Strain Name:
C57BL/6J-MtgxR7741Btlr/Mmmh
Stock Number:
045797-MU
Citation ID:
RRID:MMRRC_045797-MU
Other Names:
R7741 (G1)
Major Collection:

Strain Information

Pou2f1
Name: POU domain, class 2, transcription factor 1
Synonyms: oct-1, Oct-1A, Otf-1, Oct-1C, 2810482H01Rik, Oct-1z, Oct1, Oct-1B, Otf1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18986
HGNC: HGNC:9212
Homologene: 37658
Il17rd
Name: interleukin 17 receptor D
Synonyms: 2810004A10Rik, Sef-S, Sef
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 171463
VEGA: 14
Homologene: 9717
Col6a1
Name: collagen, type VI, alpha 1
Synonyms: Col6a-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 12833
HGNC: HGNC:2211
Homologene: 1391
Usp32
Name: ubiquitin specific peptidase 32
Synonyms: 2900074J03Rik, 6430526O11Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237898
Homologene: 13066
Dot1l
Name: DOT1 like histone lysine methyltransferase
Synonyms: KMT4, mDot1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208266
Homologene: 32779
Tpx2
Name: TPX2, microtubule-associated
Synonyms: REPP86, 2610005B21Rik, DIL2, p100
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72119
HGNC: HGNC:1249
Homologene: 8107
Zfp462
Name: zinc finger protein 462
Synonyms: 9430078C22Rik, Gt4-2, Zfpip
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242466
Homologene: 41430
Kmt2a
Name: lysine (K)-specific methyltransferase 2A
Synonyms: trithorax Drosophila, ALL-1, Mll1, Cxxc7, Mll, HTRX1, All1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 214162
HGNC: HGNC:7132
Homologene: 4338
Rbbp4
Name: retinoblastoma binding protein 4, chromatin remodeling factor
Synonyms: CAF-1 p48 subunit, RBAP48
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 19646
HGNC: HGNC:9887
Homologene: 21153
Map2k2
Name: mitogen-activated protein kinase kinase 2
Synonyms: Prkmk2, MEK2, MAP kinase/Erk kinase
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 26396
HGNC: HGNC:6842
Homologene: 48591
Tshr
Name: thyroid stimulating hormone receptor
Synonyms: hyt, hypothroid, pet
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 22095
Homologene: 315
Topbp1
Name: topoisomerase (DNA) II binding protein 1
Synonyms: D430026L04Rik, 1110031N14Rik, 2810429C13Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235559
Homologene: 38262
Rif1
Name: replication timing regulatory factor 1
Synonyms: 5730435J01Rik, D2Ertd145e, 6530403D07Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 51869
Homologene: 41231
Zkscan5
Name: zinc finger with KRAB and SCAN domains 5
Synonyms: hKraba1, Zfp95
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22757
Homologene: 8734
Cep135
Name: centrosomal protein 135
Synonyms: LOC381644, Cep4
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381644
Homologene: 45709
Adgrl1
Name: adhesion G protein-coupled receptor L1
Synonyms: Lphn1, lectomedin-2, Lec2, 2900070I05Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 330814
Homologene: 8951
Oga
Name: O-GlcNAcase
Synonyms: 2810009A20Rik, Mgea5, 5830447M11Rik, Hy5, 4833427O07Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 76055
VEGA: 19
HGNC: HGNC:7056
Homologene: 8154
Klk11
Name: kallikrein related-peptidase 11
Synonyms: hippostasin, 2310015I08Rik, TLSP, Prss20
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56538
HGNC: HGNC:6359
Homologene: 27048
Gdpd5
Name: glycerophosphodiester phosphodiesterase domain containing 5
Synonyms: Gde2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233552
Homologene: 32741
Usp39
Name: ubiquitin specific peptidase 39
Synonyms: D6Wsu157e, CGI-21, SAD1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 28035
Homologene: 13183
Cenpe
Name: centromere protein E
Synonyms: Kif10, 312kDa, CENP-E, N-7 kinesin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 229841
HGNC: HGNC:1856
Homologene: 20429
Ppp4r3b
Name: protein phosphatase 4 regulatory subunit 3B
Synonyms: Smek2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104570
