Strain Name:
C57BL/6J-MtgxR7730Btlr/Mmmh
Stock Number:
045786-MU
Citation ID:
RRID:MMRRC_045786-MU
Other Names:
R7730 (G1)
Major Collection:

Strain Information

Card11
Name: caspase recruitment domain family, member 11
Synonyms: CARMA1, BIMP3, 2410011D02Rik, 0610008L17Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 108723
Homologene: 13024
Zfp384
Name: zinc finger protein 384
Synonyms: C130073D16Rik, Ciz, Nmp4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 269800
Homologene: 15849
Cnst
Name: consortin, connexin sorting protein
Synonyms: 9630058J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226744
Homologene: 17139
Synj2
Name: synaptojanin 2
Synonyms: SJ2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20975
Homologene: 117703
Mycbp2
Name: MYC binding protein 2, E3 ubiquitin protein ligase
Synonyms: Pam, C130061D10Rik, Phr1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105689
Homologene: 9005
Psat1
Name: phosphoserine aminotransferase 1
Synonyms: PSA, D8Ertd814e, EPIP
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107272
Homologene: 6973
Tnip1
Name: TNFAIP3 interacting protein 1
Synonyms: A20-binding inhibitor of NF-kappa B activation, ABIN1, VAN, Nef
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 57783
Homologene: 31355
Zmym2
Name: zinc finger, MYM-type 2
Synonyms: SCLL, RAMP, MYM, FIM, Zfp198
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76007
VEGA: 14
Homologene: 12631
Mtf1
Name: metal response element binding transcription factor 1
Synonyms: metalloregulatory transcription factor, MTF-1, metal response element-binding transcription factor 1, Thyls
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 17764
HGNC: HGNC:7428
Homologene: 4347
Nav2
Name: neuron navigator 2
Synonyms: POMFIL2, Unc53H2, HELAD1, RAINB2, 5330421F07Rik, Rainb1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78286
Homologene: 52330
Herc1
Name: HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Synonyms: D130015N03Rik, 2810449H11Rik, tbl
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235439
HGNC: HGNC:4867
Homologene: 31207
Uhrf2
Name: ubiquitin-like, containing PHD and RING finger domains 2
Synonyms: 2310065A22Rik, Nirf, D130071B19Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 109113
Homologene: 17001
Syn3
Name: synapsin III
Synonyms: Synapsin IIIa
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 27204
Homologene: 68320
Ap4m1
Name: adaptor-related protein complex AP-4, mu 1
Synonyms: 4930443L05Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 11781
HGNC: HGNC:574
Homologene: 3467
Amotl1
Name: angiomotin-like 1
Synonyms: 4932416D09Rik, JEAP, 2310067L22Rik, 2310010G08Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 75723
Homologene: 43977
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Serinc5
Name: serine incorporator 5
Synonyms: AIGP3, A130038L21Rik, TPO1
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 218442
VEGA: 13
Homologene: 65246
Hdc
Name: histidine decarboxylase
Synonyms: Hdc-s, Hdc-e, Hdc-c, Hdc-a, L-histidine decarboxylase
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 15186
HGNC: HGNC:4855
Homologene: 20490
Lpl
Name: lipoprotein lipase
Synonyms: O 1-4-5
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 16956
HGNC: HGNC:6677
Homologene: 200
Igf2r
Name: insulin-like growth factor 2 receptor
Synonyms: Mpr300, CI-MPR, IGF-II/CI-MPR, M6P/IGF2R, CD222, mannose-6-phosphate receptor, cation independent
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16004
HGNC: HGNC:5467
Homologene: 676
Brd3
Name: bromodomain containing 3
Synonyms: RINGL3, ORFX, 2410084F24Rik, Fsrg2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67382
HGNC: HGNC:1104
Homologene: 81801
Srsf6
Name: serine and arginine-rich splicing factor 6
Synonyms: 1210001E11Rik, Sfrs6
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67996
Homologene: 110783
Tut1
Name: terminal uridylyl transferase 1, U6 snRNA-specific
