Strain Name:
C57BL/6J-MtgxR7750Btlr/Mmmh
Stock Number:
045806-MU
Citation ID:
RRID:MMRRC_045806-MU
Other Names:
R7750 (G1)
Major Collection:

Strain Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: D0Jmb2, NMHC II-A, E030044M24Rik, Myhn1, Fltn, myosin IIA, Myhn-1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Sim1
Name: single-minded family bHLH transcription factor 1
Synonyms: bHLHe14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20464
VEGA: 10
Homologene: 3715
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: b2b1562Clo, 6030440P17Rik, ne, my, 8430406N05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50492
Homologene: 55726
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: SWAP2, Sfrs16, Srsf16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53609
Homologene: 134306
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, 4921505C17Rik, D530039E11Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Trip10
Name: thyroid hormone receptor interactor 10
Synonyms: Cip4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106628
VEGA: 17
Homologene: 99728
Cox4i1
Name: cytochrome c oxidase subunit 4I1
Synonyms: Cox4, Cox4a, COXIV
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12857
HGNC: HGNC:2265
Homologene: 37537
Brd4
Name: bromodomain containing 4
Synonyms: HUNK1, WI-11513, MCAP
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 57261
Homologene: 136213
Acly
Name: ATP citrate lyase
Synonyms: A730098H14Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 104112
HGNC: HGNC:115
Homologene: 854
Zfp462
Name: zinc finger protein 462
Synonyms: Zfpip, 9430078C22Rik, Gt4-2
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242466
Homologene: 41430
Prpf40a
Name: pre-mRNA processing factor 40A
Synonyms: FBP11, 2810012K09Rik, Fnbp3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56194
Homologene: 6377
Bard1
Name: BRCA1 associated RING domain 1
Synonyms: ENSMUSG00000073653, ENSMUSG00000060893
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12021
HGNC: HGNC:952
Homologene: 400
Snap91
Name: synaptosomal-associated protein 91
Synonyms: 91kDa, AP180, F1-20
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 20616
Homologene: 8429
Slc6a11
Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Synonyms: Gabt4, Gat3, D930045G19Rik, E130202I16Rik, GAT4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243616
Homologene: 129935
Unc5b
Name: unc-5 netrin receptor B
Synonyms: Unc5h2, D10Bwg0792e, 6330415E02Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 107449
VEGA: 10
Homologene: 32538
Nol8
Name: nucleolar protein 8
Synonyms: D13Ertd548e, 5730412B09Rik, 4921532D18Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 70930
VEGA: 13
Homologene: 41210
Rprd1a
Name: regulation of nuclear pre-mRNA domain containing 1A
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 225283
VEGA: 18
Homologene: 124432
Abca16
Name: ATP-binding cassette, sub-family A member 16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233810
Homologene: 132942
Synj2bp
Name: synaptojanin 2 binding protein
Synonyms: OMP25, ARIP2, D12Wsu118e, activin receptor interacting protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 24071
Homologene: 10161
Usf3
Name: upstream transcription factor family member 3
Synonyms: 5530400K22Rik, Gm608, LOC207806, LOC385650
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 207806
Homologene: 19504
Epb41l4b
Name: erythrocyte membrane protein band 4.1 like 4b
Synonyms: Ehm2, D4Ertd346e, Lulu2, 6430543G08Rik, Epb4.1l4b
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 54357
Homologene: 69270
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Sppl2a
Name: signal peptide peptidase like 2A
Synonyms: 2010106G01Rik, C130089K23Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 66552
Homologene: 36411
Lama2
Name: laminin, alpha 2
Synonyms: merosin, mer
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16773
HGNC: HGNC:6482
Homologene: 37306
