Strain Name:
C57BL/6J-MtgxR7775Btlr/Mmmh
Stock Number:
045831-MU
Citation ID:
RRID:MMRRC_045831-MU
Other Names:
R7775 (G1)
Major Collection:

Strain Information

Chrna6
Name: cholinergic receptor, nicotinic, alpha polypeptide 6
Synonyms: alpha6 nAChR, Acra6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11440
Homologene: 20888
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: AP-2(beta), E130018K07Rik, Tcfap2b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21419
Homologene: 20688
Txndc2
Name: thioredoxin domain containing 2 (spermatozoa)
Synonyms: Sptrx-1
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 213272
VEGA: 17
Homologene: 41856
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, D230004K18Rik, Megalin, Gp330
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Dtx4
Name: deltex 4, E3 ubiquitin ligase
Synonyms: RNF155
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 207521
VEGA: 19
Homologene: 27781
Dyrk3
Name: dual-specificity tyrosine phosphorylation regulated kinase 3
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226419
HGNC: HGNC:3094
Homologene: 55762
Arhgap35
Name: Rho GTPase activating protein 35
Synonyms: Grlf1, p190RhoGAP, p190A, P190 RhoGAP, 6430596G11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 232906
HGNC: HGNC:4591
Homologene: 35136
Ep300
Name: E1A binding protein p300
Synonyms: KAT3B, p300
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 328572
HGNC: HGNC:3373
Homologene: 1094
Rapsn
Name: receptor-associated protein of the synapse
Synonyms: Nraps, 43kDa acetylcholine receptor-associated protein, Raps, rapsyn
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 19400
HGNC: HGNC:9863
Homologene: 3708
L3mbtl3
Name: L3MBTL3 histone methyl-lysine binding protein
Synonyms: MBT-1
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 237339
Homologene: 18226
Ing1
Name: inhibitor of growth family, member 1
Synonyms: mING1h, 2610028J21Rik, p33Ing1
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26356
HGNC: HGNC:6062
Homologene: 40119
Slc22a3
Name: solute carrier family 22 (organic cation transporter), member 3
Synonyms: Oct3, EMT, Orct3
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20519
VEGA: 17
Homologene: 22630
Kansl3
Name: KAT8 regulatory NSL complex subunit 3
Synonyms: 4632411B12Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 226976
Homologene: 9949
Cldn6
Name: claudin 6
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 54419
HGNC: HGNC:2048
Homologene: 10300
Setd6
Name: SET domain containing 6
Synonyms: 0610039J04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66083
Homologene: 38743
Fmnl2
Name: formin-like 2
Synonyms: 5430425K04Rik, man
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Mettl23
Name: methyltransferase like 23
Synonyms: 4933424L15Rik, 1500035B17Rik, 1110005A03Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 74319
Homologene: 12552
Arpc1a
Name: actin related protein 2/3 complex, subunit 1A
Synonyms: Sid32, 0610010H08Rik, 1110030K07Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 56443
HGNC: HGNC:703
Homologene: 4675
Tbc1d2
Name: TBC1 domain family, member 2
Synonyms: PARIS-1, LOC381605, A630005A06Rik, PARIS1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381605
Homologene: 10190
Chrm5
Name: cholinergic receptor, muscarinic 5
Synonyms: M5R, muscarinic acetylcholine receptor 5
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 213788
HGNC: HGNC:1954
Homologene: 22697
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 408022
Homologene: 14065
Gkap1
Name: G kinase anchoring protein 1
Synonyms: D13Ertd340e, 4933400B15Rik, Gkap42, 42kDa
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 56278
VEGA: 13
Homologene: 10515
Ldlrad4
Name: low density lipoprotein receptor class A domain containing 4
Synonyms: 8230401C20Rik, D330030L18Rik, D18Ertd653e, A430108L08Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 52662
VEGA: 18
HGNC: HGNC:1224
Homologene: 3202
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: mRib72-1, myoclonin1, 1700029F22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71877
Homologene: 10003
Lama4
Name: laminin, alpha 4
Synonyms: laminin [a]4
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 16775
HGNC: HGNC:6484
Homologene: 37604
Liph
Name: lipase, member H
Synonyms: PLA1B, mPA-PLA1, D16Wsu119e, C130037N08Rik, LPDLR, Lpdlr
