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Strain Name:
C57BL/6J-MtgxR7680Btlr/Mmmh
Stock Number:
045746-MU
Citation ID:
RRID:MMRRC_045746-MU
Other Names:
R7680 (G1)
Major Collection:

Strain Information

Plekha7
Name: pleckstrin homology domain containing, family A member 7
Synonyms: A430081P20Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233765
Homologene: 52172
2510002D24Rik
Name: RIKEN cDNA 2510002D24 gene
Synonyms: Pants
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 72307
Homologene: 72515
Hcn4
Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 330953
VEGA: 9
Homologene: 3997
Ttc17
Name: tetratricopeptide repeat domain 17
Synonyms: D2Bwg1005e, 9130020K17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74569
Homologene: 10100
Gphn
Name: gephyrin
Synonyms: geph, 5730552E08Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 268566
VEGA: 12
Homologene: 10820
Zc3h13
Name: zinc finger CCCH type containing 13
Synonyms: C87618, 4930570G11Rik, 2600010B19Rik, 3110050K21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 67302
VEGA: 14
Stat1
Name: signal transducer and activator of transcription 1
Synonyms: 2010005J02Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20846
Homologene: 21428
Mark3
Name: MAP/microtubule affinity regulating kinase 3
Synonyms: ETK-1, 1600015G02Rik, A430080F22Rik, C-TAK1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17169
VEGA: 12
HGNC: HGNC:6897
Homologene: 55653
Dkk3
Name: dickkopf WNT signaling pathway inhibitor 3
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 50781
HGNC: HGNC:2893
Homologene: 8303
Ahi1
Name: Abelson helper integration site 1
Synonyms: Ahi-1, 1700015F03Rik, D10Bwg0629e, Jouberin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 52906
VEGA: 10
Homologene: 9762
Tnfrsf9
Name: tumor necrosis factor receptor superfamily, member 9
Synonyms: 4-1BB, CDw137, Ly63, Cd137, ILA, A930040I11Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 21942
Homologene: 1199
Htr1a
Name: 5-hydroxytryptamine (serotonin) receptor 1A
Synonyms: 5-HT1A receptor, Gpcr18
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15550
VEGA: 13
HGNC: HGNC:5286
Homologene: 20148
Cic
Name: capicua transcriptional repressor
Synonyms: 1200010B10Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 71722
Homologene: 87637
St6galnac3
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
Synonyms: ST6GalNAc III, Siat7c
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20447
Homologene: 7938
Ncr1
Name: natural cytotoxicity triggering receptor 1
Synonyms: NKp46, MAR1 (mouse activating receptor 1), Ly94, Cd335
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17086
HGNC: HGNC:6731
Homologene: 3551
Car9
Name: carbonic anhydrase 9
Synonyms: CAIX, MN/CA9
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230099
HGNC: HGNC:1383
Homologene: 20325
Cdcp1
Name: CUB domain containing protein 1
Synonyms: 9030022E12Rik, E030027H19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 109332
Homologene: 11276
Nid2
Name: nidogen 2
Synonyms: entactin-2, entactin 2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18074
VEGA: 14
Homologene: 40575
Lrrc47
Name: leucine rich repeat containing 47
Synonyms: 2900010D03Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 72946
Homologene: 10795
Map4k3
Name: mitogen-activated protein kinase kinase kinase kinase 3
Synonyms: 9530052P13Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 225028
VEGA: 17
HGNC: HGNC:6865
Homologene: 2683
Tnks1bp1
Name: tankyrase 1 binding protein 1
Synonyms: TAB182
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228140
Homologene: 14117
Slc7a5
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5
Synonyms: TA1, D0H16S474E, LAT1, Gm42049
