Strain Name:
C57BL/6J-MtgxR7752Btlr/Mmmh
Stock Number:
045808-MU
Citation ID:
RRID:MMRRC_045808-MU
Other Names:
R7752 (G1)
Major Collection:

Strain Information

Ppp1r17
Name: protein phosphatase 1, regulatory subunit 17
Synonyms: Gsbs, G-substrate
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19051
Homologene: 4849
Ncoa3
Name: nuclear receptor coactivator 3
Synonyms: Src3, pCIP, RAC3, TRAM1, TRAM-1, KAT13B, bHLHe42, AIB1, 2010305B15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 17979
HGNC: HGNC:7670
Homologene: 4764
Sash1
Name: SAM and SH3 domain containing 1
Synonyms: 1100001C18Rik, A330076K04Rik, 2500002E12Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 70097
Homologene: 69182
Nup155
Name: nucleoporin 155
Synonyms: D930027M19Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 170762
VEGA: 15
HGNC: HGNC:8063
Homologene: 43155
Lcmt1
Name: leucine carboxyl methyltransferase 1
Synonyms: LCMT-1, Lcmt
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 30949
Homologene: 41123
Gcn1
Name: GCN1 activator of EIF2AK4
Synonyms: GCN1L, Gcn1l1, G431004K08Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231659
HGNC: HGNC:4199
Homologene: 5887
Trip11
Name: thyroid hormone receptor interactor 11
Synonyms: 2610511G22Rik, 6030460N08Rik, GMAP-210, TRIP230, 3110031G15Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 109181
Homologene: 20897
Taf4
Name: TATA-box binding protein associated factor 4
Synonyms: TAFII130, Taf2c1, Taf4a, TAFII135
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228980
Homologene: 55723
Akap13
Name: A kinase anchor protein 13
Synonyms: Ht31, PROTO-LB, 5830460E08Rik, PROTO-LBC, AKAP-Lbc, 5730522G15Rik, 1700026G02Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 75547
HGNC: HGNC:371
Homologene: 4903
Phip
Name: pleckstrin homology domain interacting protein
Synonyms: Ndrp, 2810004D21Rik, 4632404O06Rik, Wdr11
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 83946
Homologene: 41209
Ccnt1
Name: cyclin T1
Synonyms: CycT1, 2810478G24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 12455
HGNC: HGNC:1599
Homologene: 947
Ddx6
Name: DEAD-box helicase 6
Synonyms: E230023J21Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 6, HLR2, rck, C430015D01Rik, p54, 1110001P04Rik, mRCK/P54
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13209
VEGA: 9
HGNC: HGNC:2747
Homologene: 3238
Dcp1b
Name: decapping mRNA 1B
Synonyms: B930050E02Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 319618
Homologene: 51881
Gpr4
Name: G protein-coupled receptor 4
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 319197
HGNC: HGNC:4497
Homologene: 3867
Sox11
Name: SRY (sex determining region Y)-box 11
Synonyms: 6230403H02Rik, 1110038H03Rik, end1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 20666
Homologene: 37733
Frem1
Name: Fras1 related extracellular matrix protein 1
Synonyms: eyem02Jus, crf11, eyes2, QBRICK, heb
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 329872
Homologene: 27049
Tsg101
Name: tumor susceptibility gene 101
Synonyms: CC2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 22088
Homologene: 4584
Pex5
Name: peroxisomal biogenesis factor 5
Synonyms: Pxr1, ESTM1, peroxisome biogenesis factor 5, PTS1R
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 19305
HGNC: HGNC:9719
Homologene: 270
Or4m1
Name: olfactory receptor family 4 subfamily M member 1
Synonyms: GA_x6K02T2PMLR-6013665-6012724, Olfr734, MOR242-1
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 258658
Homologene: 51759
Zfp592
Name: zinc finger protein 592
Synonyms: A730014M16Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233410
Homologene: 8759
Zfp738
Name: zinc finger protein 738
Synonyms: 3830402I07Rik, 6720487G11Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408068
Homologene: 133713
Unkl
Name: unkempt family like zinc finger
Synonyms: 1300004G08Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 74154
Homologene: 62673
Zfyve28
Name: zinc finger, FYVE domain containing 28
Synonyms: 9630058O20Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231125
Homologene: 15119
Tmco5
Name: transmembrane and coiled-coil domains 5
Synonyms: 1700095F04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 67356
Homologene: 41661
