Strain Name:
C57BL/6J-MtgxR7744Btlr/Mmmh
Stock Number:
045800-MU
Citation ID:
RRID:MMRRC_045800-MU
Other Names:
R7744 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: CalDAG-GEFI, Caldaggef1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Autotaxin, Npps2, PD-Ialpha, Pdnp2, ATX
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Dyrk3
Name: dual-specificity tyrosine phosphorylation regulated kinase 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226419
HGNC: HGNC:3094
Homologene: 55762
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Ranbp3
Name: RAN binding protein 3
Synonyms: 2610024N24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71810
VEGA: 17
HGNC: HGNC:9850
Homologene: 136516
Fndc3a
Name: fibronectin type III domain containing 3A
Synonyms: 1700094E19Rik, F730017H24Rik, D14Ertd453e, Fndc3, sys
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319448
Homologene: 8952
Eif3c
Name: eukaryotic translation initiation factor 3, subunit C
Synonyms: NIPIL(A3), 110kDa, 3230401O13Rik, Eif3s8, Xsl, Xs
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 56347
Homologene: 2781
Abi2
Name: abl interactor 2
Synonyms: 8430425M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329165
Homologene: 4209
Nbr1
Name: NBR1, autophagy cargo receptor
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 17966
HGNC: HGNC:6746
Homologene: 7438
Mcm10
Name: minichromosome maintenance 10 replication initiation factor
Synonyms: C330019M07Rik, 2410041F14Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 70024
Homologene: 41275
Igsf9
Name: immunoglobulin superfamily, member 9
Synonyms: NRT1, Dasm1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 93842
Homologene: 10815
Muc16
Name: mucin 16
Synonyms: LOC385009, 1110008I14Rik, Gm21044
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 73732
Homologene: 141193
Ampd2
Name: adenosine monophosphate deaminase 2
Synonyms: Ampd-2, 1200014F01Rik, m4521Dajl
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 109674
HGNC: HGNC:469
Homologene: 2979
Mrpl10
Name: mitochondrial ribosomal protein L10
Synonyms: MRP-L8, Rpml8, 0610040E02Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 107732
Homologene: 41665
Pnpla6
Name: patatin-like phospholipase domain containing 6
Synonyms: Swiss-cheese, MSws, Nte
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 50767
Homologene: 21333
Mettl16
Name: methyltransferase 16, N6-methyladenosine
Synonyms: 2610100D03Rik, A830095F14Rik, 2810013M15Rik, Mett10d
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 67493
Homologene: 34653
Atf7ip2
Name: activating transcription factor 7 interacting protein 2
Synonyms: 4930558K11Rik, PSM2, Get-1
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 75329
Homologene: 23509
Ndufs1
Name: NADH:ubiquinone oxidoreductase core subunit S1
Synonyms: 9930026A05Rik, 5830412M15Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227197
HGNC: HGNC:7707
Homologene: 3670
Phf21b
Name: PHD finger protein 21B
Synonyms: A730032D07Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 271305
Homologene: 78154
Isx
Name: intestine specific homeobox
Synonyms: 9130012O13Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 71597
Homologene: 28312
Hes1
Name: hes family bHLH transcription factor 1
Synonyms: Hry, bHLHb39
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 15205
HGNC: HGNC:5192
Homologene: 38067
Abca13
Name: ATP-binding cassette, sub-family A member 13
Synonyms: A930002G16Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268379
Homologene: 27991
Pced1a
Name: PC-esterase domain containing 1A
Synonyms: A930025D01Rik, Fam113a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 319513
Homologene: 11241
Eml1
Name: echinoderm microtubule associated protein like 1
Synonyms: ELP79, 1110008N23Rik, A930030P13Rik, heco
