Strain Name:
C57BL/6J-MtgxR7824Btlr/Mmmh
Stock Number:
045878-MU
Citation ID:
RRID:MMRRC_045878-MU
Other Names:
R7824 (G1)
Major Collection:

Strain Information

Utrn
Name: utrophin
Synonyms: DRP, Dmdl, G-utrophin
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 22288
VEGA: 10
Homologene: 21398
Chrna6
Name: cholinergic receptor, nicotinic, alpha polypeptide 6
Synonyms: alpha6 nAChR, Acra6
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 11440
Homologene: 20888
Vcan
Name: versican
Synonyms: Cspg2, hdf, PG-M, heart defect, DPEAAE, 5430420N07Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 13003
HGNC: HGNC:2464
Homologene: 3228
Tfap2b
Name: transcription factor AP-2 beta
Synonyms: E130018K07Rik, AP-2(beta), Tcfap2b
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 21419
Homologene: 20688
Sez6
Name: seizure related gene 6
Synonyms: sez-6, D11Bhm177e
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20370
Homologene: 10948
Srd5a3
Name: steroid 5 alpha-reductase 3
Synonyms: Srd5a2l, 1110025P14Rik, D730040M03Rik
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 57357
Homologene: 41385
Ubr5
Name: ubiquitin protein ligase E3 component n-recognin 5
Synonyms: Edd, 4432411E13Rik, Edd1
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 70790
VEGA: 15
Homologene: 9295
Lrp2
Name: low density lipoprotein receptor-related protein 2
Synonyms: b2b1625.2Clo, Gp330, Megalin, D230004K18Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 14725
HGNC: HGNC:6694
Homologene: 20952
Gfpt2
Name: glutamine fructose-6-phosphate transaminase 2
Synonyms: GFAT2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 14584
HGNC: HGNC:4242
Homologene: 68439
Rsf1
Name: remodeling and spacing factor 1
Synonyms: XAP8, Hbxap, p325, 4832420A03Rik, C030033M12Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233532
Homologene: 41142
Son
Name: Son DNA binding protein
Synonyms: 2900011L12Rik
Type: Gene
Species: Mouse
Chromosome: 16
NCBI: 20658
Homologene: 10551
Ing1
Name: inhibitor of growth family, member 1
Synonyms: mING1h, p33Ing1, 2610028J21Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 26356
HGNC: HGNC:6062
Homologene: 40119
Myo9a
Name: myosin IXa
Synonyms: 4732465J09Rik, C130068I12Rik
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 270163
HGNC: HGNC:7608
Homologene: 21371
Slc22a3
Name: solute carrier family 22 (organic cation transporter), member 3
Synonyms: Orct3, Oct3, EMT
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 20519
VEGA: 17
Homologene: 22630
Lama1
Name: laminin, alpha 1
Synonyms: Lama
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 16772
VEGA: 17
HGNC: HGNC:6481
Homologene: 21146
Mfge8
Name: milk fat globule EGF and factor V/VIII domain containing
Synonyms: SED1, MFG-E8, lactadherin, EGF/factor VIII, Mfgm
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 17304
HGNC: HGNC:7036
Homologene: 4334
Bub1b
Name: BUB1B, mitotic checkpoint serine/threonine kinase
Synonyms: BUBR1
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 12236
HGNC: HGNC:1149
Homologene: 933
Farsb
Name: phenylalanyl-tRNA synthetase, beta subunit
Synonyms: Farsl, Frsb, PheRS alpha, Farslb
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 23874
Homologene: 4160
Setd6
Name: SET domain containing 6
Synonyms: 0610039J04Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 66083
Homologene: 38743
Fmnl2
Name: formin-like 2
Synonyms: man, 5430425K04Rik
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71409
Homologene: 70871
Tube1
Name: tubulin, epsilon 1
Synonyms: 2310061K05Rik
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 71924
VEGA: 10
Homologene: 17762
Ddx11
Name: DEAD/H box helicase 11
Synonyms: essa15a, CHL1, DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11, CHLR1, KRG2, 4732462I11Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320209
VEGA: 17
Homologene: 68973
Tbc1d2
Name: TBC1 domain family, member 2
Synonyms: A630005A06Rik, LOC381605, PARIS-1, PARIS1
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 381605
Homologene: 10190
Primpol
Name: primase and polymerase (DNA-directed)
Synonyms: Ccdc111
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 408022
Homologene: 14065
Ism2
Name: isthmin 2
Synonyms: Thsd3, LOC217738
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 217738
Homologene: 83509
Efhc1
Name: EF-hand domain (C-terminal) containing 1
Synonyms: myoclonin1, mRib72-1, 1700029F22Rik
