Strain Name:
C57BL/6J-MtgxR7703Btlr/Mmmh
Stock Number:
045764-MU
Citation ID:
RRID:MMRRC_045764-MU
Other Names:
R7703 (G1)
Major Collection:

Strain Information

Chrna3
Name: cholinergic receptor, nicotinic, alpha polypeptide 3
Synonyms: (a)3, alpha 3, neuronal nicotinic acetylcholine receptor, alpha 3 subunit, Acra-3, Acra3, A730007P14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 110834
VEGA: 9
HGNC: HGNC:1957
Homologene: 591
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Aasdh
Name: aminoadipate-semialdehyde dehydrogenase
Synonyms: A230062G08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231326
Homologene: 71711
Zbtb7c
Name: zinc finger and BTB domain containing 7C
Synonyms: B230208J24Rik, Zbtb36, Kr-pok
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 207259
VEGA: 18
Homologene: 17070
Skap2
Name: src family associated phosphoprotein 2
Synonyms: RA70, Saps, mSKAP55R, 2610021A10Rik, SKAP-HOM
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54353
Homologene: 2919
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur-4, Glur4, spkw1, Gluralpha4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Rbpj
Name: recombination signal binding protein for immunoglobulin kappa J region
Synonyms: CBF1, Igkrsbp, RBP-J kappa, RBPjk, Igkjrb, Rbpsuh
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 19664
HGNC: HGNC:5724
Homologene: 7511
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 6430526O11Rik, 2900074J03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Rbm25
Name: RNA binding motif protein 25
Synonyms: 2610015J01Rik, A130095G20Rik, 2600011C06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 67039
Erp44
Name: endoplasmic reticulum protein 44
Synonyms: 1110001E24Rik, Txndc4
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 76299
Homologene: 12638
Diaph1
Name: diaphanous related formin 1
Synonyms: p140mDia, Drf1, Dia1, D18Wsu154e, mDia1, Diap1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13367
HGNC: HGNC:2876
Homologene: 129567
Zeb1
Name: zinc finger E-box binding homeobox 1
Synonyms: Nil2, [delta]EF1, MEB1, Tcf8, Zfx1a, Tcf18, AREB6, ZEB, Zfhep, 3110032K11Rik, Zfhx1a, Tw
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 21417
Homologene: 31779
Mcph1
Name: microcephaly, primary autosomal recessive 1
Synonyms: 5430437K10Rik, BRIT1, D030046N04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 244329
HGNC: HGNC:6954
Homologene: 32586
Cnot1
Name: CCR4-NOT transcription complex, subunit 1
Synonyms: 6030411K04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234594
HGNC: HGNC:7877
Homologene: 9453
Ap3d1
Name: adaptor-related protein complex 3, delta 1 subunit
Synonyms: mBLVR1, Bolvr
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11776
VEGA: 10
HGNC: HGNC:568
Homologene: 2926
Dmxl2
Name: Dmx-like 2
Synonyms: E130119P06Rik, 6430411K14Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235380
HGNC: HGNC:2938
Homologene: 41022
Cacna2d3
Name: calcium channel, voltage-dependent, alpha2/delta subunit 3
Synonyms: alpha 2 delta-3, alpha2delta3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12294
Homologene: 74929
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Olfml1
Name: olfactomedin-like 1
Synonyms: MVAL564, mONT2, ONT2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244198
Homologene: 45688
Rab5a
Name: RAB5A, member RAS oncogene family
Synonyms: 2410015H04Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 271457
VEGA: 17
HGNC: HGNC:9783
Homologene: 68142
Thyn1
Name: thymocyte nuclear protein 1
Synonyms: D730042P09Rik, Thy28
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77862
VEGA: 9
Homologene: 8575
Scamp5
Name: secretory carrier membrane protein 5
Synonyms: Sc5
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 56807
VEGA: 9
Homologene: 56880
Baz2b
Name: bromodomain adjacent to zinc finger domain, 2B
Synonyms: D2Ertd794e, 5830435C13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 407823
HGNC: HGNC:963
Homologene: 8394
Pax1
Name: paired box 1
Synonyms: Pax-1, wt, hbs, hunchback, wavy tail
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18503
HGNC: HGNC:8615
Homologene: 4514
Cdh23
Name: cadherin related 23 (otocadherin)
Synonyms: 4930542A03Rik, USH1D, mdfw, ahl, nmf112, nmf181, nmf252, bob, sals
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22295
Homologene: 11142
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: 1300003D15Rik, Epac2, cAMP-GEFII, 5730402K07Rik, 6330581N18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56508