Synonyms: PAPD2, 2700038E08Rik, Rbm21, TUTase6, Tent1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 70044
VEGA: 19
Homologene: 69361
Zfhx2
Name: zinc finger homeobox 2
Synonyms: zfh-5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 239102
Homologene: 52657
Slamf7
Name: SLAM family member 7
Synonyms: novel Ly9, 4930560D03Rik, 19A, 19A24, CS1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 75345
Homologene: 49660
Rorc
Name: RAR-related orphan receptor gamma
Synonyms: thymus orphan receptor, Thor, RORgamma
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 19885
Homologene: 21051
Tnfrsf11b
Name: tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)
Synonyms: osteoclastogenesis inhibitory factor, OCIF, OPG, Opg, TR1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18383
VEGA: 15
Homologene: 1912
Cercam
Name: cerebral endothelial cell adhesion molecule
Synonyms: CerCAM, Ceecam1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99151
Homologene: 22954
Dnah12
Name: dynein, axonemal, heavy chain 12
Synonyms: Hdhc3, HL-19, DLP12, HL19, DHC3, LOC380889, 4921531P07Rik, Dnahc7l, Dnahc12
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 110083
HGNC: HGNC:2943
Homologene: 56821
Myog
Name: myogenin
Synonyms: myo, bHLHc3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 17928
HGNC: HGNC:7612
Homologene: 1854
Slc45a1
Name: solute carrier family 45, member 1
Synonyms: Dnb5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242773
Homologene: 44908
Fer1l4
Name: fer-1 like family member 4
Synonyms: 9130402C12Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74562
Homologene: 19075
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 4932416F07Rik, 1300010F03Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Jag2
Name: jagged 2
Synonyms: Serh, D12Ggc2e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16450
VEGA: 12
HGNC: HGNC:6189
Homologene: 1677
Gpr158
Name: G protein-coupled receptor 158
Synonyms: 5330427M13Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241263
Homologene: 19381
Phf19
Name: PHD finger protein 19
Synonyms: 3110009G19Rik, 3321402G02Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74016
Homologene: 12524
Adam6a
Name: a disintegrin and metallopeptidase domain 6A
Synonyms: Adam6
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238406
HGNC: HGNC:213
Homologene: 128362
Tbc1d9b
Name: TBC1 domain family, member 9B
Synonyms: 2700008N14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 76795
Homologene: 28106
Sgsm3
Name: small G protein signaling modulator 3
Synonyms: 1810012I01Rik, CIP85, Rutbc3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 105835
Homologene: 9249
Dsg1a
Name: desmoglein 1 alpha
Synonyms: Dsg1
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 13510
HGNC: HGNC:3048
Homologene: 1463
Osmr
Name: oncostatin M receptor
Synonyms: OSMRB
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18414
HGNC: HGNC:8507
Homologene: 2972
Serpinb6c
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6c
Synonyms: ovalbumin, SPIC, Spi3C
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 97848
HGNC: HGNC:8950
Kcnt2
Name: potassium channel, subfamily T, member 2
Synonyms: E330038N15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 240776
Homologene: 16121
Or7g18
Name: olfactory receptor family 7 subfamily G member 18
Synonyms: GA_x6K02T2PVTD-12618399-12619337, MOR152-1, Olfr830
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258559
HGNC: HGNC:8466
Homologene: 79360
C1ra
Name: complement component 1, r subcomponent A
Synonyms: mC1rA
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 50909
HGNC: HGNC:1246
Homologene: 1313
Vmn2r101
Name: vomeronasal 2, receptor 101
Synonyms: EG627576
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627576
Homologene: 115024
9930111J21Rik1
Name: RIKEN cDNA 9930111J21 gene 1
Synonyms: 9930111J21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 667214