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 71877
Homologene: 10003
Tpgs2
Name: tubulin polyglutamylase complex subunit 2
Synonyms: 5730494M16Rik, 5730437P09Rik
Type: Gene
Species: Mouse
Chromosome: 18
NCBI: 66648
Homologene: 9161
Capn7
Name: calpain 7
Synonyms: PalBH
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 12339
HGNC: HGNC:1484
Homologene: 7651
Rin2
Name: Ras and Rab interactor 2
Synonyms: 4632403N06Rik, 2010003K16Rik, RASSF4
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 74030
Homologene: 32430
Vwf
Name: Von Willebrand factor
Synonyms: 6820430P06Rik, B130011O06Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 22371
Homologene: 466
Prph2
Name: peripherin 2
Synonyms: rds, Nmf193, Tspan22, Rd2
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 19133
HGNC: HGNC:9942
Homologene: 273
Odf4
Name: outer dense fiber of sperm tails 4
Synonyms: Oppo1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 252868
Homologene: 17099
Vwa8
Name: von Willebrand factor A domain containing 8
Synonyms: 1300010F03Rik, 4932416F07Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 219189
VEGA: 14
Homologene: 44881
Micalcl
Name: MICAL C-terminal like
Synonyms: 4921517J23Rik, Ebitein1
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 100504195
Homologene: 13149
Mybpc2
Name: myosin binding protein C, fast-type
Synonyms: Fast-type C-protein
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 233199
HGNC: HGNC:7550
Homologene: 3331
Speg
Name: SPEG complex locus
Synonyms: SPEGalpha, SPEGbeta, D1Bwg1450e, SPEG, Apeg1, BPEG
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 11790
Homologene: 55619
Atp6v0a2
Name: ATPase, H+ transporting, lysosomal V0 subunit A2
Synonyms: TJ6s, V-ATPase a2, Tj6, 8430408C20Rik, ATP6a2, Atp6n2
Type: Gene
Species: Mouse
Chromosome: 5
NCBI: 21871
Homologene: 56523
Hic1
Name: hypermethylated in cancer 1
Synonyms: HIC-1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 15248
HGNC: HGNC:4909
Homologene: 4740
Vmn2r120
Name: vomeronasal 2, receptor 120
Synonyms: EG224916
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 224916
Togaram2
Name: TOG array regulator of axonemal microtubules 2
Synonyms: Fam179a, 4632412N22Rik
Type: Gene
Species: Mouse
Chromosome: 17
NCBI: 320159
Homologene: 65315
Arhgap40
Name: Rho GTPase activating protein 40
Synonyms: Gm14203
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 545481
Homologene: 53500
Map3k21
Name: mitogen-activated protein kinase kinase kinase 21
Synonyms: BC021891
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 234878
Homologene: 32778
Ica1l
Name: islet cell autoantigen 1-like
Synonyms: Als2cr15, 1700030B17Rik, b2b3465Clo
Type: Gene
Species: Mouse
Chromosome: 1
NCBI: 70375
Homologene: 16323
Ttll3
Name: tubulin tyrosine ligase-like family, member 3
Synonyms: 4833441J24Rik
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 101100
Homologene: 134361
Or6c5c
Name: olfactory receptor family 6 subfamily C member 5C
Synonyms: MOR111-10, GA_x6K02T2PULF-11141498-11142436, Olfr787
Type: Gene
Species: Mouse
Chromosome: 10
NCBI: 258069
Homologene: 105326
Ovch2
Name: ovochymase 2
Synonyms: 9230106D23Rik
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 244199
Homologene: 18255
Plau
Name: plasminogen activator, urokinase
Synonyms: urokinase-type plasminogen activator, u-PA, uPA
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 18792
VEGA: 14
HGNC: HGNC:9052
Homologene: 55670
Zfp874b
Name: zinc finger protein 874b
Synonyms: 9630025I21Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 408067
Homologene: 135597
Mrps15
Name: mitochondrial ribosomal protein S15
Synonyms: 1500003E24Rik
Type: Gene
Species: Mouse
Chromosome: 4
NCBI: 66407
Homologene: 32636
Cyp2f2
Name: cytochrome P450, family 2, subfamily f, polypeptide 2
Synonyms: Cyp2f
Type: Gene
Species: Mouse
Chromosome: 7
NCBI: 13107
Homologene: 73898
Apol7a
Name: apolipoprotein L 7a
Synonyms: Apol3, 9130022K13Rik
Type: Gene
Species: Mouse
Chromosome: 15
NCBI: 75761
HGNC: HGNC:619
Homologene: 40940
Klhdc2
Name: kelch domain containing 2
Synonyms: 2310022K15Rik, D12Ertd522e, HCLP-1
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 69554
Homologene: 8631
Ighg3
Name: Immunoglobulin heavy constant gamma 3
Synonyms: AI324046, IgG3
Type: Gene
Species: Mouse
Chromosome: 12
NCBI: 380795
Bbs2
Name: Bardet-Biedl syndrome 2
Synonyms: 2410125H22Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 67378
HGNC: HGNC:967
Homologene: 12122
Cysltr2
