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Strain Name:
C57BL/6J-MtgxR7680Btlr/Mmmh
Stock Number:
045746-MU
Citation ID:
RRID:MMRRC_045746-MU
Other Names:
R7680 (G1)
Major Collection:

Strain Information

Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
2510002D24Rik
Name: RIKEN cDNA 2510002D24 gene
Synonyms: Pants
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72307
Homologene: 72515
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: D2Bwg1005e, 9130020K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74569
Homologene: 10100
Gphn
Name: gephyrin
Synonyms: geph, 5730552E08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268566
VEGA: 12
Homologene: 10820
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: C87618, 4930570G11Rik, 2600010B19Rik, 3110050K21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67302
VEGA: 14
Stat1
Name: signal transducer and activator of transcription 1
Synonyms: 2010005J02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20846
Homologene: 21428
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 52,144,209 bp
  • T to C, chromosome 1 at 75,247,893 bp
  • G to T, chromosome 1 at 136,147,869 bp
  • A to G, chromosome 1 at 181,685,800 bp
  • T to A, chromosome 2 at 85,059,241 bp
  • C to T, chromosome 2 at 94,366,544 bp
  • T to C, chromosome 2 at 101,610,556 bp
  • A to G, chromosome 2 at 132,862,338 bp
  • A to G, chromosome 3 at 153,205,410 bp
  • A to T, chromosome 4 at 26,340,649 bp
  • C to A, chromosome 4 at 41,497,978 bp
  • T to A, chromosome 4 at 43,507,250 bp
  • A to G, chromosome 4 at 49,521,547 bp
  • T to C, chromosome 4 at 62,496,591 bp
  • T to C, chromosome 4 at 88,755,130 bp
  • T to G, chromosome 4 at 150,929,938 bp
  • A to C, chromosome 4 at 154,016,101 bp
  • A to G, chromosome 4 at 154,156,622 bp
  • A to T, chromosome 6 at 3,372,569 bp
  • A to G, chromosome 6 at 3,376,469 bp
  • T to A, chromosome 6 at 58,435,299 bp
  • T to A, chromosome 7 at 4,338,124 bp
  • T to C, chromosome 7 at 25,292,431 bp
  • A to G, chromosome 7 at 86,954,941 bp
  • A to T, chromosome 7 at 112,119,363 bp
  • A to T, chromosome 7 at 114,552,819 bp
  • A to G, chromosome 7 at 116,164,276 bp
  • G to C, chromosome 7 at 141,637,746 bp
  • T to C, chromosome 8 at 13,167,812 bp
  • G to T, chromosome 8 at 22,772,232 bp
  • T to A, chromosome 8 at 45,941,651 bp
  • A to T, chromosome 8 at 116,894,110 bp
  • A to C, chromosome 8 at 121,907,267 bp
  • T to A, chromosome 9 at 53,808,112 bp
  • T to C, chromosome 9 at 58,860,671 bp
  • T to A, chromosome 9 at 109,100,503 bp
  • T to C, chromosome 9 at 123,183,519 bp
  • G to T, chromosome 10 at 21,007,768 bp
  • A to T, chromosome 10 at 64,487,550 bp
  • T to C, chromosome 10 at 125,230,936 bp
  • T to C, chromosome 11 at 69,856,745 bp
  • T to C, chromosome 11 at 119,479,556 bp
  • C to A, chromosome 12 at 78,412,374 bp
  • T to C, chromosome 12 at 111,646,773 bp
  • A to G, chromosome 13 at 105,445,031 bp
  • A to G, chromosome 14 at 19,779,647 bp
  • T to A, chromosome 14 at 54,282,380 bp
  • C to A, chromosome 14 at 54,948,733 bp
  • C to T, chromosome 14 at 75,330,515 bp
  • A to G, chromosome 15 at 75,981,207 bp
  • A to G, chromosome 16 at 18,839,208 bp
  • A to T, chromosome 16 at 58,717,965 bp
  • T to C, chromosome 17 at 37,483,025 bp
  • A to G, chromosome 17 at 80,581,876 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7680 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045746-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.