Strain Name:
C57BL/6J-MtgxR7702Btlr/Mmmh
Stock Number:
045763-MU
Citation ID:
RRID:MMRRC_045763-MU
Other Names:
R7702 (G1)
Major Collection:

Strain Information

Pkp4
Name: plakophilin 4
Synonyms: Armrp, 5031422I09Rik, 9430019K17Rik, p0071
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227937
HGNC: HGNC:9026
Homologene: 2689
Ltn1
Name: listerin E3 ubiquitin protein ligase 1
Synonyms: 4930528H02Rik, Listerin, Zfp294, Rnf160
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 78913
VEGA: 16
Homologene: 32272
Ell
Name: elongation factor RNA polymerase II
Synonyms: eleven-nineteen lysine-rich leukemia gene, Men, Ell1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 13716
Homologene: 4762
Trappc8
Name: trafficking protein particle complex 8
Synonyms: 5033403J15Rik, Trs85, D030074E01Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75964
VEGA: 18
Homologene: 40993
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: Tw, Zfhx1a, Zfx1a, Zfhep, Tcf18, MEB1, Nil2, 3110032K11Rik, Tcf8, AREB6, ZEB, [delta]EF1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21417
Homologene: 31779
Banp
Name: BTG3 associated nuclear protein
Synonyms: SMAR1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 53325
Homologene: 9635
Dbnl
Name: drebrin-like
Synonyms: mAbp1, SH3P7, ABP1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 13169
HGNC: HGNC:2696
Homologene: 8468
Ralgapa1
Name: Ral GTPase activating protein, alpha subunit 1
Synonyms: Garnl1, Tulip1, 4930400K19Rik, 2310003F20Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 56784
VEGA: 12
Homologene: 84805
Syne1
Name: spectrin repeat containing, nuclear envelope 1
Synonyms: enaptin165, nesprin-1, A330049M09Rik, C130039F11Rik, SYNE-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 64009
VEGA: 10
Homologene: 52329
Ryr2
Name: ryanodine receptor 2, cardiac
Synonyms: 9330127I20Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20191
VEGA: 13
Homologene: 37423
Dsp
Name: desmoplakin
Synonyms: 5730453H04Rik, DP, rul, 2300002E22Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 109620
HGNC: HGNC:3052
Homologene: 37922
Cux2
Name: cut-like homeobox 2
Synonyms: Cutl2, Cux-2, 1700051K22Rik, Cux2, ENSMUSG00000072641
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13048
Homologene: 22426
Sqstm1
Name: sequestosome 1
Synonyms: OSF-6, p62, Osi, STAP, A170
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18412
Homologene: 31202
Tmem183a
Name: transmembrane protein 183A
Synonyms: 1300007B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 57439
Homologene: 10757
Nob1
Name: NIN1/RPN12 binding protein 1 homolog
Synonyms: Nob1p, Psmd8bp1, 1700021I09Rik, ART-4
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67619
Homologene: 31924
Ino80
Name: INO80 complex subunit
Synonyms: 2310079N15Rik, INO80, Inoc1, 4632409L19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 68142
Homologene: 75070
AU040320
Name: expressed sequence AU040320
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100317
Homologene: 11764
Bloc1s5
Name: biogenesis of lysosomal organelles complex-1, subunit 5, muted
Synonyms: BLOC-1 subunit, 1810074A19Rik, mu, Muted
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 17828
VEGA: 13
Homologene: 16374
Tmtc1
Name: transmembrane and tetratricopeptide repeat containing 1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387314
Homologene: 65299
Dnah1
Name: dynein, axonemal, heavy chain 1
Synonyms: E030034C22Rik, Dnahc1, G1-415-19, MDHC7, ferf1, B230373P09Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110084
VEGA: 14
HGNC: HGNC:2940
Homologene: 67131
Cacna1c
Name: calcium channel, voltage-dependent, L type, alpha 1C subunit
Synonyms: D930026N18Rik, (alpha)1 subunit, Cchl1a1, Cav1.2, L-type Cav1.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12288
HGNC: HGNC:1390
Homologene: 55484
Hmbs
Name: hydroxymethylbilane synthase
Synonyms: Uros1, Ups, PBGD, porphobilinogen deaminase
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 15288
VEGA: 9
HGNC: HGNC:4982
Homologene: 158
Syne2
Name: spectrin repeat containing, nuclear envelope 2
Synonyms: nesprin-2, D12Ertd777e, diminished cone electroretinogram, Cpfl8, Nesp2g, dice, syne-2, 6820443O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 319565
Homologene: 56700
Col12a1
Name: collagen, type XII, alpha 1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 12816
HGNC: HGNC:2188
Homologene: 3217
Dnah17
Name: dynein, axonemal, heavy chain 17
