Strain Name:
C57BL/6J-MtgxR7766Btlr/Mmmh
Stock Number:
045822-MU
Citation ID:
RRID:MMRRC_045822-MU
Other Names:
R7766 (G1)
Major Collection:

Strain Information

Ednrb
Name: endothelin receptor type B
Synonyms: ETb, Sox10m1, ETR-b
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 13618
VEGA: 14
HGNC: HGNC:3180
Homologene: 89
Hnrnpab
Name: heterogeneous nuclear ribonucleoprotein A/B
Synonyms: CBF-A, Cgbfa, Hnrpab
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15384
HGNC: HGNC:5034
Homologene: 74950
Itgb8
Name: integrin beta 8
Synonyms: 4832412O06Rik
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 320910
HGNC: HGNC:6163
Homologene: 18567
Ins2
Name: insulin II
Synonyms: Ins-2, Mody4, Mody, InsII
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 16334
HGNC: HGNC:6081
Homologene: 173
Kcna6
Name: potassium voltage-gated channel, shaker-related, subfamily, member 6
Synonyms: Kv1.6, MK1.6
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16494
HGNC: HGNC:6225
Homologene: 1684
Slc17a6
Name: solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
Synonyms: 2900073D12Rik, VGLUT2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 140919
Homologene: 121617
Usp28
Name: ubiquitin specific peptidase 28
Synonyms: 9830148O20Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235323
VEGA: 9
Homologene: 10840
Tacc2
Name: transforming, acidic coiled-coil containing protein 2
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 57752
Homologene: 5087
Ascc1
Name: activating signal cointegrator 1 complex subunit 1
Synonyms: ASC1p50, CGI-18, 1810015P09Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 69090
VEGA: 10
Homologene: 41079
Nat10
Name: N-acetyltransferase 10
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 98956
Homologene: 6785
Zfp180
Name: zinc finger protein 180
Synonyms: D130011P11, HHZ168, 2310040I01Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 210135
Homologene: 8306
Gfm2
Name: G elongation factor, mitochondrial 2
Synonyms: MST027, EFG2, A930009M04Rik, 6530419G12Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 320806
Homologene: 6238
Plxnb2
Name: plexin B2
Synonyms: Debt, 1110007H23Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 140570
HGNC: HGNC:9104
Homologene: 66630
Cnpy3
Name: canopy FGF signaling regulator 3
Synonyms: 2410050O22Rik, ERDA5, CAG4A, 1600025D17Rik, Tnrc5
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 72029
Homologene: 4803
Kank1
Name: KN motif and ankyrin repeat domains 1
Synonyms: D330024H06Rik, A930031B09Rik, Ankrd15
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 107351
Homologene: 17706
Ms4a4b
Name: membrane-spanning 4-domains, subfamily A, member 4B
Synonyms: Chandra, Ly116
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 60361
Homologene: 113790
Nipbl
Name: NIPBL cohesin loading factor
Synonyms: 4921518A06Rik, 4933421G18Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 71175
VEGA: 15
Homologene: 15850
Itga2
Name: integrin alpha 2
Synonyms: VLA-2 receptor, alpha 2 subunit, CD49B, DX5
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16398
VEGA: 13
HGNC: HGNC:6137
Homologene: 1662
Ttn
Name: titin
Synonyms: connectin, L56, mdm, 1100001C23Rik, D830007G01Rik, 2310036G12Rik, 2310074I15Rik, 2310057K23Rik, D330041I19Rik, shru
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 22138
Homologene: 130650
Myh13
Name: myosin, heavy polypeptide 13, skeletal muscle
Synonyms: extraocular myosin, EO Myosin, MyHC-eo
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 544791
HGNC: HGNC:7571
Homologene: 55780
Kcp
Name: kielin/chordin-like protein
Synonyms: LOC333088, KCP, Crim2
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 333088
Homologene: 87817
Tnr
Name: tenascin R
Synonyms: janusin, restrictin, TN-R, J1-tenascin
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21960
Homologene: 124416
Dscam
Name: DS cell adhesion molecule
Synonyms: 4932410A21Rik, Down syndrome cell adhesion molecule
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 13508
HGNC: HGNC:3039
Homologene: 74393
A2m
Name: alpha-2-macroglobulin
Synonyms: A2mp
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 232345
HGNC: HGNC:7
Homologene: 37248
Duox1
Name: dual oxidase 1
Synonyms: NOXEF1, THOX1, LNOX1, 9930101G15Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 99439
HGNC: HGNC:3062
Homologene: 68136
Or5p80
Name: olfactory receptor family 5 subfamily P member 80
Synonyms: GA_x6K02T2PBJ9-10959726-10960658, MOR204-6, Olfr508
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 258769
Homologene: 72039
Morc2b
Name: microrchidia 2B
Synonyms: 4932411A10Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 240069
Homologene: 18615
Egr4
Name: early growth response 4
Synonyms: pAT133, NGFI-C, NGF1-C
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 13656
HGNC: HGNC:3241
Homologene: 1485
Trp63
Name: transformation related protein 63
Synonyms: KET protein, p63, p73L, Trp53rp1, TAp63, p51/p63, deltaNp63
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 22061
Homologene: 31189
Padi6
Name: peptidyl arginine deiminase, type VI
Synonyms: ePAD, Padi5, Pad6
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 242726
Homologene: 17695
Or52d1
Name: olfactory receptor family 52 subfamily D member 1