Homologene: 4451
Ptprq
Name: protein tyrosine phosphatase receptor type Q
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237523
HGNC: HGNC:9679
Homologene: 83557
Myh7b
Name: myosin, heavy chain 7B, cardiac muscle, beta
Synonyms: Myh14
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 668940
Homologene: 66117
Nfatc1
Name: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
Synonyms: NFAT2, NFATc, NF-ATc, 2210017P03Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 18018
VEGA: 18
HGNC: HGNC:7775
Homologene: 32336
Lrp1b
Name: low density lipoprotein-related protein 1B
Synonyms: 9630004P12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 94217
HGNC: HGNC:6693
Homologene: 56810
Ryr3
Name: ryanodine receptor 3
Synonyms: calcium release channel isoform 3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20192
Homologene: 68151
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Ttc21a
Name: tetratricopeptide repeat domain 21A
Synonyms: 4921538N17Rik, Thm2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74052
Homologene: 14728
1810065E05Rik
Name: RIKEN cDNA 1810065E05 gene
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69864
Homologene: 87042
Cytip
Name: cytohesin 1 interacting protein
Synonyms: Cbp, A130053M09Rik, Pscdbp, Cybr
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227929
HGNC: HGNC:9506
Homologene: 3167
Kcnh6
Name: potassium voltage-gated channel, subfamily H (eag-related), member 6
Synonyms: m-erg2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 192775
Homologene: 32740
Col16a1
Name: collagen, type XVI, alpha 1
Synonyms: [a]1 (XVI) collagen, 2700007F12Rik, A530052M23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 107581
HGNC: HGNC:2193
Homologene: 1397
Mep1a
Name: meprin 1 alpha
Synonyms: meprin A alpha-subunit, meprin alpha, Mep-1a, Mep-1, Mep1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17287
HGNC: HGNC:7015
Homologene: 31323
Zfp91
Name: zinc finger protein 91
Synonyms: Pzf, 9130014I08Rik, A530054C17Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109910
Homologene: 43144
Sh3rf2
Name: SH3 domain containing ring finger 2
Synonyms: RNF158, 9130023G24Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 269016
Homologene: 17618
Rgsl1
Name: regulator of G-protein signaling like 1
Synonyms: 4930415K13Rik, Rgsl2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240816
Homologene: 129962
Pcolce
Name: procollagen C-endopeptidase enhancer protein
Synonyms: Astt-2, Astt2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18542
HGNC: HGNC:8738
Homologene: 1946
Fam186a
Name: family with sequence similarity 186, member A
Synonyms: LOC380973, 1700030F18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 72277
Ctsf
Name: cathepsin F
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 56464
VEGA: 19
HGNC: HGNC:2531
Homologene: 31194
Cox11
Name: cytochrome c oxidase assembly protein 11, copper chaperone
Synonyms: 2010004I09Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69802
HGNC: HGNC:2261
Homologene: 3221
Spmap2l
Name: sperm microtubule associated protein 2 like
Synonyms: 1700023E05Rik, Thegl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71868
Homologene: 128474
Or8c11
Name: olfactory receptor family 8 subfamily C member 11
Synonyms: GA_x6K02T2MYUG-9124-8183, MOR170-15, Olfr251, MOR170-13, MOR170-2, GA_x6K02T2PVTD-32071567-32072508, Olfr900
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404313
VEGA: 9
Homologene: 133654
Grsf1
Name: G-rich RNA sequence binding factor 1
Synonyms: D5Wsu31e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231413
HGNC: HGNC:4610
Homologene: 20482
Pcdhb17
Name: protocadherin beta 17
Synonyms: Pcdhb16, PcdhbQ
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93888
Homologene: 81881
Lztfl1
Name: leucine zipper transcription factor-like 1
Synonyms: 5530402H04Rik, 6130400H19Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 93730
HGNC: HGNC:6741
Homologene: 41368
Lrrc63
Name: leucine rich repeat containing 63
Synonyms: 4921509B22Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70859
Homologene: 52823
Tfpt
Name: TCF3 (E2A) fusion partner
Synonyms: 2400004F01Rik, Amida, FB1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 69714
Homologene: 8349
Ahsa2
Name: AHA1, activator of heat shock protein ATPase 2
Synonyms: 1110064P04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268390
Homologene: 72214
Prr36
Name: proline rich 36
Synonyms: BC068157
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 73072