Ttn
Name: titin
Synonyms: 2310036G12Rik, 2310057K23Rik, D330041I19Rik, mdm, connectin, D830007G01Rik, 1100001C23Rik, shru, 2310074I15Rik, L56
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Muc4
Name: mucin 4
Synonyms: 4933405I11Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 140474
HGNC: HGNC:7514
Homologene: 124469
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: Jbts17, b2b012Clo, 2410089E03Rik, Hug
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Gpld1
Name: glycosylphosphatidylinositol specific phospholipase D1
Synonyms: 6330541J12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 14756
HGNC: HGNC:4459
Homologene: 1152
Agfg2
Name: ArfGAP with FG repeats 2
Synonyms: Hrbl, A630095P14Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231801
HGNC: HGNC:5177
Homologene: 4430
Farp1
Name: FERM, ARH/RhoGEF and pleckstrin domain protein 1
Synonyms: Cdep
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 223254
HGNC: HGNC:3591
Homologene: 38098
Il36b
Name: interleukin 36B
Synonyms: 2310043N20Rik, If36b, Il1f8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69677
Homologene: 18278
Ect2l
Name: epithelial cell transforming sequence 2 oncogene-like
Synonyms: C330021H03Rik, Gm10331
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 100045792
Homologene: 46005
Diras1
Name: DIRAS family, GTP-binding RAS-like 1
Synonyms: GBTS1, Di-Ras1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 208666
Homologene: 64823
Ccdc39
Name: coiled-coil domain containing 39
Synonyms: b2b2025.1Clo, b2b1735Clo, D3Ertd789e, 4921507O14Rik, b2b1304Clo, prh
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 51938
Homologene: 12149
Col4a2
Name: collagen, type IV, alpha 2
Synonyms: Col4a-2
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 12827
HGNC: HGNC:2203
Homologene: 1390
Thbd
Name: thrombomodulin
Synonyms: TM, CD141
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 21824
Homologene: 308
Or1ak2
Name: olfactory receptor family 1 subfamily AK member 2
Synonyms: GA_x6K02T2NLDC-33631647-33632594, Olfr356, MOR134-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258617
Homologene: 85948
Aox4
Name: aldehyde oxidase 4
Synonyms: 2310003G12Rik, AOH2
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71872
Homologene: 70273
Clcn4
Name: chloride channel, voltage-sensitive 4
Synonyms: Clcn4-2, Clc4-2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 12727
HGNC: HGNC:2022
Homologene: 68207
Mrs2
Name: MRS2 magnesium transporter
Synonyms: LOC380836, Mrs2l
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 380836
Homologene: 31983
Ms4a20
Name: membrane-spanning 4-domains, subfamily A, member 20
Synonyms: 1700017D01Rik
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 69369
Eme1
Name: essential meiotic structure-specific endonuclease 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268465
Homologene: 16123
Wipf3
Name: WAS/WASL interacting protein family, member 3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330319
Homologene: 113391
Ptprb
Name: protein tyrosine phosphatase receptor type B
Synonyms: 3230402H02Rik, VE-PTP
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 19263
VEGA: 10
HGNC: HGNC:9665
Homologene: 2125
Klk1b1
Name: kallikrein 1-related peptidase b1
Synonyms: mGK-1, mK1, TK, tissue kallikrein, Klk1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16623
Homologene: 68141
Slc41a2
Name: solute carrier family 41, member 2
Synonyms: A230035L05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 338365
Homologene: 9870
Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
Synonyms: KE1.5, Rab2l, Rgt2, Rlf
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19732
HGNC: HGNC:9769
Homologene: 3494
Zfp664
Name: zinc finger protein 664
Synonyms: D930038J03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 269704
Homologene: 65046
Inf2
Name: inverted formin, FH2 and WH2 domain containing
Synonyms: 2610204M08Rik, EG629699
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 70435
VEGA: 12
Homologene: 82406
Skint1
Name: selection and upkeep of intraepithelial T cells 1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 639781
Homologene: 87538
Vwa2
Name: von Willebrand factor A domain containing 2
Synonyms: Amaco
