Strain Name:
C57BL/6J-MtgxR7754Btlr/Mmmh
Stock Number:
045810-MU
Citation ID:
RRID:MMRRC_045810-MU
Other Names:
R7754 (G1)
Major Collection:

Strain Information

Aatf
Name: apoptosis antagonizing transcription factor
Synonyms: 4933415H02Rik, Trb, 5830465M17Rik, Che-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56321
Homologene: 40811
Drd2
Name: dopamine receptor D2
Synonyms: D2 receptor, D2R, Drd-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13489
VEGA: 9
HGNC: HGNC:3023
Homologene: 22561
Gpr37
Name: G protein-coupled receptor 37
Synonyms: Pael-R, parkin-associated endothelin B-like receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Rtn4rl1
Name: reticulon 4 receptor-like 1
Synonyms: Ngr3, Ngrh2, Ngrl2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237847
Homologene: 18611
Septin3
Name: septin 3
Synonyms: Sep3, B530002E20Rik, 3110018K01Rik, Sept3, Gm46500
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 24050
VEGA: 15
Homologene: 99740
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22359
Homologene: 443
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Cep70
Name: centrosomal protein 70
Synonyms: 6720484E09Rik, C030018L16Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 68121
Homologene: 11387
Zbtb8a
Name: zinc finger and BTB domain containing 8a
Synonyms: 2410081M15Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 73680
Homologene: 12506
Tlr6
Name: toll-like receptor 6
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21899
Homologene: 21223
Rps6ka2
Name: ribosomal protein S6 kinase, polypeptide 2
Synonyms: Rsk3, Rps6ka-rs1, 90kDa, p90rsk, pp90rsk, D17Wsu134e
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20112
VEGA: 17
Homologene: 100680
Lrba
Name: LPS-responsive beige-like anchor
Synonyms: Lba, D3Ertd775e
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 80877
HGNC: HGNC:1742
Homologene: 36205
Taf4
Name: TATA-box binding protein associated factor 4
Synonyms: Taf2c1, TAFII135, TAFII130, Taf4a
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228980
Homologene: 55723
Akap9
Name: A kinase anchor protein 9
Synonyms: AKAP450, 5730481H23Rik, G1-448-15, repro12, mei2-5
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 100986
HGNC: HGNC:379
Homologene: 134583
Rnf17
Name: ring finger protein 17
Synonyms: MMIP-2
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 30054
VEGA: 14
Homologene: 23727
Rtn1
Name: reticulon 1
Synonyms: Nsp, Rtn1-b, Rtn1-c, 0710005K15Rik, Rtn1-a, 4930441F12Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 104001
Homologene: 49654
Plxna4
Name: plexin A4
Synonyms: Plxa4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 243743
HGNC: HGNC:9102
Homologene: 77587
Il22ra1
Name: interleukin 22 receptor, alpha 1
Synonyms: Il22r
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 230828
Homologene: 10943
Neto2
Name: neuropilin (NRP) and tolloid (TLL)-like 2
Synonyms: 5530601C23Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 74513
Homologene: 32387
Ssh1
Name: slingshot protein phosphatase 1
Synonyms: mSSH-1L, LOC384311
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231637
Homologene: 41299
Wscd1
Name: WSC domain containing 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216881
Homologene: 18590
Gtf3c2
Name: general transcription factor IIIC, polypeptide 2, beta
Synonyms: 2610510G03Rik, TFIIIC-BETA, TFIIIC110, 1300004C11Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 71752
HGNC: HGNC:4665
Homologene: 37490
Rapgef3
Name: Rap guanine nucleotide exchange factor (GEF) 3
Synonyms: 2310016P22Rik, 9330170P05Rik, Epac1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223864
Homologene: 21231
Muc5ac
Name: mucin 5, subtypes A and C, tracheobronchial/gastric
Synonyms: MGM, 2210005L13Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17833
HGNC: HGNC:7515
Homologene: 137237
Fbn1
Name: fibrillin 1
Synonyms: Fib-1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14118
HGNC: HGNC:3603
Homologene: 30958
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Nlgn1
Name: neuroligin 1
Synonyms: 6330415N05Rik, NL1, Nlg1
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 192167
Homologene: 56690
Dnah6
Name: dynein, axonemal, heavy chain 6
Synonyms: A730004I20Rik, Dnahc6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 330355
HGNC: HGNC:2951
Homologene: 15221
Pkhd1l1
Name: polycystic kidney and hepatic disease 1-like 1
Synonyms: D86 mRNA, PKHDL1, fibrocystin L
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 192190
Homologene: 16332
Cacna1d