Homologene: 136398
Thg1l
Name: tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
Synonyms: 1700121M19Rik, 5730409G07Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66628
Homologene: 5959
Septin14
Name: septin 14
Synonyms: 1700016K13Rik, Sept14
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74222
Homologene: 87501
Or6b1
Name: olfactory receptor family 6 subfamily B member 1
Synonyms: GA_x6K02T2P3E9-4722003-4721068, MOR103-1, Olfr449
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 259067
HGNC: HGNC:8354
Homologene: 17485
Tmem151b
Name: transmembrane protein 151B
Synonyms: LOC210573
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 210573
VEGA: 17
Homologene: 19365
2310003L06Rik
Name: RIKEN cDNA 2310003L06 gene
Type: Gene
Species: Mouse
Chromosome: 5
Vmn2r29
Name: vomeronasal 2, receptor 29
Synonyms: 6430701C03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 76229
Homologene: 113703
Pcdhgb7
Name: protocadherin gamma subfamily B, 7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93704
HGNC: HGNC:8714
Homologene: 75102
Ring1
Name: ring finger protein 1
Synonyms: Ring1A
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19763
Homologene: 68283
H3c13
Name: H3 clustered histone 13
Synonyms: H3-616, Hist2h3b
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 319154
Homologene: 136775
Ighv1-18
Name: immunoglobulin heavy variable V1-18
Synonyms: Gm16856
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 629871
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 153,793,864 bp
  • T to A, chromosome 2 at 41,110,786 bp
  • A to G, chromosome 2 at 58,147,908 bp
  • C to A, chromosome 2 at 59,917,425 bp
  • A to G, chromosome 2 at 72,179,971 bp
  • A to T, chromosome 2 at 112,859,765 bp
  • A to T, chromosome 2 at 147,366,114 bp
  • A to G, chromosome 2 at 155,620,436 bp
  • C to T, chromosome 3 at 53,522,168 bp
  • C to A, chromosome 3 at 96,268,993 bp
  • T to A, chromosome 4 at 48,196,904 bp
  • A to T, chromosome 4 at 130,096,502 bp
  • T to C, chromosome 5 at 53,645,898 bp
  • T to C, chromosome 5 at 76,888,077 bp
  • T to C, chromosome 5 at 77,016,597 bp
  • T to C, chromosome 5 at 87,972,812 bp
  • T to A, chromosome 5 at 88,671,291 bp
  • C to T, chromosome 5 at 129,686,028 bp
  • T to C, chromosome 5 at 137,605,212 bp
  • A to T, chromosome 6 at 42,838,004 bp
  • A to T, chromosome 6 at 51,907,954 bp
  • A to G, chromosome 7 at 3,620,745 bp
  • A to G, chromosome 7 at 7,231,865 bp
  • A to G, chromosome 7 at 107,571,185 bp
  • T to C, chromosome 8 at 4,212,982 bp
  • T to C, chromosome 8 at 18,671,106 bp
  • A to G, chromosome 8 at 35,799,385 bp
  • C to T, chromosome 8 at 95,760,098 bp
  • T to C, chromosome 9 at 4,503,588 bp
  • T to C, chromosome 9 at 18,605,282 bp
  • A to G, chromosome 9 at 27,006,847 bp
  • A to G, chromosome 9 at 38,378,061 bp
  • A to T, chromosome 9 at 54,461,086 bp
  • A to T, chromosome 9 at 55,016,124 bp
  • A to G, chromosome 9 at 57,447,182 bp
  • T to C, chromosome 9 at 119,959,029 bp
  • T to C, chromosome 9 at 123,702,129 bp
  • G to T, chromosome 10 at 60,337,264 bp
  • A to T, chromosome 10 at 80,717,844 bp
  • C to T, chromosome 10 at 107,644,146 bp
  • T to A, chromosome 11 at 23,490,415 bp
  • T to G, chromosome 11 at 45,955,293 bp
  • T to C, chromosome 11 at 58,425,767 bp
  • A to T, chromosome 11 at 85,077,327 bp
  • A to G, chromosome 11 at 90,638,419 bp
  • A to T, chromosome 11 at 106,023,877 bp
  • A to T, chromosome 12 at 83,675,090 bp
  • A to T, chromosome 12 at 114,682,761 bp
  • T to C, chromosome 14 at 29,043,546 bp
  • A to G, chromosome 14 at 61,206,090 bp
  • T to C, chromosome 14 at 75,123,007 bp
  • A to G, chromosome 14 at 79,026,073 bp
  • A to G, chromosome 15 at 99,954,797 bp
  • T to C, chromosome 17 at 34,023,135 bp
  • T to C, chromosome 17 at 43,478,106 bp
  • C to T, chromosome 17 at 45,545,798 bp
  • T to A, chromosome 17 at 53,500,457 bp
  • T to C, chromosome 18 at 5,766,917 bp
  • C to A, chromosome 18 at 37,486,748 bp
  • A to T, chromosome 18 at 37,752,268 bp
  • T to C, chromosome 18 at 37,890,809 bp
  • A to T, chromosome 18 at 42,156,136 bp
  • C to A, chromosome 18 at 76,137,362 bp
  • A to G, chromosome 18 at 80,682,289 bp
  • T to G, chromosome 19 at 4,856,539 bp
  • A to T, chromosome 19 at 12,776,877 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7703 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045764-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.