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Strain Name:
C57BL/6J-MtgxR7750Btlr/Mmmh
Stock Number:
045806-MU
Citation ID:
RRID:MMRRC_045806-MU
Other Names:
R7750 (G1)
Major Collection:

Strain Information

Myh9
Name: myosin, heavy polypeptide 9, non-muscle
Synonyms: D0Jmb2, E030044M24Rik, NMHC II-A, Myhn-1, Myhn1, myosin IIA, Fltn
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17886
HGNC: HGNC:7579
Homologene: 129835
Sim1
Name: single-minded family bHLH transcription factor 1
Synonyms: bHLHe14
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 20464
VEGA: 10
Homologene: 3715
Frem2
Name: Fras1 related extracellular matrix protein 2
Synonyms: 8430406N05Rik, 6030440P17Rik, my, ne, b2b1562Clo
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 242022
Homologene: 18454
Thop1
Name: thimet oligopeptidase 1
Synonyms: EP24.15
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 50492
Homologene: 55726
Clasrp
Name: CLK4-associating serine/arginine rich protein
Synonyms: SWAP2, Srsf16, Sfrs16
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 53609
Homologene: 134306
Rictor
Name: RPTOR independent companion of MTOR, complex 2
Synonyms: 6030405M08Rik, D530039E11Rik, 4921505C17Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 78757
VEGA: 15
Homologene: 34317
Trip10
Name: thyroid hormone receptor interactor 10
Synonyms: Cip4
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 106628
VEGA: 17
Homologene: 99728
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 42,698,148 bp
  • T to A, chromosome 1 at 71,066,942 bp
  • A to T, chromosome 2 at 4,601,349 bp
  • A to C, chromosome 2 at 52,280,716 bp
  • T to C, chromosome 2 at 53,151,745 bp
  • A to G, chromosome 2 at 113,288,264 bp
  • A to G, chromosome 2 at 126,919,705 bp
  • T to C, chromosome 2 at 180,471,237 bp
  • C to A, chromosome 3 at 53,523,682 bp
  • A to G, chromosome 3 at 129,912,209 bp
  • T to C, chromosome 3 at 135,326,237 bp
  • A to G, chromosome 4 at 21,780,430 bp
  • C to A, chromosome 4 at 55,016,958 bp
  • C to T, chromosome 4 at 57,076,913 bp
  • T to C, chromosome 4 at 136,890,281 bp
  • C to T, chromosome 4 at 150,644,041 bp
  • A to T, chromosome 5 at 87,140,249 bp
  • T to A, chromosome 6 at 23,075,200 bp
  • T to A, chromosome 6 at 41,972,426 bp
  • T to A, chromosome 6 at 53,926,901 bp
  • C to T, chromosome 6 at 114,230,137 bp
  • T to A, chromosome 7 at 9,976,258 bp
  • A to T, chromosome 7 at 19,584,591 bp
  • A to T, chromosome 7 at 90,223,982 bp
  • A to T, chromosome 7 at 107,106,533 bp
  • A to T, chromosome 7 at 120,514,705 bp
  • G to C, chromosome 7 at 141,809,303 bp
  • T to A, chromosome 8 at 35,807,498 bp
  • A to G, chromosome 8 at 70,770,901 bp
  • A to G, chromosome 8 at 120,673,310 bp
  • A to C, chromosome 9 at 86,798,709 bp
  • T to C, chromosome 10 at 26,990,924 bp
  • A to G, chromosome 10 at 39,970,255 bp
  • A to G, chromosome 10 at 50,896,035 bp
  • A to G, chromosome 10 at 60,775,044 bp
  • G to T, chromosome 10 at 81,080,191 bp
  • A to G, chromosome 10 at 81,646,794 bp
  • T to C, chromosome 11 at 6,514,849 bp
  • T to A, chromosome 11 at 46,815,527 bp
  • T to A, chromosome 11 at 71,168,839 bp
  • T to C, chromosome 11 at 73,286,021 bp
  • A to T, chromosome 11 at 100,478,013 bp
  • C to T, chromosome 11 at 116,183,580 bp
  • T to C, chromosome 12 at 81,504,537 bp
  • A to G, chromosome 13 at 21,479,355 bp
  • G to T, chromosome 13 at 49,662,266 bp
  • G to A, chromosome 13 at 62,369,996 bp
  • T to C, chromosome 14 at 54,876,627 bp
  • A to G, chromosome 15 at 6,660,703 bp
  • C to T, chromosome 15 at 6,772,154 bp
  • C to T, chromosome 15 at 77,783,410 bp
  • A to G, chromosome 15 at 98,256,684 bp
  • T to C, chromosome 15 at 100,353,531 bp
  • A to G, chromosome 16 at 44,220,521 bp
  • A to G, chromosome 17 at 6,233,124 bp
  • G to A, chromosome 17 at 19,522,464 bp
  • G to T, chromosome 17 at 32,213,547 bp
  • A to T, chromosome 17 at 55,938,682 bp
  • G to A, chromosome 17 at 57,261,667 bp
  • T to A, chromosome 18 at 24,508,254 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7750 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045806-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.