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 20539
Homologene: 55759
Cyp2r1
Name: cytochrome P450, family 2, subfamily r, polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244209
Homologene: 75210
Myh6
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha
Synonyms: alpha myosin, Myhc-a, alpha cardiac MHC, cardiomyopathy, hypertrophic 1, Myhca, A830009F23Rik, alpha-MHC, alphaMHC
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17888
HGNC: HGNC:7576
Homologene: 124414
Rnf213
Name: ring finger protein 213
Synonyms: D11Ertd759e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 672511
Homologene: 45439
Dnah14
Name: dynein, axonemal, heavy chain 14
Synonyms: LOC381311, A230079K17Rik, Gm980, Dnahc14
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240960
HGNC: HGNC:2945
Homologene: 90078
Vmn2r78
Name: vomeronasal 2, receptor 78
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 637896
Homologene: 115466
Bspry
Name: B-box and SPRY domain containing
Synonyms: zetin 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 192120
Homologene: 9781
Slc16a7
Name: solute carrier family 16 (monocarboxylic acid transporters), member 7
Synonyms: MCT2, 4921534N07Rik, D630004K10Rik, 9030411M13Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20503
Homologene: 20990
Ccdc110
Name: coiled-coil domain containing 110
Synonyms: LOC212392
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 212392
Homologene: 17668
Ptprn
Name: protein tyrosine phosphatase receptor type N
Synonyms: IA-2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 19275
HGNC: HGNC:9676
Homologene: 48142
Manea
Name: mannosidase, endo-alpha
Synonyms: 4932703L02Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242362
Homologene: 11636
Lamp1
Name: lysosomal-associated membrane protein 1
Synonyms: CD107a, Lamp-1, Perk
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16783
HGNC: HGNC:6499
Homologene: 4061
Samd9l
Name: sterile alpha motif domain containing 9-like
Synonyms: ESTM25
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 209086
HGNC: HGNC:1349
Homologene: 7707
Plxnb1
Name: plexin B1
Synonyms: 2900002G15Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235611
HGNC: HGNC:9103
Homologene: 130508
Wrap73
Name: WD repeat containing, antisense to Trp73
Synonyms: DD57, 2610044M17Rik, 5330425N03Rik, Wdr8
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 59002
Homologene: 9857
H2-M2
Name: histocompatibility 2, M region locus 2
Synonyms: H-2M2, Thy19.4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 14990
Homologene: 133732
Kif21b
Name: kinesin family member 21B
Synonyms: N-5 kinesin, 2610511N21Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 16565
Homologene: 56868
Iftap
Name: intraflagellar transport associated protein
Synonyms: NWC, B230118H07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68170
Homologene: 16348
Tnk1
Name: tyrosine kinase, non-receptor, 1
Synonyms: Tnk1b, Tnk1a, Kos1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 83813
Homologene: 2966
Myorg
Name: myogenesis regulating glycosidase (putative)
Synonyms: NET37, AI464131
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329828
Homologene: 19853
Ctnna3
Name: catenin alpha 3
Synonyms: Vr22, Catna3, 4930429L08Rik, alphaT-catenin, catenin (cadherin associated protein), alpha 3
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216033
HGNC: HGNC:2511
Homologene: 56583
Vmn1r30
Name: vomeronasal 1 receptor 30
Synonyms: V1rc9, V1rc22
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 171195
Homologene: 137652
Slc35f2
Name: solute carrier family 35, member F2
Synonyms: 1500009K05Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72022
VEGA: 9
Homologene: 36363
Plat
