Strain Name:
C57BL/6J-MtgxR7724Btlr/Mmmh
Stock Number:
045780-MU
Citation ID:
RRID:MMRRC_045780-MU
Other Names:
R7724 (G1)
Major Collection:

Strain Information

Fga
Name: fibrinogen alpha chain
Synonyms: ENSMUSG00000059807, Fib
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14161
HGNC: HGNC:3661
Homologene: 428
Fn1
Name: fibronectin 1
Synonyms: Fn, Fn-1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 14268
HGNC: HGNC:3778
Homologene: 1533
Atic
Name: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Synonyms: 2610509C24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 108147
HGNC: HGNC:794
Homologene: 2983
Ebf2
Name: early B cell factor 2
Synonyms: Mmot1, D14Ggc1e, O/E-3
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13592
Homologene: 56471
P2rx7
Name: purinergic receptor P2X, ligand-gated ion channel, 7
Synonyms: P2X7 receptor, P2X7R, P2X(7)
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 18439
HGNC: HGNC:8537
Homologene: 1925
Arhgef12
Name: Rho guanine nucleotide exchange factor 12
Synonyms: 2310014B11Rik, LARG
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 69632
VEGA: 9
Homologene: 9088
Lrrc59
Name: leucine rich repeat containing 59
Synonyms: C78668
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 98238
Homologene: 10229
Ulk1
Name: unc-51 like kinase 1
Synonyms: Unc51.1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22241
Homologene: 2640
Gria4
Name: glutamate receptor, ionotropic, AMPA4 (alpha 4)
Synonyms: Glur4, spkw1, Gluralpha4, Glur-4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14802
HGNC: HGNC:4574
Homologene: 20227
Tacr3
Name: tachykinin receptor 3
Synonyms: neuromedin K receptor, Nk3r, Tac3r
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 21338
Homologene: 824
Gmps
Name: guanine monophosphate synthetase
Synonyms: Gm9479
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229363
HGNC: HGNC:4378
Homologene: 68367
Uaca
Name: uveal autoantigen with coiled-coil domains and ankyrin repeats
Synonyms: 2700059D02Rik, nucling
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72565
VEGA: 9
Homologene: 74297
Ctc1
Name: CTS telomere maintenance complex component 1
Synonyms: 1500010J02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 68964
Homologene: 11830
Ogdh
Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: d1401, alpha-ketoglutarate dehydrogenase, 2210412K19Rik, 2210403E04Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18293
HGNC: HGNC:8124
Homologene: 55662
Uvrag
Name: UV radiation resistance associated gene
Synonyms: Uvragl, 9530039D02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78610
Homologene: 31150
Cir1
Name: corepressor interacting with RBPJ, 1
Synonyms: CIR, 1700023B02Rik, 2810021A19Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66935
Homologene: 3589
Arhgef17
Name: Rho guanine nucleotide exchange factor 17
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 207212
Homologene: 129601
Ak7
Name: adenylate kinase 7
Synonyms: 4930502N02Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 78801
VEGA: 12
Homologene: 14268
Klhl23
Name: kelch-like 23
Synonyms: C130068N17Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277396
Homologene: 18628
Tph2
Name: tryptophan hydroxylase 2
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216343
Homologene: 27831
Magi3
Name: membrane associated guanylate kinase, WW and PDZ domain containing 3
Synonyms: 4732496O19Rik, 6530407C02Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 99470
Homologene: 26431
Ehbp1
Name: EH domain binding protein 1
Synonyms: KIAA0903-like, Flj21950
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216565
Homologene: 22880
Cep57l1
Name: centrosomal protein 57-like 1
Synonyms: 4930484D11Rik, 2410017P07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 103268
Homologene: 12254
Tdo2
Name: tryptophan 2,3-dioxygenase
Synonyms: TDO, chky, TO
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56720
Homologene: 4132
Tex15
Name: testis expressed gene 15 meiosis and synapsis associated
