Strain Name:
C57BL/6J-MtgxR7770Btlr/Mmmh
Stock Number:
045826-MU
Citation ID:
RRID:MMRRC_045826-MU
Other Names:
R7770 (G1)
Major Collection:

Strain Information

Adamts20
Name: ADAM metallopeptidase with thrombospondin type 1 motif 20
Synonyms: ADAMTS-20, bt
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 223838
Homologene: 11808
Met
Name: met proto-oncogene
Synonyms: HGF receptor, c-Met, Par4
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17295
HGNC: HGNC:7029
Homologene: 206
Gpr83
Name: G protein-coupled receptor 83
Synonyms: RP105, RP82, RP39, glucocorticoid-induced receptor, GIR, Gpr72, Gir
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 14608
HGNC: HGNC:4523
Homologene: 7732
Rbm28
Name: RNA binding motif protein 28
Synonyms: 2810480G15Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 68272
Homologene: 135952
Tet2
Name: tet methylcytosine dioxygenase 2
Synonyms: E130014J05Rik, Ayu17-449
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 214133
Homologene: 49498
Smg6
Name: SMG6 nonsense mediated mRNA decay factor
Synonyms: Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans)
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 103677
Homologene: 23024
Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 13078
VEGA: 17
HGNC: HGNC:2597
Homologene: 68035
Trappc10
Name: trafficking protein particle complex 10
Synonyms: LOC380642, B230307C21Rik, Tmem1, b2b2613Clo, b2b2416Clo
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 216131
VEGA: 10
Homologene: 37751
Ccser2
Name: coiled-coil serine rich 2
Synonyms: 1700012P13Rik, 2900054P12Rik, Gcap14
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 72972
Homologene: 10367
Polr1b
Name: polymerase (RNA) I polypeptide B
Synonyms: RPA2, RPA116, 128kDa, D630020H17Rik, Rpo1-2
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20017
Homologene: 7133
Gucy1a1
Name: guanylate cyclase 1, soluble, alpha 1
Synonyms: alpha 1 sGC, 1200016O07Rik, sGC-alpha1, Gucy1a3
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 60596
HGNC: HGNC:4685
Homologene: 37360
Glmp
Name: glycosylated lysosomal membrane protein
Synonyms: NCU-G1, 0610031J06Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 56700
Homologene: 10562
Nrros
Name: negative regulator of reactive oxygen species
Synonyms: E430025L02Rik, Lrrc33
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 224109
Homologene: 17134
Il6st
Name: interleukin 6 signal transducer
Synonyms: gp130, CD130, D13Ertd699e, 5133400A03Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16195
HGNC: HGNC:6021
Homologene: 1645
Dnpep
Name: aspartyl aminopeptidase
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 13437
HGNC: HGNC:2981
Homologene: 6110
Def8
Name: differentially expressed in FDCP 8
Synonyms: D8Ertd713e
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 23854
Homologene: 14279
Tox4
Name: TOX high mobility group box family member 4
Synonyms: 5730589K01Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 268741
Homologene: 8889
1700017B05Rik
Name: RIKEN cDNA 1700017B05 gene
Synonyms: D9Ertd278e
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 74211
VEGA: 9
Homologene: 19283
Prmt9
Name: protein arginine methyltransferase 9
Synonyms: Prmt10
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 102182
Homologene: 16298
Slc9a4
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 4
Synonyms: NHE4, D730009J23Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 110895
Homologene: 72232
Tatdn3
Name: TatD DNase domain containing 3
Synonyms: 1500010M24Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 68972
Homologene: 45949
Hoxa13
Name: homeobox A13
Synonyms: Hox-1.10
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15398
HGNC: HGNC:5102
Homologene: 73882
Abhd8
Name: abhydrolase domain containing 8
Synonyms: 0910001L24Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 64296
Homologene: 11188
Dennd5b
Name: DENN domain containing 5B
Synonyms: 9330160C06Rik, D030011O10Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 320560
Homologene: 44911
Rapgef4
Name: Rap guanine nucleotide exchange factor (GEF) 4