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 239759
VEGA: 16
Homologene: 71802
Car4
Name: carbonic anhydrase 4
Synonyms: CA IV
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 12351
HGNC: HGNC:1375
Homologene: 20183
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Pycr3
Name: pyrroline-5-carboxylate reductase 3
Synonyms: 1110058B13Rik, Pycrl, 2700073G24Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 66194
VEGA: 15
Homologene: 56130
Prph2
Name: peripherin 2
Synonyms: Tspan22, Rd2, rds, Nmf193
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19133
HGNC: HGNC:9942
Homologene: 273
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 1300010F03Rik, 4932416F07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Matn2
Name: matrilin 2
Synonyms: Crtm2
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 17181
VEGA: 15
HGNC: HGNC:6908
Homologene: 20538
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: Tj6, TJ6s, ATP6a2, Atp6n2, 8430408C20Rik, V-ATPase a2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21871
Homologene: 56523
Grm8
Name: glutamate receptor, metabotropic 8
Synonyms: Gprc1h, mGluR8
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 14823
HGNC: HGNC:4600
Homologene: 654
Kcna5
Name: potassium voltage-gated channel, shaker-related subfamily, member 5
Synonyms: Kv1.5
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 16493
HGNC: HGNC:6224
Homologene: 1683
Kif26b
Name: kinesin family member 26B
Synonyms: N-11 kinesin, D230039L06Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 269152
Homologene: 18623
Prrt4
Name: proline-rich transmembrane protein 4
Synonyms: D330027H18Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101359
Homologene: 46116
Or8g21
Name: olfactory receptor family 8 subfamily G member 21
Synonyms: GA_x6K02T2PVTD-32691280-32690354, MOR171-11, Olfr935
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258741
VEGA: 9
Homologene: 133683
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224916
Uevld
Name: UEV and lactate/malate dehyrogenase domains
Synonyms: 8430408E05Rik, Attp
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 54122
Homologene: 69251
Chst12
Name: carbohydrate sulfotransferase 12
Synonyms: C4S-2, C4ST2, C4ST-2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 59031
Homologene: 69258
Gm14226
Name: predicted gene 14226
Type: Gene
Species: Mouse
Chromosome: 2
Or7d9
Name: olfactory receptor family 7 subfamily D member 9
Synonyms: Olfr39, GA_x6K02T2PVTD-14025733-14026668, MOR144-1
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258822
HGNC: HGNC:8380
Homologene: 81583
Coro6
Name: coronin 6
Synonyms: clipin E
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 216961
Homologene: 104099
Mpp4
Name: membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
Synonyms: DLG6
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 227157
Homologene: 23296
Plau
Name: plasminogen activator, urokinase
Synonyms: u-PA, uPA, urokinase-type plasminogen activator
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18792
VEGA: 14
HGNC: HGNC:9052
Homologene: 55670
Zfp936
Name: zinc finger protein 936
Synonyms: EG435970, Gm9272, I1C0022H11Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 668620
Mrps15
Name: mitochondrial ribosomal protein S15
Synonyms: 1500003E24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66407
Homologene: 32636
Fstl4
Name: follistatin-like 4
Synonyms: SPIG1, B230374F23Rik
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 320027
Homologene: 18543
Gal3st2b
Name: galactose-3-O-sulfotransferase 2B
Synonyms: Gm9994
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 100041596
Homologene: 41471
Bbs2
Name: Bardet-Biedl syndrome 2
Synonyms: 2410125H22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67378
HGNC: HGNC:967
Homologene: 12122
Or5ac21
Name: olfactory receptor family 5 subfamily AC member 21
Synonyms: GA_x54KRFPKG5P-55517445-55518365, Olfr203, MOR182-5
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 258479
Homologene: 122781
Pde6d
Name: phosphodiesterase 6D, cGMP-specific, rod, delta
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 18582
HGNC: HGNC:8788
Homologene: 1954
Or8b36
Name: olfactory receptor family 8 subfamily B member 36
Synonyms: MOR162-6, GA_x6K02T2PVTD-31705144-31706073, Olfr883
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258414
