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Strain Name:
C57BL/6J-MtgxR7837Btlr/Mmmh
Stock Number:
045891-MU
Citation ID:
RRID:MMRRC_045891-MU
Other Names:
R7837 (G1)
Major Collection:

Strain Information

Sptbn1
Name: spectrin beta, non-erythrocytic 1
Synonyms: beta fodrin, Spnb-2, spectrin G, brain spectrin, elf3, elf1, 9930031C03Rik, non-erythrocytic, Spnb2
Type: Gene
Species: Mouse
Chromosome: 11
NCBI: 20742
Homologene: 2354
Gria2
Name: glutamate receptor, ionotropic, AMPA2 (alpha 2)
Synonyms: GluR-B, GluR2, Glur-2, Glur2, GluA2
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 14800
HGNC: HGNC:4572
Homologene: 20225
Cemip2
Name: cell migration inducing hyaluronidase 2
Synonyms: 3110012M15Rik, Tmem2
Type: Gene
Species: Mouse
Chromosome: 19
NCBI: 83921
VEGA: 19
Homologene: 75008
Mbd4
Name: methyl-CpG binding domain protein 4
Synonyms: Med1
Type: Gene
Species: Mouse
Chromosome: 6
NCBI: 17193
HGNC: HGNC:6919
Homologene: 2916
Zbtb43
Name: zinc finger and BTB domain containing 43
Synonyms: 1700010E06Rik, Zfp297b
Type: Gene
Species: Mouse
Chromosome: 2
NCBI: 71834
Homologene: 8514
Armc1
Name: armadillo repeat containing 1
Synonyms: 2900046P06Rik, C330014L16Rik, 2310016N05Rik, 3110009G21Rik, Arcp
Type: Gene
Species: Mouse
Chromosome: 3
NCBI: 74252
Homologene: 10015
Septin7
Name: septin 7
Synonyms: Cdc10, Sept7
Type: Gene
Species: Mouse
Chromosome: 9
NCBI: 235072
VEGA: 9
HGNC: HGNC:1717
Homologene: 1354
Genetic Alterations
ENU-induced transitions at the following base pair locations (GRCm38):
  • T to A, chromosome 1 at 17,728,730 bp
  • T to C, chromosome 1 at 25,128,834 bp
  • A to T, chromosome 1 at 74,681,757 bp
  • A to G, chromosome 1 at 92,907,683 bp
  • A to C, chromosome 1 at 106,543,356 bp
  • C to T, chromosome 1 at 161,992,050 bp
  • G to A, chromosome 1 at 164,186,794 bp
  • A to T, chromosome 2 at 30,091,697 bp
  • C to T, chromosome 2 at 33,453,969 bp
  • A to T, chromosome 2 at 88,592,379 bp
  • A to G, chromosome 2 at 120,703,665 bp
  • A to G, chromosome 2 at 163,003,296 bp
  • A to T, chromosome 3 at 19,144,469 bp
  • A to T, chromosome 3 at 80,710,788 bp
  • A to T, chromosome 4 at 49,586,262 bp
  • A to G, chromosome 4 at 57,855,262 bp
  • C to T, chromosome 4 at 139,393,151 bp
  • T to C, chromosome 4 at 144,617,977 bp
  • T to A, chromosome 5 at 8,149,284 bp
  • A to G, chromosome 5 at 35,611,486 bp
  • T to A, chromosome 5 at 52,859,208 bp
  • G to T, chromosome 5 at 113,572,333 bp
  • T to A, chromosome 6 at 48,905,650 bp
  • C to T, chromosome 6 at 68,939,809 bp
  • A to T, chromosome 6 at 83,261,557 bp
  • T to C, chromosome 6 at 115,849,539 bp
  • GAAA to GAAAAA, chromosome 7 at 27,854,917 bp
  • A to T, chromosome 7 at 47,335,328 bp
  • A to T, chromosome 7 at 103,506,845 bp
  • T to C, chromosome 7 at 140,419,321 bp
  • A to G, chromosome 7 at 141,815,963 bp
  • C to T, chromosome 7 at 142,273,816 bp
  • A to T, chromosome 8 at 35,808,980 bp
  • C to T, chromosome 8 at 39,581,832 bp
  • T to C, chromosome 8 at 126,474,561 bp
  • T to A, chromosome 9 at 25,288,235 bp
  • T to C, chromosome 9 at 62,849,048 bp
  • T to A, chromosome 9 at 92,484,923 bp
  • A to G, chromosome 11 at 30,138,832 bp
  • C to A, chromosome 11 at 106,033,810 bp
  • C to A, chromosome 12 at 72,556,118 bp
  • A to G, chromosome 12 at 102,368,765 bp
  • T to A, chromosome 13 at 21,520,428 bp
  • A to T, chromosome 13 at 34,944,376 bp
  • A to T, chromosome 13 at 38,022,405 bp
  • A to T, chromosome 14 at 20,333,332 bp
  • A to G, chromosome 14 at 26,796,219 bp
  • C to A, chromosome 14 at 31,666,827 bp
  • T to C, chromosome 14 at 32,346,458 bp
  • T to A, chromosome 14 at 50,034,576 bp
  • T to C, chromosome 14 at 56,558,728 bp
  • T to C, chromosome 15 at 101,548,357 bp
  • T to C, chromosome 16 at 17,898,751 bp
  • T to A, chromosome 16 at 35,931,526 bp
  • T to C, chromosome 16 at 38,253,784 bp
  • A to T, chromosome 17 at 21,992,365 bp
  • G to A, chromosome 17 at 87,984,666 bp
  • T to A, chromosome 19 at 21,798,021 bp
Phenotype
G1 male heterozygous mice are viable and fertile. The G1 mice were not characterized prior to archiving.
Strain GQC Summary
Gene Specific Genotyping:

To request gene-specific and other genotyping services for a strain, please contact the distribution MMRRC Center for more information.

