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Strain Name:
C57BL/6J-MtgxR7733Btlr/Mmmh
Stock Number:
045789-MU
Citation ID:
RRID:MMRRC_045789-MU
Other Names:
R7733 (G1)
Major Collection:

Strain Information

Kif5a
Name: kinesin family member 5A
Synonyms: Kns, Kif5, D10Bwg0738e, Khc
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16572
VEGA: 10
HGNC: HGNC:6323
Homologene: 55861
Ptprz1
Name: protein tyrosine phosphatase receptor type Z, polypeptide 1
Synonyms: DSD-1-PG, phosphacan, PTPzeta, PTPbeta, Rptpbeta, Ptpz, Ptprz, RPTPz
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19283
HGNC: HGNC:9685
Homologene: 2136
Glt8d1
Name: glycosyltransferase 8 domain containing 1
Synonyms: 5430414N14Rik, 2410004H05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 76485
VEGA: 14
Homologene: 32720
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
Cwf19l2
Name: CWF19 like cell cycle control factor 2
Synonyms: 3230401L03Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 244672
Homologene: 12366
Prex2
Name: phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
Synonyms: 6230420N16Rik, C030045D06Rik, Depdc2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 109294
Homologene: 23523
Eprs1
Name: glutamyl-prolyl-tRNA synthetase 1
Synonyms: 3010002K18Rik, 2410081F06Rik, Qprs, Eprs
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 107508
HGNC: HGNC:3418
Homologene: 5870
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 11,181,959 bp
  • G to C, chromosome 1 at 78,688,236 bp
  • C to T, chromosome 1 at 166,389,942 bp
  • T to A, chromosome 1 at 171,840,659 bp
  • T to C, chromosome 1 at 180,600,212 bp
  • A to T, chromosome 1 at 185,397,161 bp
  • A to G, chromosome 2 at 57,112,321 bp
  • T to A, chromosome 2 at 65,508,650 bp
  • C to T, chromosome 2 at 69,220,183 bp
  • C to T, chromosome 2 at 112,130,041 bp
  • C to A, chromosome 2 at 121,442,520 bp
  • G to T, chromosome 2 at 139,631,368 bp
  • T to A, chromosome 2 at 155,823,232 bp
  • A to G, chromosome 2 at 161,575,787 bp
  • T to C, chromosome 2 at 167,512,518 bp
  • C to T, chromosome 2 at 173,117,192 bp
  • A to G, chromosome 2 at 181,230,355 bp
  • T to C, chromosome 3 at 102,895,962 bp
  • G to T, chromosome 3 at 131,303,027 bp
  • T to C, chromosome 4 at 44,981,494 bp
  • C to A, chromosome 4 at 58,049,239 bp
  • A to G, chromosome 4 at 115,120,194 bp
  • A to G, chromosome 4 at 126,835,529 bp
  • A to T, chromosome 4 at 135,960,083 bp
  • T to C, chromosome 5 at 52,538,531 bp
  • T to C, chromosome 5 at 104,519,960 bp
  • T to C, chromosome 5 at 134,593,216 bp
  • T to A, chromosome 6 at 23,000,384 bp
  • T to C, chromosome 6 at 88,376,220 bp
  • T to C, chromosome 6 at 108,076,127 bp
  • A to G, chromosome 6 at 122,932,150 bp
  • T to A, chromosome 6 at 132,803,175 bp
  • T to A, chromosome 6 at 133,294,277 bp
  • C to A, chromosome 6 at 137,414,286 bp
  • G to T, chromosome 7 at 13,296,231 bp
  • T to C, chromosome 7 at 19,222,710 bp
  • A to T, chromosome 7 at 19,760,388 bp
  • A to T, chromosome 7 at 28,139,965 bp
  • A to G, chromosome 7 at 42,012,019 bp
  • C to T, chromosome 7 at 56,188,664 bp
  • T to A, chromosome 7 at 67,735,945 bp
  • C to T, chromosome 7 at 92,901,298 bp
  • T to A, chromosome 7 at 104,141,076 bp
  • T to A, chromosome 8 at 3,522,660 bp
  • T to C, chromosome 8 at 22,258,721 bp
  • T to G, chromosome 8 at 68,120,916 bp
  • A to G, chromosome 8 at 70,717,451 bp
  • T to G, chromosome 8 at 83,608,377 bp
  • T to C, chromosome 8 at 83,729,396 bp
  • T to A, chromosome 8 at 128,993,052 bp
  • A to T, chromosome 9 at 3,450,066 bp
  • A to G, chromosome 9 at 89,981,727 bp
  • T to C, chromosome 9 at 108,208,848 bp
  • T to A, chromosome 9 at 121,367,225 bp
  • A to G, chromosome 10 at 82,739,179 bp
  • T to A, chromosome 10 at 127,236,740 bp
  • A to T, chromosome 11 at 62,265,339 bp
  • A to G, chromosome 11 at 62,873,397 bp
  • G to A, chromosome 11 at 69,990,009 bp
  • A to G, chromosome 11 at 98,635,215 bp
  • A to G, chromosome 11 at 110,054,587 bp
  • T to G, chromosome 11 at 118,317,529 bp
  • A to T, chromosome 12 at 76,597,921 bp
  • A to T, chromosome 12 at 100,144,140 bp
  • T to A, chromosome 13 at 8,752,608 bp
  • A to G, chromosome 14 at 26,912,352 bp
  • C to T, chromosome 14 at 31,001,978 bp
  • A to G, chromosome 14 at 79,477,040 bp
  • T to A, chromosome 15 at 89,024,801 bp
  • T to C, chromosome 15 at 99,308,343 bp
  • T to A, chromosome 15 at 101,463,514 bp
  • C to T, chromosome 16 at 21,921,686 bp
  • A to G, chromosome 17 at 12,739,369 bp
  • G to A, chromosome 17 at 33,883,569 bp
  • A to T, chromosome 17 at 80,265,074 bp
  • T to A, chromosome 17 at 84,583,524 bp
  • A to T, chromosome 18 at 20,048,315 bp
  • G to C, chromosome 18 at 20,048,316 bp
  • A to G, chromosome 18 at 37,437,036 bp
  • C to G, chromosome 19 at 4,749,012 bp
  • T to C, chromosome 19 at 24,940,794 bp
  • C to T, chromosome 19 at 47,897,993 bp
  • T to C, chromosome 19 at 57,701,988 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7733 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045789-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.