Name: cysteinyl leukotriene receptor 2
Synonyms: Cyslt2, CysLT2, CYSLT2R, 2300001H05Rik
Type: Gene
Species: Mouse
Chromosome: 14
NCBI: 70086
VEGA: 14
Homologene: 10688
Pax8
Name: paired box 8
Synonyms: Pax-8
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 18510
HGNC: HGNC:8622
Homologene: 2589
Thoc3
Name: THO complex 3
Synonyms: 2410044K02Rik
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 73666
Homologene: 12505
Rapgefl1
Name: Rap guanine nucleotide exchange factor (GEF)-like 1
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 268480
Homologene: 41126
Asb5
Name: ankyrin repeat and SOCs box-containing 5
Synonyms: 1110018D09Rik
Type: Gene
Species: Mouse
Chromosome: 8
NCBI: 76294
Homologene: 12637
Spata31d1b
Name: spermatogenesis associated 31 subfamily D, member 1B
Synonyms: Fam75d1b, Gm4934
Type: Gene
Species: Mouse
Chromosome: 13
NCBI: 238662
VEGA: 13
Gm8297
Name: predicted gene 8297
Type: Gene
Species: Mouse
Chromosome: 14
Homologene: 115686
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • G to A, chromosome 1 at 19,234,307 bp
  • A to T, chromosome 1 at 20,979,461 bp
  • T to G, chromosome 1 at 60,007,870 bp
  • T to A, chromosome 1 at 75,384,017 bp
  • T to C, chromosome 1 at 78,469,299 bp
  • A to G, chromosome 2 at 24,435,901 bp
  • C to T, chromosome 2 at 53,073,680 bp
  • T to A, chromosome 2 at 69,501,539 bp
  • T to G, chromosome 2 at 118,626,967 bp
  • T to A, chromosome 2 at 145,861,117 bp
  • A to T, chromosome 2 at 158,534,746 bp
  • C to T, chromosome 4 at 46,637,746 bp
  • A to T, chromosome 4 at 126,051,377 bp
  • T to A, chromosome 5 at 76,154,771 bp
  • A to G, chromosome 5 at 124,641,505 bp
  • CAAAGTAA to CAAAGTAAAGTAA, chromosome 6 at 113,399,157 bp
  • A to G, chromosome 6 at 125,658,815 bp
  • G to A, chromosome 7 at 27,129,253 bp
  • G to A, chromosome 7 at 44,504,860 bp
  • G to T, chromosome 7 at 79,145,387 bp
  • CG to CGACGGCGGGG, chromosome 7 at 97,579,908 bp
  • A to G, chromosome 7 at 107,789,088 bp
  • T to A, chromosome 7 at 112,407,637 bp
  • A to G, chromosome 8 at 11,561,814 bp
  • T to C, chromosome 8 at 27,407,364 bp
  • G to T, chromosome 8 at 46,586,424 bp
  • A to C, chromosome 8 at 54,584,792 bp
  • A to T, chromosome 8 at 94,089,760 bp
  • A to T, chromosome 8 at 95,716,238 bp
  • C to G, chromosome 8 at 125,910,963 bp
  • T to A, chromosome 9 at 59,860,109 bp
  • G to A, chromosome 10 at 12,486,610 bp
  • A to G, chromosome 10 at 39,142,298 bp
  • A to G, chromosome 10 at 129,462,796 bp
  • T to G, chromosome 11 at 49,824,441 bp
  • A to T, chromosome 11 at 68,922,072 bp
  • C to T, chromosome 11 at 75,166,216 bp
  • T to C, chromosome 11 at 77,974,549 bp
  • A to G, chromosome 11 at 98,851,154 bp
  • A to G, chromosome 12 at 69,307,228 bp
  • A to C, chromosome 12 at 87,279,860 bp
  • A to T, chromosome 12 at 113,359,806 bp
  • A to C, chromosome 13 at 54,463,778 bp
  • A to T, chromosome 13 at 59,717,233 bp
  • A to G, chromosome 13 at 67,473,974 bp
  • T to C, chromosome 13 at 89,688,654 bp
  • A to G, chromosome 14 at 4,986,951 bp
  • A to G, chromosome 14 at 20,842,325 bp
  • A to G, chromosome 14 at 31,352,410 bp
  • A to G, chromosome 14 at 73,029,763 bp
  • T to C, chromosome 14 at 79,038,147 bp
  • A to T, chromosome 15 at 37,991,322 bp
  • T to C, chromosome 15 at 77,389,075 bp
  • T to C, chromosome 16 at 91,656,528 bp
  • G to T, chromosome 17 at 12,464,463 bp
  • T to A, chromosome 17 at 23,681,607 bp
  • T to C, chromosome 17 at 46,910,806 bp
  • T to C, chromosome 17 at 57,525,942 bp
  • T to C, chromosome 17 at 66,130,548 bp
  • T to A, chromosome 17 at 67,804,473 bp
  • T to A, chromosome 17 at 71,704,751 bp
  • G to T, chromosome 18 at 25,129,865 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.
Suggested Control Mice
Wild-type littermates or C57BL/6J mice
MMRRC Genetic QC Summary
The MMRRC Centers have developed a genetic QC pipeline using MiniMUGA array genotyping to provide additional information on strain backgrounds for MMRRC congenic and inbred strains. For more information on when data may be available, or to request genotyping for a strain of interest, please contact mmrrc@missouri.edu. Older strains may not have this information.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7824 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Request Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045878-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.