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 68519
HGNC: HGNC:3330
Homologene: 20931
Gxylt2
Name: glucoside xylosyltransferase 2
Synonyms: LOC232313, Glt8d4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232313
Homologene: 16823
Mre11a
Name: MRE11A homolog A, double strand break repair nuclease
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 17535
HGNC: HGNC:7230
Homologene: 4083
Myt1l
Name: myelin transcription factor 1-like
Synonyms: Png-1, Nztf1, Pmng1, C630034G21Rik, 2900093J19Rik, 2900046C06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 17933
VEGA: 12
HGNC: HGNC:7623
Homologene: 7435
Plce1
Name: phospholipase C, epsilon 1
Synonyms: 4933403A21Rik, PLCepsilon
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74055
Homologene: 9478
Rgl3
Name: ral guanine nucleotide dissociation stimulator-like 3
Synonyms: 1300003D20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 71746
VEGA: 9
Homologene: 11363
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cPLA2, Type IV PLA2, cytosolic PLA2, cPLA2alpha, cytosolic phospholipase A2, Pla2g4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Ccng2
Name: cyclin G2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 12452
HGNC: HGNC:1593
Homologene: 3208
Or10q1
Name: olfactory receptor family 10 subfamily Q member 1
Synonyms: GA_x6K02T2RE5P-4082427-4083374, MOR266-1, Olfr1494
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258992
Homologene: 64855
Kcnb1
Name: potassium voltage gated channel, Shab-related subfamily, member 1
Synonyms: Kv2.1, Kcr1-1, Shab
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 16500
HGNC: HGNC:6231
Homologene: 37988
Cfap57
Name: cilia and flagella associated protein 57
Synonyms: C130004B06Rik, LOC384050, 1110020C03Rik, Wdr65
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 68625
Homologene: 51350
Fbxw21
Name: F-box and WD-40 domain protein 21
Synonyms: E330009P21Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 320082
Homologene: 110776
Palm2
Name: paralemmin 2
Synonyms: 53-H12, pEN70
Type: Gene
Species: Mouse
Chromosome: 4
Or4c29
Name: olfactory receptor family 4 subfamily C member 29
Synonyms: GA_x6K02T2Q125-50386882-50385950, MOR230-7, Olfr1209
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258453
Homologene: 128155
Sh3bp1
Name: SH3-domain binding protein 1
Synonyms: 3BP-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 20401
Homologene: 7534
Ptprb
Name: protein tyrosine phosphatase receptor type B
Synonyms: 3230402H02Rik, VE-PTP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Xirp1
Name: xin actin-binding repeat containing 1
Synonyms: Cmya1, mXin alpha, Xin
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 22437
VEGA: 9
Homologene: 7998
Klra10
Name: killer cell lectin-like receptor subfamily A, member 10
Synonyms: Ly49J, Ly49i2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16628
Homologene: 110821
Rab3il1
Name: RAB3A interacting protein (rabin3)-like 1
Synonyms: 1200014K04Rik, Rab3ail1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 74760
HGNC: HGNC:9780
Homologene: 40880
Tmem129
Name: transmembrane protein 129
Synonyms: 0610039G24Rik, 2410015J15Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 68366
Homologene: 44528
Plbd1
Name: phospholipase B domain containing 1
Synonyms: 1100001H23Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66857
Homologene: 11745
Setd7
Name: SET domain containing (lysine methyltransferase) 7
Synonyms: Set7, KMT7, Set7/9, 1600028F23Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 73251
Homologene: 12741
Slc26a3
Name: solute carrier family 26, member 3
Synonyms: Dra, 9030623B18Rik, 9130013M11Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 13487
HGNC: HGNC:3018
Homologene: 55435
Cd177
Name: CD177 antigen
Synonyms: Pdp3, 1190003K14Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 68891