Homologene: 86689
Or10d4
Name: olfactory receptor family 10 subfamily D member 4
Synonyms: GA_x6K02T2PVTD-33365879-33366814, MOR224-13, MOR224-7P, Olfr963
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 258087
VEGA: 9
Homologene: 105216
Cysltr2
Name: cysteinyl leukotriene receptor 2
Synonyms: 2300001H05Rik, CysLT2, Cyslt2, CYSLT2R
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70086
VEGA: 14
Homologene: 10688
Sap25
Name: sin3 associated polypeptide
Synonyms: 25 kDa
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 751865
Homologene: 104044
Pax8
Name: paired box 8
Synonyms: Pax-8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18510
HGNC: HGNC:8622
Homologene: 2589
Rapgefl1
Name: Rap guanine nucleotide exchange factor (GEF)-like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268480
Homologene: 41126
Asb5
Name: ankyrin repeat and SOCs box-containing 5
Synonyms: 1110018D09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76294
Homologene: 12637
Pcdhga5
Name: protocadherin gamma subfamily A, 5
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 93713
HGNC: HGNC:8703
Homologene: 69263
Pcdha11
Name: protocadherin alpha 11
Synonyms: Cnr7, A830022B16Rik, Crnr7
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 12942
HGNC: HGNC:8665
Homologene: 75095
Gm8297
Name: predicted gene 8297
Type: Gene
Species: Mouse
Chromosome: 14
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 19,234,307 bp
  • A to T, chromosome 1 at 20,979,461 bp
  • A to T, chromosome 1 at 36,348,677 bp
  • G to A, chromosome 1 at 59,123,513 bp
  • A to G, chromosome 1 at 86,543,528 bp
  • G to T, chromosome 1 at 93,940,784 bp
  • C to T, chromosome 1 at 131,129,627 bp
  • T to A, chromosome 1 at 178,864,876 bp
  • A to G, chromosome 2 at 24,435,901 bp
  • C to T, chromosome 2 at 53,073,680 bp
  • T to A, chromosome 2 at 69,501,539 bp
  • A to G, chromosome 2 at 91,044,948 bp
  • A to G, chromosome 2 at 112,479,956 bp
  • T to A, chromosome 2 at 155,024,710 bp
  • C to T, chromosome 4 at 46,637,746 bp
  • A to T, chromosome 4 at 126,051,377 bp
  • A to G, chromosome 5 at 124,641,505 bp
  • C to T, chromosome 5 at 137,641,924 bp
  • T to A, chromosome 5 at 140,523,621 bp
  • C to T, chromosome 5 at 145,104,812 bp
  • T to C, chromosome 6 at 27,363,672 bp
  • A to G, chromosome 6 at 29,177,719 bp
  • A to T, chromosome 6 at 126,534,805 bp
  • T to C, chromosome 7 at 16,562,648 bp
  • A to G, chromosome 7 at 43,190,296 bp
  • A to T, chromosome 7 at 46,926,352 bp
  • A to G, chromosome 8 at 11,561,814 bp
  • T to C, chromosome 8 at 27,407,364 bp
  • G to T, chromosome 8 at 46,586,424 bp
  • A to C, chromosome 8 at 54,584,792 bp
  • A to T, chromosome 8 at 94,089,760 bp
  • A to T, chromosome 8 at 95,716,238 bp
  • A to G, chromosome 9 at 20,282,412 bp
  • T to A, chromosome 9 at 38,026,667 bp
  • T to A, chromosome 9 at 38,994,907 bp
  • C to A, chromosome 9 at 39,669,238 bp
  • A to T, chromosome 10 at 26,352,317 bp
  • A to T, chromosome 10 at 39,078,847 bp
  • C to T, chromosome 11 at 53,176,971 bp
  • T to G, chromosome 11 at 77,465,773 bp
  • T to C, chromosome 11 at 84,965,623 bp
  • A to G, chromosome 11 at 98,851,154 bp
  • T to G, chromosome 11 at 116,849,270 bp
  • A to T, chromosome 13 at 58,251,152 bp
  • A to G, chromosome 14 at 4,986,951 bp
  • A to G, chromosome 14 at 20,842,325 bp
  • A to G, chromosome 14 at 31,352,410 bp
  • A to G, chromosome 14 at 73,029,763 bp
  • T to C, chromosome 14 at 79,038,147 bp
  • A to T, chromosome 15 at 34,399,077 bp
  • T to C, chromosome 15 at 75,918,289 bp
  • A to T, chromosome 15 at 76,176,935 bp
  • T to C, chromosome 15 at 81,586,686 bp
  • G to T, chromosome 16 at 21,958,914 bp
  • A to T, chromosome 16 at 59,303,251 bp
  • G to T, chromosome 17 at 12,464,463 bp
  • T to A, chromosome 17 at 23,681,607 bp
  • T to C, chromosome 17 at 46,910,806 bp
  • T to C, chromosome 17 at 57,525,942 bp
  • A to G, chromosome 17 at 65,638,243 bp
  • A to T, chromosome 18 at 37,012,680 bp
  • A to G, chromosome 18 at 37,695,525 bp
  • G to T, chromosome 18 at 68,235,669 bp
  • T to C, chromosome 18 at 68,235,756 bp
  • G to T, chromosome 19 at 12,492,010 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7775 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045831-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.