Synonyms: LOC382552, Dnahcl1, Dnahc17, 2810003K23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69926
HGNC: HGNC:2946
Homologene: 72102
Slc6a18
Name: solute carrier family 6 (neurotransmitter transporter), member 18
Synonyms: Xtrp2, XT2, D630001K16Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 22598
VEGA: 13
Homologene: 40785
Jakmip1
Name: janus kinase and microtubule interacting protein 1
Synonyms: Gababrbp, Marlin-1, 5830437M04Rik, C330021K24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76071
Homologene: 90789
Flg
Name: filaggrin
Synonyms: ft, fillagrin, profilaggrin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14246
VEGA: 3
Duox1
Name: dual oxidase 1
Synonyms: 9930101G15Rik, NOXEF1, THOX1, LNOX1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Tshz1
Name: teashirt zinc finger family member 1
Synonyms: 5730407I04Rik, Mtsh1, D18Bwg1409e, teashirt1, Tsh1, NY-CO-33, Sdccag33
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 110796
Homologene: 4227
Dpp6
Name: dipeptidylpeptidase 6
Synonyms: In(5)6H-p, LOC384168, Rw, Dpp-6, B930011P16Rik, Peplb
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 13483
HGNC: HGNC:3010
Homologene: 22560
Vmn2r63
Name: vomeronasal 2, receptor 63
Synonyms: EG435975
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 435975
Homologene: 104832
Or11g25
Name: olfactory receptor family 11 subfamily G member 25
Synonyms: Olfr741, GA_x6K02T2PMLR-6197851-6198786, MOR106-15, MOR106-10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258233
Filip1
Name: filamin A interacting protein 1
Synonyms: FILIP, 5730485H21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 70598
Homologene: 6700
Abca5
Name: ATP-binding cassette, sub-family A member 5
Synonyms: B930033A02Rik, ABC13
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217265
HGNC: HGNC:35
Homologene: 10263
Jade2
Name: jade family PHD finger 2
Synonyms: 1200017K05Rik, Phf15
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76901
Homologene: 9082
Megf6
Name: multiple EGF-like-domains 6
Synonyms: Egfl3, 2600001P17Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230971
HGNC: HGNC:3232
Homologene: 45412
Tecpr1
Name: tectonin beta-propeller repeat containing 1
Synonyms: 2210010N04Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 70381
Homologene: 9120
Map3k19
Name: mitogen-activated protein kinase kinase kinase 19
Synonyms: Ysk4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 22625
Homologene: 19318
Ctsf
Name: cathepsin F
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56464
VEGA: 19
HGNC: HGNC:2531
Homologene: 31194
Fndc7
Name: fibronectin type III domain containing 7
Synonyms: E230011A21Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 320181
Homologene: 18551
Or5ac22
Name: olfactory receptor family 5 subfamily AC member 22
Synonyms: Olfr204, MOR182-3, GA_x54KRFPKG5P-55529713-55528796
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258994
Homologene: 79425
Ipo4
Name: importin 4
Synonyms: 8430408O15Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75751
Homologene: 5835
Cd48
Name: CD48 antigen
Synonyms: BLAST-1, Sgp-60, Bcm-1, BCM1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12506
HGNC: HGNC:1683
Homologene: 1347
Pebp4
Name: phosphatidylethanolamine binding protein 4
Synonyms: 1700081D17Rik, 1700051A02Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 73523
VEGA: 14
Homologene: 51650
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Ggt1
Name: gamma-glutamyltransferase 1
Synonyms: Ggtp, CD224, dwg, GGT
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14598
Homologene: 68450
Klk6
Name: kallikrein related-peptidase 6
Synonyms: Prss18, protease M, Bssp, Prss9, Klk29, neurosin
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 19144
HGNC: HGNC:6367
Homologene: 68279
Or1e19
Name: olfactory receptor family 1 subfamily E member 19
Synonyms: MOR135-2, Olfr378, GA_x6K02T2P1NL-3586282-3585338
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 259026
Homologene: 74110
Cela3a
Name: chymotrypsin-like elastase family, member 3A
Synonyms: Gm13011
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242711
Homologene: 129880
Ccdc121rt3
Name: coiled-coil domain containing 121, retrogene 3
Synonyms: Gm6583
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 625424
Homologene: 116059
Pcdh1
Name: protocadherin 1
Synonyms: 2010005A06Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 75599
HGNC: HGNC:8655
Homologene: 12613
Mylk4