Name: calcium channel, voltage-dependent, L type, alpha 1D subunit
Synonyms: D-LTCC, Cchl1a, Cchl1a2, Cacnl1a2, 8430418G19Rik, Cav1.3alpha1, C79217
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12289
VEGA: 14
HGNC: HGNC:1391
Homologene: 578
Cplane1
Name: ciliogenesis and planar polarity effector 1
Synonyms: b2b012Clo, Jbts17, Hug, 2410089E03Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 73692
Homologene: 11315
Or7c19
Name: olfactory receptor family 7 subfamily C member 19
Synonyms: GA_x6K02T2NUPS-13298842-13299780, MOR141-3, Olfr371
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 258858
Homologene: 65998
Ppp6r2
Name: protein phosphatase 6, regulatory subunit 2
Synonyms: 1110033O10Rik, 8430411H09Rik, B230107H12Rik, Pp6r2, Saps2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71474
VEGA: 15
Homologene: 36455
D430041D05Rik
Name: RIKEN cDNA D430041D05 gene
Synonyms: G2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 241589
Homologene: 115928
Abcb11
Name: ATP-binding cassette, sub-family B member 11
Synonyms: PFIC2, ABC16, PGY4, Lith1, sister of P-glycoprotein, Bsep
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 27413
HGNC: HGNC:42
Homologene: 74509
Ltbp2
Name: latent transforming growth factor beta binding protein 2
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16997
HGNC: HGNC:6715
Homologene: 369
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240069
Homologene: 18615
Jag2
Name: jagged 2
Synonyms: Serh, D12Ggc2e
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 16450
VEGA: 12
HGNC: HGNC:6189
Homologene: 1677
Otogl
Name: otogelin-like
Synonyms: Gm6924
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 628870
Homologene: 46008
Myo5b
Name: myosin VB
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 17919
HGNC: HGNC:7603
Homologene: 49481
Apbb1
Name: amyloid beta precursor protein binding family B member 1
Synonyms: Fe65, Rir
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 11785
HGNC: HGNC:581
Homologene: 898
Fam171a2
Name: family with sequence similarity 171, member A2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 217219
Homologene: 19144
Pld2
Name: phospholipase D2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 18806
HGNC: HGNC:9068
Homologene: 55672
Cacna1e
Name: calcium channel, voltage-dependent, R type, alpha 1E subunit
Synonyms: Cav2.3, Cchra1, alpha1E
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 12290
HGNC: HGNC:1392
Homologene: 20185
Serpina3f
Name: serine (or cysteine) peptidase inhibitor, clade A, member 3F
Synonyms: 2A1, antitrypsin, alpha-1 antiproteinasin
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 238393
HGNC: HGNC:16
Homologene: 115927
4930553M12Rik
Name: RIKEN cDNA 4930553M12 gene
Type: Gene
Species: Mouse
Chromosome: 4
Lcn11
Name: lipocalin 11
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227630
Homologene: 129702
Cstpp1
Name: centriolar satellite-associated tubulin polyglutamylase complex regulator 1
Synonyms: 1110051M20Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 228356
Homologene: 11471
Idh1
Name: isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms: Id-1, Idh-1, E030024J03Rik, IDPc
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 15926
HGNC: HGNC:5382
Homologene: 21195
Fam163a
Name: family with sequence similarity 163, member A
Synonyms: A230106N23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 329274
Homologene: 18306
Pde3a
Name: phosphodiesterase 3A, cGMP inhibited
Synonyms: A930022O17Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 54611
HGNC: HGNC:8778
Homologene: 708
Lca5l
Name: Leber congenital amaurosis 5-like
Synonyms: 4921526F01Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 385668
HGNC: HGNC:1255
Homologene: 47978
Ccdc162
Name: coiled-coil domain containing 162
Synonyms: 5033413D22Rik, Gm29096, Gm6976
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 75973
Homologene: 136355
Zfp827
Name: zinc finger protein 827
Synonyms: 2810449M09Rik, D630040G17Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 622675
Homologene: 45622
Or1e25
Name: olfactory receptor family 1 subfamily E member 25
Synonyms: GA_x6K02T2P1NL-3773152-3774090, GA_x6K02T2P1NL-3739520-3740032, MOR135-5, Olfr386, Olfr384
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 193053
Homologene: 105206
Or1l4b
Name: olfactory receptor family 1 subfamily L member 4B
Synonyms: GA_x6K02T2NLDC-33831282-33832243, MOR138-4P, MOR138-7, Olfr364
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 227794
HGNC: HGNC:8216
Optc