Synonyms: 1300003D15Rik, Epac2, cAMP-GEFII, 5730402K07Rik, 6330581N18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56508
Homologene: 4451
Setd1b
Name: SET domain containing 1B
Synonyms: KMT2G
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 208043
Homologene: 134654
Ppp1r3a
Name: protein phosphatase 1, regulatory subunit 3A
Synonyms: GM, RGL
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 140491
HGNC: HGNC:9291
Homologene: 48124
Spta1
Name: spectrin alpha, erythrocytic 1
Synonyms: Spna-1, erythroid, ihj, Spna1
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 20739
Homologene: 74460
Tgfbi
Name: transforming growth factor, beta induced
Synonyms: bIG-h3, 68kDa, Beta-ig
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 21810
VEGA: 13
Homologene: 37294
Wdr24
Name: WD repeat domain 24
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 268933
Homologene: 6870
Agl
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase
Synonyms: 9430004C13Rik, 9630046L06Rik, 1110061O17Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 77559
HGNC: HGNC:321
Homologene: 536
Nadsyn1
Name: NAD synthetase 1
Synonyms: 9130012B15Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 78914
Homologene: 6098
Rhobtb3
Name: Rho-related BTB domain containing 3
Synonyms: 1700040C17Rik, 4930503C18Rik, 2610033K01Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73296
Homologene: 8932
Or10ak14
Name: olfactory receptor family 10 subfamily AK member 14
Synonyms: GA_x6K02T2QD9B-18795136-18796077, MOR259-4P, MOR259-4P, MOR259-9, Olfr1524-ps1, Olfr1338
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 258259
Homologene: 115537
Vmn2r59
Name: vomeronasal 2, receptor 59
Synonyms: EG628444
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 628444
Homologene: 129683
Gnptab
Name: N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
Synonyms: EG432486
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432486
Homologene: 32576
Igsf6
Name: immunoglobulin superfamily, member 6
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 80719
HGNC: HGNC:5953
Homologene: 36189
Zc3h15
Name: zinc finger CCCH-type containing 15
Synonyms: FM22, Ierepo4, 1810012H02Rik, 1700006A17Rik, 2610312B22Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 69082
Homologene: 10216
Or8j3b
Name: olfactory receptor family 8 subfamily J member 3B
Synonyms: GA_x6K02T2Q125-47844843-47843896, MOR185-11, Olfr1057
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 404325
Homologene: 83135
Tmprss9
Name: transmembrane protease, serine 9
Synonyms: Serase-1B
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 432478
VEGA: 10
Homologene: 115302
Drc1
Name: dynein regulatory complex subunit 1
Synonyms: LOC381738, Gm1060, b2b1654Clo, Ccdc164
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 381738
Homologene: 35977
Cdc20b
Name: cell division cycle 20B
Synonyms: EG238896, EG622422
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238896
Homologene: 65056
Wfdc8
Name: WAP four-disulfide core domain 8
Synonyms: LOC277343
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 277343
Homologene: 33799
Gzmd
Name: granzyme D
Synonyms: CCP5, Ctla-5, Ctla5
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 14941
Homologene: 133275
Slc22a19
Name: solute carrier family 22 (organic anion transporter), member 19
Synonyms: Oat5, D630043A20Rik, Slc22a9
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 207151
Homologene: 133125
Serpinb6b
Name: serine (or cysteine) peptidase inhibitor, clade B, member 6b
Synonyms: ovalbumin, Spi12, NK13
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 20708
HGNC: HGNC:8950
Homologene: 22633
Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Synonyms: Gpr49
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 14160
HGNC: HGNC:4504
Homologene: 20807
Pih1d2
Name: PIH1 domain containing 2
Synonyms: 2700059L22Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 72614
Homologene: 12474
Kcnh3
Name: potassium voltage-gated channel, subfamily H (eag-related), member 3
Synonyms: ether a go-go like, Elk2, Melk2, C030044P22Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 16512
