologene: 37883
Arhgap45
Name: Rho GTPase activating protein 45
Synonyms: Hmha1, 6330406L22Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70719
Homologene: 69120
Zfp764l1
Name: zinc finger protein 764 like 1
Synonyms: E430018J23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101604
Homologene: 138471
Slc26a9
Name: solute carrier family 26, member 9
Synonyms: anion transporter/exchanger-9, E030002L01Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 320718
Homologene: 14179
Klhl3
Name: kelch-like 3
Synonyms: EG627648, 7530408C15Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100503085
HGNC: HGNC:6354
Homologene: 79542
Gm11127
Name: predicted gene 11127
Synonyms: Gm11127
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 100529082
Homologene: 133121
Ddah2
Name: DDAH family member 2, ADMA independent
Synonyms: Clone 7u, NG30, G6a, Ddah
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 51793
HGNC: HGNC:2716
Homologene: 8510
Phospho1
Name: phosphatase, orphan 1
Synonyms: D11Moh36
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237928
Homologene: 13330
Krtap4-6
Name: keratin associated protein 4-6
Synonyms: 1110054P19Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68768
Homologene: 124486
Rab18
Name: RAB18, member RAS oncogene family
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 19330
VEGA: 18
Homologene: 40765
Gm8005
Name: predicted gene 8005
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 666253
Homologene: 128452
Gm3269
Name: predicted gene 3269
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 118568164
Homologene: 115686
Fam107b
Name: family with sequence similarity 107, member B
Synonyms: 3110001A13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66540
Homologene: 75316
Zfp729b
Name: zinc finger protein 729b
Synonyms: AA987161
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 100416706
Homologene: 133713
Anxa2r2
Name: annexin A2 receptor 2
Synonyms: Gm36079
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 102639868
VEGA: 13
Homologene: 141115
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • C to T, chromosome 1 at 131,271,832 bp
  • A to T, chromosome 1 at 131,763,896 bp
  • T to A, chromosome 1 at 175,093,830 bp
  • A to G, chromosome 2 at 3,772,847 bp
  • A to T, chromosome 2 at 35,316,029 bp
  • A to G, chromosome 2 at 87,693,360 bp
  • C to T, chromosome 2 at 89,013,549 bp
  • A to G, chromosome 2 at 155,632,236 bp
  • C to A, chromosome 3 at 36,638,528 bp
  • A to G, chromosome 3 at 57,764,351 bp
  • A to T, chromosome 3 at 122,953,235 bp
  • A to C, chromosome 3 at 131,200,354 bp
  • A to G, chromosome 4 at 59,020,483 bp
  • T to C, chromosome 4 at 94,928,337 bp
  • A to T, chromosome 4 at 101,606,677 bp
  • T to C, chromosome 4 at 151,974,225 bp
  • A to G, chromosome 4 at 156,169,218 bp
  • T to A, chromosome 5 at 24,383,612 bp
  • T to C, chromosome 5 at 25,315,719 bp
  • A to T, chromosome 5 at 64,926,787 bp
  • T to A, chromosome 5 at 87,001,510 bp
  • G to C, chromosome 5 at 90,467,355 bp
  • A to G, chromosome 5 at 103,529,712 bp
  • C to A, chromosome 5 at 143,382,638 bp
  • A to G, chromosome 6 at 60,977,506 bp
  • A to T, chromosome 6 at 83,563,928 bp
  • G to A, chromosome 6 at 113,121,764 bp
  • A to T, chromosome 6 at 134,511,245 bp
  • G to T, chromosome 7 at 19,696,610 bp
  • A to T, chromosome 7 at 43,796,090 bp
  • A to G, chromosome 7 at 59,243,354 bp
  • T to C, chromosome 7 at 81,649,666 bp
  • C to T, chromosome 7 at 127,393,324 bp
  • A to G, chromosome 8 at 44,953,299 bp
  • A to G, chromosome 8 at 68,825,119 bp
  • T to C, chromosome 8 at 69,805,559 bp
  • A to G, chromosome 8 at 123,526,536 bp
  • T to C, chromosome 9 at 13,621,649 bp
  • TTCCTCCTCCTCCTCCTCCTCCTCCTCCTC to TTCCTCCTCCTCCTCCTCCTCCTCCTC, chromosome 9 at 21,281,056 bp
  • T to C, chromosome 9 at 66,784,541 bp
  • T to A, chromosome 9 at 86,755,970 bp
  • T to C, chromosome 9 at 107,524,198 bp
  • T to C, chromosome 9 at 108,855,944 bp
  • C to T, chromosome 10 at 21,364,760 bp
  • C to T, chromosome 10 at 80,028,838 bp
  • A to T, chromosome 10 at 129,874,477 bp
  • T to C, chromosome 11 at 49,513,685 bp
  • T to C, chromosome 11 at 51,605,573 bp
  • A to G, chromosome 11 at 87,875,334 bp
  • T to C, chromosome 11 at 95,830,819 bp
  • T to C, chromosome 11 at 99,665,614 bp
  • A to G, chromosome 11 at 103,812,464 bp
  • G to A, chromosome 11 at 120,816,328 bp
  • A to T, chromosome 12 at 108,112,289 bp
  • G to A, chromosome 13 at 58,113,332 bp
  • T to C, chromosome 13 at 67,591,252 bp
  • A to T, chromosome 13 at 120,026,993 bp
  • T to C, chromosome 14 at 4,839,095 bp
  • A to G, chromosome 14 at 30,677,816 bp
  • C to A, chromosome 14 at 42,436,962 bp
  • G to T, chromosome 14 at 67,390,567 bp
  • A to G, chromosome 15 at 5,012,105 bp
  • A to G, chromosome 15 at 8,079,216 bp
  • G to A, chromosome 15 at 12,859,436 bp
  • T to G, chromosome 17 at 18,573,570 bp
  • C to A, chromosome 17 at 35,061,050 bp
  • A to T, chromosome 17 at 36,056,783 bp
  • A to T, chromosome 18 at 6,783,123 bp
  • T to A, chromosome 18 at 37,954,919 bp
  • G to T, chromosome 18 at 37,978,452 bp
  • C to A, chromosome 19 at 12,322,287 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7652 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045729-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.