Synonyms: GA_x6K02T2PBJ9-6841330-6842268, MOR33-2, Olfr646
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 259058
Homologene: 17481
Pla2g4a
Name: phospholipase A2, group IVA (cytosolic, calcium-dependent)
Synonyms: cPLA2, Type IV PLA2, cytosolic PLA2, cPLA2alpha, cytosolic phospholipase A2, Pla2g4
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18783
HGNC: HGNC:9035
Homologene: 32059
Abca2
Name: ATP-binding cassette, sub-family A member 2
Synonyms: Abc2, D2H0S1474E
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 11305
HGNC: HGNC:32
Homologene: 55590
Lrrc17
Name: leucine rich repeat containing 17
Synonyms: 6130400C22Rik, 4833425M04Rik, 37kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 74511
Homologene: 55929
Polb
Name: polymerase (DNA directed), beta
Synonyms: Pol beta, A430088C08Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 18970
HGNC: HGNC:9174
Homologene: 2013
Pdcl2
Name: phosducin-like 2
Synonyms: 1700016K07Rik, 1700010B22Rik, Mgcphlp
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 79455
Homologene: 74832
Or9g4b
Name: olfactory receptor family 9 subfamily G member 4B
Synonyms: GA_x6K02T2Q125-47264151-47265089, MOR213-3, Olfr1015
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 258564
Homologene: 115499
Ugt2b35
Name: UDP glucuronosyltransferase 2 family, polypeptide B35
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 243085
Homologene: 128251
Ift88
Name: intraflagellar transport 88
Synonyms: Tg737, polaris, Oak Ridge polycystic kidneys, orpk, IFT88, fxo, TgN737Rpw, Tg737Rpw, Ttc10
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 21821
Homologene: 4761
Cyp3a41a
Name: cytochrome P450, family 3, subfamily a, polypeptide 41A
Synonyms: steroid inducible, Cyp3a41
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 53973
HGNC: HGNC:2638
Homologene: 133568
Nelfcd
Name: negative elongation factor complex member C/D, Th1l
Synonyms: 2410003I03Rik, trihydrophobin 1, Th1l
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 57314
Homologene: 9496
Hexim2
Name: hexamethylene bis-acetamide inducible 2
Synonyms: 4933402L21Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 71059
Homologene: 16946
Vmn2r44
Name: vomeronasal 2, receptor 44
Synonyms: EG434113
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 434113
Homologene: 113703
Oasl1
Name: 2'-5' oligoadenylate synthetase-like 1
Synonyms: 7530414C13Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 231655
HGNC: HGNC:8090
Homologene: 2769
Fv1
Name: Friend virus susceptibility 1
Synonyms: Fv-1, Rv-1, Rv1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14349
Ccdc85b
Name: coiled-coil domain containing 85B
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 240514
VEGA: 19
Homologene: 4989
Tmem176a
Name: transmembrane protein 176A
Synonyms: 0610011I04Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 66058
Homologene: 10224
Tsga8
Name: testis specific gene A8
Synonyms: Halap-X, Halapx
Type: Gene
Species: Mouse
Chromosome: X
NCBI: 100502723
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 149,861,058 bp
  • A to T, chromosome 1 at 159,888,310 bp
  • T to A, chromosome 2 at 25,441,528 bp
  • T to C, chromosome 2 at 76,814,698 bp
  • T to A, chromosome 2 at 85,785,658 bp
  • T to C, chromosome 2 at 103,725,707 bp
  • T to C, chromosome 2 at 122,337,301 bp
  • G to A, chromosome 2 at 174,426,832 bp
  • T to C, chromosome 4 at 140,730,975 bp
  • T to A, chromosome 4 at 143,699,239 bp
  • T to A, chromosome 4 at 147,869,270 bp
  • A to T, chromosome 5 at 21,561,044 bp
  • T to C, chromosome 5 at 76,317,896 bp
  • A to T, chromosome 5 at 87,001,202 bp
  • G to T, chromosome 5 at 114,937,110 bp
  • A to G, chromosome 5 at 145,718,017 bp
  • A to G, chromosome 6 at 29,496,847 bp
  • A to T, chromosome 6 at 48,844,182 bp
  • C to T, chromosome 6 at 85,512,199 bp
  • T to C, chromosome 6 at 121,638,341 bp
  • T to A, chromosome 6 at 126,739,719 bp
  • A to T, chromosome 7 at 8,368,220 bp
  • A to G, chromosome 7 at 24,104,659 bp
  • A to T, chromosome 7 at 51,669,166 bp
  • T to A, chromosome 7 at 104,106,994 bp
  • C to T, chromosome 7 at 108,630,376 bp
  • C to T, chromosome 7 at 130,743,598 bp
  • T to A, chromosome 7 at 142,678,757 bp
  • T to C, chromosome 8 at 22,653,091 bp
  • T to C, chromosome 9 at 49,035,883 bp
  • A to T, chromosome 10 at 60,004,819 bp
  • G to A, chromosome 11 at 51,601,466 bp
  • A to C, chromosome 11 at 67,358,329 bp
  • C to G, chromosome 11 at 103,139,012 bp
  • T to C, chromosome 12 at 119,163,359 bp
  • C to T, chromosome 13 at 97,150,400 bp
  • T to C, chromosome 13 at 114,853,891 bp
  • T to C, chromosome 14 at 57,447,654 bp
  • A to G, chromosome 14 at 103,843,289 bp
  • T to C, chromosome 15 at 8,296,849 bp
  • A to G, chromosome 15 at 89,161,271 bp
  • A to T, chromosome 16 at 25,868,219 bp
  • A to T, chromosome 16 at 96,790,901 bp
  • A to T, chromosome 17 at 33,138,423 bp
  • G to T, chromosome 17 at 46,737,235 bp
  • A to T, chromosome 19 at 5,456,852 bp
  • A to C, chromosome 19 at 11,449,988 bp
  • GCGAACG to GCG, chromosome 19 at 25,411,205 bp
  • A to G, chromosome X at 83,487,098 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7766 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045822-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.