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Strain Name:
C57BL/6J-MtgxR7792Btlr/Mmmh
Stock Number:
045848-MU
Citation ID:
RRID:MMRRC_045848-MU
Other Names:
R7792 (G1)
Major Collection:

Strain Information

Adora2a
Name: adenosine A2a receptor
Synonyms: A2aR, A2AAR, AA2AR, A2a, Rs, ARA2A
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 11540
VEGA: 10
HGNC: HGNC:263
Homologene: 20166
Scn3a
Name: sodium channel, voltage-gated, type III, alpha
Synonyms: LOC381367, Nav1.3
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 20269
Homologene: 56005
B4galt1
Name: UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
Synonyms: Ggtb, Ggtb2, B-1,4-GalT1, beta-1,4-GalT1, GalT, beta 1,4-Galactosyltransferase I, b1,4-Galactosyltransferase I
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 14595
HGNC: HGNC:924
Homologene: 20378
Kif2a
Name: kinesin family member 2A
Synonyms: Kns2, Kif2, M-kinesin
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 16563
HGNC: HGNC:6318
Homologene: 3320
Mapk14
Name: mitogen-activated protein kinase 14
Synonyms: p38-alpha, p38, p38 MAP Kinase, Mxi2, CSBP2, Crk1, Csbp1, p38MAPK, p38a, p38 alpha, p38alpha, p38 MAP kinase alpha, p38 MAPK
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 26416
HGNC: HGNC:6876
Homologene: 31777
Hsd17b12
Name: hydroxysteroid (17-beta) dehydrogenase 12
Synonyms: KIK-I, 2610510O05Rik, keratoadhesin, keratonectin
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 56348
Homologene: 95094
Plekhm1
Name: pleckstrin homology domain containing, family M (with RUN domain) member 1
Synonyms: D330036J23Rik, AP162, B2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 353047
Homologene: 8871
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 17,004,378 bp
  • T to C, chromosome 1 at 36,207,984 bp
  • A to T, chromosome 1 at 82,747,081 bp
  • T to G, chromosome 1 at 106,018,252 bp
  • A to T, chromosome 2 at 24,677,965 bp
  • G to T, chromosome 2 at 30,070,311 bp
  • A to G, chromosome 2 at 30,266,770 bp
  • A to C, chromosome 2 at 36,734,330 bp
  • T to A, chromosome 2 at 65,466,990 bp
  • T to C, chromosome 2 at 75,976,929 bp
  • A to G, chromosome 2 at 93,642,711 bp
  • C to A, chromosome 2 at 94,033,641 bp
  • T to C, chromosome 2 at 111,369,403 bp
  • A to G, chromosome 2 at 118,927,775 bp
  • G to A, chromosome 2 at 154,546,280 bp
  • G to T, chromosome 2 at 158,210,162 bp
  • T to A, chromosome 2 at 164,617,902 bp
  • C to A, chromosome 3 at 96,919,776 bp
  • T to A, chromosome 3 at 144,749,731 bp
  • C to T, chromosome 4 at 40,809,373 bp
  • T to C, chromosome 4 at 45,890,389 bp
  • A to G, chromosome 4 at 143,654,553 bp
  • A to T, chromosome 5 at 35,710,951 bp
  • A to C, chromosome 5 at 37,284,095 bp
  • A to G, chromosome 5 at 52,644,049 bp
  • G to A, chromosome 5 at 110,297,466 bp
  • G to C, chromosome 5 at 110,340,344 bp
  • A to T, chromosome 5 at 115,112,781 bp
  • T to C, chromosome 6 at 48,454,690 bp
  • A to T, chromosome 6 at 134,432,314 bp
  • A to G, chromosome 6 at 140,589,224 bp
  • T to C, chromosome 7 at 15,950,758 bp
  • A to T, chromosome 7 at 16,561,528 bp
  • T to A, chromosome 7 at 23,321,757 bp
  • G to T, chromosome 7 at 29,143,102 bp
  • G to A, chromosome 7 at 33,288,487 bp
  • G to A, chromosome 7 at 35,429,928 bp
