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Strain Name:
C57BL/6J-MtgxR7661Btlr/Mmmh
Stock Number:
045736-MU
Citation ID:
RRID:MMRRC_045736-MU
Other Names:
R7661 (G1)
Major Collection:

Strain Information

Ptprk
Name: protein tyrosine phosphatase receptor type K
Synonyms: PTPk, RPTPkappa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19272
VEGA: 10
HGNC: HGNC:9674
Homologene: 55693
Dst
Name: dystonin
Synonyms: bullous pemphigoid antigen 1, BPAG1-n, BPAG1, Bpag1, Bpag, ah, bullous pemphigoid antigen 1, athetoid, Macf2, 2310001O04Rik, nmf203, A830042E19Rik, nmf339
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13518
HGNC: HGNC:1090
Homologene: 136716
Mindy3
Name: MINDY lysine 48 deubiquitinase 3
Synonyms: 1810041E18Rik, 5830410F13Rik, 2310047O13Rik, Fam188a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66960
Homologene: 11478
Sash1
Name: SAM and SH3 domain containing 1
Synonyms: A330076K04Rik, 1100001C18Rik, 2500002E12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70097
Homologene: 69182
Arid5b
Name: AT-rich interaction domain 5B
Synonyms: 5430435G07Rik, Desrt, Mrf2beta, Mrf2alpha, Mrf2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71371
VEGA: 10
Homologene: 45872
Cilk1
Name: ciliogenesis associated kinase 1
Synonyms: 2210420N10Rik, Ick
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56542
Homologene: 69218
Paip1
Name: polyadenylate binding protein-interacting protein 1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218693
Homologene: 4709
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 13,174,537 bp
  • C to T, chromosome 1 at 24,072,762 bp
  • T to A, chromosome 1 at 34,256,353 bp
  • A to T, chromosome 1 at 123,384,952 bp
  • A to T, chromosome 2 at 12,397,517 bp
  • T to C, chromosome 2 at 37,844,829 bp
  • T to C, chromosome 2 at 131,322,215 bp
  • T to C, chromosome 3 at 89,430,731 bp
  • C to T, chromosome 3 at 94,198,402 bp
  • T to A, chromosome 4 at 3,172,149 bp
  • A to G, chromosome 4 at 32,691,229 bp
  • G to A, chromosome 4 at 88,303,535 bp
  • A to G, chromosome 4 at 100,441,490 bp
  • T to C, chromosome 4 at 109,253,754 bp
  • C to T, chromosome 5 at 92,587,525 bp
  • G to A, chromosome 5 at 108,338,619 bp
  • T to C, chromosome 5 at 149,215,017 bp
  • A to G, chromosome 6 at 24,518,725 bp
  • T to C, chromosome 6 at 28,829,763 bp
  • A to G, chromosome 6 at 120,865,597 bp
  • C to A, chromosome 6 at 121,861,220 bp
  • A to T, chromosome 6 at 122,713,472 bp
  • C to A, chromosome 6 at 140,041,772 bp
  • A to G, chromosome 7 at 22,691,804 bp
  • T to A, chromosome 7 at 43,023,158 bp
  • A to T, chromosome 7 at 103,538,619 bp
  • A to T, chromosome 7 at 127,384,963 bp
  • T to C, chromosome 9 at 50,618,258 bp
  • G to C, chromosome 9 at 78,167,620 bp
  • A to G, chromosome 9 at 124,442,696 bp
  • C to T, chromosome 10 at 8,729,391 bp
  • A to G, chromosome 10 at 19,622,078 bp
  • T to C, chromosome 10 at 22,372,257 bp
  • T to C, chromosome 10 at 28,466,040 bp
  • T to G, chromosome 10 at 45,605,553 bp
  • A to C, chromosome 10 at 60,049,807 bp
  • C to T, chromosome 10 at 68,098,587 bp
  • A to G, chromosome 10 at 86,069,076 bp
  • A to G, chromosome 11 at 73,486,600 bp
  • T to A, chromosome 11 at 76,986,515 bp
  • T to A, chromosome 11 at 104,726,677 bp
  • A to T, chromosome 12 at 107,488,956 bp
  • C to T, chromosome 12 at 110,868,792 bp
  • T to C, chromosome 13 at 4,508,219 bp
  • C to T, chromosome 13 at 119,450,770 bp
  • G to A, chromosome 14 at 30,047,220 bp
  • A to T, chromosome 14 at 70,579,836 bp
  • A to G, chromosome 14 at 103,212,623 bp
  • A to G, chromosome 15 at 90,980,919 bp
  • T to A, chromosome 16 at 56,632,900 bp
  • T to A, chromosome 17 at 3,532,858 bp
  • A to G, chromosome 17 at 46,135,087 bp
  • G to T, chromosome 18 at 77,774,102 bp
  • T to A, chromosome 19 at 34,619,028 bp
  • C to A, chromosome 19 at 44,339,071 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7661 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045736-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.