Name: myosin light chain kinase family, member 4
Synonyms: EG238564
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238564
Homologene: 66243
Gm4952
Name: predicted gene 4952
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240549
Homologene: 72602
Prr5l
Name: proline rich 5 like
Synonyms: 2600010E01Rik, 4833411O04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72446
Homologene: 11753
Mmp21
Name: matrix metallopeptidase 21
Synonyms: b2b2458Clo, b2b873Clo
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 214766
Homologene: 17519
Nckipsd
Name: NCK interacting protein with SH3 domain
Synonyms: WISH, ORF1, AF3P21, SPIN90, DIP1, Wasbp
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 80987
Homologene: 9514
Vmn1r123
Name: vomeronasal 1 receptor 123
Synonyms: Gm1446, LOC384695
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384695
Homologene: 104166
Golim4
Name: golgi integral membrane protein 4
Synonyms: P138, 3110027H23Rik, Golph4, GPP130
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73124
Homologene: 8716
Cidec
Name: cell death-inducing DFFA-like effector c
Synonyms: CIDE-3, CIDE-3alpha, Fsp27
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14311
Homologene: 11128
H3c13
Name: H3 clustered histone 13
Synonyms: Hist2h3b, H3-616
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319154
Homologene: 136775
Fer1l5
Name: fer-1 like family member 5
Synonyms: 4930533C12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100534273
Homologene: 85232
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 36,420,694 bp
  • G to T, chromosome 1 at 127,829,090 bp
  • T to C, chromosome 1 at 134,360,801 bp
  • A to G, chromosome 1 at 171,695,780 bp
  • T to C, chromosome 2 at 59,308,413 bp
  • T to A, chromosome 2 at 101,717,097 bp
  • T to C, chromosome 2 at 119,442,573 bp
  • T to C, chromosome 2 at 122,329,639 bp
  • A to T, chromosome 3 at 75,886,784 bp
  • A to T, chromosome 3 at 93,292,782 bp
  • C to A, chromosome 3 at 96,268,993 bp
  • G to T, chromosome 3 at 108,862,813 bp
  • T to A, chromosome 4 at 126,814,373 bp
  • A to G, chromosome 4 at 137,408,190 bp
  • G to A, chromosome 4 at 154,270,470 bp
  • T to A, chromosome 5 at 27,652,276 bp
  • C to T, chromosome 5 at 37,117,497 bp
  • T to C, chromosome 5 at 112,355,197 bp
  • T to C, chromosome 5 at 121,868,585 bp
  • A to G, chromosome 5 at 144,203,418 bp
  • CAAAGTAA to CAAAGTAAAGTAA, chromosome 6 at 113,399,157 bp
  • A to G, chromosome 6 at 113,434,454 bp
  • A to G, chromosome 6 at 118,598,766 bp
  • A to T, chromosome 6 at 148,443,917 bp
  • A to C, chromosome 7 at 21,162,377 bp
  • A to T, chromosome 7 at 42,928,129 bp
  • T to C, chromosome 7 at 43,829,265 bp
  • A to G, chromosome 7 at 133,679,062 bp
  • C to A, chromosome 8 at 70,539,714 bp
  • G to A, chromosome 8 at 107,413,105 bp
  • T to A, chromosome 8 at 121,978,587 bp
  • A to C, chromosome 9 at 44,336,850 bp
  • C to G, chromosome 9 at 79,681,521 bp
  • G to T, chromosome 9 at 79,820,649 bp
  • A to T, chromosome 9 at 108,814,017 bp
  • T to C, chromosome 10 at 5,245,835 bp
  • A to G, chromosome 10 at 75,576,282 bp
  • C to T, chromosome 11 at 5,798,048 bp
  • T to G, chromosome 11 at 50,206,105 bp
  • C to T, chromosome 11 at 51,816,917 bp
  • T to A, chromosome 11 at 73,433,349 bp
  • A to G, chromosome 11 at 110,276,452 bp
  • T to C, chromosome 11 at 118,025,640 bp
  • T to C, chromosome 11 at 118,121,478 bp
  • C to G, chromosome 12 at 55,709,555 bp
  • T to A, chromosome 12 at 55,709,556 bp
  • A to G, chromosome 12 at 75,990,387 bp
  • T to C, chromosome 13 at 11,690,333 bp
  • C to T, chromosome 13 at 32,720,602 bp
  • C to T, chromosome 13 at 38,175,207 bp
  • T to C, chromosome 13 at 38,603,874 bp
  • A to T, chromosome 13 at 73,672,796 bp
  • C to A, chromosome 14 at 31,310,909 bp
  • A to G, chromosome 14 at 50,486,294 bp
  • A to C, chromosome 14 at 55,632,330 bp
  • T to A, chromosome 14 at 70,059,607 bp
  • A to G, chromosome 16 at 59,314,634 bp
  • A to T, chromosome 16 at 87,426,278 bp
  • T to C, chromosome 18 at 5,766,802 bp
  • C to T, chromosome 18 at 20,825,062 bp
  • A to G, chromosome 18 at 38,203,516 bp
  • A to G, chromosome 18 at 84,014,336 bp
  • T to G, chromosome 19 at 4,856,539 bp
  • A to T, chromosome 19 at 12,627,064 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7702 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045763-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.