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Strain Name:
C57BL/6J-MtgxR7691Btlr/Mmmh
Stock Number:
045755-MU
Citation ID:
RRID:MMRRC_045755-MU
Other Names:
R7691 (G1)
Major Collection:

Strain Information

Dock1
Name: dedicator of cytokinesis 1
Synonyms: D630004B07Rik, 9130006G06Rik, Dock180, b2b3190Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 330662
HGNC: HGNC:2987
Homologene: 55575
Crybg3
Name: beta-gamma crystallin domain containing 3
Synonyms: Gm9581
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224273
Homologene: 28544
Mllt10
Name: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10
Synonyms: Af10, B130021D15Rik, D630001B22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17354
Homologene: 20973
Brpf3
Name: bromodomain and PHD finger containing, 3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268936
Homologene: 16092
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Zfp294, Listerin, Rnf160
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Mtcl1
Name: microtubule crosslinking factor 1
Synonyms: t8219b25, 1110012J17Rik, Soga2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68617
Homologene: 41017
Herc2
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 2
Synonyms: D7H15F32S1, D15F32S1h, D7H15F37S1, rjs, jdf2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 15204
HGNC: HGNC:4868
Homologene: 3430
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • TC to T, chromosome 1 at 74,486,760 bp
  • G to A, chromosome 1 at 85,579,092 bp
  • T to C, chromosome 1 at 118,309,775 bp
  • T to C, chromosome 1 at 136,293,004 bp
  • C to A, chromosome 1 at 189,658,207 bp
  • A to G, chromosome 2 at 18,203,611 bp
  • G to C, chromosome 2 at 18,203,612 bp
  • T to C, chromosome 2 at 27,010,094 bp
  • T to A, chromosome 2 at 27,297,738 bp
  • T to A, chromosome 2 at 53,101,498 bp
  • A to G, chromosome 2 at 68,471,639 bp
  • A to G, chromosome 2 at 120,729,567 bp
  • G to A, chromosome 2 at 144,506,171 bp
  • G to T, chromosome 3 at 45,381,197 bp
  • A to G, chromosome 3 at 89,099,367 bp
  • A to T, chromosome 3 at 96,188,411 bp
  • T to A, chromosome 3 at 133,486,849 bp
  • A to G, chromosome 4 at 32,580,271 bp
  • A to G, chromosome 4 at 107,273,689 bp
  • C to T, chromosome 6 at 5,175,819 bp
  • A to T, chromosome 6 at 48,484,229 bp
  • A to T, chromosome 6 at 92,796,238 bp
  • C to T, chromosome 7 at 4,944,169 bp
  • T to A, chromosome 7 at 10,159,182 bp
  • T to C, chromosome 7 at 45,735,284 bp
  • C to T, chromosome 7 at 56,191,845 bp
  • T to A, chromosome 7 at 84,943,643 bp
  • A to G, chromosome 7 at 87,037,903 bp
  • C to T, chromosome 7 at 99,336,292 bp
  • G to A, chromosome 7 at 100,929,642 bp
  • T to C, chromosome 7 at 126,492,610 bp
  • G to A, chromosome 7 at 126,551,990 bp
  • G to A, chromosome 7 at 135,138,157 bp
  • C to T, chromosome 7 at 135,701,992 bp
  • T to C, chromosome 8 at 4,234,534 bp
  • A to T, chromosome 8 at 71,620,754 bp
  • T to C, chromosome 8 at 109,721,239 bp
  • T to A, chromosome 9 at 64,156,091 bp
  • T to C, chromosome 9 at 95,773,673 bp
  • T to A, chromosome 10 at 24,091,538 bp
  • T to C, chromosome 10 at 27,208,393 bp
  • A to T, chromosome 11 at 43,583,201 bp
  • A to G, chromosome 11 at 53,537,587 bp
  • A to T, chromosome 11 at 57,236,987 bp
  • T to C, chromosome 12 at 4,206,540 bp
  • C to A, chromosome 12 at 91,497,741 bp
  • G to A, chromosome 13 at 21,142,970 bp
  • A to T, chromosome 13 at 75,878,937 bp
  • T to C, chromosome 14 at 101,507,641 bp
  • A to G, chromosome 15 at 47,741,173 bp
  • C to A, chromosome 15 at 63,893,791 bp
  • A to G, chromosome 16 at 57,572,433 bp
  • A to G, chromosome 16 at 59,556,134 bp
  • G to T, chromosome 16 at 87,398,686 bp
  • G to C, chromosome 17 at 28,806,831 bp
  • T to A, chromosome 17 at 57,194,024 bp
  • A to G, chromosome 17 at 66,380,357 bp
  • A to G, chromosome 17 at 71,716,410 bp
  • C to T, chromosome 18 at 61,061,268 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7691 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045755-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.