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240675
Homologene: 18238
Cfhr2
Name: complement factor H-related 2
Synonyms: FHR-B
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 545366
Homologene: 134349
Nlrp6
Name: NLR family, pyrin domain containing 6
Synonyms: Nalp6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 101613
Homologene: 15881
Ifi213
Name: interferon activated gene 213
Synonyms: Pyr-A, E030037K03Rik, Pydc4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 623121
HGNC: HGNC:5395
Homologene: 115929
Ppl
Name: periplakin
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 19041
VEGA: 16
HGNC: HGNC:9273
Homologene: 2026
Csf1r
Name: colony stimulating factor 1 receptor
Synonyms: Csfmr, Fim-2, CD115, Fim2, M-CSFR, Fms, CSF-1R
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12978
HGNC: HGNC:2433
Homologene: 3817
Or10v1
Name: olfactory receptor family 10 subfamily V member 1
Synonyms: GA_x6K02T2RE5P-2247227-2248156, Olfr1420, MOR266-4
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 258405
Homologene: 17234
Prox2
Name: prospero homeobox 2
Synonyms: 1700058C01Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 73422
Homologene: 18421
Pramel51
Name: PRAME like 51
Synonyms: Gm10436
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 100039315
VEGA: 12
Homologene: 103830
Traj16
Name: T cell receptor alpha joining 16
Synonyms: Gm16656
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 100124387
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 58,253,948 bp
  • T to A, chromosome 1 at 139,813,584 bp
  • A to T, chromosome 1 at 173,567,218 bp
  • C to T, chromosome 2 at 24,158,814 bp
  • A to T, chromosome 2 at 36,937,618 bp
  • T to C, chromosome 2 at 76,725,026 bp
  • T to C, chromosome 2 at 116,892,262 bp
  • C to A, chromosome 2 at 148,406,974 bp
  • T to A, chromosome 2 at 166,065,768 bp
  • G to A, chromosome 2 at 179,932,029 bp
  • T to C, chromosome 3 at 33,832,617 bp
  • G to T, chromosome 4 at 82,959,377 bp
  • A to C, chromosome 4 at 112,019,202 bp
  • C to T, chromosome 5 at 34,224,982 bp
  • T to A, chromosome 5 at 115,615,568 bp
  • A to T, chromosome 5 at 124,885,775 bp
  • A to T, chromosome 5 at 137,667,704 bp
  • A to G, chromosome 6 at 54,481,911 bp
  • G to A, chromosome 6 at 56,022,456 bp
  • G to T, chromosome 6 at 119,175,357 bp
  • A to G, chromosome 6 at 124,403,901 bp
  • T to C, chromosome 6 at 124,414,018 bp
  • T to C, chromosome 7 at 7,293,937 bp
  • C to A, chromosome 7 at 19,222,415 bp
  • T to C, chromosome 7 at 43,971,245 bp
  • G to T, chromosome 7 at 46,913,435 bp
  • T to A, chromosome 7 at 75,677,258 bp
  • T to G, chromosome 7 at 81,024,721 bp
  • G to T, chromosome 7 at 123,369,807 bp
  • T to C, chromosome 7 at 140,927,440 bp
  • A to T, chromosome 8 at 11,429,358 bp
  • T to G, chromosome 9 at 44,627,663 bp
  • T to G, chromosome 9 at 82,890,150 bp
  • C to T, chromosome 10 at 8,780,564 bp
  • T to A, chromosome 10 at 18,141,964 bp
  • C to T, chromosome 10 at 81,022,061 bp
  • A to G, chromosome 10 at 83,256,041 bp
  • C to G, chromosome 10 at 116,369,428 bp
  • G to T, chromosome 11 at 94,650,819 bp
  • A to T, chromosome 12 at 27,341,440 bp
  • T to A, chromosome 12 at 85,088,041 bp
  • T to C, chromosome 12 at 88,175,999 bp
  • A to G, chromosome 12 at 101,886,974 bp
  • A to G, chromosome 12 at 112,609,684 bp
  • T to A, chromosome 13 at 24,962,775 bp
  • T to A, chromosome 13 at 25,018,566 bp
  • A to T, chromosome 13 at 67,672,991 bp
  • A to T, chromosome 14 at 50,320,116 bp
  • T to C, chromosome 14 at 54,203,188 bp
  • G to C, chromosome 14 at 121,257,947 bp
  • C to T, chromosome 15 at 8,116,442 bp
  • A to G, chromosome 15 at 8,269,706 bp
  • A to T, chromosome 15 at 98,543,916 bp
  • T to G, chromosome 16 at 5,102,302 bp
  • A to G, chromosome 16 at 32,768,734 bp
  • T to C, chromosome 17 at 25,218,653 bp
  • T to C, chromosome 17 at 33,935,825 bp
  • T to A, chromosome 18 at 61,110,296 bp
  • A to G, chromosome 19 at 11,101,860 bp
  • A to T, chromosome 19 at 11,896,534 bp
  • T to A, chromosome 19 at 56,909,240 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7752 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045808-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.