Strain Name:
C57BL/6J-MtgxR7669Btlr/Mmmh
Stock Number:
045741-MU
Citation ID:
RRID:MMRRC_045741-MU
Other Names:
R7669 (G1)
Major Collection:

Strain Information

Sulf2
Name: sulfatase 2
Synonyms: 2010004N24Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72043
Homologene: 10313
Bmp6
Name: bone morphogenetic protein 6
Synonyms: Vgr1, D13Wsu115e
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 12161
VEGA: 13
HGNC: HGNC:1073
Homologene: 1300
Aldh1l1
Name: aldehyde dehydrogenase 1 family, member L1
Synonyms: Fthfd, 1810048F20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 107747
HGNC: HGNC:3978
Homologene: 122031
Nfia
Name: nuclear factor I/A
Synonyms: 1110047K16Rik, NF1A, NF1-A, 9430022M17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 18027
HGNC: HGNC:7784
Homologene: 4086
Prss12
Name: serine protease 12 neurotrypsin (motopsin)
Synonyms: Bssp-3, motopsin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19142
HGNC: HGNC:9477
Homologene: 7490
Sgsm1
Name: small G protein signaling modulator 1
Synonyms: D5Bwg1524e, Rutbc2, 2410098H20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 52850
Homologene: 64485
Macroh2a1
Name: macroH2A.1 histone
Synonyms: H2afy, mH2a1, MACROH2A1.2, H2AF12M
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 26914
HGNC: HGNC:4740
Homologene: 3598
Zfp523
Name: zinc finger protein 523
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224656
Homologene: 2569
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Gluralpha4, Glur-4, Glur4, spkw1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Alox12b
Name: arachidonate 12-lipoxygenase, 12R type
Synonyms: 12R-LOX, e-LOX2, Aloxe2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11686
HGNC: HGNC:430
Homologene: 884
Nbea
Name: neurobeachin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 26422
HGNC: HGNC:7648
Homologene: 69190
Ttc5
Name: tetratricopeptide repeat domain 5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219022
VEGA: 14
Homologene: 14397
Patj
Name: PATJ, crumbs cell polarity complex component
Synonyms: Cipp, Inadl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12695
Homologene: 72199
Gpbp1
Name: GC-rich promoter binding protein 1
Synonyms: 1700034P14Rik, D230035M11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73274
Homologene: 11292
Tcf7l2
Name: transcription factor 7 like 2, T cell specific, HMG box
Synonyms: Tcf-4, mTcf-4E, TCF4B, Tcf4, mTcf-4B, TCF4E
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 21416
Homologene: 7564
Trappc12
Name: trafficking protein particle complex 12
Synonyms: D930014A20Rik, CGI-87, Ttc15
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217449
VEGA: 12
Homologene: 34805
Heatr1
Name: HEAT repeat containing 1
Synonyms: B130016L12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 217995
VEGA: 13
Homologene: 34562
Nol6
Name: nucleolar protein family 6 (RNA-associated)
Synonyms: Nrap
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230082
Homologene: 41505
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: SYNE-1, A330049M09Rik, enaptin165, nesprin-1, C130039F11Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Mier2
Name: MIER family member 2
Synonyms: 2700087H15Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70427
Homologene: 18941
Traf7
Name: TNF receptor-associated factor 7
Synonyms: RFWD1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224619
Homologene: 12998
Flii
Name: flightless I actin binding protein
Synonyms: 3632430F08Rik, Fliih
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14248
HGNC: HGNC:3750
Homologene: 11092
Gm14496
Name: predicted gene 14496
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 672125
Homologene: 129606
Alb
Name: albumin
Synonyms: Alb1, Alb-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11657
HGNC: HGNC:399
Homologene: 405
Trmt1
Name: tRNA methyltransferase 1
Synonyms: D8Ertd812e, 6720406L13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212528
Homologene: 5632
Csmd1
Name: CUB and Sushi multiple domains 1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 94109
Homologene: 69536
Mlxipl
Name: MLX interacting protein-like
Synonyms: bHLHd14, WS-bHLH, Wbscr14, ChREBP
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 58805
Homologene: 32507
Mgam
Name: maltase-glucoamylase
Synonyms: 6030407P20Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232714
HGNC: HGNC:7043
Homologene: 130099
Xirp2
Name: xin actin-binding repeat containing 2
Synonyms: 2310008C07Rik, myomaxin, mXin beta, A530024P18Rik, 2310003D02Rik, Cmya3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241431
Homologene: 19388
BC024139
Name: cDNA sequence BC024139
Synonyms: 6230424I18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 271278
Homologene: 129974
Scart2
Name: scavenger receptor family member expressed on T cells 2
Synonyms: 5830411N06Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244234
Homologene: 133218
Arhgap29
Name: Rho GTPase activating protein 29
Synonyms: C76601, Parg1, 6720461J18Rik, B130017I01Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214137
Homologene: 3539
Zfp804b
Name: zinc finger protein 804B
Synonyms: LOC207618
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 207618
Homologene: 52304
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: bl, E130113P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Mtrf1l