Homologene: 83188
Zfp964
Name: zinc finger protein 964
Synonyms: Gm7187
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 636741
Homologene: 130114
Tc2n
Name: tandem C2 domains, nuclear
Synonyms: 4933406D09Rik, Tac2-N, Mtac2d1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 74413
Homologene: 12560
Mcpt4
Name: mast cell protease 4
Synonyms: myonase, MMCP-4B, MMCP-4A, MMCP-4, Mcp-4, Mcp4
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 17227
VEGA: 14
Homologene: 130645
Dld
Name: dihydrolipoamide dehydrogenase
Synonyms: dihydrolipoyl dehydrogenase, branched chain alpha-keto acid dehydrogenase complex subunit E3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13382
VEGA: 12
HGNC: HGNC:2898
Homologene: 84
Slc17a4
Name: solute carrier family 17 (sodium phosphate), member 4
Synonyms: 9130214H05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319848
Homologene: 21127
Slc35a5
Name: solute carrier family 35, member A5
Synonyms: D16Ertd450e, 1010001J06Rik, D730043G07Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 74102
Homologene: 9930
Reep1
Name: receptor accessory protein 1
Synonyms: D6Ertd253e
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 52250
Homologene: 41504
Tmbim4
Name: transmembrane BAX inhibitor motif containing 4
Synonyms: 0610007H07Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 68212
Homologene: 56740
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 134,291,176 bp
  • T to A, chromosome 1 at 140,518,948 bp
  • C to T, chromosome 1 at 171,641,021 bp
  • T to C, chromosome 1 at 179,625,085 bp
  • T to C, chromosome 2 at 21,826,347 bp
  • T to C, chromosome 2 at 27,456,955 bp
  • G to A, chromosome 2 at 29,872,562 bp
  • T to A, chromosome 2 at 34,895,804 bp
  • A to T, chromosome 2 at 126,594,082 bp
  • G to T, chromosome 2 at 156,048,934 bp
  • T to C, chromosome 2 at 162,931,723 bp
  • A to G, chromosome 3 at 94,393,114 bp
  • C to A, chromosome 4 at 124,838,619 bp
  • C to T, chromosome 4 at 150,630,940 bp
  • T to C, chromosome 5 at 138,172,815 bp
  • C to A, chromosome 5 at 140,885,996 bp
  • T to A, chromosome 6 at 71,780,741 bp
  • G to A, chromosome 6 at 124,517,725 bp
  • A to G, chromosome 6 at 125,031,672 bp
  • T to C, chromosome 7 at 49,572,397 bp
  • A to T, chromosome 8 at 68,887,448 bp
  • A to G, chromosome 8 at 69,663,710 bp
  • T to G, chromosome 9 at 14,555,763 bp
  • T to G, chromosome 9 at 18,875,413 bp
  • CAACCCTGGTAAC to CAAC, chromosome 9 at 66,493,190 bp
  • T to G, chromosome 10 at 86,448,909 bp
  • T to C, chromosome 10 at 120,223,862 bp
  • T to A, chromosome 11 at 48,947,876 bp
  • T to C, chromosome 11 at 50,135,915 bp
  • T to C, chromosome 11 at 54,937,979 bp
  • G to T, chromosome 12 at 31,340,865 bp
  • A to G, chromosome 12 at 101,651,147 bp
  • A to T, chromosome 12 at 112,922,041 bp
  • T to A, chromosome 12 at 113,544,040 bp
  • A to T, chromosome 13 at 23,900,520 bp
  • T to C, chromosome 13 at 33,899,309 bp
  • T to G, chromosome 13 at 92,685,190 bp
  • T to A, chromosome 14 at 26,785,933 bp
  • T to C, chromosome 14 at 55,066,900 bp
  • T to A, chromosome 14 at 56,059,971 bp
  • A to T, chromosome 14 at 56,956,181 bp
  • A to G, chromosome 14 at 78,995,149 bp
  • A to T, chromosome 14 at 103,123,355 bp
  • T to A, chromosome 15 at 6,824,482 bp
  • T to A, chromosome 15 at 54,254,074 bp
  • A to T, chromosome 15 at 81,008,726 bp
  • A to G, chromosome 15 at 89,162,330 bp
  • T to C, chromosome 16 at 45,143,883 bp
  • T to C, chromosome 17 at 6,016,287 bp
  • A to T, chromosome 17 at 12,735,991 bp
  • A to G, chromosome 17 at 19,611,688 bp
  • T to G, chromosome 18 at 20,331,711 bp
  • T to C, chromosome 19 at 8,964,376 bp
  • A to G, chromosome 19 at 15,918,356 bp
  • T to A, chromosome 19 at 30,075,101 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7730 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045786-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.