Name: opticin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269120
HGNC: HGNC:8158
Homologene: 8652
Rptn
Name: repetin
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 20129
Homologene: 84780
Or9k2
Name: olfactory receptor family 9 subfamily K member 2
Synonyms: GA_x6K02T2PULF-11834065-11833103, MOR210-1, Olfr825
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258672
Homologene: 121503
Acss2
Name: acyl-CoA synthetase short-chain family member 2
Synonyms: acetyl-CoA synthetase 1, ACAS, AceCS1, Acas1, Acs1, Acas2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 60525
Homologene: 6469
Efcab9
Name: EF-hand calcium binding domain 9
Synonyms: 4930403C08Rik, 1700007I06Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 69306
Homologene: 12309
Or52e19b
Name: olfactory receptor family 52 subfamily E member 19B
Synonyms: GA_x6K02T2PBJ9-6096387-6095449, GA_x6K02T2PBJ9-6092550-6092362, MOR32-2, MOR32-14_i, Olfr604, Olfr603
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259073
Homologene: 121535
Pcdhgb2
Name: protocadherin gamma subfamily B, 2
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93700
HGNC: HGNC:8709
Homologene: 49571
Malrd1
Name: MAM and LDL receptor class A domain containing 1
Synonyms: Gm13318, Gm13364, Diet1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 102635496
Homologene: 136214
Trbv13-2
Name: T cell receptor beta, variable 13-2
Synonyms: Tcrb-V8.2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 100124675
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 65,159,490 bp
  • C to A, chromosome 1 at 71,302,887 bp
  • A to G, chromosome 1 at 133,906,992 bp
  • C to T, chromosome 1 at 154,413,117 bp
  • A to T, chromosome 1 at 156,079,983 bp
  • G to A, chromosome 2 at 15,797,799 bp
  • G to A, chromosome 2 at 25,777,818 bp
  • A to G, chromosome 2 at 37,146,846 bp
  • T to A, chromosome 2 at 69,286,818 bp
  • A to T, chromosome 2 at 76,788,196 bp
  • A to T, chromosome 2 at 76,825,505 bp
  • A to T, chromosome 2 at 91,304,843 bp
  • A to T, chromosome 2 at 104,257,159 bp
  • A to T, chromosome 2 at 125,479,280 bp
  • T to A, chromosome 2 at 155,561,166 bp
  • G to A, chromosome 2 at 179,932,029 bp
  • C to T, chromosome 3 at 25,434,303 bp
  • A to G, chromosome 3 at 86,445,397 bp
  • A to T, chromosome 3 at 93,395,921 bp
  • A to G, chromosome 4 at 88,603,178 bp
  • A to T, chromosome 4 at 88,868,259 bp
  • A to G, chromosome 4 at 129,357,703 bp
  • A to G, chromosome 4 at 135,734,250 bp
  • T to C, chromosome 5 at 4,046,736 bp
  • T to C, chromosome 5 at 31,172,831 bp
  • T to C, chromosome 5 at 64,954,350 bp
  • C to A, chromosome 5 at 113,966,234 bp
  • A to T, chromosome 6 at 25,689,050 bp
  • G to T, chromosome 6 at 32,152,872 bp
  • G to A, chromosome 6 at 41,121,700 bp
  • T to C, chromosome 6 at 73,025,720 bp
  • A to T, chromosome 6 at 141,459,249 bp
  • C to A, chromosome 7 at 103,383,738 bp
  • C to T, chromosome 7 at 105,559,302 bp
  • G to C, chromosome 7 at 141,809,303 bp
  • T to C, chromosome 8 at 79,190,329 bp
  • T to A, chromosome 8 at 85,230,798 bp
  • C to A, chromosome 8 at 85,669,700 bp
  • A to G, chromosome 9 at 49,404,977 bp
  • A to G, chromosome 9 at 99,281,092 bp
  • G to T, chromosome 10 at 41,587,375 bp
  • A to G, chromosome 10 at 107,869,546 bp
  • T to G, chromosome 10 at 130,162,829 bp
  • T to C, chromosome 11 at 32,522,941 bp
  • G to A, chromosome 11 at 70,552,869 bp
  • A to G, chromosome 11 at 71,784,365 bp
  • C to T, chromosome 11 at 73,603,506 bp
  • A to T, chromosome 11 at 75,265,045 bp
  • G to A, chromosome 11 at 84,511,509 bp
  • C to T, chromosome 11 at 102,438,563 bp
  • T to C, chromosome 12 at 72,308,429 bp
  • A to G, chromosome 12 at 84,813,238 bp
  • G to T, chromosome 12 at 104,217,306 bp
  • A to T, chromosome 12 at 112,915,469 bp
  • A to T, chromosome 14 at 30,075,852 bp
  • T to A, chromosome 14 at 56,462,072 bp
  • C to A, chromosome 15 at 8,243,826 bp
  • A to G, chromosome 15 at 44,586,408 bp
  • A to G, chromosome 15 at 82,290,773 bp
  • T to C, chromosome 15 at 89,256,701 bp
  • T to C, chromosome 15 at 97,757,746 bp
  • T to C, chromosome 16 at 96,159,561 bp
  • T to A, chromosome 17 at 7,277,449 bp
  • C to A, chromosome 17 at 33,137,244 bp
  • T to C, chromosome 18 at 37,689,970 bp
  • A to T, chromosome 18 at 74,634,559 bp
  • A to T, chromosome 19 at 27,217,615 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7754 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045810-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.