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Strain Name:
C57BL/6J-MtgxR7754Btlr/Mmmh
Stock Number:
045810-MU
Citation ID:
RRID:MMRRC_045810-MU
Other Names:
R7754 (G1)
Major Collection:

Strain Information

Aatf
Name: apoptosis antagonizing transcription factor
Synonyms: 4933415H02Rik, Trb, 5830465M17Rik, Che-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 56321
Homologene: 40811
Drd2
Name: dopamine receptor D2
Synonyms: D2 receptor, D2R, Drd-2
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 13489
VEGA: 9
HGNC: HGNC:3023
Homologene: 22561
Gpr37
Name: G protein-coupled receptor 37
Synonyms: Pael-R, parkin-associated endothelin B-like receptor
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14763
HGNC: HGNC:4494
Homologene: 3875
Rtn4rl1
Name: reticulon 4 receptor-like 1
Synonyms: Ngr3, Ngrh2, Ngrl2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 237847
Homologene: 18611
Septin3
Name: septin 3
Synonyms: Sep3, B530002E20Rik, 3110018K01Rik, Gm46500, Sept3
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 24050
VEGA: 15
Homologene: 99740
Vldlr
Name: very low density lipoprotein receptor
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 22359
Homologene: 443
Abca12
Name: ATP-binding cassette, sub-family A member 12
Synonyms: 4832428G11Rik, 4833417A11Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 74591
Homologene: 45441
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to T, chromosome 1 at 65,159,490 bp
  • C to A, chromosome 1 at 71,302,887 bp
  • A to G, chromosome 1 at 133,906,992 bp
  • C to T, chromosome 1 at 154,413,117 bp
  • A to T, chromosome 1 at 156,079,983 bp
  • G to A, chromosome 2 at 15,797,799 bp
  • G to A, chromosome 2 at 25,777,818 bp
  • A to G, chromosome 2 at 37,146,846 bp
  • T to A, chromosome 2 at 69,286,818 bp
  • A to T, chromosome 2 at 76,788,196 bp
  • A to T, chromosome 2 at 76,825,505 bp
  • A to T, chromosome 2 at 91,304,843 bp
  • A to T, chromosome 2 at 104,257,159 bp
  • A to T, chromosome 2 at 125,479,280 bp
  • T to A, chromosome 2 at 155,561,166 bp
  • G to A, chromosome 2 at 179,932,029 bp
  • C to T, chromosome 3 at 25,434,303 bp
  • A to G, chromosome 3 at 86,445,397 bp
  • A to T, chromosome 3 at 93,395,921 bp
  • A to G, chromosome 4 at 88,603,178 bp
  • A to T, chromosome 4 at 88,868,259 bp
  • A to G, chromosome 4 at 129,357,703 bp
  • A to G, chromosome 4 at 135,734,250 bp
  • T to C, chromosome 5 at 4,046,736 bp
  • T to C, chromosome 5 at 31,172,831 bp
  • T to C, chromosome 5 at 64,954,350 bp
  • C to A, chromosome 5 at 113,966,234 bp
  • A to T, chromosome 6 at 25,689,050 bp
  • G to T, chromosome 6 at 32,152,872 bp
  • G to A, chromosome 6 at 41,121,700 bp
  • T to C, chromosome 6 at 73,025,720 bp
  • A to T, chromosome 6 at 141,459,249 bp
  • C to A, chromosome 7 at 103,383,738 bp
  • C to T, chromosome 7 at 105,559,302 bp
  • G to C, chromosome 7 at 141,809,303 bp
  • T to C, chromosome 8 at 79,190,329 bp
  • T to A, chromosome 8 at 85,230,798 bp
  • C to A, chromosome 8 at 85,669,700 bp
  • A to G, chromosome 9 at 49,404,977 bp
  • A to G, chromosome 9 at 99,281,092 bp
  • G to T, chromosome 10 at 41,587,375 bp
  • A to G, chromosome 10 at 107,869,546 bp
  • T to G, chromosome 10 at 130,162,829 bp
  • T to C, chromosome 11 at 32,522,941 bp
  • G to A, chromosome 11 at 70,552,869 bp
  • A to G, chromosome 11 at 71,784,365 bp
  • C to T, chromosome 11 at 73,603,506 bp
  • A to T, chromosome 11 at 75,265,045 bp
  • G to A, chromosome 11 at 84,511,509 bp
  • C to T, chromosome 11 at 102,438,563 bp
  • T to C, chromosome 12 at 72,308,429 bp
  • A to G, chromosome 12 at 84,813,238 bp
  • G to T, chromosome 12 at 104,217,306 bp
  • A to T, chromosome 12 at 112,915,469 bp
  • A to T, chromosome 14 at 30,075,852 bp
  • T to A, chromosome 14 at 56,462,072 bp
  • C to A, chromosome 15 at 8,243,826 bp
  • A to G, chromosome 15 at 44,586,408 bp
  • A to G, chromosome 15 at 82,290,773 bp
  • T to C, chromosome 15 at 89,256,701 bp
  • T to C, chromosome 15 at 97,757,746 bp
  • T to C, chromosome 16 at 96,159,561 bp
  • T to A, chromosome 17 at 7,277,449 bp
  • C to A, chromosome 17 at 33,137,244 bp
  • T to C, chromosome 18 at 37,689,970 bp
  • A to T, chromosome 18 at 74,634,559 bp
  • A to T, chromosome 19 at 27,217,615 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7754 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045810-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.