Background Genetic Quality:

The MMRRC has developed a Genetic Quality Control pipeline using the MiniMUGA array to provide additional information to identify and validate genetic backgrounds of MMRRC strains. For more information on whether genetic background data is available, please contact MMRRC_GeneticQC@med.unc.edu. Note: that MiniMUGA genetic background data is not available on all strains, but can be ordered if desired.

Suggested Control Mice
Littermates of all relevant genotypes.
Donor
Bruce Beutler, M.D., University of Texas Southwestern Medical Center.
Primary Reference
MUTAGENETIX record for R7837 (G1). B. Beutler and colleagues, Center for the Genetics of Host Defense, UT Southwestern, Dallas, TX.
Strain Development
C57BL/6J mice were injected with ENU, resulting in G0 mice that were bred back to C57BL/6J. Sperm was archived from G1 male mice that produced viable G2 mice.


Disclaimer: If MMRRC Strain Genetic Quality Control (GQC; based on MiniMUGA genotyping and analysis) has been completed for this strain, the information might differ from the genetic background information provided by the submitter. MiniMUGA genetic analysis is done on a strain’s tissue samples taken when archived by or ordered from the assigned MMRRC Center.

Colony and Husbandry Information

Colony Surveillance Program and Current Health Reports

Mice recovered from a cryo-archive will have health surveillance performed on recipient females. Health reports will be provided prior to shipment. If you require additional health status information, please email mmrrc@missouri.edu.
Coat Color
Black
MMRRC Breeding System
Random intra-strain mating
Breeding Scheme(s)
When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J inbred mice.
Overall Breeding Performance
Undetermined; during development, mating was done with heterozygous males; viability, fertility and other breeding statistics for heterozygous females and homozygotes are unverified, but presumably would be similar to the C57BL/6J background strain
Average litter size
Undetermined
Recommended wean age
3 weeks

Order Information

Limited quantities of breeder mice (recovered litter) are available from a cryoarchive; recovered litter usually available to ship in 3 to 4 months.

Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

Distribution of this strain requires submission of the MMRRC Conditions of Use (COU). A link to the COU web form will be provided via email after an order has been placed; the form should be completed then or the email forwarded to your institutional official for completion.

The donor or their institution limits the distribution to non-profit institutions only.

Additional charges may apply for any special requests. Shipping costs are in addition to the basic distribution/resuscitation fees. Information on shipping costs and any additional charges will be provided by the supplying MMRRC facility.

Click button to Request this one strain. (Use the MMRRC Catalog Search to request more than one strain.)
MMRRC Item # Description Distribution Fee / Unit (US $)
*Shipping & Handling not included*
Units Notes
045891-MU-RESUS Litter recovered from cryo-archive $5,475.00 / Non-Profit Litter Recovered litter4; additional fees for any special requests.
Cryopreserved material may be available upon request, please inquire to mmrrc@missouri.edu for more information.

1 The distribution fee covers the expense of rederiving mice from a live mouse; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

2 An aliquot contains a sufficient number of embryos (in one or more vials or straws and based on the transfer success rate of the MMRRC facility) to transfer into one to three recipients. The MMRRC makes no guarantee concerning embryo transfer success experienced in the recipient investigator's laboratory. Neither gender nor genotype ratios are guaranteed.

3 An aliquot is one straw or vial with sufficient sperm to recover at least one litter of mice, as per provided protocols, when performed at the MMRRC facility. The MMRRC makes no guarantee concerning the success of these procedures when performed outside the MMRRC facilities.

4 The distribution fee covers the expense of resuscitating mice from the cryo-archive; you will receive the resulting litter. The litter will contain at minimum one mutant carrier; the actual number of animals and the gender and genotype ratios will vary. (Typically, multiple breeder pairs can be established from the recovered litter.) Prior to shipment, the MMRRC will provide information about the animals recovered. If you anticipate or find that you need to request specific genotypes, genders or quantities of mice in excess of what is likely from a resuscitated litter, you may discuss available options and pricing with the supplying MMRRC facility.

To request material from the MMRRC: Please fill out our on-line request form (accessible from the catalog search results page, or click the Request this Strain button in the fees section). If you have questions or need assistance completing this form, you may call Customer Service at (800) 910-2291 (in USA or Canada) or (530) 757-5710 (international calls). Before you call, please have with you: the MMRRC item number, quantity needed, Bill-to and Ship-to contact information.