Casp6
Name: caspase 6
Synonyms: Mch2, mCASP-6
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 12368
HGNC: HGNC:1507
Homologene: 37455
Fyb1
Name: FYN binding protein 1
Synonyms: FYB-120/130, ADAP, Fyb, B630013F22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 23880
HGNC: HGNC:4036
Homologene: 22664
Nlrp1b
Name: NLR family, pyrin domain containing 1B
Synonyms: Nalp1b
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 637515
Homologene: 19080
Myo1g
Name: myosin IG
Synonyms: E430002D17Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246177
Homologene: 27996
Slc9b2
Name: solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2
Synonyms: Nhedc2, C80638, NHA2, nha-oc, NHE10
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 97086
Homologene: 45381
Vmn2r100
Name: vomeronasal 2, receptor 100
Synonyms: EG627537
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 627537
Homologene: 129750
Slc45a1
Name: solute carrier family 45, member 1
Synonyms: Dnb5
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242773
Homologene: 44908
Pik3r2
Name: phosphoinositide-3-kinase regulatory subunit 2
Synonyms: p85beta
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18709
HGNC: HGNC:8980
Homologene: 3687
Gm19410
Name: predicted gene, 19410
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 100502846
Homologene: 132117
Frmd4a
Name: FERM domain containing 4A
Synonyms: Gm13190, C230040M21Rik, 2700017I06Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 209630
Homologene: 9971
Tulp4
Name: TUB like protein 4
Synonyms: 1110057P05Rik, 2210038L17Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 68842
Homologene: 32467
Trpv3
Name: transient receptor potential cation channel, subfamily V, member 3
Synonyms: 1110036I10Rik, VRL3, Nh
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 246788
Homologene: 17040
Zkscan4
Name: zinc finger with KRAB and SCAN domains 4
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 544922
Homologene: 128718
Ankrd24
Name: ankyrin repeat domain 24
Synonyms: 5730519E19Rik, 4631433D01Rik, D10Bur2e
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70615
Homologene: 49885
Aass
Name: aminoadipate-semialdehyde synthase
Synonyms: LOR/SDH, Lorsdh
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 30956
Homologene: 4212
Ccdc83
Name: coiled-coil domain containing 83
Synonyms: 4932423M01Rik, 4930549K11Rik, 4930554C01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75338
Homologene: 32709
Cpvl
Name: carboxypeptidase, vitellogenic-like
Synonyms: 4933436L16Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 71287
Homologene: 80235
Sval3
Name: seminal vesicle antigen-like 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 387564
Homologene: 133811
Usp45
Name: ubiquitin specific petidase 45
Synonyms: 3110003C05Rik, Gcap7, 4930550B20Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 77593
Homologene: 17674
Timd4
Name: T cell immunoglobulin and mucin domain containing 4
Synonyms: Tim4, B430010N18Rik, TIM-4
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 276891
Homologene: 51381
Vmn2r49
Name: vomeronasal 2, receptor 49
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 625605
Homologene: 113703
Ugt2b5
Name: UDP glucuronosyltransferase 2 family, polypeptide B5
Synonyms: Udpgt-3, m-1
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 22238
Homologene: 137225
Acox1
Name: acyl-Coenzyme A oxidase 1, palmitoyl
Synonyms: AOX, Acyl-CoA oxidase, D130055E20Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 11430
HGNC: HGNC:119
Homologene: 38299
Ppp1r3e
Name: protein phosphatase 1, regulatory subunit 3E
Synonyms: A630071A11Rik, LOC382898
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 105651
Homologene: 34797
H1f7
Name: H1.7 linker histone
Synonyms: H1T2, 1700026P10Rik, H1-7, H1fnt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70069
VEGA: 15
Pou3f3
Name: POU domain, class 3, transcription factor 3
Synonyms: HST011, urehr2, Brn1, Brn-1, Otf8
