Strain Name:
C57BL/6J-MtgxR7722Btlr/Mmmh
Stock Number:
045778-MU
Citation ID:
RRID:MMRRC_045778-MU
Other Names:
R7722 (G1)
Major Collection:

Strain Information

Stx8
Name: syntaxin 8
Synonyms: 0610007H08Rik, 4930571E13Rik, 1110002H11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 55943
Homologene: 37973
Lamb1
Name: laminin B1
Synonyms: Lamb1-1, C81607, D130003D08Rik, C80098, Lamb-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16777
HGNC: HGNC:6486
Homologene: 1722
Ank2
Name: ankyrin 2, brain
Synonyms: ankyrin B, Gm4392, Ankyrin-B, Ank-2, Ankyrin-2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109676
HGNC: HGNC:493
Kmt2e
Name: lysine (K)-specific methyltransferase 2E
Synonyms: 9530077A04Rik, Mll5, 1810033J14Rik, D230038D11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 69188
Homologene: 18822
Mtss1
Name: MTSS I-BAR domain containing 1
Synonyms: MIM, 2310003N14Rik, D130001D01Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211401
VEGA: 15
Homologene: 8841
Tti1
Name: TELO2 interacting protein 1
Synonyms: 2610036D13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75425
Homologene: 40969
Med13l
Name: mediator complex subunit 13-like
Synonyms: 9030618F05Rik, Trap240L, Thrap2, 6330591G05Rik, 2210413I17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76199
Homologene: 25256
Luc7l2
Name: LUC7-like 2 (S. cerevisiae)
Synonyms: CGI-74, 4930471C18Rik, CGI-59
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 192196
Homologene: 56737
Fbxl17
Name: F-box and leucine-rich repeat protein 17
Synonyms: C130023C01Rik, 6330576B01Rik, Fbxo13, Fbx13
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 50758
Homologene: 79859
Hsd17b4
Name: hydroxysteroid (17-beta) dehydrogenase 4
Synonyms: MFP2, Mfp-2, 17[b]-HSD, perMFE-2, multifunctional protein 2, MFE-2, D-bifunctional protein
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 15488
HGNC: HGNC:5213
Homologene: 358
Brd1
Name: bromodomain containing 1
Synonyms: 1110059H06Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223770
HGNC: HGNC:1102
Homologene: 40956
Rsf1
Name: remodeling and spacing factor 1
Synonyms: Hbxap, p325, XAP8, C030033M12Rik, 4832420A03Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Afdn
Name: afadin, adherens junction formation factor
Synonyms: AF6, S-afadin, 5033403D15Rik, Afadin, I-afadin, Mllt4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 17356
HGNC: HGNC:7137
Homologene: 21202
Itprid2
Name: ITPR interacting domain containing 2
Synonyms: Ssfa2, SPAG13, KRAP, CS1, CS-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70599
Homologene: 4912
Tg
Name: thyroglobulin
Synonyms: Tgn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 21819
Homologene: 2430
Mlh3
Name: mutL homolog 3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217716
VEGA: 12
HGNC: HGNC:7128
Homologene: 91153
Zbtb40
Name: zinc finger and BTB domain containing 40
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230848
Homologene: 8912
Sgo2a
Name: shugoshin 2A
Synonyms: 1110007N04Rik, Sgol2, Tripin, 5730576N04Rik, Sgol2a, D1Ertd8e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68549
Homologene: 51867
Mms22l
Name: MMS22-like, DNA repair protein
Synonyms: F730047E07Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 212377
Homologene: 18874
Mtmr2
Name: myotubularin related protein 2
Synonyms: 6030445P13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 77116
HGNC: HGNC:7450
Homologene: 22951
Cspp1
Name: centrosome and spindle pole associated protein 1
Synonyms: 4930413O22Rik, 2310020J12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 211660
Homologene: 23487
Gpr183
Name: G protein-coupled receptor 183
Synonyms: Ebi2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 321019
VEGA: 14
HGNC: HGNC:3128
Homologene: 28066
Muc20
Name: mucin 20
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224116
Homologene: 17135
Limk2
Name: LIM domain kinase 2
Synonyms: A930024P04Rik, whe, LIM kinase 2, Limk2b, Limk2a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 16886
HGNC: HGNC:6614
Homologene: 55911
Fmnl2
Name: formin-like 2