Homologene: 68886
Vac14
Name: Vac14 homolog (S. cerevisiae)
Synonyms: ingls, Trx, D8Wsu151e, Tax1bp2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234729
Homologene: 6528
Foxn3
Name: forkhead box N3
Synonyms: 5430426H20Rik, Ches1l, Ches1, HTLFL1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 71375
HGNC: HGNC:1928
Homologene: 135955
Mst1r
Name: macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms: Fv-2, Fv2, STK, CDw136, PTK8, friend virus susceptibility 2, Ron
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 19882
HGNC: HGNC:7381
Homologene: 1835
Akr1c18
Name: aldo-keto reductase family 1, member C18
Synonyms: 20alpha-HSD, 20alpha-hydroxysteroid dehydrogenase
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 105349
HGNC: HGNC:386
Homologene: 128661
Grn
Name: granulin
Synonyms: epithelin, acrogranulin, PC cell-derived growth factor, Pgrn, progranulin
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14824
HGNC: HGNC:4601
Homologene: 1577
Nr3c2
Name: nuclear receptor subfamily 3, group C, member 2
Synonyms: mineralocorticoid receptor, Mlr, aldosterone receptor, MR
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 110784
HGNC: HGNC:7979
Homologene: 121495
Snx7
Name: sorting nexin 7
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 76561
Homologene: 22941
Celsr1
Name: cadherin, EGF LAG seven-pass G-type receptor 1
Synonyms: crash, Adgrc1, Crsh, Scy
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12614
VEGA: 15
HGNC: HGNC:1850
Homologene: 7665
2610028H24Rik
Name: RIKEN cDNA 2610028H24 gene
Synonyms: ORF67
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 76964
HGNC: HGNC:1300
Homologene: 50540
Capn2
Name: calpain 2
Synonyms: Capa-2, m-calpain, Capa2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12334
HGNC: HGNC:1479
Homologene: 1326
Vars2
Name: valyl-tRNA synthetase 2, mitochondrial
Synonyms: 1190004I24Rik, Vars2l
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68915
Homologene: 57502
Sel1l3
Name: sel-1 suppressor of lin-12-like 3 (C. elegans)
Synonyms: 2310045A20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231238
Homologene: 9054
Gstm7
Name: glutathione S-transferase, mu 7
Synonyms: 0610005A07Rik, Cd203c
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 68312
HGNC: HGNC:4634
Homologene: 41816
Afap1l2
Name: actin filament associated protein 1-like 2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 226250
Homologene: 13057
Trpv3
Name: transient receptor potential cation channel, subfamily V, member 3
Synonyms: Nh, VRL3, 1110036I10Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246788
Homologene: 17040
Psd4
Name: pleckstrin and Sec7 domain containing 4
Synonyms: EFA6B, SEC7 homolog
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 215632
Homologene: 8261
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Ogfod3
Name: 2-oxoglutarate and iron-dependent oxygenase domain containing 3
Synonyms: 1110031I02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 66179
Homologene: 11640
Cfap119
Name: cilia and flagella associated protein 119
Synonyms: Ccdc189, LOC233899, Gm166
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233899
Homologene: 79950
Plscr4
Name: phospholipid scramblase 4
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235527
Homologene: 23217
Tas2r131
Name: taste receptor, type 2, member 131
Synonyms: mGR31, T2R31, Tas2r31, mt2r61
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387356
Homologene: 52298
Klhl29
Name: kelch-like 29
Synonyms: A230106N14Rik, Kbtbd9
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 208439
VEGA: 12
Homologene: 66272
Dyrk2
Name: dual-specificity tyrosine phosphorylation regulated kinase 2
Synonyms: 1810038L18Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69181
VEGA: 10
HGNC: HGNC:3093
Homologene: 48437
Scgb2b7
Name: secretoglobin, family 2B, member 7
Synonyms: Gm4684, Abpbg7