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18993
HGNC: HGNC:9216
Homologene: 68509
Mfsd4b5
Name: major facilitator superfamily domain containing 4B5
Synonyms: BC021785
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 215928
Homologene: 129849
C1qc
Name: complement component 1, q subcomponent, C chain
Synonyms: C1qg
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 12262
HGNC: HGNC:1245
Homologene: 32020
Tmco5b
Name: transmembrane and coiled-coil domains 5B
Synonyms: 4930563P21Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 75275
Homologene: 52839
Slco4a1
Name: solute carrier organic anion transporter family, member 4a1
Synonyms: OATP-E, Slc21a12
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 108115
Homologene: 9482
Or2d2b
Name: olfactory receptor family 2 subfamily D member 2B
Synonyms: Gm10081, EG384732, Olfr715b
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 384732
HGNC: HGNC:8244
Homologene: 81541
Methig1
Name: methyltransferase hypoxia inducible domain containing 1
Synonyms: Mettl7a2-Higd1c, UbiE2-Hig1-4, AB099516, UbiE-YGHL1, Mettl7a2Higd1c
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 554292
Homologene: 128515
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 42,698,148 bp
  • T to A, chromosome 1 at 71,066,942 bp
  • A to T, chromosome 2 at 4,601,349 bp
  • A to C, chromosome 2 at 52,280,716 bp
  • T to C, chromosome 2 at 53,151,745 bp
  • A to G, chromosome 2 at 113,288,264 bp
  • A to G, chromosome 2 at 126,919,705 bp
  • T to C, chromosome 2 at 180,471,237 bp
  • C to A, chromosome 3 at 53,523,682 bp
  • A to G, chromosome 3 at 129,912,209 bp
  • T to C, chromosome 3 at 135,326,237 bp
  • A to G, chromosome 4 at 21,780,430 bp
  • C to A, chromosome 4 at 55,016,958 bp
  • C to T, chromosome 4 at 57,076,913 bp
  • T to C, chromosome 4 at 136,890,281 bp
  • C to T, chromosome 4 at 150,644,041 bp
  • A to T, chromosome 5 at 87,140,249 bp
  • T to A, chromosome 6 at 23,075,200 bp
  • T to A, chromosome 6 at 41,972,426 bp
  • T to A, chromosome 6 at 53,926,901 bp
  • C to T, chromosome 6 at 114,230,137 bp
  • T to A, chromosome 7 at 9,976,258 bp
  • A to T, chromosome 7 at 19,584,591 bp
  • A to T, chromosome 7 at 90,223,982 bp
  • A to T, chromosome 7 at 107,106,533 bp
  • A to T, chromosome 7 at 120,514,705 bp
  • G to C, chromosome 7 at 141,809,303 bp
  • T to A, chromosome 8 at 35,807,498 bp
  • A to G, chromosome 8 at 70,770,901 bp
  • A to G, chromosome 8 at 120,673,310 bp
  • A to C, chromosome 9 at 86,798,709 bp
  • T to C, chromosome 10 at 26,990,924 bp
  • A to G, chromosome 10 at 39,970,255 bp
  • A to G, chromosome 10 at 50,896,035 bp
  • A to G, chromosome 10 at 60,775,044 bp
  • G to T, chromosome 10 at 81,080,191 bp
  • A to G, chromosome 10 at 81,646,794 bp
  • T to C, chromosome 11 at 6,514,849 bp
  • T to A, chromosome 11 at 46,815,527 bp
  • T to A, chromosome 11 at 71,168,839 bp
  • T to C, chromosome 11 at 73,286,021 bp
  • A to T, chromosome 11 at 100,478,013 bp
  • C to T, chromosome 11 at 116,183,580 bp
  • T to C, chromosome 12 at 81,504,537 bp
  • A to G, chromosome 13 at 21,479,355 bp
  • G to T, chromosome 13 at 49,662,266 bp
  • G to A, chromosome 13 at 62,369,996 bp
  • T to C, chromosome 14 at 54,876,627 bp
  • A to G, chromosome 15 at 6,660,703 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • C to T, chromosome 15 at 77,783,410 bp
  • A to G, chromosome 15 at 98,256,684 bp
  • T to C, chromosome 15 at 100,353,531 bp
  • A to G, chromosome 16 at 44,220,521 bp
  • A to G, chromosome 17 at 6,233,124 bp
  • G to A, chromosome 17 at 19,522,464 bp
  • G to T, chromosome 17 at 32,213,547 bp
  • A to T, chromosome 17 at 55,938,682 bp
  • G to A, chromosome 17 at 57,261,667 bp
  • T to A, chromosome 18 at 24,508,254 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7750 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045806-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.