Synonyms: 5430425K04Rik, man
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Fancm
Name: Fanconi anemia, complementation group M
Synonyms: C730036B14Rik, D12Ertd364e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104806
VEGA: 12
Homologene: 35378
Ehbp1
Name: EH domain binding protein 1
Synonyms: KIAA0903-like, Flj21950
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216565
Homologene: 22880
Pgap3
Name: post-GPI attachment to proteins 3
Synonyms: Perld1, D430035D22Rik, CAB2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320655
Homologene: 5484
Mturn
Name: maturin, neural progenitor differentiation regulator homolog (Xenopus)
Synonyms: B230212L03Rik, 2410066E13Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68235
Skor2
Name: SKI family transcriptional corepressor 2
Synonyms: Fussel18, Corl2, Gm7348
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 664805
VEGA: 18
Homologene: 64797
Smarcc2
Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
Synonyms: 5930405J04Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68094
VEGA: 10
Homologene: 2312
Hmcn2
Name: hemicentin 2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 665700
Homologene: 90772
Med17
Name: mediator complex subunit 17
Synonyms: Trap80, C330002H14Rik, Crsp6
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 234959
VEGA: 9
HGNC: HGNC:2375
Homologene: 3151
Hmcn1
Name: hemicentin 1
Synonyms: LOC240793, EG545370
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545370
Homologene: 23741
Map3k5
Name: mitogen-activated protein kinase kinase kinase 5
Synonyms: ASK, ASK1, Mekk5, 7420452D20Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26408
HGNC: HGNC:6857
Homologene: 38114
Slc35f4
Name: solute carrier family 35, member F4
Synonyms: 4930550L21Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 75288
Homologene: 45939
Zfp990
Name: zinc finger protein 990
Synonyms: Gm13225
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 101056073
Slc9b2
Name: solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Synonyms: nha-oc, NHA2, C80638, NHE10, Nhedc2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 97086
Homologene: 45381
Clrn1
Name: clarin 1
Synonyms: A130002D11Rik, USH3, Ush3a, clarin-1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229320
Homologene: 17738
Fras1
Name: Fraser extracellular matrix complex subunit 1
Synonyms: E130113P14Rik, bl
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231470
Homologene: 23516
Tshz2
Name: teashirt zinc finger family member 2
Synonyms: 2900073F20Rik, Tsh2, Mtsh2, Sdccag33l, Zfp218, teashirt2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228911
Homologene: 35258
Alpk2
Name: alpha-kinase 2
Synonyms: Hak
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225638
Homologene: 50475
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Kif14
Name: kinesin family member 14
Synonyms: N-3 kinesin, D1Ertd367e
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 381293
Homologene: 8916
Sdcbp
Name: syndecan binding protein
Synonyms: syntenin-1, MDA-9, syndecan interacting protein, syntenin, Sycl
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 53378
Homologene: 4110
Atp8a1
Name: ATPase phospholipid transporting 8A1
Synonyms: B230107D19Rik, Atp3a2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11980
Homologene: 48402
Sorcs2
Name: sortilin-related VPS10 domain containing receptor 2
Synonyms: VPS10 domain receptor protein
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 81840
Homologene: 56899
Sphkap
Name: SPHK1 interactor, AKAP domain containing
Synonyms: 4930544G21Rik, SKIP, A930009L15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 77629
Homologene: 18172
Stc1
Name: stanniocalcin 1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 20855
VEGA: 14
Homologene: 2374
Scart1
Name: scavenger receptor family member expressed on T cells 1
Synonyms: E430002D04Rik, Cd163l1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244233
Homologene: 129778
Ano7
Name: anoctamin 7
Synonyms: Pcanap5, NGEP-L, IPCA-5, NGEP, Tmem16g
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 404545