Synonyms: 2210014E14Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 104271
Homologene: 12837
Fat2
Name: FAT atypical cadherin 2
Synonyms: EMI2, mKIAA0811, LOC245827, Fath2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 245827
HGNC: HGNC:3596
Homologene: 1110
Helz2
Name: helicase with zinc finger 2, transcriptional coactivator
Synonyms: BC006779
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 229003
Homologene: 14118
Ces2g
Name: carboxylesterase 2G
Synonyms: 2210023G05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 72361
HGNC: HGNC:1864
Homologene: 77154
Myoc
Name: myocilin
Synonyms: GLC1A, TIGR
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17926
HGNC: HGNC:7610
Homologene: 220
Npas3
Name: neuronal PAS domain protein 3
Synonyms: bHLHe12, 4930423H22Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 27386
VEGA: 12
Homologene: 8461
Skint10
Name: selection and upkeep of intraepithelial T cells 10
Synonyms: A030001H23Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230613
Homologene: 136292
Rdh1
Name: retinol dehydrogenase 1 (all trans)
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107605
Homologene: 129514
Frmpd1
Name: FERM and PDZ domain containing 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 666060
Homologene: 8939
Zfp541
Name: zinc finger protein 541
Synonyms: EG666528
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 666528
Homologene: 12991
Mical2
Name: microtubule associated monooxygenase, calponin and LIM domain containing 2
Synonyms: Micalcl, Ebitein1, 4921517J23Rik, 5330438E18Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 320878
Homologene: 8760
St6galnac1
Name: ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1
Synonyms: ST6GalNAc I, Siat7a
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20445
Homologene: 7937
Hrnr
Name: hornerin
Synonyms: S100a18, A530063N20Rik, 1110033K19Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68723
Homologene: 138092
Pcdhb14
Name: protocadherin beta 14
Synonyms: Pcdhb17, 2210006M07Rik, PcdhbN
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93885
Homologene: 70876
Synj1
Name: synaptojanin 1
Synonyms: A930006D20Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 104015
Homologene: 48252
Adarb2
Name: adenosine deaminase, RNA-specific, B2
Synonyms: RED2, Adar3
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 94191
HGNC: HGNC:227
Homologene: 10276
Cdh15
Name: cadherin 15
Synonyms: M cadherin, Mcad, Cdh14
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12555
HGNC: HGNC:1754
Homologene: 3622
9130401M01Rik
Name: RIKEN cDNA 9130401M01 gene
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75758
Homologene: 12622
Atp8b4
Name: ATPase, class I, type 8B, member 4
Synonyms: Im
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241633
Homologene: 133162
Or8k30
Name: olfactory receptor family 8 subfamily K member 30
Synonyms: MOR189-2, Olfr1076, GA_x6K02T2Q125-47993761-47994702
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258401
Homologene: 17233
Ccdc202
Name: coiled-coil domain containing 202
Synonyms: 4921530L21Rik, Spertl
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 66732
VEGA: 14
Homologene: 41645
Gm10549
Name: predicted gene 10549
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 433171
VEGA: 18
Prdx6b
Name: peroxiredoxin 6B
Synonyms: Prdx6-ps1, 4930414C22Rik, Aop2-rs1, 1-cysPrx-P1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 320769
Homologene: 71226
Ifit1bl1
Name: interferon induced protein with tetratricpeptide repeats 1B like 1
Synonyms: Gm14446
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 667373
Homologene: 78213
Or8s5
Name: olfactory receptor family 8 subfamily S member 5
Synonyms: GA_x6K02T2NBG7-5395976-5396893, MOR160-4, Olfr284
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 258278
Homologene: 74250
Or52r1c
Name: olfactory receptor family 52 subfamily R member 1C
Synonyms: GA_x6K02T2PBJ9-5796876-5797820, Olfr584, MOR30-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259056