Name: plasminogen activator, tissue
Synonyms: t-PA, tPA, D8Ertd2e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18791
HGNC: HGNC:9051
Homologene: 717
Cmc2
Name: C-X9-C motif containing 2
Synonyms: 1110046L09Rik, 2310061C15Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66531
Homologene: 41350
Gpr15
Name: G protein-coupled receptor 15
Synonyms: 4933439K08Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 71223
VEGA: 16
HGNC: HGNC:4469
Homologene: 3869
Zfp189
Name: zinc finger protein 189
Synonyms: C430015I23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230162
Homologene: 20737
Or6e1
Name: olfactory receptor family 6 subfamily E member 1
Synonyms: IC6, GA_x6K02T2QVSB-39745261-39746202, MOR118-1, Olfr49
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18348
Homologene: 106373
Ccdc166
Name: coiled-coil domain containing 166
Synonyms: 2410075B13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223648
Homologene: 109421
Crls1
Name: cardiolipin synthase 1
Synonyms: 5730490M08Rik, 4930557M15Rik, 0610009I22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66586
Homologene: 32438
Gm13271
Name: predicted gene 13271
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 435791
Homologene: 45671
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 52,144,209 bp
  • T to C, chromosome 1 at 75,247,893 bp
  • G to T, chromosome 1 at 136,147,869 bp
  • A to G, chromosome 1 at 181,685,800 bp
  • T to A, chromosome 2 at 85,059,241 bp
  • C to T, chromosome 2 at 94,366,544 bp
  • T to C, chromosome 2 at 101,610,556 bp
  • A to G, chromosome 2 at 132,862,338 bp
  • A to G, chromosome 3 at 153,205,410 bp
  • A to T, chromosome 4 at 26,340,649 bp
  • C to A, chromosome 4 at 41,497,978 bp
  • T to A, chromosome 4 at 43,507,250 bp
  • A to G, chromosome 4 at 49,521,547 bp
  • T to C, chromosome 4 at 62,496,591 bp
  • T to C, chromosome 4 at 88,755,130 bp
  • T to G, chromosome 4 at 150,929,938 bp
  • A to C, chromosome 4 at 154,016,101 bp
  • A to G, chromosome 4 at 154,156,622 bp
  • A to T, chromosome 6 at 3,372,569 bp
  • A to G, chromosome 6 at 3,376,469 bp
  • T to A, chromosome 6 at 58,435,299 bp
  • T to A, chromosome 7 at 4,338,124 bp
  • T to C, chromosome 7 at 25,292,431 bp
  • A to G, chromosome 7 at 86,954,941 bp
  • A to T, chromosome 7 at 112,119,363 bp
  • A to T, chromosome 7 at 114,552,819 bp
  • A to G, chromosome 7 at 116,164,276 bp
  • G to C, chromosome 7 at 141,637,746 bp
  • T to C, chromosome 8 at 13,167,812 bp
  • G to T, chromosome 8 at 22,772,232 bp
  • T to A, chromosome 8 at 45,941,651 bp
  • A to T, chromosome 8 at 116,894,110 bp
  • A to C, chromosome 8 at 121,907,267 bp
  • T to A, chromosome 9 at 53,808,112 bp
  • T to C, chromosome 9 at 58,860,671 bp
  • T to A, chromosome 9 at 109,100,503 bp
  • T to C, chromosome 9 at 123,183,519 bp
  • G to T, chromosome 10 at 21,007,768 bp
  • A to T, chromosome 10 at 64,487,550 bp
  • T to C, chromosome 10 at 125,230,936 bp
  • T to C, chromosome 11 at 69,856,745 bp
  • T to C, chromosome 11 at 119,479,556 bp
  • C to A, chromosome 12 at 78,412,374 bp
  • T to C, chromosome 12 at 111,646,773 bp
  • A to G, chromosome 13 at 105,445,031 bp
  • A to G, chromosome 14 at 19,779,647 bp
  • T to A, chromosome 14 at 54,282,380 bp
  • C to A, chromosome 14 at 54,948,733 bp
  • C to T, chromosome 14 at 75,330,515 bp
  • A to G, chromosome 15 at 75,981,207 bp
  • A to G, chromosome 16 at 18,839,208 bp
  • A to T, chromosome 16 at 58,717,965 bp
  • T to C, chromosome 17 at 37,483,025 bp
  • A to G, chromosome 17 at 80,581,876 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7680 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045746-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.