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Strain Detail Sheet

Strain Name:
C57BL/6J-MtgxR7730Btlr/Mmmh
Stock Number:
045786-MU
Citation ID:
RRID:MMRRC_045786-MU
Other Names:
R7730 (G1)
Major Collection:
Beutler Mutagenetix

Strain Information

Gene Details

Card11
Name: caspase recruitment domain family, member 11
Synonyms: CARMA1, BIMP3, 2410011D02Rik, 0610008L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024

Additional Resources
IMPC
Google
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IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Zfp384
Name: zinc finger protein 384
Synonyms: C130073D16Rik, Ciz, Nmp4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269800
Homologene: 15849

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Cnst
Name: consortin, connexin sorting protein
Synonyms: 9630058J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226744
Homologene: 17139

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20975
Homologene: 117703

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Psat1
Name: phosphoserine aminotransferase 1
Synonyms: PSA, D8Ertd814e, EPIP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107272
Homologene: 6973

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: A20-binding inhibitor of NF-kappa B activation, ABIN1, VAN, Nef
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57783
Homologene: 31355

Additional Resources
IMPC
Google
Entrez
PubMed
IMSR
Gene Ontology
BioGPS
Gene Cloud
IGTC
Mouse Phenome DB
Mouse Mine
KOMP Phenotyping
Monarch
GeneCards
ClinGen
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 134,291,176 bp
  • T to A, chromosome 1 at 140,518,948 bp
  • C to T, chromosome 1 at 171,641,021 bp
  • T to C, chromosome 1 at 179,625,085 bp
  • T to C, chromosome 2 at 21,826,347 bp
  • T to C, chromosome 2 at 27,456,955 bp
  • G to A, chromosome 2 at 29,872,562 bp
  • T to A, chromosome 2 at 34,895,804 bp
  • A to T, chromosome 2 at 126,594,082 bp
  • G to T, chromosome 2 at 156,048,934 bp
  • T to C, chromosome 2 at 162,931,723 bp
  • A to G, chromosome 3 at 94,393,114 bp
  • C to A, chromosome 4 at 124,838,619 bp
  • C to T, chromosome 4 at 150,630,940 bp
  • T to C, chromosome 5 at 138,172,815 bp
  • C to A, chromosome 5 at 140,885,996 bp
  • T to A, chromosome 6 at 71,780,741 bp
  • G to A, chromosome 6 at 124,517,725 bp
  • A to G, chromosome 6 at 125,031,672 bp
  • T to C, chromosome 7 at 49,572,397 bp
  • A to T, chromosome 8 at 68,887,448 bp
  • A to G, chromosome 8 at 69,663,710 bp
  • T to G, chromosome 9 at 14,555,763 bp
  • T to G, chromosome 9 at 18,875,413 bp
  • CAACCCTGGTAAC to CAAC, chromosome 9 at 66,493,190 bp
  • T to G, chromosome 10 at 86,448,909 bp
  • T to C, chromosome 10 at 120,223,862 bp
  • T to A, chromosome 11 at 48,947,876 bp
  • T to C, chromosome 11 at 50,135,915 bp
  • T to C, chromosome 11 at 54,937,979 bp
  • G to T, chromosome 12 at 31,340,865 bp
  • A to G, chromosome 12 at 101,651,147 bp
  • A to T, chromosome 12 at 112,922,041 bp
  • T to A, chromosome 12 at 113,544,040 bp
  • A to T, chromosome 13 at 23,900,520 bp
  • T to C, chromosome 13 at 33,899,309 bp
  • T to G, chromosome 13 at 92,685,190 bp
  • T to A, chromosome 14 at 26,785,933 bp
  • T to C, chromosome 14 at 55,066,900 bp
  • T to A, chromosome 14 at 56,059,971 bp
  • A to T, chromosome 14 at 56,956,181 bp
  • A to G, chromosome 14 at 78,995,149 bp
  • A to T, chromosome 14 at 103,123,355 bp
  • T to A, chromosome 15 at 6,824,482 bp
  • T to A, chromosome 15 at 54,254,074 bp
  • A to T, chromosome 15 at 81,008,726 bp
  • A to G, chromosome 15 at 89,162,330 bp
  • T to C, chromosome 16 at 45,143,883 bp
  • T to C, chromosome 17 at 6,016,287 bp
  • A to T, chromosome 17 at 12,735,991 bp
  • A to G, chromosome 17 at 19,611,688 bp
  • T to G, chromosome 18 at 20,331,711 bp
  • T to C, chromosome 19 at 8,964,376 bp
  • A to G, chromosome 19 at 15,918,356 bp
  • T to A, chromosome 19 at 30,075,101 bp

Strain Description

Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.

Strain Origin

Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7730 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Health Status Report

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.

Appearance

Coat Color
Black

Breeding

MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain

Reproductive Statistics

Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Availability Level

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Conditions of Distribution

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Fees

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*		 Units Notes
045786-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.