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Strain Name:
C57BL/6J-MtgxR7744Btlr/Mmmh
Stock Number:
045800-MU
Citation ID:
RRID:MMRRC_045800-MU
Other Names:
R7744 (G1)
Major Collection:

Strain Information

Chd7
Name: chromodomain helicase DNA binding protein 7
Synonyms: GENA 60, GENA 47, Gena 52, Cyn, A730019I05Rik, WBE1, Whi, Todo, Obt, Mt, Lda, Flo, Edy, Dz, Cycn
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 320790
Homologene: 19067
Rasgrp2
Name: RAS, guanyl releasing protein 2
Synonyms: CalDAG-GEFI, Caldaggef1
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 19395
HGNC: HGNC:9879
Homologene: 4250
Enpp2
Name: ectonucleotide pyrophosphatase/phosphodiesterase 2
Synonyms: Autotaxin, Npps2, PD-Ialpha, Pdnp2, ATX
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 18606
HGNC: HGNC:3357
Homologene: 4526
Dyrk3
Name: dual-specificity tyrosine phosphorylation regulated kinase 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226419
HGNC: HGNC:3094
Homologene: 55762
Kif1b
Name: kinesin family member 1B
Synonyms: D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, N-3 kinesin, A530096N05Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 16561
Homologene: 99835
Ranbp3
Name: RAN binding protein 3
Synonyms: 2610024N24Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 71810
VEGA: 17
HGNC: HGNC:9850
Homologene: 136516
Fndc3a
Name: fibronectin type III domain containing 3A
Synonyms: 1700094E19Rik, F730017H24Rik, D14Ertd453e, Fndc3, sys
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 319448
Homologene: 8952
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • A to G, chromosome 1 at 60,437,203 bp
  • A to G, chromosome 1 at 63,160,940 bp
  • A to G, chromosome 1 at 131,129,806 bp
  • A to G, chromosome 1 at 149,861,102 bp
  • A to T, chromosome 1 at 154,465,792 bp
  • A to G, chromosome 1 at 172,492,185 bp
  • A to T, chromosome 2 at 4,991,442 bp
  • C to T, chromosome 2 at 25,373,496 bp
  • C to T, chromosome 2 at 88,909,659 bp
  • C to T, chromosome 2 at 130,422,052 bp
  • A to T, chromosome 2 at 167,188,331 bp
  • C to T, chromosome 3 at 51,526,840 bp
  • T to C, chromosome 3 at 88,383,651 bp
  • C to A, chromosome 3 at 108,080,116 bp
  • T to A, chromosome 4 at 8,862,485 bp
  • T to C, chromosome 4 at 57,709,519 bp
  • C to T, chromosome 4 at 118,614,931 bp
  • G to C, chromosome 4 at 149,237,075 bp
  • G to A, chromosome 4 at 156,132,525 bp
  • A to G, chromosome 5 at 33,654,388 bp
  • C to G, chromosome 5 at 93,273,343 bp
  • T to C, chromosome 6 at 100,783,317 bp
  • T to A, chromosome 6 at 130,272,761 bp
  • T to C, chromosome 6 at 136,617,246 bp
  • A to G, chromosome 7 at 24,750,375 bp
  • G to T, chromosome 7 at 102,782,390 bp
  • C to A, chromosome 7 at 126,558,894 bp
  • T to A, chromosome 8 at 3,531,677 bp
  • T to A, chromosome 8 at 74,873,657 bp
  • G to A, chromosome 9 at 14,809,832 bp
  • T to A, chromosome 9 at 18,585,096 bp
  • T to C, chromosome 9 at 21,987,570 bp
  • C to A, chromosome 9 at 109,157,652 bp
  • T to A, chromosome 9 at 120,016,846 bp
  • T to C, chromosome 10 at 116,277,484 bp
  • T to A, chromosome 11 at 9,290,421 bp
  • T to A, chromosome 11 at 74,803,003 bp
  • C to T, chromosome 11 at 97,044,576 bp
  • C to T, chromosome 11 at 101,569,384 bp
  • T to C, chromosome 12 at 29,827,549 bp
  • A to T, chromosome 12 at 31,463,465 bp
  • A to G, chromosome 12 at 108,516,604 bp
  • C to A, chromosome 13 at 23,901,784 bp
  • A to G, chromosome 14 at 35,450,079 bp
  • C to A, chromosome 14 at 72,561,716 bp
  • A to T, chromosome 15 at 54,901,233 bp
  • T to A, chromosome 15 at 59,654,663 bp
  • A to C, chromosome 15 at 78,910,009 bp
  • A to G, chromosome 15 at 84,804,869 bp
  • T to A, chromosome 16 at 10,241,658 bp
  • A to G, chromosome 16 at 30,066,179 bp
  • C to T, chromosome 17 at 56,708,219 bp
  • T to C, chromosome 19 at 6,405,001 bp
  • T to A, chromosome 19 at 10,028,277 bp
  • A to G, chromosome 19 at 13,750,055 bp
  • G to A, chromosome 19 at 38,620,455 bp
  • A to C, chromosome 19 at 61,127,572 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7744 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045800-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.