Homologene: 45787
Hcn1
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1
Synonyms: C630013B14Rik, hyperpolarization-activated, cyclic nucleotide-gated K+ 1, HAC2, Bcng1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 15165
HGNC: HGNC:4845
Homologene: 32093
Or52u1
Name: olfactory receptor family 52 subfamily U member 1
Synonyms: Olfr654, MOR38-2, GA_x6K02T2PBJ9-7215221-7216195
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258377
Homologene: 90859
Neurl1b
Name: neuralized E3 ubiquitin protein ligase 1B
Synonyms: EG240055, C230078M08Rik, Neur2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240055
Homologene: 35443
Amh
Name: anti-Mullerian hormone
Synonyms: MIS, Mullerian inhibiting substance
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11705
VEGA: 10
HGNC: HGNC:464
Homologene: 68060
Cyp2a5
Name: cytochrome P450, family 2, subfamily a, polypeptide 5
Synonyms: Coh
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13087
Homologene: 85917
Nde1
Name: nudE neurodevelopment protein 1
Synonyms: mNudE, 2810027M15Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 67203
Homologene: 32354
Or8g18
Name: olfactory receptor family 8 subfamily G member 18
Synonyms: MOR171-32P, Olfr144, MOR171-41P, MOR171-32P, GA_x6K02T2PVTD-32935684-32934749, K4, Olfr1537, Olfr1537-ps1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 257959
VEGA: 9
HGNC: HGNC:8484
Homologene: 110610
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 10,074,901 bp
  • T to G, chromosome 1 at 58,016,537 bp
  • T to C, chromosome 1 at 83,278,921 bp
  • G to A, chromosome 1 at 93,390,423 bp
  • A to G, chromosome 1 at 136,468,295 bp
  • A to G, chromosome 1 at 150,667,880 bp
  • A to T, chromosome 2 at 31,382,500 bp
  • A to C, chromosome 2 at 53,054,467 bp
  • T to C, chromosome 2 at 79,662,345 bp
  • A to G, chromosome 2 at 158,007,607 bp
  • T to A, chromosome 2 at 169,885,272 bp
  • T to A, chromosome 3 at 58,846,334 bp
  • T to A, chromosome 3 at 127,029,302 bp
  • T to A, chromosome 3 at 135,329,835 bp
  • T to A, chromosome 4 at 6,385,063 bp
  • T to A, chromosome 4 at 24,517,201 bp
  • A to G, chromosome 4 at 136,991,518 bp
  • A to C, chromosome 4 at 145,536,962 bp
  • T to G, chromosome 5 at 23,497,018 bp
  • T to C, chromosome 5 at 36,043,527 bp
  • T to A, chromosome 5 at 67,622,698 bp
  • G to A, chromosome 5 at 96,769,554 bp
  • C to A, chromosome 5 at 118,747,407 bp
  • T to A, chromosome 6 at 38,603,308 bp
  • T to C, chromosome 6 at 54,699,560 bp
  • T to C, chromosome 7 at 26,837,118 bp
  • GGCG to GGCGACGGCCGCG, chromosome 7 at 97,579,906 bp
  • C to A, chromosome 7 at 104,588,298 bp
  • C to A, chromosome 7 at 140,222,386 bp
  • T to A, chromosome 9 at 13,804,808 bp
  • G to T, chromosome 9 at 15,271,691 bp
  • A to T, chromosome 9 at 39,237,589 bp
  • A to G, chromosome 10 at 20,132,145 bp
  • T to C, chromosome 10 at 80,806,624 bp
  • T to C, chromosome 10 at 88,379,528 bp
  • A to G, chromosome 10 at 128,481,728 bp
  • T to C, chromosome 11 at 3,356,092 bp
  • G to A, chromosome 11 at 22,089,572 bp
  • T to C, chromosome 11 at 68,203,718 bp
  • G to A, chromosome 11 at 98,390,784 bp
  • T to A, chromosome 12 at 31,323,571 bp
  • T to A, chromosome 12 at 65,106,461 bp
  • A to G, chromosome 12 at 85,267,492 bp
  • A to G, chromosome 13 at 117,902,778 bp
  • A to T, chromosome 14 at 49,306,274 bp
  • T to A, chromosome 14 at 69,032,280 bp
  • T to G, chromosome 14 at 121,954,858 bp
  • G to A, chromosome 15 at 59,055,086 bp
  • C to T, chromosome 15 at 66,764,309 bp
  • A to T, chromosome 15 at 88,729,559 bp
  • T to C, chromosome 16 at 14,190,264 bp
  • A to C, chromosome 16 at 32,797,386 bp
  • A to G, chromosome 17 at 13,808,969 bp
  • A to G, chromosome 17 at 26,441,158 bp
  • A to T, chromosome 17 at 63,356,828 bp
  • A to C, chromosome 18 at 50,146,524 bp
  • A to T, chromosome 18 at 65,350,157 bp
  • A to C, chromosome 18 at 76,862,644 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7722 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045778-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.