Homologene: 49628
Grid1
Name: glutamate receptor, ionotropic, delta 1
Synonyms: GluRdelta1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14803
HGNC: HGNC:4575
Homologene: 69017
Bglap
Name: bone gamma carboxyglutamate protein
Synonyms: osteocalcin, mOC-A, bone Gla protein, OG1, OC, Bglap1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12096
HGNC: HGNC:1043
Homologene: 104130
Slc17a4
Name: solute carrier family 17 (sodium phosphate), member 4
Synonyms: 9130214H05Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 319848
Homologene: 21127
Sapcd2
Name: suppressor APC domain containing 2
Synonyms: ang, 2010317E24Rik, 6030458L21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 72080
Homologene: 18664
Trib1
Name: tribbles pseudokinase 1
Synonyms: Trb1, A530090O15Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 211770
Homologene: 75216
Rnf223
Name: ring finger 223
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 100045778
Homologene: 27073
Or51f23c-ps1
Name: olfactory receptor family 51 subfamily F member 23C, pseudogene 1
Synonyms: GA_x6K02T2PBJ9-5498153-5499103, MOR14-5, Olfr562-ps1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259090
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 60,437,203 bp
  • A to G, chromosome 1 at 63,160,940 bp
  • A to G, chromosome 1 at 131,129,806 bp
  • A to G, chromosome 1 at 149,861,102 bp
  • A to T, chromosome 1 at 154,465,792 bp
  • A to G, chromosome 1 at 172,492,185 bp
  • A to T, chromosome 2 at 4,991,442 bp
  • C to T, chromosome 2 at 25,373,496 bp
  • C to T, chromosome 2 at 88,909,659 bp
  • C to T, chromosome 2 at 130,422,052 bp
  • A to T, chromosome 2 at 167,188,331 bp
  • C to T, chromosome 3 at 51,526,840 bp
  • T to C, chromosome 3 at 88,383,651 bp
  • C to A, chromosome 3 at 108,080,116 bp
  • T to A, chromosome 4 at 8,862,485 bp
  • T to C, chromosome 4 at 57,709,519 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • G to C, chromosome 4 at 149,237,075 bp
  • G to A, chromosome 4 at 156,132,525 bp
  • A to G, chromosome 5 at 33,654,388 bp
  • C to G, chromosome 5 at 93,273,343 bp
  • T to C, chromosome 6 at 100,783,317 bp
  • T to A, chromosome 6 at 130,272,761 bp
  • T to C, chromosome 6 at 136,617,246 bp
  • A to G, chromosome 7 at 24,750,375 bp
  • G to T, chromosome 7 at 102,782,390 bp
  • C to A, chromosome 7 at 126,558,894 bp
  • T to A, chromosome 8 at 3,531,677 bp
  • T to A, chromosome 8 at 74,873,657 bp
  • G to A, chromosome 9 at 14,809,832 bp
  • T to A, chromosome 9 at 18,585,096 bp
  • T to C, chromosome 9 at 21,987,570 bp
  • C to A, chromosome 9 at 109,157,652 bp
  • T to A, chromosome 9 at 120,016,846 bp
  • T to C, chromosome 10 at 116,277,484 bp
  • T to A, chromosome 11 at 9,290,421 bp
  • T to A, chromosome 11 at 74,803,003 bp
  • C to T, chromosome 11 at 97,044,576 bp
  • C to T, chromosome 11 at 101,569,384 bp
  • T to C, chromosome 12 at 29,827,549 bp
  • A to T, chromosome 12 at 31,463,465 bp
  • A to G, chromosome 12 at 108,516,604 bp
  • C to A, chromosome 13 at 23,901,784 bp
  • A to G, chromosome 14 at 35,450,079 bp
  • C to A, chromosome 14 at 72,561,716 bp
  • A to T, chromosome 15 at 54,901,233 bp
  • T to A, chromosome 15 at 59,654,663 bp
  • A to C, chromosome 15 at 78,910,009 bp
  • A to G, chromosome 15 at 84,804,869 bp
  • T to A, chromosome 16 at 10,241,658 bp
  • A to G, chromosome 16 at 30,066,179 bp
  • C to T, chromosome 17 at 56,708,219 bp
  • T to C, chromosome 19 at 6,405,001 bp
  • T to A, chromosome 19 at 10,028,277 bp
  • A to G, chromosome 19 at 13,750,055 bp
  • G to A, chromosome 19 at 38,620,455 bp
  • A to C, chromosome 19 at 61,127,572 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7744 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045800-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.