VEGA: 15
HGNC: HGNC:6252
Homologene: 32150
Mettl22
Name: methyltransferase 22, Kin17 lysine
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239706
Homologene: 16619
Dnah7c
Name: dynein, axonemal, heavy chain 7C
Synonyms: Dnahc7c
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100101919
Homologene: 41287
Sesn1
Name: sestrin 1
Synonyms: 1110002G11Rik, SEST1, PA26
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 140742
Homologene: 8697
Cav3
Name: caveolin 3
Synonyms: M-caveolin, Cav-3
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 12391
HGNC: HGNC:1529
Homologene: 7255
Gm5431
Name: predicted gene 5431
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 432555
Or5w1
Name: olfactory receptor family 5 subfamily W member 1
Synonyms: GA_x6K02T2Q125-49162076-49161138, MOR176-1, Olfr1134
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 259032
Homologene: 37013
Dnajc5b
Name: DnaJ heat shock protein family (Hsp40) member C5 beta
Synonyms: 1700008A05Rik
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 66326
Homologene: 32634
Hoxa10
Name: homeobox A10
Synonyms: Hoxa-10, Hox-1.8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 15395
HGNC: HGNC:5100
Homologene: 7365
Commd8
Name: COMM domain containing 8
Synonyms: IMAGE:1958590, D5Buc26e
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 27784
Homologene: 9873
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to C, chromosome 1 at 40,600,963 bp
  • A to T, chromosome 1 at 46,626,300 bp
  • G to A, chromosome 1 at 75,317,246 bp
  • C to A, chromosome 1 at 174,195,981 bp
  • G to A, chromosome 1 at 191,058,856 bp
  • T to A, chromosome 2 at 72,198,395 bp
  • T to A, chromosome 2 at 83,658,132 bp
  • C to T, chromosome 2 at 86,375,260 bp
  • T to C, chromosome 2 at 87,656,469 bp
  • C to A, chromosome 2 at 129,125,544 bp
  • A to G, chromosome 2 at 164,597,674 bp
  • T to A, chromosome 3 at 19,579,017 bp
  • A to T, chromosome 3 at 82,108,805 bp
  • A to G, chromosome 3 at 88,325,770 bp
  • A to G, chromosome 3 at 116,758,237 bp
  • C to T, chromosome 3 at 133,480,295 bp
  • A to T, chromosome 4 at 118,754,057 bp
  • C to T, chromosome 5 at 30,350,512 bp
  • A to G, chromosome 5 at 72,159,880 bp
  • G to A, chromosome 5 at 123,158,752 bp
  • A to G, chromosome 6 at 14,754,978 bp
  • T to A, chromosome 6 at 17,491,407 bp
  • G to A, chromosome 6 at 29,164,628 bp
  • A to G, chromosome 6 at 52,234,265 bp
  • G to A, chromosome 6 at 52,260,267 bp
  • A to T, chromosome 6 at 112,472,186 bp
  • T to C, chromosome 6 at 149,041,716 bp
  • A to G, chromosome 7 at 42,058,912 bp
  • A to G, chromosome 7 at 121,068,325 bp
  • G to A, chromosome 7 at 143,806,003 bp
  • C to T, chromosome 8 at 71,458,250 bp
  • T to A, chromosome 8 at 77,559,185 bp
  • C to A, chromosome 8 at 123,460,059 bp
  • G to A, chromosome 9 at 14,866,874 bp
  • G to A, chromosome 9 at 50,621,801 bp
  • A to T, chromosome 9 at 57,258,611 bp
  • T to A, chromosome 10 at 41,894,058 bp
  • A to T, chromosome 10 at 78,210,845 bp
  • A to G, chromosome 10 at 80,898,069 bp
  • T to A, chromosome 10 at 88,411,920 bp
  • A to G, chromosome 10 at 115,471,994 bp
  • A to T, chromosome 11 at 48,888,458 bp
  • T to A, chromosome 11 at 74,993,861 bp
  • T to C, chromosome 13 at 32,977,529 bp
  • T to A, chromosome 13 at 56,632,844 bp
  • A to T, chromosome 13 at 75,917,815 bp
  • A to T, chromosome 13 at 112,502,804 bp
  • T to C, chromosome 13 at 113,078,659 bp
  • T to A, chromosome 14 at 36,926,874 bp
  • T to C, chromosome 14 at 52,279,842 bp
  • T to C, chromosome 14 at 56,131,263 bp
  • A to G, chromosome 15 at 94,333,698 bp
  • G to A, chromosome 15 at 99,233,266 bp
  • A to T, chromosome 16 at 8,485,900 bp
  • T to G, chromosome 16 at 32,143,528 bp
  • C to A, chromosome 17 at 25,827,096 bp
  • G to A, chromosome 17 at 79,713,299 bp
  • T to A, chromosome 19 at 7,703,995 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7770 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045826-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.