Sema6c
Name: sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
Synonyms: Sema Y, Semay
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20360
Homologene: 7931
Gbp8
Name: guanylate-binding protein 8
Synonyms: 5830443L24Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 76074
Or56a42-ps1
Name: olfactory receptor family 56 subfamily A member 42, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-7755919-7755070, Olfr682-ps1, Olfr217-ps1, MOR40-19_p, MOR40-6P, GA_x6K02SYW8DF-188-1037
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258187
Or2t46
Name: olfactory receptor family 2 subfamily T member 46
Synonyms: MOR275-11_p, MOR275-5, Olfr325, GA_x6K02T2NKPP-844642-843680
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 258261
Homologene: 133015
Celf4
Name: CUGBP, Elav-like family member 4
Synonyms: Brunol4, C130060B05Rik, Brul4, A230070D14Rik, BRUNOL-4
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 108013
VEGA: 18
Homologene: 23202
Serpinb5
Name: serine (or cysteine) peptidase inhibitor, clade B, member 5
Synonyms: ovalbumin, Spi7, Maspin, 1110036M19Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20724
HGNC: HGNC:8949
Homologene: 20580
Ldhal6b
Name: lactate dehydrogenase A-like 6B
Synonyms: 4933402O15Rik, LDHAL
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106557
Homologene: 69533
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 71,564,901 bp
  • A to T, chromosome 1 at 71,603,735 bp
  • A to T, chromosome 1 at 106,875,142 bp
  • T to A, chromosome 1 at 162,639,827 bp
  • A to G, chromosome 2 at 69,824,712 bp
  • T to C, chromosome 2 at 73,306,890 bp
  • A to G, chromosome 2 at 80,293,402 bp
  • A to G, chromosome 2 at 86,508,605 bp
  • T to A, chromosome 2 at 126,322,893 bp
  • T to C, chromosome 2 at 181,231,996 bp
  • T to A, chromosome 3 at 63,985,653 bp
  • A to G, chromosome 3 at 81,968,083 bp
  • A to G, chromosome 3 at 83,029,125 bp
  • A to G, chromosome 3 at 93,323,016 bp
  • A to T, chromosome 3 at 95,173,199 bp
  • A to C, chromosome 3 at 104,015,927 bp
  • T to A, chromosome 3 at 134,929,908 bp
  • A to T, chromosome 4 at 45,229,888 bp
  • A to T, chromosome 4 at 112,765,092 bp
  • A to T, chromosome 5 at 105,031,294 bp
  • A to T, chromosome 5 at 110,792,404 bp
  • A to T, chromosome 5 at 122,673,373 bp
  • T to C, chromosome 7 at 16,071,994 bp
  • T to C, chromosome 7 at 98,991,963 bp
  • C to T, chromosome 7 at 100,880,609 bp
  • T to A, chromosome 7 at 103,086,263 bp
  • A to G, chromosome 7 at 105,128,252 bp
  • T to A, chromosome 7 at 112,323,626 bp
  • T to A, chromosome 8 at 33,546,263 bp
  • T to A, chromosome 8 at 104,966,852 bp
  • G to T, chromosome 8 at 122,866,961 bp
  • A to G, chromosome 9 at 4,472,074 bp
  • A to T, chromosome 9 at 43,027,271 bp
  • A to G, chromosome 9 at 60,869,905 bp
  • G to A, chromosome 10 at 41,745,842 bp
  • T to C, chromosome 10 at 115,079,822 bp
  • A to G, chromosome 10 at 127,764,707 bp
  • T to C, chromosome 11 at 6,324,887 bp
  • G to A, chromosome 11 at 22,089,572 bp
  • C to T, chromosome 11 at 55,284,796 bp
  • T to A, chromosome 11 at 58,581,382 bp
  • C to A, chromosome 11 at 69,026,344 bp
  • C to T, chromosome 11 at 94,643,344 bp
  • C to T, chromosome 11 at 116,766,072 bp
  • C to A, chromosome 12 at 54,068,341 bp
  • T to A, chromosome 12 at 105,716,030 bp
  • C to A, chromosome 13 at 8,570,256 bp
  • A to T, chromosome 14 at 67,424,040 bp
  • A to G, chromosome 14 at 95,882,250 bp
  • A to C, chromosome 15 at 58,022,461 bp
  • A to T, chromosome 15 at 98,340,894 bp
  • G to A, chromosome 16 at 90,961,499 bp
  • A to G, chromosome 17 at 5,418,602 bp
  • C to T, chromosome 18 at 25,486,793 bp
  • A to T, chromosome 18 at 33,470,859 bp
  • A to T, chromosome 18 at 37,448,884 bp
  • T to C, chromosome 19 at 34,594,005 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7724 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045780-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.