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100043836
Homologene: 83171
Or5b102
Name: olfactory receptor family 5 subfamily B member 102
Synonyms: MOR202-14, Olfr1454, GA_x6K02T2RE5P-3390804-3391727
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258687
HGNC: HGNC:8324
Homologene: 120159
Brdt
Name: bromodomain, testis-specific
Synonyms: Fsrg3, 7420412D09Rik, Brd6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 114642
HGNC: HGNC:1105
Homologene: 21064
Or8d2
Name: olfactory receptor family 8 subfamily D member 2
Synonyms: GA_x6K02T2PVTD-32543982-32544908, Olfr1520-ps1, MOR171-27P, MOR171-47, MOR171-27P, Olfr924
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 404322
VEGA: 9
HGNC: HGNC:8482
Homologene: 128215
Snx31
Name: sorting nexin 31
Synonyms: 4631426E05Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66696
Homologene: 23551
Tbx20
Name: T-box 20
Synonyms: Tbx12, 9430010M06Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 57246
VEGA: 9
Homologene: 32476
Cyp4a14
Name: cytochrome P450, family 4, subfamily a, polypeptide 14
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 13119
Homologene: 134697
Sdc1
Name: syndecan 1
Synonyms: Synd, CD138, syn-1, Synd1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20969
Homologene: 2252
Rmi1
Name: RecQ mediated genome instability 1
Synonyms: 4932432N11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 74386
VEGA: 13
Homologene: 41601
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 165,875,875 bp
  • C to A, chromosome 1 at 182,479,723 bp
  • T to G, chromosome 2 at 24,401,096 bp
  • T to A, chromosome 2 at 52,085,141 bp
  • T to A, chromosome 2 at 152,867,343 bp
  • A to T, chromosome 3 at 107,931,647 bp
  • A to G, chromosome 3 at 117,838,839 bp
  • C to G, chromosome 3 at 135,247,335 bp
  • C to A, chromosome 4 at 55,008,637 bp
  • T to A, chromosome 4 at 115,489,959 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • T to C, chromosome 4 at 129,334,563 bp
  • T to C, chromosome 5 at 53,200,251 bp
  • A to G, chromosome 5 at 76,630,970 bp
  • G to A, chromosome 5 at 107,358,886 bp
  • A to G, chromosome 5 at 145,221,037 bp
  • A to G, chromosome 6 at 72,338,538 bp
  • C to T, chromosome 6 at 132,957,475 bp
  • A to G, chromosome 7 at 31,705,029 bp
  • G to A, chromosome 7 at 43,776,997 bp
  • T to C, chromosome 7 at 99,453,794 bp
  • C to A, chromosome 7 at 127,587,987 bp
  • A to G, chromosome 8 at 77,210,646 bp
  • T to A, chromosome 8 at 83,929,714 bp
  • T to C, chromosome 8 at 110,634,388 bp
  • A to T, chromosome 9 at 24,740,285 bp
  • T to C, chromosome 9 at 38,848,318 bp
  • A to G, chromosome 9 at 44,808,062 bp
  • A to T, chromosome 9 at 92,482,640 bp
  • A to T, chromosome 9 at 103,320,557 bp
  • G to T, chromosome 9 at 107,907,120 bp
  • C to T, chromosome 10 at 76,454,717 bp
  • C to A, chromosome 10 at 76,709,909 bp
  • C to T, chromosome 10 at 80,783,544 bp
  • T to C, chromosome 10 at 81,121,043 bp
  • T to C, chromosome 10 at 118,859,689 bp
  • T to G, chromosome 11 at 29,205,701 bp
  • T to A, chromosome 11 at 73,288,262 bp
  • G to T, chromosome 11 at 84,987,281 bp
  • A to G, chromosome 11 at 102,435,734 bp
  • T to G, chromosome 11 at 121,183,536 bp
  • T to C, chromosome 12 at 5,137,500 bp
  • A to G, chromosome 12 at 8,791,370 bp
  • G to A, chromosome 12 at 91,533,969 bp
  • T to C, chromosome 12 at 99,196,328 bp
  • T to A, chromosome 13 at 4,144,333 bp
  • A to G, chromosome 13 at 58,409,253 bp
  • A to G, chromosome 14 at 27,100,336 bp
  • A to G, chromosome 15 at 36,523,441 bp
  • A to T, chromosome 15 at 85,979,102 bp
  • A to G, chromosome 17 at 35,660,943 bp
  • A to T, chromosome 19 at 13,064,059 bp
  • A to T, chromosome 19 at 45,776,062 bp
  • T to C, chromosome 19 at 56,914,482 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7741 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045797-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.