Name: mitochondrial translational release factor 1-like
Synonyms: 9130004K12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 108853
Homologene: 5905
Ada
Name: adenosine deaminase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11486
HGNC: HGNC:186
Homologene: 37249
Grin2a
Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms: NMDAR2A, GluN2A, GluRepsilon1, NR2A
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 14811
HGNC: HGNC:4585
Homologene: 645
Kmt2b
Name: lysine (K)-specific methyltransferase 2B
Synonyms: Wbp7, 2610014H22Rik, Mll2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75410
Homologene: 22838
Mroh1
Name: maestro heat-like repeat family member 1
Synonyms: D330001F17Rik, Heatr7a
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223658
Homologene: 44882
Pcnx1
Name: pecanex 1
Synonyms: Pcnx, 3526401J03Rik, 2900024E21Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 54604
VEGA: 12
Homologene: 40997
Tex55
Name: testis expressed 55
Synonyms: 4930435E12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74663
Homologene: 17614
Aars2
Name: alanyl-tRNA synthetase 2, mitochondrial
Synonyms: Aarsl
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224805
VEGA: 17
Homologene: 56897
Cfd
Name: complement factor D
Synonyms: factor D, DF, D component (adipsin) of complement, Adn
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11537
VEGA: 10
HGNC: HGNC:2771
Homologene: 20453
Fmn1
Name: formin 1
Synonyms: formin-1, Fmn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14260
HGNC: HGNC:3768
Homologene: 121778
Suox
Name: sulfite oxidase
Synonyms: SO
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 211389
VEGA: 10
Homologene: 394
Gstm2
Name: glutathione S-transferase, mu 2
Synonyms: Gstb-2, Gstb2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14863
Homologene: 121492
Neurl1b
Name: neuralized E3 ubiquitin protein ligase 1B
Synonyms: Neur2, C230078M08Rik, EG240055
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240055
Homologene: 35443
Or7e165
Name: olfactory receptor family 7 subfamily E member 165
Synonyms: IG6, MOR146-3, Olfr58, GA_x6K02T2PVTD-13523015-13523944, MOR146-7P
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 18358
Homologene: 134093
Foxe1
Name: forkhead box E1
Synonyms: thyroid transcription factor 2, Titf2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 110805
HGNC: HGNC:3806
Homologene: 3291
Aloxe3
Name: arachidonate lipoxygenase 3
Synonyms: e-LOX-3
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 23801
Homologene: 8013
Or6c203
Name: olfactory receptor family 6 subfamily C member 203
Synonyms: MOR114-3, Olfr772, GA_x6K02T2PULF-10860457-10859522
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 257666
Homologene: 123776
Nectin4
Name: nectin cell adhesion molecule 4
Synonyms: Pvrl4, nectin 4, Prr4, 1200017F15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71740
Homologene: 32744
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 171,380,259 bp
  • T to A, chromosome 2 at 67,512,177 bp
  • T to A, chromosome 2 at 113,365,477 bp
  • T to A, chromosome 2 at 163,728,191 bp
  • T to C, chromosome 2 at 166,093,596 bp
  • A to G, chromosome 2 at 181,995,918 bp
  • G to T, chromosome 3 at 55,717,779 bp
  • T to G, chromosome 3 at 107,985,676 bp
  • C to T, chromosome 3 at 121,992,812 bp
  • A to G, chromosome 3 at 123,447,396 bp
  • A to G, chromosome 4 at 41,118,717 bp
  • C to A, chromosome 4 at 46,344,545 bp
  • G to A, chromosome 4 at 97,783,505 bp
  • A to G, chromosome 4 at 98,518,942 bp
  • A to T, chromosome 5 at 6,769,362 bp
  • T to C, chromosome 5 at 90,463,991 bp
  • T to C, chromosome 5 at 96,692,624 bp
  • C to A, chromosome 5 at 113,253,024 bp
  • T to C, chromosome 5 at 135,132,370 bp
  • T to A, chromosome 6 at 40,659,010 bp
  • G to A, chromosome 6 at 90,570,862 bp
  • T to C, chromosome 7 at 30,583,231 bp
  • A to G, chromosome 7 at 140,296,321 bp
  • C to T, chromosome 8 at 15,917,273 bp
  • G to A, chromosome 8 at 84,697,551 bp
  • A to T, chromosome 9 at 4,462,029 bp
  • A to G, chromosome 9 at 19,783,543 bp
  • G to A, chromosome 10 at 5,061,531 bp
  • G to T, chromosome 10 at 5,815,620 bp
  • A to T, chromosome 10 at 79,549,676 bp
  • G to A, chromosome 10 at 79,891,613 bp
  • T to C, chromosome 10 at 128,670,911 bp
  • A to G, chromosome 10 at 129,174,259 bp
  • G to A, chromosome 11 at 60,722,664 bp
  • A to G, chromosome 11 at 69,135,120 bp
  • A to T, chromosome 11 at 69,169,341 bp
  • T to C, chromosome 12 at 28,711,958 bp
  • A to G, chromosome 12 at 81,990,551 bp
  • T to A, chromosome 13 at 12,411,262 bp
  • G to T, chromosome 13 at 38,484,920 bp
  • T to C, chromosome 13 at 56,128,333 bp
  • A to T, chromosome 13 at 111,439,124 bp
  • T to C, chromosome 14 at 50,777,330 bp
  • G to A, chromosome 15 at 76,120,568 bp
  • A to G, chromosome 15 at 76,451,848 bp
  • T to G, chromosome 16 at 9,992,463 bp
  • C to T, chromosome 16 at 38,828,091 bp
  • C to A, chromosome 17 at 24,513,308 bp
  • C to G, chromosome 17 at 26,438,746 bp
  • C to T, chromosome 17 at 28,201,041 bp
  • C to T, chromosome 17 at 45,520,295 bp
  • T to A, chromosome 19 at 55,924,543 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7669 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045741-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.