  • T to A, chromosome 7 at 96,774,014 bp
  • T to A, chromosome 7 at 102,588,883 bp
  • G to T, chromosome 8 at 22,243,098 bp
  • A to G, chromosome 8 at 40,447,141 bp
  • A to G, chromosome 8 at 46,562,467 bp
  • G to A, chromosome 8 at 46,807,279 bp
  • A to T, chromosome 8 at 88,252,554 bp
  • G to T, chromosome 8 at 111,043,264 bp
  • G to A, chromosome 8 at 119,952,001 bp
  • A to G, chromosome 8 at 120,031,070 bp
  • A to G, chromosome 8 at 122,884,231 bp
  • G to A, chromosome 8 at 123,145,441 bp
  • A to T, chromosome 8 at 125,892,018 bp
  • A to T, chromosome 8 at 128,892,437 bp
  • T to C, chromosome 9 at 72,331,319 bp
  • T to A, chromosome 9 at 104,326,966 bp
  • A to C, chromosome 10 at 7,919,133 bp
  • A to T, chromosome 10 at 40,037,415 bp
  • A to T, chromosome 10 at 41,722,940 bp
  • A to G, chromosome 10 at 75,333,646 bp
  • A to T, chromosome 10 at 80,125,437 bp
  • A to G, chromosome 10 at 115,221,587 bp
  • T to A, chromosome 10 at 121,925,967 bp
  • T to C, chromosome 11 at 9,000,133 bp
  • T to A, chromosome 11 at 49,134,669 bp
  • T to C, chromosome 11 at 60,742,964 bp
  • T to A, chromosome 11 at 65,850,013 bp
  • T to A, chromosome 11 at 77,518,734 bp
  • A to T, chromosome 11 at 103,397,060 bp
  • G to T, chromosome 11 at 105,390,228 bp
  • T to C, chromosome 11 at 106,236,996 bp
  • A to T, chromosome 13 at 40,142,826 bp
  • G to A, chromosome 13 at 54,547,330 bp
  • A to T, chromosome 13 at 67,390,439 bp
  • A to G, chromosome 13 at 67,826,016 bp
  • A to G, chromosome 13 at 72,631,374 bp
  • T to C, chromosome 13 at 106,987,982 bp
  • A to T, chromosome 13 at 112,872,909 bp
  • A to T, chromosome 14 at 4,984,945 bp
  • C to T, chromosome 14 at 52,316,064 bp
  • T to G, chromosome 14 at 57,810,055 bp
  • T to A, chromosome 14 at 61,209,773 bp
  • T to C, chromosome 14 at 69,705,508 bp
  • A to T, chromosome 15 at 10,381,386 bp
  • T to C, chromosome 15 at 39,198,528 bp
  • C to T, chromosome 15 at 76,454,348 bp
  • A to G, chromosome 15 at 96,369,375 bp
  • C to A, chromosome 16 at 25,868,224 bp
  • A to G, chromosome 16 at 32,619,167 bp
  • A to G, chromosome 16 at 36,918,730 bp
  • C to A, chromosome 16 at 38,757,810 bp
  • G to A, chromosome 16 at 66,771,637 bp
  • A to T, chromosome 16 at 79,003,387 bp
  • T to A, chromosome 17 at 6,736,578 bp
  • T to C, chromosome 17 at 28,746,297 bp
  • T to A, chromosome 17 at 32,671,169 bp
  • T to C, chromosome 17 at 56,622,515 bp
  • G to A, chromosome 18 at 12,181,599 bp
  • T to C, chromosome 19 at 7,579,295 bp
  • T to A, chromosome 19 at 42,563,964 bp
  • A to C, chromosome 19 at 45,040,218 bp
  • T to C, chromosome 19 at 46,889,946 bp
  • T to C, chromosome 19 at 53,850,136 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
The MMRRC Centers have developed a Strain GQC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC strains. For more information on whether data may be available, or to request genotyping for a strain of interest, please contact MMRRC_GeneticQC@med.unc.edu. Older strains may not have this information available.
Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7792 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045848-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.